Cited by 311Vitamin D Research StudiesBalance, Gait, and Falls PreventionBone health and osteoporosis research

Vitamin D status in relation to one-year risk of recurrent falling in older men and women

Open access
Snijder, Marieke B., van Schoor, Natasja M., Pluijm, Saskia M. F., van Dam, Rob M., Visser, Marjolein, Lips, Paul·2006·The Journal of Clinical Endocrinology & Metabolism

Abstract

BACKGROUND: Falls frequently occur in the elderly and are a major cause of morbidity and mortality. OBJECTIVE: The objective of the study was to prospectively investigate the association between serum 25-hydroxyvitamin D [25(OH)D] levels and risk of recurrent falling in older men and women. DESIGN: This was a prospective cohort study. SETTING: An age- and sex-stratified random sample of the Dutch older population was determined. SUBJECTS: Subjects included 1231 men and women (aged 65 yr and older) participating in the Longitudinal Aging Study Amsterdam. MEASUREMENTS: Baseline serum 25(OH)D was determined by a competitive protein binding assay. During 1 yr, falls were prospectively recorded by means of a fall calendar. RESULTS: Low 25(OH)D (<10 ng/ml) was associated with an increased risk of falling. After adjustment for age, sex, education level, region, season, physical activity, smoking, and alcohol intake, the odds ratios (95% confidence interval) were 1.78 (1.06-2.99) for subjects who experienced two falls or more as compared with those who did not fall or fell once and 2.23 (1.17-4.25) for subjects who fell three or more times as compared with those who fell two times or less. There was a statistically significant effect modification by age, and stratified analyses (<75 and > or = 75 yr) showed that the associations were particularly strong in the younger age group; the odds ratios (95% confidence interval) were 5.21 (2.03-13.40) for two falls or more and 4.96 (1.52-16.23) for three falls or more. CONCLUSIONS: Poor vitamin D status is independently associated with an increased risk of falling in the elderly, particularly in those aged 65-75 yr.

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Crossref · 10.1210/jc.2006-0510

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Authors
Snijder, M. B., van Schoor, N. M., Pluijm, S. M. F., van Dam, R. M., Visser, M., & Lips, P.
Affiliations
  • Vrije Universiteit Amsterdam (NL)
  • Erasmus MC (NL)
  • Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
Venue
The Journal of Clinical Endocrinology & Metabolism
Published
2006-08
Volume
91
Issue
8
Pages
2980-2985
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
OpenAlex
W1997618964
Cited by
311
References
31
Citations by year
2026: 2 · 2025: 4 · 2024: 6 · 2023: 12 · 2022: 8 · 2021: 10 · 2020: 36 · 2019: 12 · 2018: 15 · 2017: 21 · 2016: 17 · 2015: 28 · 2014: 31 · 2013: 20 · 2012: 17
FWCI
8.81
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Pure Amsterdam UMC (publishedVersion, other-oa)
  • Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion, other-oa)
  • VU Research Portal (publishedVersion)
  • RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
  • Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Balance, Gait, and Falls Prevention
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Keywords
vitamin D status, 25-hydroxyvitamin D, falls, recurrent falls, older adults, fall risk, vitamin D deficiency, age effect modification, Longitudinal Aging Study Amsterdam
MeSH terms
Accidental Falls, Age Factors, Aged, Aging, Calcifediol, Female, Humans, Male, Netherlands, Nutritional Status, Prospective Studies, Recurrence, Risk Factors, Seasons, Odds Ratio

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