Cited by 578Berberine and alkaloids researchNatural Antidiabetic Agents StudiesMetabolism, Diabetes, and Cancer

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Treatment of Type 2 Diabetes and Dyslipidemia with the Natural Plant Alkaloid Berberine

Zhang, Yifei, Li, Xiaoying, Zou, Dajin, Liu, Wei, Yang, Jialin, Zhu, Na, Huo, Li, Wang, Miao, Hong, Jie, Wu, Peihong, Ren, Guoguang, Ning, Guang·2008·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jc.2007-2404

Open this paper in CoChat — free account

Abstract

Context: Berberine, a natural plant alkaloid, is usually used as an antibiotic drug. The potential glucose-lowering effect of berberine was noted when it was used for diarrhea in diabetic patients. In vitro and in vivo studies have then showed its effects on hyperglycemia and dyslipidemia. Objective: The objective of the study was to evaluate the efficacy and safety of berberine in the treatment of type 2 diabetic patients with dyslipidemia. Design: One hundred sixteen patients with type 2 diabetes and dyslipidemia were randomly allocated to receive berberine (1.0 g daily) and the placebo for 3 months. The primary outcomes were changes in plasma glucose and serum lipid concentrations. Glucose disposal rate (GDR) was measured using a hyperinsulinemic euglycemic clamp to assess insulin sensitivity. Results: In the berberine group, fasting and postload plasma glucose decreased from 7.0 ± 0.8 to 5.6 ± 0.9 and from 12.0 ± 2.7 to 8.9 ± 2.8 mm/liter, HbA1c from 7.5 ± 1.0% to 6.6 ± 0.7%, triglyceride from 2.51 ± 2.04 to 1.61 ± 1.10 mm/liter, total cholesterol from 5.31 ± 0.98 to 4.35 ± 0.96 mm/liter, and low-density lipoprotein-cholesterol from 3.23 ± 0.81 to 2.55 ± 0.77 mm/liter, with all parameters differing from placebo significantly (P < 0.0001, P < 0.0001, P < 0.0001, P = 0.001, P < 0.0001, and P <0.0001, respectively). The glucose disposal rate was increased after berberine treatment (P = 0.037), although no significant change was found between berberine and placebo groups (P = 0.063). Mild to moderate constipation was observed in five participants in the berberine group. Conclusions: Berberine is effective and safe in the treatment of type 2 diabetes and dyslipidemia.

Integrity signals

Registry

Crossref · 10.1210/jc.2007-2404

Cites

23 of 23 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)
Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944
Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011
Glucose clamp technique: a method for quantifying insulin secretion and resistance.
DeFronzo, R. A., Tobin, J. D., & Andres, R. (1979) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1979.237.3.e214 · Cited by 7,425
Risks for All-Cause Mortality, Cardiovascular Disease, and Diabetes Associated With the Metabolic Syndrome
Ford, E. S. (2005) · Diabetes Care · doi:10.2337/diacare.28.7.1769 · Cited by 1,718
Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins
Kong, W., Wei, J., Abidi, P., Lin, M., Inaba, S., Li, C., Wang, Y., Wang, Z., Si, S., Pan, H., et al. (2004) · Nature Medicine · doi:10.1038/nm1135 · Cited by 1,391
Berberine, a Natural Plant Product, Activates AMP-Activated Protein Kinase With Beneficial Metabolic Effects in Diabetic and Insulin-Resistant States
Lee, Y. S., Kim, W. S., Kim, K. H., Yoon, M. J., Cho, H. J., Shen, Y., Ye, J.-M., Lee, C. H., Oh, W. K., Kim, C. T., et al. (2006) · Diabetes · doi:10.2337/db06-0006 · Cited by 1,054
The 1997 American Diabetes Association and 1999 World Health Organization criteria for hyperglycemia in the diagnosis and prediction of diabetes
Gabir, M. M., Hanson, R. L., Dabelea, D., Imperatore, G., Roumain, J., Bennett, P. H., & Knowler, W. C. (2000) · Diabetes Care · doi:10.2337/diacare.23.8.1108 · Cited by 568
Berberine improves glucose metabolism through induction of glycolysis
Yin, J., Gao, Z., Liu, D., Liu, Z., & Ye, J. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00211.2007 · Cited by 418
Pharmacokinetics of Berberine and Its Main Metabolites in Conventional and Pseudo Germ-Free Rats Determined by Liquid Chromatography/Ion Trap Mass Spectrometry
Zuo, F., Nakamura, N., Akao, T., & Hattori, M. (2006) · Drug Metabolism and Disposition · doi:10.1124/dmd.106.011361 · Cited by 284
Therapeutic effects of berberine in impaired glucose tolerance rats and its influence on insulin secretion.
Leng, S.-H., Lu, F., & Xu, L. (2004) · PubMed · Cited by 237

Flagged first, then by citations

Show all 23 references

Research works printed but not linked: 3

Ni, 1988, Therapeutic effect of berberine on 60 patients with type II diabetes mellitus and experimental research [article in Chinese]., Zhong Xi Yi Jie He Za Zhi, 8, 711
Xie, 2005, The clinical efficacy of berberine in treatment of type 2 diabetes mellitus [article in Chinese]., Chin J Clin Healthcare, 8, 402
Wei, 2004, Clinical study on improvement of type 2 diabetes mellitus complicated with fatty liver treatment by berberine [article in Chinese], Zhong Xi Yi Jie He Ganbing Za Zhi, 14, 334

Sorted by citations

Items 401–500 of 578

Effect of Berberine Plus Bezafibrate Administration on the Lipid Profile of Patients with Mixed Dyslipidemia: A Pilot Clinical Trial
León-Martínez, J. M., Martínez‐Abundis, E., González-Ortı́z, M., & Pérez-Rubio, K. G. (2020) · Journal of Medicinal Food · doi:10.1089/jmf.2020.0029 · Cited by 11
“18 In contrast, ﬁbrates modify the lipid proﬁle, improving TG, TC, LDL-C, and HDL-C levels 19 ; they have numerous pleiotropic effects, and seem to be drugs of choice in both monotherapy and in combined therapy for patients with dyslipidemia.”
Application of dietary supplements in the prevention of type 2 diabetes-related cardiovascular complications
Jin, Y., & Arroo, R. (2020) · Phytochemistry Reviews · doi:10.1007/s11101-020-09710-8 · Cited by 11
Dietary supplements in therapy to support weight reduction in obese patients
Wawrzyniak, N., Skrypnik, K., & Suliburska, J. (2022) · Acta Scientiarum Polonorum Technologia Alimentaria · doi:10.17306/j.afs.1010 · Cited by 11
“The consumption by diabetics of 1g of berberine daily for three months successfully lowered fasting blood glucose, including after meals (Zhang et al., 2008).”
Background
Isoquinoline Alkaloid Berberine Exerts its Antineoplastic Activity by Inducing Molecular DNA Damage in HeLa Cells: A Comet Assay Study
Rao, G. C. J. (2014) · Biology and Medicine · doi:10.4172/0974-8369.1000223 · Cited by 11
“Recent clinical trials have shown that berberine has potential as a safe oral hypoglycemic agent to treat type II diabetes in patients with dyslipidemia [24].”
Background
Berberine ameliorates high-fat diet-induced metabolic disorders through promoting gut Akkermansia and modulating bile acid metabolism
Hang, W., Yin, R., Kang, X.-W., He, L., Cao, X., & Chen, J. (2025) · Chinese Medicine · doi:10.1186/s13020-025-01251-6 · Cited by 11
Integrating Metabolomic Analysis, Network Pharmacology, and Molecular Docking to Underlying Pharmacological Mechanism and Ethnobotanical Rationalization for Diabetes Mellitus: Study on Medicinal Plant Fibraurea tinctoria Lour.
Umar, A. H., Widuri, S. A., Sulıstyanıngsıh, Y. C., & Ratnadewi, D. (2024) · Phytochemical Analysis · doi:10.1002/pca.3477 · Cited by 10
“…unveiled that this compound is also capable of inhibiting FOXO1 transcription factor in the gluconeogenesis pathway [34], and clinical stage with a randomized controlled trial model with a dose of 1.0 g daily, it can reduce HbA1c effectively and safely in patients with type 2 diabetes [35].”
Influential
The effect of berberine on insulin resistance in women with polycystic ovary syndrome: detailed statistical analysis plan (SAP) for a multicenter randomized controlled trial
Zhang, Y., Sun, J., Zhang, Y., Chai, Q., Zhang, K., Ma, H., Wu, X., & Liu, J. (2016) · Trials · doi:10.1186/s13063-016-1633-5 · Cited by 10
Self-citation
Antidiabetic Phytocompounds Acting as Glucose Transport Stimulators
Eddouks, M., Akdad, M., Hassani, R. A. E., Khallouki, F., & Bakri, Y. (2022) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530322666220510093720 · Cited by 11
The Possible Synergistic Pharmacological Effect of an Oral Berberine (BBR) and Curcumin (CUR) Complementary Therapy Alleviates Symptoms of Irritable Bowel Syndrome (IBS): Results from a Real-Life, Routine Clinical Practice Settings-Based Study
Wade, U., Pascual-Figal, D. A., Rabbani, F., Ernst, M., Albert, A., Janssens, I., Dierckxsens, Y., Iqtadar, S., Khokhar, N. A., Kanwal, A., et al. (2024) · Nutrients · doi:10.3390/nu16081204 · Cited by 10
“Berberine is generally well tolerated with a good safety profile [87].”
Background
A Validated Liquid Chromatographic Method for Berberine Analysis in Tissue and Application
Zhou, N., Liu, D., & Bao, X. (2020) · International Journal of Analytical Chemistry · doi:10.1155/2020/8892696 · Cited by 9
The effect of Chinese herbal formulas combined with metformin on modulating the gut microbiota in the amelioration of type 2 diabetes mellitus: A systematic review and meta-analysis
Yun-xi, X., Zheng, S., Jiang, S., Chen, J., Zhu, X., & Zhang, Y. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.927959 · Cited by 9
“Berberine, which was hypothesized as the key pharmaceutical ingredient in GQD, was reported to significantly alleviate hyperglycaemia and alter gut microbiota structure as GQD did (56, 88) by preventing and alleviating obesity and insulin resistance (69).”
BackgroundSelf-citation
Treatment of berberine alleviates diabetic nephropathy by reducing iron overload and inhibiting oxidative stress.
Wang, Y., Yue, S., Cai, F., Zhu, W., Zhong, Y., Chen, J., & Li, C. (2023) · PubMed · doi:10.14670/hh-18-599 · Cited by 9
Caracterización de un modelo de diabetes tipo 2 en ratas Wistar hembra
G, M. C. F., H, I. H. P., & Mejía‐Zepeda, R. (2013) · Revista Mvz Córdoba · doi:10.21897/rmvz.137 · Cited by 9
Dietary Supplements for Diabetes Are Decidedly Popular: Help Your Patients Decide
Shane‐McWhorter, L. (2013) · Diabetes Spectrum · doi:10.2337/diaspect.26.4.259 · Cited by 10
Antidiabetic bioactive compounds from plants
Missoun, F. (2018) · Medical Technologies Journal · doi:10.26415/2572-004x-vol2iss2p199-214 · Cited by 9
“It seems to perform this activity by decreasing the activity of certain genes that work to form and store more fat [32,33,34,35,36].”
Background
The Beneficial Effects of Curcumin on Lipids: Possible Effects on Dyslipidemia-induced Cardiovascular Complications
Yaribeygi, H., Maleki, M., Butler, A. E., Jamialahmadi, T., Gumpricht, E., & Sahebkar, A. (2023) · Current Medicinal Chemistry · doi:10.2174/0929867331666230707094644 · Cited by 9
Causal relationship between fertility nutrients supplementation and PCOS risk: a Mendelian randomization study
Shao, F., Xu, S., Zhao, H., Zhang, F., Wang, X., & Wang, H. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1420004 · Cited by 8
“Berberine is an alkaloid with a variety of pharmacological effects, including anti-in ﬂ ammatory, antioxidant, and insulin sensitivity-improving actions (41, 42).”
Background
Berberine-induced browning and energy metabolism: mechanisms and implications
Ağaçdiken, A., & Göktaş, Z. (2025) · PeerJ · doi:10.7717/peerj.18924 · Cited by 8
Berberine and Palmatine Distribution Across Plant Organs in Berberis darwinii: Basis for Selecting Superior-Producing Accessions
Chacón-Fuentes, M., Burgos‐Díaz, C., Opazo‐Navarrete, M., Mercado, A., & Westermeyer, F. (2025) · Molecules · doi:10.3390/molecules30081849 · Cited by 8
Clinical Efficacy of Curcumin, Resveratrol, Silymarin, and Berberine on Cardio‐Metabolic Risk Factors Among Patients With Type 2 Diabetes Mellitus: A Systemic Review and Bayesian Network Meta‐Analysis
Miao, R., Zhang, B., Zhou, D., Kang, M., Tian, J., Zhao, L., & Tong, X. (2025) · Phytotherapy Research · doi:10.1002/ptr.8431 · Cited by 12
A comprehensive review of Indian medicinal plants effective in diabetes management: Current status and future prospects
Pundarikakshudu, K., Shah, P., & Patel, M. G. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95719-9.00013-6 · Cited by 8
Metabolic effects of the association Berberis aristata/Silybum marianum: a preliminary double-blind, placebo-controlled study in obese patients with type 2 diabetes
Guarino, G., Corte, T. D., Sofia, M., Carbone, L., Marino, G., Martedì, E., & Gentile, S. (2015) · Nutrafoods · doi:10.1007/s13749-015-0052-7 · Cited by 9
Different effects of two dipeptidyl peptidase‐4 inhibitors and glimepiride on β‐cell function in a newly designed two‐step hyperglycemic clamp 应用双重高糖钳夹新技术比较两种DPP‐IV抑制剂与格列美脲对胰岛β细胞功能的不同影响
Zhang, Y., Chi, J., Wang, W., Hong, J., Gu, W., Wang, B., & Ning, G. (2014) · Journal of Diabetes · doi:10.1111/1753-0407.12175 · Cited by 8
“infusion of glucose, which has been described in details elsewhere.(19) The two-step hyperglycemic clamp was divided into three clamp periods (Figs 1,2), as described below.”
MethodSelf-citation
Anti‐Diabetic Effects of Berberis kansuensis Extract on Type 2 Diabetic Rats Revealed by 1H‐NMR‐Based Metabolomics and Biochemistry Analysis
Du, H., Li, Q., Yi, H., Xu, T., Xu, X., Kuang, T., Zhang, J., Huang, A., & Fan, G. (2020) · Chemistry & Biodiversity · doi:10.1002/cbdv.202000413 · Cited by 8
Combination of Berberine and Evodiamine Alleviates Obesity by Promoting Browning in 3T3-L1 Cells and High-Fat Diet-Induced Mice
Zhang, H., Xiong, P., Zheng, T., Hu, Y., Guo, P., Shen, T., & Zhou, X. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26094170 · Cited by 7
“Clinical trials have demonstrated that berberine at doses of 1000–1200 mg/day for 3–6 months significantly improves glycemic and lipid profiles and provides renal protection in patients with type 2 diabetes mellitus (T2DM), without serious adverse effects [48,49].”
The effect of berberine on obesity indices: a systematic review and meta-analysis
Vahed, I. E., Shahir-Roudi, E., Nojumi, S., Golmohammadi, S., Shahrebabak, M. M., Moghadam, N. S. T., Bagheryan, A. S., Moftakhar, M., Shamsipour, F., Jafari, M., et al. (2025) · International Journal of Obesity · doi:10.1038/s41366-025-01943-x · Cited by 9
“For instance, Soltani and Yan showed high risk of bias related to deviations from interventions and overall risk, potentially in ﬂ uencing the outcomes.”
Influential
Renoprotective Effect of Berberine on Streptozotocin-induced Diabetic Nephropathy Rats
Wu, Z., Xie, Z., Liu, J., Wu, Q., & Wang, X. (2017) · International Journal of Pharmacology · doi:10.3923/ijp.2017.247.256 · Cited by 7
Physicochemical Characterization of Berberine-loaded Pluronic F127 Polymeric Micelles and In Vivo Evaluation of Hypoglycemic Effect
Wang, Z., Chen, P., Guo, M., Yang, X., Song, W., & Huang, F. (2022) · Journal of Pharmaceutical Innovation · doi:10.1007/s12247-022-09658-6 · Cited by 7
“Berberine has had a large number of significant bioac-tivities since discovered, such as anti-diabetic, anti-obesity, antibacterial, anti-inflammation, anti-cancer, cardiovascular protective, and antiulcer activity [6, 25–27] .”
Background
Metabolic Interaction of the Active Constituents ofCoptis chinensisin Human Liver Microsomes
Liu, S., Zhang, X., Qiu, F., Miao, P., Shen, S., Zhu, L., Zeng, J., & Jiang, J. C. (2015) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2015/802903 · Cited by 7
“The isoquinoline alkaloids are responsible for its various pharmacological effects, such as antibacterial [3], blood glucose-lowering [4] and lipid-lowering [5] effects.”
Assessment of Genotoxic Effects of Selected Herbal Dietary Supplements**The information in this chapter is not a formal dissemination of information by the US Food and Drug Administration and does not represent agency position or policy.
Zhang, Z., Mei, N., Chen, S., Guo, L., & Guo, X. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802147-7.00062-0 · Cited by 7
Natural Products Modulating Autophagy Pathway Against the Pathogenesis of Diabetes Mellitus
Li, L., Qi, J., & Li, H. (2018) · Current Drug Targets · doi:10.2174/1389450119666180726115805 · Cited by 8
The Effect of Combined Herbal Capsule on Glycemic Indices and Lipid Profile in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Clinical Trial
Ghafarzadegan, R., Javaheri, J., Asgari, M., Golitaleb, M., Maraki, F., Ghafarzadegan, R., & Zarei, M. (2021) · Jundishapur Journal of Natural Pharmaceutical Products · doi:10.5812/jjnpp.109488 · Cited by 6
Berberine
Srivastava, A., Sinha, A., Lall, R., & Gupta, R. C. (2019) · Springer eBooks · doi:10.1007/978-3-030-04624-8_5 · Cited by 6
Quality evaluation of berberine food supplements with high-field and compact 1H NMR spectrometers
Danoun, S., Balayssac, S., Gilard, V., Martino, R., & Malet‐Martino, M. (2022) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2022.115161 · Cited by 6
Effects of Shenlian formula on microbiota and inflammatory cytokines in adults with type 2 diabetes: a double-blind randomized clinical trial.
Jiang, L., Qiang, F. U., Shidong, W., Jinxi, Z., Chen, Y., Jiayue, L. I., Yonghua, X., Weijun, H., Sun, R., Yao, X., et al. (2023) · PubMed Central · doi:10.19852/j.cnki.jtcm.20230608.003 · Cited by 6
Berberine Analogues: Progress towards Versatile Applications
Yang, F., Wang, J., Tang, J., Yu, L.-F., Li, J., & Li, J.-Y. (2015) · Heterocycles · doi:10.3987/rev-15-825 · Cited by 6
An in vitro approach to study the absorption of a new oral formulation of berberine
Marino, M., Gardana, C., Scialpi, A., Giorgini, G., Simonetti, P., & Bo’, C. D. (2021) · PharmaNutrition · doi:10.1016/j.phanu.2021.100279 · Cited by 7
Sustainable spectrofluorimetric determination of berberine in dietary supplements via Erythrosin B Ion-Pair complexation with mechanistic investigation, Box-Behnken optimization, and green chemistry assessment
Shmrany, H. A., Alqahtani, A., Alqahtani, T., Alshehri, A., & Almrasy, A. A. (2026) · Scientific Reports · doi:10.1038/s41598-026-36903-6 · Cited by 5
The role of berberine in polycystic ovary syndrome — a summary of knowledge
Jurgiel, J., Graniak, A., Opyd, P., Zawodny, T., & Lis, M. (2023) · Ginekologia Polska · doi:10.5603/gpl.95138 · Cited by 8
Proteomics analysis reveals a potential new target protein for the lipid-lowering effect of Berberine8998
Yu, C., Liu, X., Liu, X., Gui, Y., Liu, H.-M., Hong-chao, Z., Górecki, D. C., Patel, A. V., Yu, C., & Wang, Y. (2018) · Acta Pharmacologica Sinica · doi:10.1038/aps.2017.200 · Cited by 5
Health effects of peptides obtained from hydrolysed chicken by-products by the action of Bromelia pinguin and B. karatas proteases in Wistar rats induced with metabolic syndrome
Romero-Garay, M. G., Becerra-Verdín, E. M., Soto‐Domínguez, A., Montalvo‐González, E., & García‐Magaña, M. D. L. (2022) · International Food Research Journal · doi:10.47836/ifrj.29.5.10 · Cited by 5
“…MS+HC control group, with a lack of radial distribution between the hepatocytes and sinusoidal capillaries, and accumulation of lipid inclusions around the central vein; lipid accumulation in hepatocytes, mainly as triglycerides, can generate lipotoxicity and possible damage (Zhang et al., 2008).”
Background
The effect of phytochemicals in prediabetic patients: A systematic review of randomized controlled trials
Kiani, Z., Amini, S., Askari, G., Kesharwani, P., Bagherniya, M., & Sahebkar, A. (2023) · Phytotherapy Research · doi:10.1002/ptr.7892 · Cited by 5
Hydrastis canadensis (Goldenseal) and Other Berberine-Containing Botanicals
Upton, R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-43044-9.00086-8 · Cited by 5
Effect of RG (Coptis root and ginseng) formula in patients with type 2 diabetes mellitus: a study protocol for a randomized controlled and double-blinding trial
Jiang, L., Fu, Q., Wang, S., Chen, Y., Li, J., Xiao, Y., Sun, R., Shen, E. A., Wang, J., Zhang, Y., et al. (2022) · Trials · doi:10.1186/s13063-022-06229-5 · Cited by 5
Self-citation
Coptidis Rhizoma Water Extract Stimulates 5′-AMP-Activated Protein Kinase in Rat Skeletal Muscle
Tatsuro, Egawa, T., Oshima, R., Oshima, Eriko, Kurogi, Hiroko, Tanabe, Satoshi, S., Tsuda, et al. (2011) · Chinese Journal of Natural Medicines · doi:10.3724/sp.j.1009.2011.00215 · Cited by 4
Corn
Xu, J., Li, Y., & Wang, W. (2019) · Springer eBooks · doi:10.1007/978-981-13-6167-8_3 · Cited by 4
Novel Considerations about Diabetes Management Strategies in Chinese Immigrants in America: Possible Corollaries of the Use of Traditional Chinese Medicines
Devonish, J. A., Singh, S., Tomkinson, E., & Morse, G. D. (2017) · INNOVATIONS in pharmacy · doi:10.24926/iip.v8i2.509 · Cited by 4
“9% [50] - 90% effective in reversing DM with few side effects [51] - Same effects as metformin and rosiglitazone on reducing glucose and HbA1C - More effective at lower lipids than (above) - Can be used with hepatic insufficiency [52, 53] - A randomized double-blind, placebo controlled and multiple center trial by Gu…”
Background
Herbal Therapies for Weight Gain and Metabolic Abnormalities Induced by Atypical Antipsychotics: A Review Article
Naghibi, H., Salari, R., Yousefi, M., Khadem‐Rezaiyan, M., Ghanbarzadeh, M. R., & Bordbar, M. R. F. (2023) · Current Drug Discovery Technologies · doi:10.2174/1570163820666230411111343 · Cited by 4
Effect of berberine on lipopolysaccharide-induced monocyte chemotactic protein-1 and interleukin-8 expression in a human retinal pigment epithelial cell line
Cui, H.-S., Li, Y., Fang, W. J., Li, J., Dai, Y., & Zheng, L. (2017) · International Ophthalmology · doi:10.1007/s10792-017-0697-x · Cited by 4
Astaxanthin plus berberine: a nutraceutical strategy for replicating the benefits of a metformin/fibrate regimen in metabolic syndrome
DiNicolantonio, J. J., McCarty, M. F., & O’Keefe, J. H. (2019) · Open Heart · doi:10.1136/openhrt-2018-000977 · Cited by 4
“The most common side effect is constipation, which tends to remit during continuing treatment.(6) Unlike metformin, however, berberine upregulates the hepatic expression of LDL receptors, through a mechanism that is complementary to that of statins or red yeast rice (RYR); whereas statins increase transcription of the…”
Background
Treating Chronic Diseases by Regulating the Gut Microbiota
Hong, B., & Jiang, J. (2021) · Engineering · doi:10.1016/j.eng.2021.08.015 · Cited by 4
The Efficacy of Psychological Care and Chinese Herbal Decoction in Postoperative Chemotherapy Patients with Endometrial Cancer
Liu, J., Wang, J., Guo, Y., & Zhang, H. (2022) · Journal of Healthcare Engineering · doi:10.1155/2022/5700637 · Cited by 4
“If the patient is at risk, adjuvant pelvic radiation radiotherapy, systemic chemotherapy, and hormone therapy are required to control the disease [34].”
Background
Retracted
Alleviation of Diabetic Tendon Injury via Activation of Tendon Fibroblasts Autophagy under Berberine Treatment
Zhu, M., Li, Q., Yuan, J.-Q., Song, F.-C., Liu, S., Zhang, L., & Zhao, C. (2022) · Journal of Visualized Experiments · doi:10.3791/63224 · Cited by 4
Mitochondria as a Target for Safety and Toxicity Evaluation of Nutraceuticals
Teodoro, J. S., Duarte, F. V., Rolo, A. P., & Palmeira, C. M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802147-7.00028-0 · Cited by 4
Study on the efficacy and safety of J inlida in patients with inadequately controlled type‐2 diabetes and dyslipidemia under life style intervention ( ENJOY LIFE Study) 合并血脂异常的2型糖尿病患者在生活方式干预控制效果不佳时使用金利达治疗的有效性与安全性研究（ENJOY LIFE研究）
Zhang, Y., Wang, W., & Ning, G. (2014) · Journal of Diabetes · doi:10.1111/1753-0407.12244 · Cited by 4
“The hyperinsulinemic euglycemic clamp studies, known as the gold standard for insulin resistance evaluation, will be performed at 0 and 16 weeks in approximately 60 patients from selected centers to obtain the glucose disposal rate (GDR, mg/kg per min), defined as the amount of glucose required to maintain stable bloo…”
MethodSelf-citation
Recent Clinical Advances with Berberine
Abascal, K., & Yarnell, E. L. (2010) · Alternative and Complementary Therapies · doi:10.1089/act.2010.16505 · Cited by 4
Effect of the Consumption of Species from the Zingiberaceae or Berberidaceae Family on Glycemic Profile Parameters: A Systematic Review and Meta-Analysis
Victoria‐Montesinos, D., Cerdá, B., Zafrilla, P., Ballester, P., & García‐Muñoz, A. M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26125565 · Cited by 3
“In relation to the variable HbA1c, 38 studies assessed the effect of species from the Zingiberaceae and Berberidaceae families on this outcome [5,16,17,19–23, 25 , 28, 29 , 31, 34 , 35 Sensitivity analysis (Figure S3) was conducted by excluding three studies with a high risk of bias [22,23,37].”
Influential
Bitter taste receptor-mediated regulation of glycolipid metabolism and natural product-based targeted therapies: A review
Bao, T., Xue, C., Wang, Y., Chen, J., Dong, L., Yang, Y., Shi, J., Wang, Z., Tang, R., Wang, X., et al. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.145759 · Cited by 5
Activation of 5′AMP-activated protein kinase in skeletal muscle by exercise and phytochemicals
Egawa, T., Tsuda, S., Oshima, R., Goto, K., & Hayashi, T. (2014) · The Journal of Physical Fitness and Sports Medicine · doi:10.7600/jpfsm.3.55 · Cited by 3
Effect of Natural Compounds on Insulin Signaling
Paoli, P. D., Caselli, A., Camici, G., & Cirri, P. (2014) · Current Medicinal Chemistry · doi:10.2174/0929867321666140815123249 · Cited by 4
“Furthermore, berberine lowers hyperglycaemia and improves impaired glucose tolerance in diabetic mice [83], as well as elicits antidiabetic effects in clinical trials [84].”
Background
In silico molecular docking analysis of potential antidiabetic phytochemicals from Ocimum sanctum L. against therapeutic targets of type 2 diabetes
Garg, B., Yashveer, S., Redhu, N. S., Anita, A., Duhan, J., & Sindhu, S. R. (2023) · Annals of Phytomedicine An International Journal · doi:10.54085/ap.2023.12.2.60 · Cited by 3
Evaluation of the bioactivity of Berberis microphylla G. Forst (Calafate) leaves infusion
Nova-Baza, D., Olivares-Caro, L., Vallejos‐Almirall, A., Mennickent, D., Sáez-Orellana, F., Bustamante-Salazar, L. A., Radojkovic, C., Vergara, C., Fuentealba, J., & Mardones, C. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.105097 · Cited by 3
Invited article Herbs that heal: Natural remedies for health promotion and longevity
Ansari, M. H. R., & Ahmad, S. (2019) · Annals of Phytomedicine An International Journal · doi:10.21276/ap.2019.8.1.2 · Cited by 3
Nutrition in the management of type 2 diabetes mellitus: review
El-Tantawy, W. H. (2019) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2019.1657899 · Cited by 3
“Moreover, there were also significant decreases favouring berberine in LDL-c (p< .0001), weight (p¼ .034), and systolic blood pressure (p¼ .038) (Zhang et al. 2008).”
Background
The Molecular Basis of Hepatic De Novo Lipogenesis in Insulin Resistance
Zang, M. (2015) · Springer eBooks · doi:10.1007/978-3-319-25065-6_2 · Cited by 3
“Clinical trials of berberine in newly diagnosed type 2 diabetic subjects reveal favorable effects on plasma glucose, lipids, and HbA 1c , although plasma berberine levels and AMPK activity are not assessed (Zhang et al. 2008 ; Yin et al. 2008 ).”
Background
Berberine mitigates diabetes-induced erectile dysfunction in rats through modulation of antioxidant status and critical enzyme activity
Adefegha, S. A., Oboh, G., Dada, F. A., Okeke, B. M., & Oyeleye, S. I. (2021) · Comparative Clinical Pathology · doi:10.1007/s00580-021-03217-0 · Cited by 3
Effects of Dietary Inclusion of Dry Hydrastis canadensis on Laying Performance, Egg Quality, Serum Biochemical Parameters and Cecal Microbiota in Laying Hens
Tzeng, T.-R. J., Liu, T., Lin, C.-W., Chang, P.-E., Liao, P.-X., Yang, W., Cheng, C., Liao, P., Chiang, W.-D., Ding, S., et al. (2021) · Animals · doi:10.3390/ani11051381 · Cited by 3
“It has been confirmed that Hydrastis canadensis can ameliorate several pathological statuses and has anti-inflammation [35], anti-cancer [36], anti-diabetic [37], anti-obesity, and anti-hyperlipidemia properties [38,39], in addition to offering myocardial protection [40].”
Background
Natural products in regeneration
Wilson, R. B., Lee, J. J., Pickering, J. G., & Borradaile, N. M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823318-4.00027-5 · Cited by 3
Coscinium fenestratum: A Review on Phytochemicals and Pharmacological Properties
Taher, M., Amri, M. S., Darnis, D. S., Kudos, M. B. A., Shafawi, A. N., & Yazid, S. N. (2019) · Springer eBooks · doi:10.1007/978-981-13-7205-6_5 · Cited by 3
Overall and sex-specific effect of berberine for dyslipidemia: systematic review and meta-analysis of placebo-controlled trials
Blais, J. E., Huang, X., & Zhao, J. V. (2022) · medRxiv · doi:10.1101/2022.06.20.22276676 · Cited by 31
“2 shows records for each study).(16-18, 23, 24, 29, 31-40) All studies were conducted in young or middle-aged adults and none of the studies enrolled participants with a history of coronary artery disease or stroke.”
BackgroundResult
Rethinking Synthetic Berberine in Nutraceuticals: Nitrosamine Risks, Regulatory Oversight, and Safer Alternatives
Meher, A. K., Zarouri, A., & Kumar, M. (2025) · Molecules · doi:10.3390/molecules30214274 · Cited by 2
“Berberine hydrochloride, a quaternary isoquinolinium alkaloid [1], is widely recognized for its pharmacological effects, particularly in the management of type 2 diabetes, hyperlipidemia, and microbial infections [2].”
Mechanisms and applications of natural plant ingredients in modulating amino acid metabolism for the improvement of diabetic retinopathy: a review
Zhang, L.-Y., Zhang, T., Zheng, Y.-J., Li, J.-X., Chen, H., Cao, J., & Dan, T. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1745507 · Cited by 2
“Clinical studies demonstrate berberine (1.0 g/day) combined with metformin achieving additional 0.5% HbA1c reduction after 3 months of treatment (166), with this synergistic effect potentially permitting metformin dose reduction while decreasing gastrointestinal adverse reactions.”
Influential
Herbal medicines for diabetes: Insights and recent advancement
Fareed, M., & Chaudhary, A. A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90572-5.00026-3 · Cited by 2
An Outlook on Pathological Pathways of Diabetes and Molecular Mechanisms of Anti-diabetic Phytobioactives
Anwar, K. R., Badruddeen, B., Akhtar, J., Khan, M. I., & Ahmad, M. (2023) · Letters in Functional Foods · doi:10.2174/2666939001666230718142652 · Cited by 2
Adverse effects of the dietary supplement berberine studied on ants as models
Cammaerts, M., & Cammaerts, R. (2023) · MOJ Biology and Medicine · doi:10.15406/mojbm.2023.08.00196 · Cited by 2
Biochemical Investigation of Therapeutic Efficacy of Berberine-Enriched Extract in Streptozotocin-Induced Metabolic Impairment
Akash, M. S. H., Yaqoob, S., Rehman, K., Hussain, A., Chauhdary, Z., Nadeem, A., Shahzad, A., Shah, M. A., & Panichayupakaranant, P. (2024) · ACS Omega · doi:10.1021/acsomega.4c00696 · Cited by 2
Plant Extracts for Type 2 Diabetes: Mechanisms, Clinical Implications and Future Directions—A Systematic Review
Wang, Y., Liu, X., & Li, Q. (2024) · Journal of Biobased Materials and Bioenergy · doi:10.1166/jbmb.2024.2418 · Cited by 2
Pulsatilla chinensis functions as a novel antihyperlipidemic agent by upregulating LDLR in an ERK-dependent manner
Song, W., Wang, R., Yao, R.-X., Jiang, Q., Feng, J., Luo, K., Di, Z.-H., Ma, C., & Xie, L. (2024) · Chinese Medicine · doi:10.1186/s13020-024-01044-3 · Cited by 2
Beyond pharmaceuticals: Integrating Chinese culinary medicine with modern nutritional science for holistic diabetes management
Lim, E. C. N., Yu, X. F., & Lim, C. E. D. (2025) · Journal of Traditional Chinese Medical Sciences · doi:10.1016/j.jtcms.2025.08.003 · Cited by 3
Dietary supplements in therapy to support weight reduction in obese patients [pdf]
Wawrzyniak, N., Skrypnik, K., & Suliburska, J. (2022) · Acta Scientiarum Polonorum Technologia Alimentaria · doi:10.17306/j.afs.2022.1010 · Cited by 2
A Blend of Phellodendron and Crape Myrtle Improves Glucose Tolerance in Exercise-Trained Men
Canale, R. E., Farney, T. M., McCarthy, C. G., & Bloomer, R. J. (2011) · Nutrition and Metabolic Insights · doi:10.4137/nmi.s7837 · Cited by 2
Dietary Supplements for Cholesterol Management
Almandoz, J. P. (2015) · Contemporary Endocrinology · doi:10.1007/978-1-60761-424-1_23 · Cited by 2
Natural Compounds Extracted from Medicinal Plants and Their Applications in the Treatment of Diabetes and Hypertension
Rawat, P., Singh, P. K., & Kumar, V. (2019) · Springer eBooks · doi:10.1007/978-981-13-7205-6_11 · Cited by 2
Evaluation of Antihyperglycemic potential of homeopathic medicines Insulinum, Pancreatinum and Uranium nitricum in Streptozotocin Induced diabetic Rats.
Patil, A. D., Patil, C. D., & Patil, D. K. (2021) · International Journal of High Dilution Research · doi:10.51910/ijhdr.v19i3.1009 · Cited by 2
Medical Herbs and the Treatment of Diabetes Mellitus
McGrowder, D. A., Miller, F. G., Nwokocha, C. R., Wilson-Clarke, C. F., Anderson, M., Anderson-Jackson, L., Williams, L., & Alexander-Lindo, R. L. (2020) · Advances in medical diagnosis, treatment, and care (AMDTC) book series · doi:10.4018/978-1-7998-4808-0.ch003 · Cited by 2
Genotoxicity evaluation of nutraceuticals
Mei, N., Li, X., Chen, S., Guo, L., & Guo, X. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821038-3.00071-9 · Cited by 2
Self-citation
[Etiologic factors of malignant melanoma in young adults].
Borbola, K., Bánfalvi, T., Fejôs, Z., Liszkay, G., Papp, A., Horváth, B., & Gilde, K. (2005) · PubMed · Cited by 2
Effect of berberine on irritable bowel syndrome: A symptom-based review
Başhan, İ. (2022) · International Journal of Plant Based Pharmaceuticals · doi:10.55484/ijpbp.1084455 · Cited by 2
Mitochondria as a target for safety and toxicity evaluation of nutraceuticals
Teodoro, J. S., Machado, I. F., Castela, A. C., Rolo, A. P., & Palmeira, C. M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821038-3.00030-6 · Cited by 3
Tinospora cordifolia (Giloy): A Review of the Various Pharmacological Pathways of a Highly Potential Medicinal Ayurveda Plant
Bhardwaj, A. K., Sahani, V., & Patil, S. M. (2024) · Journal for Research in Applied Sciences and Biotechnology · doi:10.55544/jrasb.3.5.27 · Cited by 1
“[81 ][82][83] Fig: 3 Pharmacological activities of T. cordifolia Market Products Based on T. cordifolia : In order to promote wellness and avoid sickness, there are a number of products on the market that are based on T. cordifolia, and each of these items plays an important role in the process.”
Clinical Trials and Evidence-Based Nutraceutical Interventions
Ghosh, S., Singh, D. K. K., Raghunath, M., & Sinha, J. K. (2025) · Nutritional neurosciences · doi:10.1007/978-981-95-2790-8_15 · Cited by 1
Alteration of gut microbiota and their metabolites by dietary phytochemicals
Mehrotra, N., Sharma, S., & Tripathi, P. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-36372-6.00008-2 · Cited by 1
Plant derived natural products as antidiabetic agents
Swati, K., Bhatt, P., Singh, S., & Bhandari, P. (2026) · Studies in natural products chemistry · doi:10.1016/b978-0-443-49146-7.00003-0 · Cited by 1
Pharmacological restoration of mitochondrial permeability transition pore flickering by high-content drug repurposing
Franchini, E., Bulloni, M., Sorgente, A., PAULÍKOVÁ, K., Cassina, L., Marafelli, I., Sambri, I., Pattini, L., & Casari, G. (2026) · Pharmacological Research · doi:10.1016/j.phrs.2026.108234 · Cited by 1
Adjunctive berberine improves hormonal, metabolic, and inflammatory profiles in women with polycystic ovary syndrome: a retrospective case–control study
Gao, L., Ju, Y., Zhu, Y., Xu, J., & Lu, D. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1700331 · Cited by 2
“In patients with type 2 diabetes and metabolic syndrome, randomized and comparative clinical studies have demonstrated that berberine signi ﬁ cantly reduced fasting glucose and insulin levels and improved lipid metabolism (6, 7), with ef ﬁ cacy partly comparable to metformin in some cohorts (8).”
MULTI-THERAPEUTIC ACTIVITY OF BERBERIS LYCIUM ROYLE: A REVIEW
Sharma, M., Iqbal, J., Kailash, S., Asgher, M., Younis, M., Tripathi, J., Shezad, F., & Hura, M. (2016) · International Journal of Advanced Research · doi:10.21474/ijar01/2668 · Cited by 1
“Berberine have been widely investigated in lipid metabolism, it has been observed that berberine was capable of lowering lipid concentration by increasing the transcriptional activity of LDLR promoter by a JNK pathway and stabilization of hepatic LDL-C receptor (LDLR) by an extracellular signal-regulated kinase (ERK)-…”
Background
The Use of Berberine in Diabetes and Metabolic Syndrome: Two Sides of the Same Coin. A Bibliometric Analysis
Infantino, V., Riva, A., Petrangolini, G., Allegrini, P., Perna, S., Iannello, G., Peroni, G., Gasparri, C., & Rondanelli, M. (2021) · Current Nutrition & Food Science · doi:10.2174/1573401317666211125101041 · Cited by 1
Clinical Roundup: Selected Treatment Options for Polycystic Ovary Syndrome
(2013) · Alternative and Complementary Therapies · doi:10.1089/act.2013.19205 · Cited by 1
Review of berberine use for the treatment of type 2 diabetes mellitus & students’ survey
Iheme, K. N., Ayiwue, Pierre, Hailemeskel, B., Smith, S. A., & Kulkarni, A. (2023) · International Journal of Science and Research Archive · doi:10.30574/ijsra.2023.9.1.0342 · Cited by 1
Effect of Aqueous Extract of Irvingia wombolu Seeds on Lipid Profile and Atherogenic Indices in Hyperlipidemic Wistar Rats
Uba, J. O., & Ezim, O. E. (2024) · Asian Journal of Biochemistry Genetics and Molecular Biology · doi:10.9734/ajbgmb/2024/v16i6378 · Cited by 1

Authors: Zhang, Y., Li, X., Zou, D., Liu, W., Yang, J., Zhu, N., Huo, L., Wang, M., Hong, J., Wu, P., Ren, G., & Ning, G.
Affiliations: Shanghai Jiao Tong University (CN)
Second Military Medical University (CN)
Department of Endocrinology (J.Y., G.R.), Min-Hang Hospital, Shanghai 201100, People’s Republic of China
Corresponding author: Ning, Guang
ORCID: Zhang, Yifei
Liu, Wei
Yang, Jialin
Zhu, Na
Wang, Miao
Hong, Jie
Ning, Guang
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 2008-07-01
Volume: 93
Issue: 7
Pages: 2559-2565
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jc.2007-2404
OpenAlex: W1969395627
Cited by: 573
References: 23
Citations by year: 2026: 30 · 2025: 27 · 2024: 28 · 2023: 33 · 2022: 41 · 2021: 54 · 2020: 46 · 2019: 42 · 2018: 33 · 2017: 23 · 2016: 29 · 2015: 32 · 2014: 34 · 2013: 31 · 2012: 25
FWCI: 14.72
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Berberine and alkaloids research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: berberine, type 2 diabetes, dyslipidemia, glucose-lowering effect, insulin sensitivity, glucose disposal rate, hyperinsulinemic-euglycemic clamp, HbA1c, serum lipids, triglycerides, LDL cholesterol, total cholesterol, plant alkaloids, constipation, drug safety, antidiabetic therapy, lipid-lowering therapy
MeSH terms: Adult, Aged, Berberine, Diabetes Mellitus, Type 2, Double-Blind Method, Female, Glycated Hemoglobin, Humans, Insulin, Insulin Resistance, Cholesterol, LDL, Male, Middle Aged, Triglycerides, Dyslipidemias

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Treatment of Type 2 Diabetes and Dyslipidemia with the Natural Plant Alkaloid Berberine

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks