The prevalence of prediabetes in population of polish men with late-onset hypogonadism
Open accessAbstract
OBJECTIVE: Prediabetes patients are likely to develop type 2 diabetes (T2DM). Low testosterone is a risk factor for impaired glucose tolerance (IGT) in men. The aim of this study was to investigate the prevalence of prediabetes in population of Polish men with late-onset hypogonadism (LOH). METHODS: This study was performed in 246 men with LOH and in 184 eugonadal control group. Prediabetes was diagnosed in patients with impaired fasting glucose (IFG), IGT or with HbA1c from 5.7 to 6.4%. Sex hormones and metabolic parameters were measured. RESULTS: The mean TT concentration in the LOH group was 9.55 ± 1.5 nmol/l and 16.45 ± 1.8 nmol/l in the control group (p < 0.001). We observed negative relationships between cFT and HbA1c (r = -0.336; p < 0.005) and between TT and HbA1c (r = -0.366, p < 0.002), In the LOH group, prediabetes was diagnosed in 41.5% men. In the control group, prediabetes was diagnosed in 13% of patients. In the LOH group, TT and cFT levels were lower in prediabetic patients, when compared with normoglycemic patients and patients with IGT had lower TT levels than subgroups with IFG or elevated HbA1c. CONCLUSIONS: In a population of Polish men with LOH, we observed high prevalence of prediabetes and routine fasting glucose and glucose tolerance test should be performed in these patients.
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Men with diabetes may have lower testosterone because of reduced hypothalamic GnRH drive or testicular damage.
“Men with DM also may have lower testosterone levels due to decreased hypothalamic gonadotropin-releasing hormone drive and/or damage to the testes.”
From American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update. (2022) · cites this paper as [1553]
The Introduction reports that 30–50% of men with type 2 diabetes have low testosterone, and the Discussion reports a high prevalence of hypogonadotropic hypogonadism in a previous study of Polish men with type 2 diabetes. Neither section attributes low testosterone to reduced hypothalamic GnRH drive or testicular damage; searches for those mechanisms found no supporting passage. (LLM, conf=0.85)
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- Authors
- Rabijewski, M., Papierska, L., & Piątkiewicz, P.
- Affiliations
- Medical University of Warsaw (PL)
- Corresponding author
- Rabijewski, Michał
- Venue
- The Aging Male
- Publisher
- Informa UK Limited
- Published
- 2014-07-04
- Volume
- 17
- Issue
- 3
- Pages
- 141-146
- ISSN
- 1368-5538 (ISSN-L)
- 1473-0790
- OpenAlex
- W2085211701
- Cited by
- 19
- References
- 34
- Citations by year
- 2026: 2 · 2024: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 5 · 2018: 4 · 2017: 1 · 2016: 1 · 2015: 1
- FWCI
- 0.80
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Aging Male (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- prediabetes, andropause, androgen deficiency, impaired glucose tolerance, impaired fasting glucose, HbA1c, sex hormone-binding globulin, type 2 diabetes risk, Polish men
- MeSH terms
- Blood Glucose, Diabetes Mellitus, Type 2, Eunuchism, Glycated Hemoglobin, Humans, Male, Middle Aged, Poland, Prediabetic State, Testosterone, Prevalence, Case-Control Studies
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