Vitamin D status in relation to one-year risk of recurrent falling in older men and women
Open accessAbstract
BACKGROUND: Falls frequently occur in the elderly and are a major cause of morbidity and mortality. OBJECTIVE: The objective of the study was to prospectively investigate the association between serum 25-hydroxyvitamin D [25(OH)D] levels and risk of recurrent falling in older men and women. DESIGN: This was a prospective cohort study. SETTING: An age- and sex-stratified random sample of the Dutch older population was determined. SUBJECTS: Subjects included 1231 men and women (aged 65 yr and older) participating in the Longitudinal Aging Study Amsterdam. MEASUREMENTS: Baseline serum 25(OH)D was determined by a competitive protein binding assay. During 1 yr, falls were prospectively recorded by means of a fall calendar. RESULTS: Low 25(OH)D (<10 ng/ml) was associated with an increased risk of falling. After adjustment for age, sex, education level, region, season, physical activity, smoking, and alcohol intake, the odds ratios (95% confidence interval) were 1.78 (1.06-2.99) for subjects who experienced two falls or more as compared with those who did not fall or fell once and 2.23 (1.17-4.25) for subjects who fell three or more times as compared with those who fell two times or less. There was a statistically significant effect modification by age, and stratified analyses (<75 and > or = 75 yr) showed that the associations were particularly strong in the younger age group; the odds ratios (95% confidence interval) were 5.21 (2.03-13.40) for two falls or more and 4.96 (1.52-16.23) for three falls or more. CONCLUSIONS: Poor vitamin D status is independently associated with an increased risk of falling in the elderly, particularly in those aged 65-75 yr.
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- Authors
- Snijder, M. B., van Schoor, N. M., Pluijm, S. M. F., van Dam, R. M., Visser, M., & Lips, P.
- Affiliations
- Vrije Universiteit Amsterdam (NL)
- Erasmus MC (NL)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2006-08
- Volume
- 91
- Issue
- 8
- Pages
- 2980-2985
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W1997618964
- Cited by
- 311
- References
- 31
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 6 · 2023: 12 · 2022: 8 · 2021: 10 · 2020: 36 · 2019: 12 · 2018: 15 · 2017: 21 · 2016: 17 · 2015: 28 · 2014: 31 · 2013: 20 · 2012: 17
- FWCI
- 8.81
- Type
- journal article
- Language
- en
- Open access
- green
- pure.amsterdamumc.nl
- Licence
- other-oa
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion, other-oa)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion, other-oa)
- VU Research Portal (publishedVersion)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Balance, Gait, and Falls Prevention
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Keywords
- vitamin D status, 25-hydroxyvitamin D, falls, recurrent falls, older adults, fall risk, vitamin D deficiency, age effect modification, Longitudinal Aging Study Amsterdam
- MeSH terms
- Accidental Falls, Age Factors, Aged, Aging, Calcifediol, Female, Humans, Male, Netherlands, Nutritional Status, Prospective Studies, Recurrence, Risk Factors, Seasons, Odds Ratio
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