Neuroendocrine Phenotype Analysis in Five Patients with Isolated Hypogonadotropic Hypogonadism due to a L102P Inactivating Mutation of GPR54

The <i>GPR54</i> Gene as a Regulator of Puberty

Seminara, S. B., Messager, S., Chatzidaki, E. E., Thresher, R. R., Acierno, J. S., Shagoury, J. K., Bo-Abbas, Y., Kuohung, W., Schwinof, K. M., Hendrick, A. G., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa035322 · Cited by 2,557 · see citing works

Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54

de Roux, N., Genin, E., Carel, J.-C., Matsuda, F., Chaussain, J.-L., & Milgrom, E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1834399100 · Cited by 2,431 · see citing works

The Metastasis Suppressor Gene KiSS-1 Encodes Kisspeptins, the Natural Ligands of the Orphan G Protein-coupled Receptor GPR54

Kotani, M., Detheux, M., Vandenbogaerde, A., Communi, D., Vanderwinden, J.-M., Le Poul, E., Brézillon, S., Tyldesley, R., Suarez-Huerta, N., Vandeput, F., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104847200 · Cited by 1,546 · see citing works

Uncovering Molecular Mechanisms Involved in Activation of G Protein-Coupled Receptors

Gether, U. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.1.0390 · Cited by 1,264 · see citing works

Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54

Messager, S., Chatzidaki, E. E., Ma, D., Hendrick, A. G., Zahn, D., Dixon, J., Thresher, R. R., Malinge, I., Lomet, D., Carlton, M. B. L., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409330102 · Cited by 1,215 · see citing works

A role for kisspeptins in the regulation of gonadotropin secretion in the mouse

Gottsch, M. L., Cunningham, M. J., Smith, J. T., Popa, S. M., Acohido, B. V., Crowley, W. F., Seminara, S., Clifton, D. K., & Steiner, R. A. (2004) · Endocrinology · doi:10.1210/en.2004-0431 · Cited by 1,161 · see citing works

Increased hypothalamic GPR54 signaling: A potential mechanism for initiation of puberty in primates

Shahab, M., Mastronardi, C. A., Seminara, S. B., Crowley, W. F., Ojeda, S. R., & Plant, T. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409822102 · Cited by 875 · see citing works

Cluster analysis: a simple, versatile, and robust algorithm for endocrine pulse detection

Veldhuis, J. D., & Johnson, M. L. (1986) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1986.250.4.e486 · Cited by 855 · see citing works

Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males

Dhillo, W. S., Chaudhri, O. B., Patterson, M., Thompson, E. L., Murphy, K. G., Badman, M. K., McGowan, B. M., Amber, V., Patel, S., Ghatei, M. A., et al. (2005) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2005-1468 · Cited by 656 · see citing works

Peripheral administration of metastin induces marked gonadotropin release and ovulation in the rat

Matsui, H., Takatsu, Y., Kumano, S., Matsumoto, H., & Ohtaki, T. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.05.185 · Cited by 520 · see citing works

A Family with Hypogonadotropic Hypogonadism and Mutations in the Gonadotropin-Releasing Hormone Receptor

de Roux, N., Young, J., Misrahi, M., Genet, R., Chanson, P., Schaison, G., & Milgrom, E. (1997) · New England Journal of Medicine · doi:10.1056/nejm199711273372205 · Cited by 518 · see citing works

Characterization of the physiological pattern of episodic gonadotropin secretion throughout the human menstrual cycle

FILICORI, M., SANTORO, N., MERRIAM, G. R., & CROWLEY, W. F. (1986) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jcem-62-6-1136 · Cited by 489 · see citing works

Central and Peripheral Administration of Kisspeptin‐10 Stimulates the Hypothalamic‐Pituitary‐Gonadal Axis

Thompson, E. L., Patterson, M., Murphy, K. G., Smith, K. L., Dhillo, W. S., Todd, J. F., Ghatei, M. A., & Bloom, S. R. (2004) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2004.01240.x · Cited by 482 · see citing works

Advanced vaginal opening and precocious activation of the reproductive axis by KiSS‐1 peptide, the endogenous ligand of GPR54

Navarro, V. M., Fernández‐Fernández, R., Castellano, J. M., Roa, J., Mayen, A., Barreiro, M. L., Gaytán, F., Aguilar, E., Pinilla, L., Diéguez, C., et al. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.072298 · Cited by 466 · see citing works

Characterization of the potent luteinizing hormone-releasing activity of KiSS-1 peptide, the natural ligand of GPR54

Navarro, V. M., Castellano, J. M., Fernández-Fernández, R., Tovar, S., Roa, J., Mayen, A., Nogueiras, R., Vazquez, M. J., Barreiro, M. L., Magni, P., et al. (2005) · Endocrinology · doi:10.1210/en.2004-0836 · Cited by 449 · see citing works

Effects of KiSS-1 Peptide, the Natural Ligand of GPR54, on Follicle-Stimulating Hormone Secretion in the Rat

Navarro, V. M., Castellano, J. M., Fernández-Fernández, R., Tovar, S. A., Roa, J., Mayen, A., Barreiro, M. L., Casanueva, F. F., Aguilar, E., Diéguez, C., et al. (2005) · Endocrinology · doi:10.1210/en.2004-1353 · Cited by 307 · see citing works

Two Novel Missense Mutations in G Protein-Coupled Receptor 54 in a Patient with Hypogonadotropic Hypogonadism

Semple, R. K., Achermann, J. C., Ellery, J., Farooqi, I. S., Karet, F. E., Stanhope, R. G., O’Rahilly, S., & Aparicio, S. A. (2005) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2004-1418 · Cited by 291 · see citing works

Generation and synchronization of gonadotropin-releasing hormone (GnRH) pulses: intrinsic properties of the GT1-1 GnRH neuronal cell line.

de la Escalera, G. M., Choi, A. L. H., & Weiner, R. I. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.5.1852 · Cited by 265 · see citing works

Prevalence, Phenotypic Spectrum, and Modes of Inheritance of Gonadotropin-Releasing Hormone Receptor Mutations in Idiopathic Hypogonadotropic Hypogonadism

Beranova, M., Oliveira, L. M. B., Bédécarrats, G. Y., Schipani, E., Vallejo, M., Ammini, A. C., Quintos, J. B., Hall, J. E., Martin, K. A., Hayes, F. J., et al. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.4.7395 · Cited by 251 · see citing works

Gonadotropin Secretory Dynamics During Puberty in Normal Girls and Boys

Oerter, K. E., Uriarte, M., Rose, S. R., Barnes, K. M., & Cutler, G. B. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-71-5-1251 · Cited by 247 · see citing works

Neurobiological mechanisms of puberty in higher primates

Plant, T. M. (2004) · Human Reproduction Update · doi:10.1093/humupd/dmh001 · Cited by 187 · see citing works

Pulsatile Release of Luteinizing Hormone-Releasing Hormone (LHRH) in Cultured LHRH Neurons Derived from the Embryonic Olfactory Placode of the Rhesus Monkey

Terasawa, E., Keen, K. L., Mogi, K., & Claude, P. (1999) · Endocrinology · doi:10.1210/endo.140.3.6559 · Cited by 171 · see citing works

Mechanisms underlying episodic gonadotropin-releasing hormone secretion.

Moenter, S., DeFazio, A., Pitts, G. R., & Nunemaker, C. S. (2003) · Frontiers in neuroendocrinology (Print) · doi:10.1016/s0091-3022(03)00013-x · Cited by 152 · see citing works

The Same Molecular Defects of the Gonadotropin-Releasing Hormone Receptor Determine a Variable Degree of Hypogonadism in Affected Kindred1

de Roux, N., Young, J., Brailly‐Tabard, S., Misrahi, M., Milgröm, E., & SCHAISON, G. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.2.5449 · Cited by 144 · see citing works

Role of sequence variations of the GnRH receptor and G protein-coupled receptor 54 gene in male idiopathic hypogonadotropic hypogonadism

Lanfranco, F., Gromoll, J., von Eckardstein, S., Herding, E. M., Nieschlag, E., & Simoni, M. (2005) · European Journal of Endocrinology · doi:10.1530/eje.1.02031 · Cited by 126 · see citing works

The Same Molecular Defects of the Gonadotropin-Releasing Hormone Receptor Determine a Variable Degree of Hypogonadism in Affected Kindred

de Roux, N. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.2.567 · Cited by 120 · see citing works

Treatment of Central Precocious Puberty by Subcutaneous Injections of Leuprorelin 3-Month Depot (11.25 mg)

Carel, J., Lahlou, N., Jaramillo, O., Montauban, V., Teinturier, C., Colle, M., Lucas, C., T. F. L. T. G., & Chaussain, J. L. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2001-020243 · Cited by 107 · see citing works

The midcycle gonadotropin surge in normal women occurs in the face of an unchanging gonadotropin-releasing hormone pulse frequency

Adams, J. M., Taylor, A. E., Schoenfeld, D., Crowley, W. F., & Hall, J. E. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.3.7521353 · Cited by 91 · see citing works

Hypothalamic Regulation of Cyclic Ovulation: Evidence That the Increase in Gonadotropin-Releasing Hormone Pulse Frequency during the Follicular Phase Reflects the Gradual Loss of the Restraining Effects of Progesterone

McCartney, C. R., Gingrich, M. B., Hu, Y. F., Evans, W. S., & Marshall, J. C. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.5.8484 · Cited by 77 · see citing works

New Gatekeepers of Reproduction: GPR54 and Its Cognate Ligand, KiSS-1

Seminara, S. B., & Kaiser, U. B. (2005) · Endocrinology · doi:10.1210/en.2005-0070 · Cited by 63 · see citing works

Pulsatile Gonadotropin-Releasing Hormone (GnRH) Secretion Is an Inherent Function of GnRH Neurons, as Revealed by the Culture of Medial Olfactory Placode Obtained from Embryonic Rats

Funabashi, T., Daikoku, S., Shinohara, K., & Kimura, F. (2000) · Neuroendocrinology · doi:10.1159/000054529 · Cited by 59 · see citing works

Clinical and molecular genetics of the human GnRH receptor

Karges, B., Karges, W., & de Roux, N. (2003) · Human Reproduction Update · doi:10.1093/humupd/dmg040 · Cited by 50 · see citing works

Gonadotropin-Releasing Hormone-Induced Stimulation and Desensitization of Free α-Subunit Secretion Mirrors Luteinizing Hormone and Follicle-Stimulating Hormone in Perifused Rat Pituitary Cells

Weiss, J., Duca, K., & Crowley, W. F. (1990) · Endocrinology · doi:10.1210/endo-127-5-2364 · Cited by 40 · see citing works

Pulsatile Secretion of Immunoreactive a-Subunit in Man*

Winters, S. J., & Troen, P. (1985) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-60-2-344 · Cited by 40 · see citing works

Pulsatile GnRH secretion from primary cultures of sheep olfactory placode explants

Duittoz, A. H., & Batailler, M. (2000) · Reproduction · doi:10.1530/reprod/120.2.391 · Cited by 39 · see citing works

Endocrinology: Effect of mifepristone (RU486) on the pituitary response to gonadotrophin releasing hormone in women

Kazem, R., Messinis, L. E., Fowler, P., Groome, N. P., Knight, P. G., & Templeton, A. (1996) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a019174 · Cited by 27 · see citing works

Pulsatile GnRH secretion from primary cultures of sheep olfactory placode explants

Duittoz, A. H., & Batailler, M. (2000) · Reproduction · doi:10.1530/jrf.0.1200391 · Cited by 25 · see citing works

Short-term regulation of LH and FSH secretion in cyclic women. III. Effects of varying doses of two consecutive LH-RH injections on pituitary and ovarian response.

Römmler, A., Viebahn, C., Schwartz, U., & Hammerstein, J. (1979) · PubMed · Cited by 3 · see citing works

SHORT-TERM REGULATION OF LH AND FSH SECRETION IN CYCLIC WOMEN

Römmler, A., Viebahn, C., Schwartz, U., & Hammerstein, J. (1979) · European Journal of Endocrinology · doi:10.1530/acta.0.0900394 · Cited by 3 · see citing works

Kisspeptin Signaling in the Brain

Oakley, A. E., Clifton, D. K., & Steiner, R. A. (2009) · Endocrine Reviews · doi:10.1210/er.2009-0005 · Cited by 842 · see citing works

Kisspeptins and Reproduction: Physiological Roles and Regulatory Mechanisms

Pinilla, L., Aguilar, E., Diéguez, C., Millar, R. P., & Tena‐Sempere, M. (2012) · Physiological Reviews · doi:10.1152/physrev.00037.2010 · Cited by 802 · see citing works

A <i>GPR54</i> -Activating Mutation in a Patient with Central Precocious Puberty

Teles, M. G., Bianco, S. D. C., Brito, V. N., Trarbach, E. B., Kuohung, W., Xu, S., Seminara, S. B., Mendonca, B. B., Kaiser, U. B., & Latronico, A. C. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa073443 · Cited by 572 · see citing works

Kiss1 −/− Mice Exhibit More Variable Hypogonadism than Gpr54−/− Mice

Lapatto, R., Pallais, J. C., Zhang, D., Chan, Y.-M., Mahan, A., Cerrato, F. E., Le, W. W., Hoffman, G. E., & Seminara, S. B. (2007) · Endocrinology · doi:10.1210/en.2007-0078 · Cited by 533 · see citing works

Control of puberty onset and fertility by gonadotropin-releasing hormone neurons

Herbison, A. E. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.70 · Cited by 515 · see citing works

Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation

Roseweir, A. K., Kauffman, A. S., Smith, J. T., Guerriero, K. A., Morgan, K., Pielecka-Fortuna, J., Pineda, R., Gottsch, M. L., Tena-Sempere, M., Moenter, S. M., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5740-08.2009 · Cited by 379 · see citing works

New frontiers in kisspeptin/GPR54 physiology as fundamental gatekeepers of reproductive function

Roa, J., Aguilar, E., Diéguez, C., Pinilla, L., & Tena‐Sempere, M. (2007) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2007.07.002 · Cited by 343 · see citing works

The genetic and molecular basis of idiopathic hypogonadotropic hypogonadism

Bianco, S. D. C., & Kaiser, U. B. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.177 · Cited by 336 · see citing works

Development of a Methodology for and Assessment of Pulsatile Luteinizing Hormone Secretion in Juvenile and Adult Male Mice

Steyn, F. J., Wan, Y., Clarkson, J., Veldhuis, J. D., Herbison, A. E., & Chen, C. (2013) · Endocrinology · doi:10.1210/en.2013-1502 · Cited by 304 · see citing works

TAC3/TACR3 mutations reveal preferential activation of gonadotropin-releasing hormone release by neurokinin B in neonatal life followed by reversal in adulthood

Gianetti, E., Tusset, C., Noel, S. D., Au, M. G., Dwyer, A. A., Hughes, V. A., Abreu, A. P., Carroll, J., Trarbach, E., Silveira, L. F. G., et al. (2010) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2009-2320 · Cited by 294 · see citing works

Structural Interactions between Kisspeptin and GnRH Neurons in the Mediobasal Hypothalamus of the Male Rhesus Monkey (Macaca mulatta) as Revealed by Double Immunofluorescence and Confocal Microscopy

Ramaswamy, S., Guerriero, K. A., Gibbs, R. B., & Plant, T. M. (2008) · Endocrinology · doi:10.1210/en.2008-0438 · Cited by 279 · see citing works

The Gonadotropin-Releasing Hormone Pulse Generator

Herbison, A. E. (2018) · Endocrinology · doi:10.1210/en.2018-00653 · Cited by 261 · see citing works

The Role of Kisspeptins and GPR54 in the Neuroendocrine Regulation of Reproduction

Popa, S. M., Clifton, D. K., & Steiner, R. A. (2007) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.113006.100540 · Cited by 245 · see citing works

Postnatal Development of an Estradiol-Kisspeptin Positive Feedback Mechanism Implicated in Puberty Onset

Clarkson, J., Boon, W. C., Simpson, E. R., & Herbison, A. E. (2009) · Endocrinology · doi:10.1210/en.2008-1733 · Cited by 232 · see citing works

The role of kisspeptin in the control of gonadotrophin secretion

Roseweir, A. K., & Millar, R. P. (2008) · Human Reproduction Update · doi:10.1093/humupd/dmn058 · Cited by 213 · see citing works

Neurokinin B and the hypothalamic regulation of reproduction

Rance, N. E., Krajewski, S. J., Smith, M. A., Cholanian, M., & Dacks, P. A. (2010) · Brain Research · doi:10.1016/j.brainres.2010.08.059 · Cited by 203 · see citing works

Kisspeptin Signalling in the Hypothalamic Arcuate Nucleus Regulates GnRH Pulse Generator Frequency in the Rat

Li, X., Kinsey‐Jones, J. S., Cheng, Y., Knox, A. M. I., Lin, Y., Petrou, N. A., Roseweir, A. K., Lightman, S. L., Milligan, S. R., Millar, R. P., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008334 · Cited by 194 · see citing works

Down‐Regulation of Hypothalamic <i>Kisspeptin</i> and its Receptor, <i>Kiss1r</i> , mRNA Expression is Associated with Stress‐Induced Suppression of Luteinising Hormone Secretion in the Female Rat

Kinsey‐Jones, J. S., Li, X. F., Knox, A. M. I., Wilkinson, E. S., Zhu, X. L., Chaudhary, A. A., Milligan, S. R., Lightman, S. L., & O’Byrne, K. T. (2009) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01807.x · Cited by 196 · see citing works

Selective optogenetic activation of arcuate kisspeptin neurons generates pulsatile luteinizing hormone secretion

Han, S. Y., McLennan, T., Czieselsky, K., & Herbison, A. E. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1512243112 · Cited by 189 · see citing works

Genetics of congenital hypogonadotropic hypogonadism: peculiarities and phenotype of an oligogenic disease

Cangiano, B., Swee, D. S., Quinton, R., & Bonomi, M. (2020) · Human Genetics · doi:10.1007/s00439-020-02147-1 · Cited by 182 · see citing works

Comprehensive Review on Kisspeptin and Its Role in Reproductive Disorders

Clarke, H., Dhillo, W. S., & Jayasena, C. N. (2015) · Endocrinology and Metabolism · doi:10.3803/enm.2015.30.2.124 · Cited by 175 · see citing works

Kisspeptin Signaling Is Indispensable for Neurokinin B, but not Glutamate, Stimulation of Gonadotropin Secretion in Mice

García-Galiano, D., Schenau, D. V. I., León, S., Krajnc-Franken, M. A. M., Manfredi-Lozano, M., Romero‐Ruíz, A., Navarro, V. M., Gaytán, F., van Noort, P. I., Pinilla, L., et al. (2011) · Endocrinology · doi:10.1210/en.2011-1260 · Cited by 165 · see citing works

Neonatal gonadotropin therapy in male congenital hypogonadotropic hypogonadism

Bouvattier, C. M., Maione, L., Bouligand, J., Dodé, C., Guiochon‐Mantel, A., & Young, J. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.164 · Cited by 143 · see citing works

KiSS‐1 and GPR54 Genes are Co‐Expressed in Rat Gonadotrophs and Differentially Regulated In Vivo by Oestradiol and Gonadotrophin‐Releasing Hormone

Richard, N., Galmiche, G., Corvaisier, S., Caraty, A., & Kottler, M. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01653.x · Cited by 142 · see citing works

Intracellular signaling pathways activated by kisspeptins through GPR54: Do multiple signals underlie function diversity?

Castano, J. P., Martínez‐Fuentes, A. J., Gutiérrez‐Pascual, E., Vaudry, H., Tena‐Sempere, M., & Malagón, M. M. (2008) · Peptides · doi:10.1016/j.peptides.2008.07.025 · Cited by 130 · see citing works

Kisspeptin/GPR54 System: What Do We Know About Its Role in Human Reproduction?

Trevisan, C. M., Montagna, E., de Oliveira, R., Christofolini, D. M., Barbosa, C. P., Crandall, K. A., & Bianco, B. A. V. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000493406 · Cited by 130 · see citing works

MOLECULAR EVOLUTION OF GPCRS: Kisspeptin/kisspeptin receptors

Pasquier, J., Kamech, N., Lafont, A.-G., Vaudry, H., Rousseau, K., & Dufour, S. (2014) · Journal of Molecular Endocrinology · doi:10.1530/jme-13-0224 · Cited by 128 · see citing works

Reproduction, Smell, and Neurodevelopmental Disorders: Genetic Defects in Different Hypogonadotropic Hypogonadal Syndromes

Valdes‐Socin, H., Rubio-Almanza, M., Fernández-Ladreda, M. T., Debray, F. G., Bours, V., & Beckers, A. M. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00109 · Cited by 125 · see citing works

The recent genetics of hypogonadotrophic hypogonadism—novel insights and new questions

Semple, R. K., & Topaloglu, A. K. (2010) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2009.03687.x · Cited by 117 · see citing works

Disrupted Kisspeptin Signaling in GnRH Neurons Leads to Hypogonadotrophic Hypogonadism

Novaira, H. J., Sonko, M. L., Hoffman, G. E., Koo, Y., Ko, C. J., Wolfe, A., & Radovick, S. (2014) · Molecular Endocrinology · doi:10.1210/me.2013-1319 · Cited by 113 · see citing works

Kisspeptin/Gpr54‐Independent Gonadotrophin‐Releasing Hormone Activity in Kiss1 and Gpr54 Mutant Mice

Chan, Y.-M., Broder‐Fingert, S., Wong, K. M., & Seminara, S. B. (2009) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2009.01926.x · Cited by 114 · see citing works

Non-syndromic congenital hypogonadotropic hypogonadism: clinical presentation and genotype–phenotype relationships

Brioude, F., Bouligand, J., Trabado, S., Francou, B., Salenave, S., Kamenický, P., Brailly‐Tabard, S., Chanson, P., Guiochon‐Mantel, A., & Young, J. (2010) · European Journal of Endocrinology · doi:10.1530/eje-10-0083 · Cited by 113 · see citing works

Hypothalamic Control of the Pituitary‐Gonadal Axis in Higher Primates: Key Advances over the Last Two Decades

Plant, T. M. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01708.x · Cited by 105 · see citing works

Potential roles for the kisspeptin/kisspeptin receptor system in implantation and placentation

Hu, K.-L., Chang, H., Zhao, H., Yu, Y., Li, R., & Qiao, J. (2018) · Human Reproduction Update · doi:10.1093/humupd/dmy046 · Cited by 108 · see citing works

Kisspeptin and Puberty in Mammals

Terasawa, E., Guerriero, K. A., & Plant, T. M. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-6199-9_12 · Cited by 103 · see citing works

Human GnRH Deficiency: A Unique Disease Model to Unravel the Ontogeny of GnRH Neurons

Balasubramanian, R., Dwyer, A. A., Seminara, S. B., Pitteloud, N., Kaiser, U. B., & Crowley, W. F. (2010) · Neuroendocrinology · doi:10.1159/000314193 · Cited by 99 · see citing works

Fasting Reduces KiSS‐1 Expression in the Anteroventral Periventricular Nucleus (AVPV): Effects of Fasting on the Expression of KiSS‐1 and Neuropeptide Y in the AVPV or Arcuate Nucleus of Female Rats

Κalamatianos, T., Grimshaw, S. E., Poorun, R., Hahn, J. D., & Coen, C. W. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01757.x · Cited by 101 · see citing works

A Novel Loss-of-Function Mutation inGPR54/KISS1RLeads to Hypogonadotropic Hypogonadism in a Highly Consanguineous Family

Nimri, R., Lebenthal, Y., Lazar, L., Chevrier, L., Phillip, M., Bar, M., Hernández, E., de Roux, N., & Gat‐Yablonski, G. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-1676 · Cited by 100 · see citing works

Kisspeptin and GPR54: Discovery of a Novel Pathway in Reproduction

Seminara, S. B., & Crowley, W. F. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01731.x · Cited by 90 · see citing works

Pathological pulses in PCOS

Coyle, C., & Campbell, R. E. (2019) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2019.110561 · Cited by 89 · see citing works

Genetics basis for GnRH-dependent pubertal disorders in humans

Silveira, L. F. G., Trarbach, E. B., & Latronico, A. C. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.02.023 · Cited by 84 · see citing works

Relative Importance of the Arcuate and Anteroventral Periventricular Kisspeptin Neurons in Control of Puberty and Reproductive Function in Female Rats

Hu, M., Li, X. F., McCausland, B., Li, S. Y., Gresham, R., Kinsey‐Jones, J. S., Gardiner, J., Sam, A. H., Bloom, S. R., Poston, L., et al. (2015) · Endocrinology · doi:10.1210/en.2014-1655 · Cited by 78 · see citing works

Implantation Failure in Female Kiss1−/− Mice Is Independent of Their Hypogonadic State and Can Be Partially Rescued by Leukemia Inhibitory Factor

Calder, M. D., Chan, Y.-M., Raj, R. S., Pampillo, M., Elbert, A., Noonan, M. M., Gillio‐Meina, C., Caligioni, C. S., Bérubé, N. G., Bhattacharya, M. M., et al. (2014) · Endocrinology · doi:10.1210/en.2013-1916 · Cited by 81 · see citing works

Puberty in Mice and Rats

Prévot, V. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397175-3.00030-2 · Cited by 78 · see citing works

KISS1R Intracellular Trafficking and Degradation: Effect of the Arg386Pro Disease-Associated Mutation

Bianco, S. D. C., Vandepas, L. E., Correa-Medina, M., Gereben, B., Mukherjee, A., Kuohung, W., Carroll, R. S., Teles, M. G., Latronico, A. C., & Kaiser, U. B. (2011) · Endocrinology · doi:10.1210/en.2010-0903 · Cited by 76 · see citing works

Effects of Kisspeptin-10 on the Electrophysiological Manifestation of Gonadotropin-Releasing Hormone Pulse Generator Activity in the Female Rat

Kinsey‐Jones, J. S., Li, X. F., Luckman, S. M., & O’Byrne, K. T. (2007) · Endocrinology · doi:10.1210/en.2007-1505 · Cited by 74 · see citing works

KiSS-1 and GPR54 at the pituitary level: Overview and recent insights

Richard, N., Corvaisier, S., Camacho, E., & Kottler, M. (2008) · Peptides · doi:10.1016/j.peptides.2008.09.015 · Cited by 72 · see citing works

Genetics of Isolated Hypogonadotropic Hypogonadism: Role of GnRH Receptor and Other Genes

Karges, B., Joseph, N., de Roux, N., & Karges, W. (2011) · International Journal of Endocrinology · doi:10.1155/2012/147893 · Cited by 70 · see citing works

Kisspeptin antagonists: Unraveling the role of kisspeptin in reproductive physiology

Millar, R. P., Roseweir, A. K., Tello, J. A., Anderson, R. A., George, J. T., Morgan, K., & Pawson, A. J. (2010) · Brain Research · doi:10.1016/j.brainres.2010.09.044 · Cited by 69 · see citing works

High tumoral levels of Kiss1 and G-protein-coupled receptor 54 expression are correlated with poor prognosis of estrogen receptor-positive breast tumors

Marot, D., Bièche, I., Aumas, C., Esselin, S., Bouquet, C., Vacher, S., Lazennec, G., Perricaudet, M., Kuttenn, F., Lidereau, R., et al. (2007) · Endocrine Related Cancer · doi:10.1677/erc-07-0012 · Cited by 69 · see citing works

Transcriptional regulation of the human KiSS1 gene

Mueller, J. K., Dietzel, A., Lomniczi, A., Loche, A., Tefs, K., Kieß, W., Danne, T., Ojeda, S. R., & Heger, S. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.04.025 · Cited by 66 · see citing works

Complex Genetics in Idiopathic Hypogonadotropic Hypogonadism

Pitteloud, N., Durrani, S., Raivio, T., & Sykiotis, G. P. (2010) · Frontiers of hormone research · doi:10.1159/000312700 · Cited by 65 · see citing works

GPR54 and Kisspeptins

Colledge, W. H. (2008) · Springer eBooks · doi:10.1007/400_2007_050 · Cited by 62 · see citing works

A novel homozygous splice acceptor site mutation of KISS1R in two siblings with normosmic isolated hypogonadotropic hypogonadism

Teles, M. G., Trarbach, E. B., Noel, S. D., Guerra‐Júnior, G., Jorge, A. A. L., Beneduzzi, D., Bianco, S. D. C., Mukherjee, A., Baptista, M. T. M., Costa, E. M. F., et al. (2010) · European Journal of Endocrinology · doi:10.1530/eje-10-0012 · Cited by 61 · see citing works

Kisspeptin and the regulation of the hypothalamic–pituitary–gonadal axis in the rhesus monkey (Macaca mulatta)

Plant, T. M., & Ramaswamy, S. (2008) · Peptides · doi:10.1016/j.peptides.2008.06.029 · Cited by 59 · see citing works

Recent Discoveries on the Control of Gonadotrophin‐Releasing Hormone Neurones in Nonhuman Primates

Terasawa, E., Kurian, J. R., Guerriero, K. A., Kenealy, B. P., Hutz, E. D., & Keen, K. L. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.02027.x · Cited by 58 · see citing works

Prevalence ofKISS1 Receptormutations in a series of 603 patients with normosmic congenital hypogonadotrophic hypogonadism and characterization of novel mutations: a single-centre study

Francou, B., Paul, C., Amazit, L., Cartes, A., Bouvattier, C. M., Albarel, F., Maiter, D. M., Chanson, P., Trabado, S., Brailly‐Tabard, S., et al. (2016) · Human Reproduction · doi:10.1093/humrep/dew073 · Cited by 59 · see citing works

New genetic factors implicated in human GnRH-dependent precocious puberty: The role of kisspeptin system

Teles, M. G., Silveira, L. F. G., Tusset, C., & Latronico, A. C. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.05.019 · Cited by 58 · see citing works

The Emerging Therapeutic Potential of Kisspeptin and Neurokinin B

Patel, B., Koysombat, K., Mills, E., Tsoutsouki, J., Comninos, A. N., Abbara, A., & Dhillo, W. S. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnad023 · Cited by 61 · see citing works

Kisspeptin across the human lifespan:evidence from animal studies and beyond

Clarke, S. A., & Dhillo, W. S. (2016) · Journal of Endocrinology · doi:10.1530/joe-15-0538 · Cited by 54 · see citing works

A potential mechanism for the sexual dimorphism in the onset of puberty and incidence of idiopathic central precocious puberty in children: sex-specific kisspeptin as an integrator of puberty signals

Bianco, S. D. C. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00149 · Cited by 54 · see citing works

Negative Fetal FSH/LH Regulation in Late Pregnancy Is Associated with Declined Kisspeptin/KISS1R Expression in the Tuberal Hypothalamus

Guimiot, F., Chevrier, L., Dreux, S., Chevenne, D., Caraty, A., Delezoide, A., & de Roux, N. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2078 · Cited by 53 · see citing works

Clinical Manifestations of Impaired GnRH Neuron Development and Function

Kim, H., Bhagavath, B., & Layman, L. C. (2008) · Neurosignals · doi:10.1159/000111561 · Cited by 51 · see citing works

Kisspeptin and KISS1R: a critical pathway in the reproductive system

Gianetti, E., & Seminara, S. B. (2008) · Reproduction · doi:10.1530/rep-08-0091 · Cited by 50 · see citing works

Analysis on DNA sequence of KiSS-1 gene and its association with litter size in goats

Cao, G., Chu, M., Fang, L., Di, R., Feng, T., & Li, N. (2010) · Molecular Biology Reports · doi:10.1007/s11033-010-0049-7 · Cited by 49 · see citing works

GPCR structure and activation: an essential role for the first extracellular loop in activating the adenosine A 2B receptor

Peeters, M. C., van Westen, G. J. P., Guo, D. M., Wisse, L. E., Müller, C. E., Beukers, M. W., & IJzerman, A. P. (2010) · The FASEB Journal · doi:10.1096/fj.10-164319 · Cited by 49 · see citing works

Clinical Potential of Kisspeptin in Reproductive Health

Abbara, A., Clarke, S. A., & Dhillo, W. S. (2021) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2021.05.008 · Cited by 45 · see citing works

G protein-coupled receptors involved in GnRH regulation: Molecular insights from human disease

Noel, S. D., & Kaiser, U. B. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.06.022 · Cited by 43 · see citing works

Reproductive functions of kisspeptin and Gpr54 across the life cycle of mice and men

Chan, Y.-M., Broder‐Fingert, S., & Seminara, S. B. (2008) · Peptides · doi:10.1016/j.peptides.2008.06.015 · Cited by 43 · see citing works

Two Families with Normosmic Congenital Hypogonadotropic Hypogonadism and Biallelic Mutations in KISS1R (KISS1 Receptor): Clinical Evaluation and Molecular Characterization of a Novel Mutation

Brioude, F., Bouligand, J., Francou, B., Fagart, J., Roussel, R., Viengchareun, S., Combettes, L., Brailly‐Tabard, S., Lombès, M., Young, J., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053896 · Cited by 42 · see citing works

The kisspeptin signaling pathway and its role in human isolated GnRH deficiency

Wahab, F., Quinton, R., & Seminara, S. B. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.05.043 · Cited by 42 · see citing works

Kisspeptins and the control of gonadotrophin secretion

Dedes, I. (2012) · Systems Biology in Reproductive Medicine · doi:10.3109/19396368.2011.651555 · Cited by 42 · see citing works

Genetics of puberty

Herbison, A. E. (2007) · Hormone Research in Paediatrics · doi:10.1159/000110583 · Cited by 44 · see citing works

Biased signaling in naturally occurring mutations of G protein-coupled receptors associated with diverse human diseases

Yang, L.-K., Hou, Z.-S., & Tao, Y. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165973 · Cited by 37 · see citing works

Advances in clinical applications of kisspeptin-GnRH pathway in female reproduction

Hu, K.-L., Chen, Z., Li, X., Cai, E., Yang, H., Chen, Y., Wang, C., Ju, L., Deng, W., & Mu, L. (2022) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-022-00953-y · Cited by 42 · see citing works

KISS1 gene analysis in Korean girls with central precocious puberty: a polymorphism, p.P110T, suggested to exert a protective effect

Ko, J. M., Lee, H. S., & Hwang, J. S. (2010) · Endocrine Journal · doi:10.1507/endocrj.k10e-073 · Cited by 38 · see citing works

Translating genomics to the clinical diagnosis of disorders/differences of sex development

Parivesh, A., Barseghyan, H., Délot, E. C., & Vilain, E. J. N. (2019) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2019.01.005 · Cited by 36 · see citing works

KISS1R Signals Independently of Gαq/11 and Triggers LH Secretion via the β-Arrestin Pathway in the Male Mouse

Ahow, M. R., Min, L., Pampillo, M., Nash, C. P., Wen, J., Soltis, K. A., Carroll, R. S., Glidewell-Kenney, C., Mellon, P. L., Bhattacharya, M. M., et al. (2014) · Endocrinology · doi:10.1210/en.2014-1304 · Cited by 36 · see citing works

KISS1 in metastatic cancer research and treatment: potential and paradoxes

Ly, T., Harihar, S., & Welch, D. R. (2020) · Cancer and Metastasis Reviews · doi:10.1007/s10555-020-09868-9 · Cited by 35 · see citing works

Polymorphisms of KiSS-1 and GPR54 genes and their relationships with litter size in sheep

Chu, M., Xiao, C., Feng, T., Fu, Y. H. H., Cao, G., Li, F., Di, R., Tang, Q., Huang, D., Ma, Y., et al. (2011) · Molecular Biology Reports · doi:10.1007/s11033-011-1097-3 · Cited by 32 · see citing works

Mechanism of pulsatile GnRH release in primates: Unresolved questions

Terasawa, E. (2019) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2019.110578 · Cited by 32 · see citing works

Does the KNDy Model for the Control of Gonadotropin-Releasing Hormone Pulses Apply to Monkeys and Humans?

Lehman, M. N., He, W., Coolen, L. M., Levine, J. E., & Goodman, R. L. (2019) · Seminars in Reproductive Medicine · doi:10.1055/s-0039-3400254 · Cited by 33 · see citing works

MKRN3 and KISS1R mutations in precocious and early puberty

Pagani, S., Calcaterra, V., Acquafredda, G., Montalbano, C., Bozzola, E., Ferrara, P., Gasparri, M., Villani, A., & Bozzola, M. (2020) · The Italian Journal of Pediatrics/Italian journal of pediatrics · doi:10.1186/s13052-020-0808-6 · Cited by 32 · see citing works

Changes in Methylation Patterns of Kiss1 and Kiss1r Gene Promoters across Puberty

Wyatt, A. K., Závodná, M., Viljoen, J. L., Stanton, J. L., Gemmell, N. J., & Jasoni, C. L. (2013) · Genetics & Epigenetics · doi:10.4137/geg.s12897 · Cited by 31 · see citing works

Control of the Menstrual Cycle

Zeleznik, A. J., & Plant, T. M. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397175-3.00028-4 · Cited by 30 · see citing works

Characterization of the porcine Kisspeptins receptor gene and evaluation as candidate for timing of puberty in sows

Li, S., Ren, J., Guo-qiang, Y., Guo, Y., & Huang, L. (2008) · Journal of Animal Breeding and Genetics · doi:10.1111/j.1439-0388.2008.00732.x · Cited by 30 · see citing works

KISS1 Gene Polymorphisms in Korean Girls with Central Precocious Puberty

Rhie, Y., Lee, K., Ko, J. M., Lee, W. J., Kim, J. H., & Kim, H.-S. (2014) · Journal of Korean Medical Science · doi:10.3346/jkms.2014.29.8.1120 · Cited by 29 · see citing works

Kisspeptin and Clinical Disorders

Silveira, L. F. G., Latronico, A. C., & Seminara, S. B. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-6199-9_9 · Cited by 26 · see citing works

Pathology or Normal Variant: What Constitutes a Delay in Puberty?

Villanueva, C., & Argente, J. (2014) · Hormone Research in Paediatrics · doi:10.1159/000362600 · Cited by 27 · see citing works

Kisspeptin: A Novel Regulator of Reproductive Function

Dhillo, W. S. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01753.x · Cited by 27 · see citing works

Molecular causes of hypogonadotropic hypogonadism

Topaloglu, A. K., & Kotan, L. D. (2010) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0b013e32833bb425 · Cited by 27 · see citing works

DNA polymorphisms of the KiSS1 3′ Untranslated region interfere with the folding of a G-rich sequence into G-quadruplex

Huijbregts, L., Rozé, C., Bonafè, G., Houang, M., Bouc, Y. L., Carel, J., Léger, J., Alberti, P., & de Roux, N. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.12.014 · Cited by 25 · see citing works

Neurokinin B signaling in puberty: Human and animal studies

Topaloglu, A. K. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.02.020 · Cited by 25 · see citing works

Normosmic idiopathic hypogonadotropic hypogonadism due to a novel homozygous nonsense c.C969A (p.Y323X) mutation in the KISS 1R gene in three unrelated families

Demirbilek, H., Özbek, M. N., Demir, K., Kotan, L. D., Cesur, Y., Doğan, M., Temiz, F., Mengen, E., Gürbüz, F., Yüksel, B., et al. (2014) · Clinical Endocrinology · doi:10.1111/cen.12618 · Cited by 24 · see citing works

Understanding the functions of kisspeptin and kisspeptin receptor (Kiss1R) from clinical case studies

Ke, R., Ma, X., & Lee, L. T. O. (2018) · Peptides · doi:10.1016/j.peptides.2018.09.007 · Cited by 24 · see citing works

PRR Repeats in the Intracellular Domain of KISS1R Are Important for Its Export to Cell Membrane

Chevrier, L., de Brevern, A. G., Hernández, E., Leprince, J., Vaudry, H., Guedj, A. M., & de Roux, N. (2013) · Molecular Endocrinology · doi:10.1210/me.2012-1386 · Cited by 23 · see citing works

Analysis on DNA sequence of GPR54 gene and its association with litter size in goats

Cao, G., Chu, M., Fang, L., Feng, T., Di, R., & Li, N. (2010) · Molecular Biology Reports · doi:10.1007/s11033-010-0499-y · Cited by 22 · see citing works

Computational Analysis of Missense Variants of G Protein-Coupled Receptors Involved in the Neuroendocrine Regulation of Reproduction

Min, L., Nie, M., Zhang, A., Wen, J., Noel, S. D., Lee, V., Carroll, R. S., & Kaiser, U. B. (2015) · Neuroendocrinology · doi:10.1159/000435884 · Cited by 21 · see citing works

Role of Kisspeptin/GPR54 System in Human Reproductive Axis

Silveira, L. F. G., Teles, M. G., Trarbach, E. B., & Latronico, A. C. (2010) · Frontiers of hormone research · doi:10.1159/000312689 · Cited by 21 · see citing works

Structural basis for the ligand recognition and G protein subtype selectivity of kisspeptin receptor

Wu, Z., Chen, G., Qiu, C., Yan, X., Xu, L., Jiang, S., Xu, J. Z., Han, R., Shi, T., Liu, Y., et al. (2024) · Science Advances · doi:10.1126/sciadv.adn7771 · Cited by 22 · see citing works

A Novel Loss-of-Function Mutation in GPR54/KISS1R Leads to Hypogonadotropic Hypogonadism in a Highly Consanguineous Family

Nimri, R., Lebenthal, Y., Lazar, L., Chevrier, L., Phillip, M., Bar, M., Hernández, E., de Roux, N., & Gat‐Yablonski, G. (2011) · Endocrinology · doi:10.1210/endo.152.1.9993 · Cited by 8 · see citing works

Chapter 2 Human Diseases Associated with GPR54 Mutations

Teles, M. G., Silveira, L. F. G., Bianco, S. D. C., & Latronico, A. C. (2009) · Progress in molecular biology and translational science · doi:10.1016/s1877-1173(09)88002-2 · Cited by 3 · see citing works

GnRH receptor and GPR54 inactivation in isolated gonadotropic deficiency

de Roux, N. (2006) · Best Practice &amp; Research Clinical Endocrinology &amp; Metabolism · doi:10.1016/j.beem.2006.10.005 · Cited by 35 · see citing works

GPR54, kisspcptins and the onset of puberty

Zeng, Y. (2006)

Two Novel Missense Mutations in G Protein-Coupled Receptor 54 in a Patient with Hypogonadotropic Hypogonadism

Semple, R. K., Achermann, J. C., Ellery, J., Farooqi, I. S., Karet, F. E., Stanhope, R. G., O’Rahilly, S., & Aparicio, S. A. (2005) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2004-1418 · Cited by 291 · see citing works