Down‐Regulation of Hypothalamic Kisspeptin and its Receptor, Kiss1r , mRNA Expression is Associated with Stress‐Induced Suppression of Luteinising Hormone Secretion in the Female Rat

Kinsey‐Jones, J. S.; Li, X. F.; Knox, A. M. I.; Wilkinson, E. S.; Zhu, X. L.; Chaudhary, A. A.; Milligan, S. R.; Lightman, S. L.; O’Byrne, K. T.

doi:10.1111/j.1365-2826.2008.01807.x

Cited by 196Hypothalamic control of reproductive hormonesNeuropeptides and Animal PhysiologyStress Responses and Cortisol

Down‐Regulation of Hypothalamic Kisspeptin and its Receptor, Kiss1r , mRNA Expression is Associated with Stress‐Induced Suppression of Luteinising Hormone Secretion in the Female Rat

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Kinsey‐Jones, J. S., Li, X. F., Knox, A. M. I., Wilkinson, E. S., Zhu, X. L., Chaudhary, A. A., Milligan, S. R., Lightman, S. L. +1 more·2009·Journal of Neuroendocrinology

DOI 10.1111/j.1365-2826.2008.01807.x

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Abstract

Identification of kisspeptin (Kiss1) and its G protein‐coupled receptor 54 (Kiss1r) as an essential component of the hypothalamic‐pituitary‐gonadal (HPG) axis controlling gonadotrophin secretion raises the possibility that kisspeptin‐Kiss1r signalling may play a critical role in the transduction of stress‐induced suppression of reproduction. We examined the effects of: (i) three different stressors, known to suppress pulsatile luteinising hormone (LH) secretion; (ii) corticotrophin‐releasing factor (CRF); and (iii) corticosterone on Kiss1 and Kiss1r expression in key hypothalamic sites regulating gonadotrophin secretion: the medial preoptic area (mPOA) and arcuate nucleus (ARC). Ovariectomised oestrogen‐replaced rats were implanted with i.v., subcutaneous or i.c.v. cannulae. Blood samples were collected at 5‐min intervals for 5–6 h for detection of LH. Quantitative reverse transcriptase‐polymerase chain reaction was used to determine Kiss1 and Kiss1r mRNA levels in brain punches of the mPOA and ARC collected 6 h after restraint, insulin‐induced hypoglycaemia or lipopolysaccharide stress, or after i.c.v. administration of CRF, or acute or chronic subcutaneous administration of corticosterone. We observed down‐regulation of at least one component of the kisspeptin‐Kiss1r signalling system by each of the stress paradigms within the mPOA and ARC. CRF decreased Kiss1 and Kiss1r expression in both the mPOA and ARC. Both acute and chronic stress levels of corticosterone resulted in a concomitant decrease in Kiss1 and an increase in kiss1r mRNA expression in the mPOA and ARC. This differential regulation of Kiss1 and Kiss1r might account for the lack of effect corticosterone has on pulsatile LH secretion. Considering the pivotal role for kisspeptin‐Kiss1r signalling in the control of the HPG axis, these results suggest that the reduced Kiss1‐Kiss1r expression may be a contributing factor in stress‐related suppression of LH secretion.

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In multiple species, psychosocial stress exposure or exogenous CORT inhibited pulsatile LH release.
“In multiple species, psychosocial stress exposure or treatment with exogenous CORT inhibited the pulsatile release of LH79–81”
From Emerging insights into hypothalamic‐pituitary‐gonadal axis regulation and interaction with stress signalling (2018) · cites this paper as [80]
The Results (p. 4) report that restraint, hypoglycaemic and LPS stress suppressed pulsatile LH secretion in female rats. The Discussion (pp. 6–7) says the opposite for exogenous corticosterone at physiological stress levels: neither acute nor chronic administration suppressed LH pulsatility in these rats. It discusses glucocorticoid-related suppression in other species, but that does not support the claim as stated for corticosterone treatment in this study. (LLM, conf=0.88)
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Authors: Kinsey‐Jones, J. S., Li, X. F., Knox, A. M. I., Wilkinson, E. S., Zhu, X. L., Chaudhary, A. A., Milligan, S. R., Lightman, S. L., & O’Byrne, K. T.
Affiliations: King's College London (GB)
University of Bristol (GB)
Corresponding author: O’Byrne, K. T.
ORCID: Lightman, S. L.
Venue: Journal of Neuroendocrinology
Publisher: Wiley
Published: 2008-12-15
Volume: 21
Issue: 1
Pages: 20-29
ISSN: 0953-8194 (ISSN-L)
1365-2826
DOI: 10.1111/j.1365-2826.2008.01807.x
OpenAlex: W2009659460
Cited by: 196
References: 67
Citations by year: 2026: 7 · 2025: 7 · 2024: 10 · 2023: 9 · 2022: 15 · 2021: 11 · 2020: 9 · 2019: 9 · 2018: 13 · 2017: 10 · 2016: 5 · 2015: 16 · 2014: 13 · 2013: 18 · 2012: 11
FWCI: 12.78
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Neuroendocrinology (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Research Portal (King's College London) (submittedVersion)
Bristol Research (University of Bristol) (submittedVersion)
Explore Bristol Research (submittedVersion)
Funders: Wellcome Trust
Home Office
Biotechnology and Biological Sciences Research Council (BB/F007396/1)
Topics: Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: kisspeptin, KISS1R, hypothalamic-pituitary-gonadal axis, corticotropin-releasing factor, corticosterone, medial preoptic area, arcuate nucleus, insulin-induced hypoglycemia, restraint stress, pulsatile LH secretion, female reproduction
MeSH terms: Receptors, Kisspeptin-1, Animals, Corticosterone, Corticotropin-Releasing Hormone, Estradiol, Female, Hypothalamus, Luteinizing Hormone, Ovariectomy, Proteins, Restraint, Physical, Stress, Psychological, Down-Regulation, Rats, Sprague-Dawley, Tumor Suppressor Proteins, Receptors, G-Protein-Coupled, Rats, Kisspeptins

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Down‐Regulation of Hypothalamic Kisspeptin and its Receptor, Kiss1r , mRNA Expression is Associated with Stress‐Induced Suppression of Luteinising Hormone Secretion in the Female Rat

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