The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index; none of the 20 sources its claims cite is checked for support yet.
Low Testosterone Levels Are Common and Associated with Insulin Resistance in Men with Diabetes
Abstract
Context: Low testosterone levels are common in men with type 2 diabetes and may be associated with insulin resistance. Objective: We investigated prevalence of testosterone deficiency and the relationship between testosterone and insulin resistance in a large cohort of men with type 2 and type 1 diabetes. Design: The study was a cross-sectional survey of 580 men with type 2 diabetes and 69 men with type 1 diabetes. A subgroup of 262 men with type 2 diabetes was then reassessed after a median of 6 months. Results: Forty-three percent of men with type 2 diabetes had a reduced total testosterone, and 57% had a reduced calculated free testosterone. Only 7% of men with type 1 diabetes had low total testosterone. By contrast, 20.3% of men with type 1 diabetes had low calculated free testosterone, similar to that observed in type 2 diabetes (age-body mass index adjusted odds ratio = 1.4; 95% confidence interval = 0.7–2.9). Low testosterone levels were independently associated with insulin resistance in men with type 1 diabetes as well as type 2 diabetes. Serial measurements also revealed an inverse relationship between changes in testosterone levels and insulin resistance. Conclusions: Testosterone deficiency is common in men with diabetes, regardless of the type. Testosterone levels are partly influenced by insulin resistance, which may represent an important avenue for intervention, whereas the utility of testosterone replacement remains to be established in prospective trials.
Overview
AI snapshot
Written from the paper’s full text.
TL;DR
In a single-center cross-sectional survey, testosterone deficiency was common in men with diabetes: 43% of men with type 2 diabetes had low total testosterone and 57% had low calculated free testosterone, while 20.3% of men with type 1 diabetes had low calculated free testosterone. Low testosterone indices were independently associated with insulin resistance in both diabetes types, and longitudinal changes in testosterone were inversely related to changes in insulin resistance in a type 2 diabetes subgroup.
Key findings
- Among men with type 2 diabetes, 43% had low total testosterone (<10 nmol/L) and 57% had low calculated free testosterone (<0.23 nmol/L); among men with type 1 diabetes, 7% had low total testosterone but 20.3% had low calculated free testosterone, similar to age- and BMI-adjusted men with type 2 diabetes (adjusted odds ratio 1.4; 95% CI 0.7–2.9).
- Low total testosterone in type 2 diabetes was independently associated with insulin resistance by HOMA-IR (odds ratio 1.2; 95% CI 1.0–1.4), and calculated free testosterone was independently associated with insulin sensitivity in type 2 diabetes (partial correlation coefficient −0.10; P = 0.02) and with eGDR in type 1 diabetes (P = 0.04).
- In 262 men with type 2 diabetes reassessed after a median of 6 months, the change in total testosterone was inversely related to the change in HOMA-IR (P = 0.01), and the change in calculated free testosterone was inversely correlated with the change in HOMA-IR (P = 0.03).
- The prevalence of low calculated free testosterone approximately doubled per decade of age in type 2 diabetes (adjusted odds ratio 2.0; 95% CI 1.4–2.4) and in type 1 diabetes (adjusted odds ratio 2.4; 95% CI 1.4–3.9).
Methods
- Cross-sectional survey of 580 men with type 2 diabetes and 69 men with type 1 diabetes at a single clinic; 6 men with type 2 diabetes were excluded from statistical analysis, and a randomly selected subgroup of 262 men with type 2 diabetes was reassessed after a median of 6 months (range 1–15 months).
- Fasting blood samples were drawn between 0800 and 1000 h; total testosterone was measured by Access assay, SHBG by Immulite, and calculated free testosterone was derived using Vermeulen’s formula. Low total testosterone was defined as <10 nmol/L and low calculated free testosterone as <0.23 nmol/L.
- Insulin resistance was estimated by HOMA-IR in type 2 diabetes and by eGDR in type 1 diabetes; analyses used logistic regression, multiple regression, ANOVA, analysis of covariance, and nonparametric tests as appropriate.
Limitations
- The paper states that it did not obtain a detailed symptomatology history, so the biochemical testosterone deficiency may not represent a true hypogonadal state; it also states that a single low testosterone level is inadequate for diagnosing hypogonadism because of variability, and on repeat testing 27% of men with low total testosterone and 33% with low calculated free testosterone had normal levels.
- The paper states that longitudinal changes in testosterone in type 1 diabetes remain to be explored and that the utility of testosterone replacement remains to be established in prospective trials.
- Evident from the text: the study was observational and single-center, with a tertiary referral cohort that had longstanding diabetes and high complication prevalence, which may limit generalizability and cannot establish causality.
Model-written summary. Check it against the paper before relying on it.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
29 Own result · 14 Not checked yet · 7 Own interpretation · 5 Own method
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Only 7% of men with type 1 diabetes had low total testosterone.”
- Also stated in: § Prevalence of testosterone deficiency in men with type 1 diabetes · plain
“Few men with type 1 diabetes had low TT (7.2%, P Ͻ 0.001, vs. type 2 diabetes, Fig. 1).”
- Also stated in: § Statistical analysis · plain
“Low TT (Ͻ10 nmol/liter) (%) 7% 43% 42%”
§ Low Testosterone Levels Are Common and Associated with Insulin Resistance in Men with Diabetes > Abstract
plainn = 69- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Also stated in: § Prevalence of testosterone deficiency in men with type 1 diabetes · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“57% had a reduced calculated free testosterone”
- Also stated in: § Discussion · plain
“57% had low cFT levels”
- Also stated in: § Statistical analysis · plain
“Low cFT (Ͻ0.23 nmol/liter) (%) 20% 57% 60%”
§ Low Testosterone Levels Are Common and Associated with Insulin Resistance in Men with Diabetes > Abstract
plainn = 580- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Also stated in: § Discussion · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“After adjusting for age, body mass index (BMI), and other confounding factors, the frequency of low TT levels remained significantly higher in men with type 2 diabetes when compared with those with type 1 diabetes (adjusted odds ratio ϭ 4.0; 95% CI ϭ 1.5-10.7;P ϭ 0.005).”
§ Low Testosterone Levels Are Common and Associated with Insulin Resistance in Men with Diabetes > Prevalence of testosterone deficiency in men with type 1 diabetes
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“For each decade of life, the prevalence of low cFT levels effectively doubled (adjusted odds ratio for low cFT levels ϭ 2.4; 95% CI ϭ 1.4 -3.9).”
§ Low Testosterone Levels Are Common and Associated with Insulin Resistance in Men with Diabetes > Prevalence of testosterone deficiency in men with type 1 diabetes
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
In the paper
“This frequency of low TT levels in men with type 1 diabetes was not significantly greater than observed in reproductively normal young men (21).”
§ Low Testosterone Levels Are Common and Associated with Insulin Resistance in Men with Diabetes > Prevalence of testosterone deficiency in men with type 1 diabetes
What the sources say
- Not checked yetcites [21] Sikaris, 2005, Reproductive hormone reference intervals for healthy fertile young men: evaluation of automated platform assays., J Clin Endocrinol Metab source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“As in men with type 2 diabetes, the major predictor of cFT levels in individuals with type 1 diabetes was age (Fig. 2B).”
§ Low Testosterone Levels Are Common and Associated with Insulin Resistance in Men with Diabetes > Prevalence of testosterone deficiency in men with type 1 diabetes
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“However, when SHBG was included in the model, this difference between type 1 and type 2 diabetes was eliminated (P ϭ 0.16).”
- Also stated in: § Discussion · plain
“When SHBG was included into the model, this difference between type 1 and type 2 diabetes was eliminated (P ϭ 0.16).”
§ Low Testosterone Levels Are Common and Associated with Insulin Resistance in Men with Diabetes > Prevalence of testosterone deficiency in men with type 1 diabetes
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Also stated in: § Discussion · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“20.3% of men with type 1 diabetes had low calculated free testosterone”
- Also stated in: § Prevalence of testosterone deficiency in men with type 1 diabetes · plain
“one in five men with type 1 diabetes had low cFT levels (20.3%, Fig. 1)”
- Also stated in: § Statistical analysis · plain
“Low cFT (Ͻ0.23 nmol/liter) (%) 20% 57% 60%”
§ Low Testosterone Levels Are Common and Associated with Insulin Resistance in Men with Diabetes > Abstract
plainn = 69- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Also stated in: § Prevalence of testosterone deficiency in men with type 1 diabetes · plain
In the paper
“insulin resistance (as estimated by the HOMA-IR equation) (23) was independently associated with low TT levels (odds ratio ϭ 1.2; 95% CI ϭ 1.0 -1.4), after adjusting for age, BMI, treatment regimens, and other potentially confounding variables.”
§ Low Testosterone Levels Are Common and Associated with Insulin Resistance in Men with Diabetes > Testosterone indices and insulin resistance
What the sources say
- Not checked yetcites [23] Wallace, 2004, Use and abuse of HOMA modeling., Diabetes Care source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The inverse association between cFT levels and age (Fig. 2B) was significantly stronger that that observed for TT (P Ͻ 0.01)”
§ Low Testosterone Levels Are Common and Associated with Insulin Resistance in Men with Diabetes > Prevalence of testosterone deficiency in men with type 2 diabetes
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- It may state two separate claims as one. 6
- Probably not a substantial claim. 10
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“finding that 27 and 33% of individuals with low TT and cFT levels respectively had levels in the normal range when retested.”
§ Low Testosterone Levels Are Common and Associated with Insulin Resistance in Men with Diabetes > Discussion
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“At the second analysis, the prevalence of testosterone deficiency defined by low TT levels (Ͻ10 nmol/liter) was not significantly different from obtained at the first estimation (39 vs. 42%, P ϭ 0.2), and there was a strong correlation between estimations (r 2 ϭ 0.73, Fig. 3A).”
§ Low Testosterone Levels Are Common and Associated with Insulin Resistance in Men with Diabetes > Changes in testosterone levels over time
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“whereas the utility of testosterone replacement remains to be established in prospective trials.”
- Also stated in: § Discussion · hedged
“Although there is a strong rationale for testosterone replacement, the balance of benefits and risks is currently unknown and still to be defined by large and long-term clinical trials.”
§ Low Testosterone Levels Are Common and Associated with Insulin Resistance in Men with Diabetes > Abstract
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
- Also stated in: § Discussion · hedged
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“possibly because of the age-associated rise in SHBG (Fig. 2C).”
§ Low Testosterone Levels Are Common and Associated with Insulin Resistance in Men with Diabetes > Prevalence of testosterone deficiency in men with type 2 diabetes
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“None of these men received testosterone therapy.”
§ Low Testosterone Levels Are Common and Associated with Insulin Resistance in Men with Diabetes > Changes in testosterone levels over time
plainn = 262- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Interpretation of our study is therefore limited because we did not obtain a detailed record of symptomatology history.”
§ Low Testosterone Levels Are Common and Associated with Insulin Resistance in Men with Diabetes > Discussion
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“All men gave written informed consent, and the study was approved by the Human Research Ethics Committee, Research Ethics Unit, Austin Health.”
§ Low Testosterone Levels Are Common and Associated with Insulin Resistance in Men with Diabetes > Cross-sectional survey
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
In the paper
“However, testosterone may have deleterious actions on prostate disease, sleep apnea, and possibly cardiovascular risk (35).”
§ Low Testosterone Levels Are Common and Associated with Insulin Resistance in Men with Diabetes > Discussion
What the sources say
- Not checked yetcites [35] Rhoden, 2004, Risks of testosterone-replacement therapy and recommendations for monitoring., N Engl J Med source
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Consequently, the appropriate clinical response to this emerging problem remains to be determined.”
§ Low Testosterone Levels Are Common and Associated with Insulin Resistance in Men with Diabetes > Discussion
plain- Asserted: passes — The authors put it forward as true.
- Checkable: fails — It may be too vague to check against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. It may be too vague to check against evidence. The paper’s conclusions may not depend on it.
In the paper
“previous studies have reported an association of loss of weight in obese insulinresistant men with increased testosterone levels (30).”
§ Low Testosterone Levels Are Common and Associated with Insulin Resistance in Men with Diabetes > Discussion
What the sources say
- Not checked yetcites [30] Niskanen, 2004, Changes in sex hormone-binding globulin and testosterone during weight loss and weight maintenance in abdominally obese men with the metabolic syndrome., Diabetes Obes Metab source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim have been checked yet.
In the paper
“Certainly, testosterone replacement can improve performance, mood, and libido in men with hypogonadism (22) and augments insulin sensitivity (11,15).”
§ Low Testosterone Levels Are Common and Associated with Insulin Resistance in Men with Diabetes > Discussion
What the sources say
- Not checked yetcites [22] Bhasin, 2006, Testosterone therapy in adult men with androgen deficiency syndromes: an endocrine society clinical practice guideline., J Clin Endocrinol Metab [Erratum (2006) 91:1995–2010] source
- Not checked yetcites [11] Kapoor, 2006, Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolaemia in hypogonadal men with type 2 diabetes., Eur J Endocrinol source
- Not checked yetcites [15] Simon, 2001, Androgen therapy improves insulin sensitivity and decreases leptin level in healthy adult men with low plasma total testosterone: a 3-month randomized placebo-controlled trial., Diabetes Care source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The strengths of this study include the large number subjects, inclusion of a large cohort of patients with type 1 diabetes, measurement of serum testosterone levels at the appropriate time of day (early morning), accurate assays for total and free testosterone levels, and longitudinal follow-up in a substantial number of men with type 2 diabetes.”
§ Low Testosterone Levels Are Common and Associated with Insulin Resistance in Men with Diabetes > Discussion
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. The paper may give no reason why it holds. It may state two separate claims as one.
In the paper
“Indeed, reduced SHBG has been suggested as a surrogate marker for insulin resistance (33).”
§ Low Testosterone Levels Are Common and Associated with Insulin Resistance in Men with Diabetes > Discussion
What the sources say
- Not checked yetcites [33] Jayagopal, 2003, The biological variation of testosterone and sex hormone-binding globulin (SHBG) in polycystic ovarian syndrome: implications for SHBG as a surrogate marker of insulin resistance., J Clin Endocrinol Metab source
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
The paper relies on this without support.
The cohort of men attending a single tertiary referral clinic is representative of men with diabetes generally.
“in a large, unselected cohort of men with type 1 or type 2 diabetes presenting at a single center”
“large unselected cohort of men presenting to a single tertiary referral center”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“In fact, multiple studies confirmed the association between low or inappropriate T levels in men and T2D and obesity [167–170].”
From Role of sex hormone-binding globulin in the free hormone hypothesis and the relevance of free testosterone in androgen physiology (2022) · cites this paper as [168]
In the citing paper
“A longitudinal study in 265 men with a baseline hemoglobin A1c of 7.6% reported an inverse relationship between changes in glycemic control and testosterone levels.”
From A Perspective on Middle-Aged and Older Men With Functional Hypogonadism: Focus on Holistic Management (2017) · cites this paper as [35]
In the citing paper
“In those whose glycemic control improved over time, testosterone increased, whereas in those whose control worsened, testosterone decreased (35).”
From A Perspective on Middle-Aged and Older Men With Functional Hypogonadism: Focus on Holistic Management (2017) · cites this paper as [35]
In the citing paper
“Approximately, 50% of older (age >40 years) male patients with type 2 diabetes mellitus (DM2) have decreased testosterone (T) levels”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Rated major: it would touch a result — a value a result rests on, reported and recomputed p-values on opposite sides of the significance level, two passages that conflict with no sign which is right, or a cited work retracted before this paper was published.
In the paper
§ Low Testosterone Levels Are Common and Associated with Insulin Resistance in Men with Diabetes > Testosterone indices and insulin resistance
“higher hs-CRP levels (median 7.7 vs. 4.5, P Ͻ 0.01)”
§ Low Testosterone Levels Are Common and Associated with Insulin Resistance in Men with Diabetes > Statistical analysis
“hs-CRP (IU/ml) 1.5 (0.2-11.5) 3.0 (0.2-192) 2.9 (0.2-58)”
Rated minor: it would not touch a result — a value no result rests on, a p-value that stays on the same side of the significance level, or a conflict that is clerical, resolved elsewhere in the paper, or outside its own findings.
In the paper
§ Low Testosterone Levels Are Common and Associated with Insulin Resistance in Men with Diabetes > Cohort characteristics
“One third of men with type 2 diabetes had documented macrovascular disease”
§ Low Testosterone Levels Are Common and Associated with Insulin Resistance in Men with Diabetes > Statistical analysis
“Macrovascular disease (%) 16% 42% 40%”
Citations
Cites
Use and Abuse of HOMA Modeling
Wallace, T. M., Levy, J. C., & Matthews, D. R. (2004) · Diabetes Care · doi:10.2337/diacare.27.6.1487 · Cited by 5,114
A Critical Evaluation of Simple Methods for the Estimation of Free Testosterone in Serum
Vermeulen, A., Verdonck, L., & Kaufman, J. M. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.10.6079 · Cited by 3,824
Hyperinsulinemia as an independent risk factor for ischemic heart disease
Després, J.-P., Lamarche, B., Mauriège, P., Cantin, B., Dagenais, G. R., Moorjani, S., & Lupien, P.-J. (1996) · New England Journal of Medicine · doi:10.1056/nejm199604113341504 · Cited by 1,699
Ding, E. L., Song, Y., Malik, V. S., & Liu, S. (2006) · JAMA · doi:10.1001/jama.295.11.1288 · Cited by 1,354
Bhasin, S., Cunningham, G. R., Hayes, F. J., Matsumoto, A. M., Snyder, P. J., Swerdloff, R. S., & Montori, V. M. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2847 · Cited by 965
Kapoor, D., Goodwin, E., Channer, K. S., & Jones, T. H. (2006) · European Journal of Endocrinology · doi:10.1530/eje.1.02166 · Cited by 791
Risks of testosterone-replacement therapy and recommendations for monitoring.
Rhoden, E. L., & Morgentaler, A. (2004) · New England Journal of Medicine · doi:10.1056/nejmra022251 · Cited by 705
Androgens and Cardiovascular Disease
Liu, P. Y., Death, A. K., & Handelsman, D. J. (2003) · Endocrine Reviews · doi:10.1210/er.2003-0005 · Cited by 695
PLYMATE, S. R., MATEJ, L. A., JONES, R. E., & FRIEDL, K. E. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-67-3-460 · Cited by 693
Can clinical factors estimate insulin resistance in type 1 diabetes?
Williams, K. V., Erbey, J. R., Becker, D., Arslanian, S., & Orchard, T. J. (2000) · Diabetes · doi:10.2337/diabetes.49.4.626 · Cited by 640
Cited by
Sorted by citations
Items 101–200 of 469
Biswas, M., Hampton, D., Newcombe, R. G., & Rees, A. (2011) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2011.04196.x · Cited by 46
Pelusi, C., Giagulli, V. A., Baccini, M., Fanelli, F., Mezzullo, M., Fazzini, A., Bianchi, N., Carbone, M. D., De Pergola, G., Mastroroberto, M., et al. (2017) · PLOS ONE · doi:10.1371/journal.pone.0183369 · Cited by 45
Maggio, M. G., Vita, F. D., Fisichella, A., Lauretani, F., Ticinesi, A., Ceresini, G., Cappola, A. R., Ferrucci, L., & Ceda, G. P. (2015) · International Journal of Endocrinology · doi:10.1155/2015/292574 · Cited by 44
Benefits and Health Implications of Testosterone Therapy in Men With Testosterone Deficiency
Traish, A. M. (2017) · Sexual Medicine Reviews · doi:10.1016/j.sxmr.2017.10.001 · Cited by 46
Evaluation of the hypothalamic‐pituitary‐gonadal axis in eugonadal men with type 2 diabetes mellitus
Costanzo, P., Suárez, S. M., Scaglia, H. E., Zylbersztein, C., Litwak, L., & Knoblovits, P. (2013) · Andrology · doi:10.1111/j.2047-2927.2013.00163.x · Cited by 44
Is the Risk and Nature of CVD the Same in Type 1 and Type 2 Diabetes?
Duca, L. M., Sippl, R., & Snell‐Bergeon, J. K. (2013) · Current Diabetes Reports · doi:10.1007/s11892-013-0380-1 · Cited by 43
Alemany, M. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00027 · Cited by 45
Espeland, M. A., Carmichael, O. T., Yaşar, S., Hugenschmidt, C. E., Hazzard, W. R., Hayden, K. M., Rapp, S. R., Neiberg, R. H., Johnson, K., Hoscheidt, S. M., et al. (2018) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2018.05.015 · Cited by 45
Testosterone therapy and cardiovascular diseases
Cittadini, A., Isidori, A. M., & Salzano, A. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab241 · Cited by 42
The association between serum testosterone and insulin resistance: a longitudinal study
Ottarsdottir, K., Nilsson, A. G., Hellgren, M. I., Lindblad, U., & Daka, B. (2018) · Endocrine Connections · doi:10.1530/ec-18-0480 · Cited by 51
Yip, T. C., Wong, G. L., Chan, H. L., Tse, Y., Liang, L. Y., Hui, V. W., Lee, H. W., Lui, G. C.-Y., Kong, A. P. S., & Wong, V. W. (2020) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.15079 · Cited by 34
Grossmann, M., Hoermann, R., Fui, M. N. T., Zajac, J. D., Ierino, F. L., & Roberts, M. A. (2014) · Clinical Endocrinology · doi:10.1111/cen.12656 · Cited by 41
Self-citationHo, C.-H., Yu, H.-J., Wang, C.-Y., Jaw, F.-S., Hsieh, J.-T., Liao, W.-C., Pu, Y.-S., & Liu, S.-P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074173 · Cited by 40
Testosterone levels and type 2 diabetes in men: current knowledge and clinical implications
Kumar, M., Dutta, D., Anne, B., Shivaprasad, Sinha, A., Ray, S., & Chowdhury, S. (2014) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s50777 · Cited by 42
Predictive value of serum testosterone for type 2 diabetes risk assessment in men
Atlantis, E. E., Fahey, P. P., Martin, S., O’Loughlin, P. D., Taylor, A. W., Adams, R., Shi, Z., & Wittert, G. (2016) · BMC Endocrine Disorders · doi:10.1186/s12902-016-0109-7 · Cited by 42
Hypogonadism, Type-2 Diabetes Mellitus, and Bone Health: A Narrative Review
Russo, V., Chen, R., & Armamento‐Villareal, R. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.607240 · Cited by 41
Pintana, H., Pongkan, W., Pratchayasakul, W., Chattipakorn, N., & Chattipakorn, S. C. (2015) · AGE · doi:10.1007/s11357-015-9827-4 · Cited by 39
Knapp, A., Myhill, P. C., Davis, W. A., Peters, K. E., Hillman, D. R., Hamilton, E. J., Lim, E. M., & Davis, T. M. E. (2014) · Clinical Endocrinology · doi:10.1111/cen.12401 · Cited by 39
Sex Differences in Diabetes- and TGF-β1-Induced Renal Damage
Ziller, N., Kotolloshi, R., Esmaeili, M., Liebisch, M., Mrowka, R., Baniahmad, A., Liehr, T., Wolf, G., & Loeffler, I. (2020) · Cells · doi:10.3390/cells9102236 · Cited by 39
Tint, A. N., Hoermann, R., Wong, H., Ekinci, E. I., MacIsaac, R. J., Jerums, G., Zajac, J. D., & Grossmann, M. (2015) · European Journal of Endocrinology · doi:10.1530/eje-15-0672 · Cited by 38
Self-citationHo, C., Jaw, F.-S., Wu, C., Chen, K., Wang, C., Hsieh, J., Yu, H., & Liu, S. (2014) · The Journal of Sexual Medicine · doi:10.1111/jsm.12777 · Cited by 38
Type 2 Diabetes: A Protective Factor for Prostate Cancer? An Overview of Proposed Mechanisms
Rastmanesh, R., Hejazi, J., Marotta, F., & Hara, N. (2014) · Clinical Genitourinary Cancer · doi:10.1016/j.clgc.2014.01.001 · Cited by 38
Systematic Literature Review of the Epidemiology of Nongenetic Forms of Hypogonadism in Adult Males
Zarotsky, V., Huang, M., Carman, W. J., Morgentaler, A., Singhal, P. K., Coffin, D., & Jones, T. H. (2014) · Journal of Hormones · doi:10.1155/2014/190347 · Cited by 38
Wittert, G., Atlantis, E. E., Allan, C. A., Bracken, K., Conway, A. J., Daniel, M., Gebski, V., Grossmann, M., Hague, W. E., Handelsman, D. J., et al. (2018) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13601 · Cited by 36
Self-citationCai, T., Hu, Y., Ding, B., Yan, R., Liu, B., Cai, L., Jing, T., Jiang, L., Xie, X., Wang, Y., et al. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.813067 · Cited by 37
Li, Y., Wang, L., Xu, B., Zhao, L., Li, L., Xu, K., Tang, A., Zhou, S., Song, L., Zhang, X., et al. (2021) · Journal of Diabetes Research · doi:10.1155/2021/8891093 · Cited by 37
Saad, F., Yassin, A. A., Almehmadi, Y., Doros, G. D., & Gooren, L. J. (2015) · The Aging Male · doi:10.3109/13685538.2015.1034687 · Cited by 36
Janjgava, S., Zerekidze, T., Uchava, L., Giorgadze, E., & Asatiani, K. (2014) · European journal of medical research · doi:10.1186/s40001-014-0056-6 · Cited by 38
Høst, C., Bojesen, A., Erlandsen, M., Groth, K. A., Kristensen, K., Jurik, A. G., Birkebæk, N., & Gravholt, C. H. (2019) · Endocrine Connections · doi:10.1530/ec-19-0323 · Cited by 35
Sinclair, M. J., Gow, P. J., Grossmann, M., Shannon, A., Hoermann, R., & Angus, P. (2016) · Liver Transplantation · doi:10.1002/lt.24607 · Cited by 35
Self-citationSex steroids and glucose metabolism
Allan, C. A. (2014) · Asian Journal of Andrology · doi:10.4103/1008-682x.122589 · Cited by 38
Taylor, S. R., Meadowcraft, L., & Williamson, B. (2015) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/phar.1623 · Cited by 34
Serum free testosterone and metabolic syndrome in Japanese men
Katabami, T., Kato, H., Asahina, T., Hinohara, S., Shin, T., Kawata, T., Ohta, A., Iwamoto, T., & Tanaka, Y. (2010) · Endocrine Journal · doi:10.1507/endocrj.k10e-018 · Cited by 34
Multiple Mechanisms Linking Type 2 Diabetes and Alzheimer’s Disease: Testosterone as a Modifier
Asih, P. R., Tegg, M., Sohrabi, H. R., Carruthers, M. E., Gandy, S., Saad, F., Verdile, G., Ittner, L. M., & Martins, R. N. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161259 · Cited by 34
Role of sex hormones in diabetic nephropathy
Liu, J., Liu, Z., Sun, W., Luo, L., An, X., Yu, D., & Wang, W. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1135530 · Cited by 36
Dose-dependent effects of dihydrotestosterone in the streptozotocin-induced diabetic rat kidney
Xu, Q. S., Prabhu, A., Xu, S., Manigrasso, M. B., & Maric, C. (2009) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00135.2009 · Cited by 34
Roles of Testosterone Replacement in Cardiac Ischemia–Reperfusion Injury
Pongkan, W., Chattipakorn, S. C., & Chattipakorn, N. (2015) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248415587977 · Cited by 34
Global Perspective on Diabetic Foot Ulcerations
Dinh, T. (2011) · InTech eBooks · doi:10.5772/1173 · Cited by 34
Luconi, M., Samavat, J., Seghieri, G., Iannuzzi, G., Lucchese, M., Rotella, C. M., Forti, G., Maggi, M., & Mannucci, E. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.02.039 · Cited by 33
Sex Hormones, Insulin Resistance, and Diabetes Mellitus Among Men With or at Risk for HIV Infection
Monroe, A. K., Dobs, A. S., Xu, X., Palella, F. J., Kingsley, L., Witt, M. D., & Brown, T. T. (2011) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e3182278c09 · Cited by 34
Obesity and age as dominant correlates of low testosterone in men irrespective of diabetes status
Fui, M. N. T., Hoermann, R., Cheung, A. S., Gianatti, E., Zajac, J. D., & Grossmann, M. (2013) · Andrology · doi:10.1111/j.2047-2927.2013.00124.x · Cited by 33
Self-citationTestosterone deficiency, insulin-resistant obesity and cognitive function
Pintana, H., Chattipakorn, N., & Chattipakorn, S. C. (2015) · Metabolic Brain Disease · doi:10.1007/s11011-015-9655-3 · Cited by 33
McGill, J., Shoskes, D. A., & Sabanegh, E. S. (2012) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.79a.12010 · Cited by 33
Time for international action on treating testosterone deficiency syndrome
Carruthers, M. E. (2009) · The Aging Male · doi:10.1080/13685530802699067 · Cited by 33
Detecting people at high risk of type 2 diabetes- How do we find them and who should be treated?
Kong, A. P. S., Luk, A. O. Y., & Chan, J. C. N. (2016) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2016.06.003 · Cited by 36
Chodari, L., Mohammadi, M., Ghorbanzadeh, V., Dariushnejad, H., & Mohaddes, G. (2016) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2016.03.004 · Cited by 32
Effects of metformin on endothelial health and erectile dysfunction
Patel, J. P., Lee, E. H., Mena, C. I., & Walker, C. N. (2017) · Translational Andrology and Urology · doi:10.21037/tau.2017.03.52 · Cited by 33
Déficit de testosterona, síndrome metabólico y diabetes mellitus
Fernández-Miró, M., Chillarón, J. J., & Pedro‐Botet, J. (2015) · Medicina Clínica · doi:10.1016/j.medcli.2015.06.020 · Cited by 33
The impact of type 1 diabetes mellitus on male sexual functions and sex hormone levels
Hylmarova, S., Štechová, K., Pavlínková, G., Pěknicová, J., Maçek, M., & Kvapil, M. (2019) · Endocrine Journal · doi:10.1507/endocrj.ej19-0280 · Cited by 34
Antonič, K. G., Antonič, B., Žuran, I., & Pfeifer, M. (2020) · The Aging Male · doi:10.1080/13685538.2020.1793132 · Cited by 33
Guay, A. T., & Traish, A. M. (2011) · Urologic Clinics of North America · doi:10.1016/j.ucl.2011.02.004 · Cited by 32
Nesfatin-1 ameliorates type-2 diabetes-associated reproductive dysfunction in male mice
Ranjan, A. K., Choubey, M., Yada, T., & Krishna, A. (2019) · Journal of Endocrinological Investigation · doi:10.1007/s40618-019-01136-0 · Cited by 32
Hannan, A. J. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-5434-2_1 · Cited by 34
RETRACTED: 5α-Dihydrotestosterone enhances wound healing in diabetic rats
Gonçalves, R. V., Novaes, R. D., Sarandy, M. M., Damasceno, E. M., da Matta, S. L. P., de Gouveia, N. M., Freitas, M. B., & Espíndola, F. S. (2016) · Life Sciences · doi:10.1016/j.lfs.2016.03.019 · Cited by 31
RetractedHypogonadism, Erectile Dysfunction, and Type 2 Diabetes Mellitus: What the Clinician Needs to Know
Tamler, R., & Deveney, T. K. (2010) · Postgraduate Medicine · doi:10.3810/pgm.2010.11.2234 · Cited by 31
Bakhtyukov, A. A., Derkach, K. V., Gureev, M., Dar’in, D. V., Sorokoumov, V. N., Romanova, I. V., Morina, I. Y., Stepochkina, A. M., & Shpakov, A. O. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207493 · Cited by 30
Furini, C., Spaggiari, G., Simoni, M., Greco, C., & Santi, D. (2022) · Endocrine · doi:10.1007/s12020-022-03195-5 · Cited by 31
Hanchang, W., Semprasert, N., Limjindaporn, T., Yenchitsomanus, P., & Kooptiwut, S. (2013) · Endocrinology · doi:10.1210/en.2013-1351 · Cited by 31
Osmancevic, A., Daka, B., Michos, E. D., Trimpou, P., & Allison, M. (2023) · Clinical Endocrinology · doi:10.1111/cen.14930 · Cited by 29
Negative Effects of High Glucose Exposure in Human Gonadotropin-Releasing Hormone Neurons
Morelli, A., Comeglio, P., Sarchielli, E., Cellai, I., Vignozzi, L., Vannelli, G. B., & Maggi, M. (2013) · International Journal of Endocrinology · doi:10.1155/2013/684659 · Cited by 31
Androgen Deficiency in Aging and Metabolically Challenged Men
Shelton, J. B., & Rajfer, J. (2011) · Urologic Clinics of North America · doi:10.1016/j.ucl.2011.09.007 · Cited by 30
Ermetici, F., Donadio, F., Iorio, L., Malavazos, A. E., Dolci, A., Peverelli, E., Barbieri, A. M., Morricone, L. F., Chiodini, I., Arosio, M., et al. (2009) · European Journal of Endocrinology · doi:10.1530/eje-09-0203 · Cited by 30
Magnussen, L. V., Andersen, P. E., Diaz, A., Ostojic, J. N., Højlund, K., HOUGAARD, D. M., Christensen, A. N., Nielsen, T. L., & Andersen, M. (2017) · European Journal of Endocrinology · doi:10.1530/eje-17-0071 · Cited by 29
Androgen Deficiency and Erectile Dysfunction in Patients with Type 2 Diabetes
Saghier, E. O. A. E., Shebl, S. E., Fawzy, O., Eltayeb, L. M., Bekhet, L. M. A., & Gharib, A. (2015) · Clinical Medicine Insights Endocrinology and Diabetes · doi:10.4137/cmed.s27700 · Cited by 27
Malik, R. D., Lapin, B. R., Wang, C. E., Lakeman, J. C., & Helfand, B. T. (2014) · The Journal of Sexual Medicine · doi:10.1111/jsm.12730 · Cited by 28
Manigrasso, M. B., Sawyer, R. T., Marbury, D. C., Flynn, E. R., & Maric, C. (2011) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00718.2010 · Cited by 28
Mohammed, M., Al‐Habori, M., Abdullateef, A. A., & Saif-Ali, R. (2018) · Journal of Diabetes Research · doi:10.1155/2018/4926789 · Cited by 29
Testosterone deprivation accelerates cardiac dysfunction in obese male rats
Pongkan, W., Pintana, H., Sivasinprasasn, S., Jaiwongkam, T., Chattipakorn, S. C., & Chattipakorn, N. (2016) · Journal of Endocrinology · doi:10.1530/joe-16-0002 · Cited by 27
Role of Metabolic Factors in the Association Between Osteocalcin and Testosterone in Chinese Men
Liao, M., Guo, X., Yu, X., Pang, G., Zhang, S., Li, J., Tan, A., Gao, Y., Yang, X., Zhang, H., et al. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1805 · Cited by 27
Li, S., Kumar, S., Gu, X., & DeFalco, T. (2024) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2024.101323 · Cited by 30
Diabetes Mellitus Type 2: A Driving Force for Urological Complications
Sayyid, R. K., & Fleshner, N. E. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2016.02.006 · Cited by 27
Malik, R. D., Wang, C. E., Lapin, B., Lakeman, J. C., & Helfand, B. T. (2015) · Urology · doi:10.1016/j.urology.2015.01.027 · Cited by 26
Magnussen, L. V., Hvid, L. G., Hermann, A., HOUGAARD, D. M., Gram, B., Caserotti, P., & Andersen, M. (2017) · Andrology · doi:10.1111/andr.12396 · Cited by 26
Effects of treatment for diabetes mellitus on testosterone concentrations: A systematic review
Cauwenberghe, J. V., Block, C. E. M. D., Vanderschueren, D., & Antonio, L. (2022) · Andrology · doi:10.1111/andr.13318 · Cited by 25
Grossmann, M., Jayasena, C. N., & Anawalt, B. D. (2023) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgad180 · Cited by 25
Self-citationApostolov, R., Gianatti, E., Wong, D. J., Kutaiba, N., Gow, P. J., Grossmann, M., & Sinclair, M. J. (2022) · World Journal of Hepatology · doi:10.4254/wjh.v14.i4.754 · Cited by 24
Self-citationLiu, N., Luo, X., Li, P., & Xiong, W. (2022) · Andrology · doi:10.1111/andr.13207 · Cited by 24
Sex-Related Aspects in Diabetic Kidney Disease—An Update
Loeffler, I., & Ziller, N. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12082834 · Cited by 24
Elabbady, A. A., Hashad, M. M., Kotb, A. F., & Ghanem, A. (2016) · Prostate International · doi:10.1016/j.prnil.2016.07.005 · Cited by 24
Wang, L., Ma, C., Wei, D., Wang, M., Xu, Q., Wang, J., Yu, S., Huo, W., Jing, T., Wang, C., et al. (2023) · Environmental Pollution · doi:10.1016/j.envpol.2023.122213 · Cited by 25
The Interactions between Insulin and Androgens in Progression to Castrate-Resistant Prostate Cancer
Gunter, J. H., Lubik, A. A., McKenzie, I., Pollak, M., & Nelson, C. C. (2012) · Advances in Urology · doi:10.1155/2012/248607 · Cited by 23
Hypogonadism, ADAM, and hormone replacement
Pinsky, M. R., & Hellstrom, W. J. G. (2010) · Therapeutic Advances in Urology · doi:10.1177/1756287210369805 · Cited by 22
Low Testosterone Levels are Common and Associated with Insulin Resistance in Men with Diabetes
Meikle, W. A. (2008) · Yearbook of Endocrinology · doi:10.1016/s0084-3741(08)79227-8 · Cited by 22
The Incidence of Hypogonadotropic Hypogonadism in Type 2 Diabetic Men in Polish Population
Rabijewski, M., Papierska, L., Zgliczyński, W., & Piątkiewicz, P. (2013) · BioMed Research International · doi:10.1155/2013/767496 · Cited by 23
Cheung, K. K.-T., Lau, E. S. H., So, W., Ronald, C. W., Ozaki, R., Kong, A. P. S., Chow, F. C., Chan, J. C. N., & Luk, A. O. Y. (2016) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2016.11.012 · Cited by 21
Khajehlandi, M., Bolboli, L., Siahkuhian, M., Rami, M., Tabandeh, M. R., Khoramipour, K., & Suzuki, K. (2021) · Biomolecules · doi:10.3390/biom11040498 · Cited by 21
Prostate Cancer Risk in Pre-Diabetic Men: A Matched Cohort Study
Onitilo, A. A., Berg, R. L., Engel, J. M., Stankowski, R. V., Glurich, I., Williams, G. M., & Doi, S. A. R. (2013) · Clinical Medicine & Research · doi:10.3121/cmr.2013.1160 · Cited by 21
Clinical and biochemical correlates of male hypogonadism in type 2 diabetes
Herrero, A., Marcos, M., Galindo‐Villardón, P., Miralles, J. M., & Hernández, J. J. C. (2017) · Andrology · doi:10.1111/andr.12433 · Cited by 21
Male gonadal axis function in patients with type 2 diabetes
Costanzo, P., & Knoblovits, P. (2016) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2016-0014 · Cited by 21
The effects of type 1 and type 2 diabetes mellitus on bone health in chronic kidney disease
Aleksova, J., Ebeling, P., & Elder, G. (2025) · Nature Reviews Endocrinology · doi:10.1038/s41574-024-01083-8 · Cited by 20
Beyond reproduction: unraveling the impact of sex hormones on cardiometabolic health
Xega, V., & Liu, J. (2024) · Medical Review · doi:10.1515/mr-2024-0012 · Cited by 33
The Impact of Diabetes Mellitus‐Related Oxidative Stress on Male Fertility: A Review
Dena, S. M., Adeleye, A. O., Mohlala, K., Langa, B., & Opuwari, C. S. (2025) · Journal of Diabetes · doi:10.1111/1753-0407.70157 · Cited by 27
Andlib, N., Sajad, M., & Thakur, S. C. (2024) · Acta Histochemica · doi:10.1016/j.acthis.2024.152173 · Cited by 20
Nday, C. M., Eleftheriadou, D., & Jackson, G. E. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14256 · Cited by 21
Zhang, K., Zhao, M. ‐., An, Q., Jia, Y., Fu, L., Xu, J., & Gu, Y. (2017) · Andrology · doi:10.1111/andr.12425 · Cited by 21
The prevalence of prediabetes in population of polish men with late-onset hypogonadism
Rabijewski, M., Papierska, L., & Piątkiewicz, P. (2014) · The Aging Male · doi:10.3109/13685538.2014.936000 · Cited by 19
Prevalence of hypogonadism in patients with type 2 diabetes mellitus among the Indian population
Anupam, B., Shivaprasad, C., Vijaya, S., Atluri, S., Aiswarya, Y., & Nikhil, K. (2020) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2020.07.006 · Cited by 19
Testosterone, Diabetes Risk, and Diabetes Prevention in Men
Yeap, B. B., & Wittert, G. (2022) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2021.11.004 · Cited by 19
The Prevalence and Predictors of Androgen Deficiency in Taiwanese Men With Type 2 Diabetes
Liu, R., Chung, M., Wang, P., Chen, C., Lee, J., Lee, W., Chancellor, M. B., Yang, K. D., & Chuang, Y. (2013) · Urology · doi:10.1016/j.urology.2013.03.023 · Cited by 20
Marcelli, M., & Mediwala, S. N. (2020) · Journal of Investigative Medicine · doi:10.1136/jim-2019-001233 · Cited by 23
Metadata
- Authors
- Grossmann, M., Thomas, M. C., Panagiotopoulos, S., Sharpe, K., MacIsaac, R. J., Clarke, S., Zajac, J. D., & Jerums, G.
- Affiliations
- The University of Melbourne (AU)
- Baker Heart and Diabetes Institute (AU)
- Corresponding author
- Grossmann, Mathis
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2008-05-01
- Volume
- 93
- Issue
- 5
- Pages
- 1834-1840
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W1975633687
- Semantic Scholar
- 02f5d7f00e960755b4687b5424387d4da02771b3
- Cited by
- 468
- References
- 37
- Citations by year
- 2026: 22 · 2025: 22 · 2024: 22 · 2023: 23 · 2022: 28 · 2021: 24 · 2020: 23 · 2019: 15 · 2018: 24 · 2017: 33 · 2016: 34 · 2015: 30 · 2014: 41 · 2013: 31 · 2012: 30
- FWCI
- 15.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council
- National Health and Medical Research Council
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Keywords
- androgen deficiency, insulin resistance, type 2 diabetes, type 1 diabetes, men, free testosterone, total testosterone, testosterone replacement therapy, prevalence
- MeSH terms
- Adult, Aged, Cross-Sectional Studies, Diabetes Mellitus, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Humans, Insulin Resistance, Male, Middle Aged, Sex Hormone-Binding Globulin, Testosterone
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
A language model drew the claims from the paper on 2026-10-10, under version 3 of the claim definition (model deepseek-v4.1-flash, prompt extract-v3).
A second model labelled each claim on 2026-10-10 (model jev-1.13-20260917, definition revision gold-guideline-v0.2).
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
