Cited by 578Berberine and alkaloids researchNatural Antidiabetic Agents StudiesMetabolism, Diabetes, and Cancer

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Treatment of Type 2 Diabetes and Dyslipidemia with the Natural Plant Alkaloid Berberine

Zhang, Yifei, Li, Xiaoying, Zou, Dajin, Liu, Wei, Yang, Jialin, Zhu, Na, Huo, Li, Wang, Miao, Hong, Jie, Wu, Peihong, Ren, Guoguang, Ning, Guang·2008·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jc.2007-2404

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Abstract

Context: Berberine, a natural plant alkaloid, is usually used as an antibiotic drug. The potential glucose-lowering effect of berberine was noted when it was used for diarrhea in diabetic patients. In vitro and in vivo studies have then showed its effects on hyperglycemia and dyslipidemia. Objective: The objective of the study was to evaluate the efficacy and safety of berberine in the treatment of type 2 diabetic patients with dyslipidemia. Design: One hundred sixteen patients with type 2 diabetes and dyslipidemia were randomly allocated to receive berberine (1.0 g daily) and the placebo for 3 months. The primary outcomes were changes in plasma glucose and serum lipid concentrations. Glucose disposal rate (GDR) was measured using a hyperinsulinemic euglycemic clamp to assess insulin sensitivity. Results: In the berberine group, fasting and postload plasma glucose decreased from 7.0 ± 0.8 to 5.6 ± 0.9 and from 12.0 ± 2.7 to 8.9 ± 2.8 mm/liter, HbA1c from 7.5 ± 1.0% to 6.6 ± 0.7%, triglyceride from 2.51 ± 2.04 to 1.61 ± 1.10 mm/liter, total cholesterol from 5.31 ± 0.98 to 4.35 ± 0.96 mm/liter, and low-density lipoprotein-cholesterol from 3.23 ± 0.81 to 2.55 ± 0.77 mm/liter, with all parameters differing from placebo significantly (P < 0.0001, P < 0.0001, P < 0.0001, P = 0.001, P < 0.0001, and P <0.0001, respectively). The glucose disposal rate was increased after berberine treatment (P = 0.037), although no significant change was found between berberine and placebo groups (P = 0.063). Mild to moderate constipation was observed in five participants in the berberine group. Conclusions: Berberine is effective and safe in the treatment of type 2 diabetes and dyslipidemia.

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Items 301–400 of 578

Effect of Berberine on Glycation, Aldose Reductase Activity, and Oxidative Stress in the Lenses of Streptozotocin-Induced Diabetic Rats In Vivo—A Preliminary Study
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“It reduces the levels of blood glucose and glycated hemoglobin, improves the lipid profile in the serum, reduces body mass, and enhances insulin sensitivity [20,21].”
Background
The therapeutic potential of typical plant‐derived compounds for the management of metabolic disorders
Roy, D., Kaur, P., Ghosh, M., Choudhary, D., & Rangra, N. K. (2024) · Phytotherapy Research · doi:10.1002/ptr.8238 · Cited by 31
“While berberine is generally considered safe, high doses can cause gastrointestinal side effects and can interact with certain medications (Zhang et al., 2008).”
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“Although some clinical studies carried out with berberine have reported adverse effects such as constipation, diarrhea, nausea, or abdominal discomfort [134–136], to date, no serious adverse effects have been reported.”
Result
Berberine and Dyslipidemia: Different Applications and Biopharmaceutical Formulations Without Statin-Like Molecules—A Meta-Analysis
Bertuccioli, A., Moricoli, S., Amatori, S., Rocchi, M., Vici, G., & Sisti, D. (2019) · Journal of Medicinal Food · doi:10.1089/jmf.2019.0088 · Cited by 23
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Self-citation
The effect of berberine adjunctive treatment on glycolipid metabolism in patients with schizophrenia: A randomized, double-blind, placebo-controlled clinical trial
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Berberine improves intralipid-induced insulin resistance in murine
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“months of BBR treatment reduces fasting blood glucose and was accompanied by improved insulin sensitivity and decreased body weight [25].”
Background
Roles of Therapeutic Bioactive Compounds in Hepatocellular Carcinoma
Jain, D., Murti, Y., Khan, W. U., Hossain, R., Hossain, M. N., Agrawal, K. K., Ashraf, R. A., Islam, M. T., Janmeda, P., Taheri, Y., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/9068850 · Cited by 24
“While investigations are undertaken via the large quantity of information on preclinical e ﬃ cacy, clinical studies are limited in the evaluation of berberines and andrographolide genuine potential as a carcinoma operator [179].”
Background
Berberine exposure triggers developmental effects on planarian regeneration
Balestrini, L., Isolani, M. E., Pietra, D., Borghini, A., Bianucci, A. M., Deri, P., & Batistoni, R. (2014) · Scientific Reports · doi:10.1038/srep04914 · Cited by 22
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Berberine ameliorates nonalcoholic fatty liver disease-induced bone loss by inhibiting ferroptosis
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Jiao Tai Wan Attenuates Hepatic Lipid Accumulation in Type 2 Diabetes Mellitus
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“Among the main constituents in JTW extract, berberine, cinnamaldehyde, and cinnamic acid have also been demonstrated to exhibit beneficial effects in attenuating disturbances of glucose and lipid metabolism [17, 25, 26].”
Background
Berberine as a Bioactive Alkaloid: Multi-Omics Perspectives on Its Role in Obesity Management
Zieniuk, B., & Pawełkowicz, M. E. (2025) · Metabolites · doi:10.3390/metabo15070467 · Cited by 24
“Clinical trials echo these pre-clinical findings: treating patients with type 2 diabetes and mixed dyslipidemia with 1 g per day BBR for three months cut total cholesterol by about 18% and LDL-C by 21% [51].”
A comprehensive review of recent advances in the extraction and therapeutic potential of berberine
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“23 The Nrf2 pathway is also involved in berberine inhibiting oxidative stress and improving the condition of diabetes.”
Anti-apoptotic and moderate anti-inflammatory effects of berberine in sulfur mustard exposed keratinocytes
Lang, S., Popp, T., Kriegs, C. S., Schmidt, A., Balszuweit, F., Menacher, G., Kehe, K., Thiermann, H., Gudermann, T. W., & Steinritz, D. (2017) · Toxicology Letters · doi:10.1016/j.toxlet.2017.09.004 · Cited by 20
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“Zhang and collaborators (NCT00462046) tested berberine as a potential treatment for patients with newly diagnosed Type 2 diabetes and dyslipidemia (Y. Zhang et al., 2008).”
Background
Nanomedicine-based potential phyto-drug delivery systems for diabetes
Bahloul, B., Henríquez, L. C., Jenhani, L., Aroua, N., Ftouh, M., Kalboussi, N., Vega‐Baudrit, J. R., & Mignet, N. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.104377 · Cited by 19
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Berberine inhibits glucose oxidation and insulin secretion in rat islets
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“It has been shown that berberine is a potent hypoglycemic agent with beneficial metabolic effects on peripheral tissues [6, 7], which is attributed to the activation of AMP-activated protein kinase (AMPK) [8, 9].”
BackgroundSelf-citation
Effectiveness and safety of bifidobacteria and berberine in people with hyperglycemia: study protocol for a randomized controlled trial
Ming, J., Xu, S., Liu, C., Liu, X., Jia, A., & Ji, Q. (2018) · Trials · doi:10.1186/s13063-018-2438-5 · Cited by 19
“The berberine sample size was estimated with reference to the STOP-NIDDM study [4] and Yifei Zhang’s study [11] on the use of berberine to treat type 2 diabetes with hyperlipidemia.”
Method
Enhanced Anti-diabetic Effect of Berberine Combined With Timosaponin B2 in Goto-Kakizaki Rats, Associated With Increased Variety and Exposure of Effective Substances Through Intestinal Absorption
Tian, X., Liu, F., Li, Z., Lin, Y., Liu, H., Hu, P., Chen, M., Sun, Z., Zhou, X., Zhang, Y., et al. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00019 · Cited by 19
Self-citation
Berberine against gastrointestinal peptides elevation and mucous secretion in hyperthyroid diarrheic rats
Cheng, Z., Zhang, Y., & Liu, F. (2009) · Regulatory Peptides · doi:10.1016/j.regpep.2008.12.008 · Cited by 19
“Recent studies show that Berberine and its derivatives have a potential therapeutic effect on diabetes [12,13], hyperlipoidemia [14], and CNS disorders [15,16].”
Self-citation
Comparative Effects of Gymnema sylvestre and Berberine on Adipokines, Body Composition, and Metabolic Parameters in Obese Patients: A Randomized Study
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“Another study reported that glycosylated hemoglobin decreased after BBR treatment (0.5 g b.i.d.), and there were significant improvements in blood glucose and lipid levels [88].”
BackgroundInfluential
Berberine's impact on health: Comprehensive biological, pharmacological, and nutritional perspectives
Asghari, P., Babaei, A., Zamanian, N., & Nattagh‐Eshtivani, E. (2025) · Metabolism Open · doi:10.1016/j.metop.2025.100399 · Cited by 23
“Zhang et al. reported that a daily intake of 1 g of BBR resulted in a 20 % reduction in blood glucose, a 12 % decrease in HbA1c, and an improvement in lipid profiles among 116 diabetic subjects [52].”
The renoprotective effects of berberineviathe EP4-Gαs-cAMP signaling pathway in different stages of diabetes in rats
Yang, Y., Ni, W., Cai, M., Tang, L., & Wei, W. (2014) · Journal of Receptors and Signal Transduction · doi:10.3109/10799893.2014.917324 · Cited by 18
“In addition, BBR has been shown to reduce serum TC, TG, LDL-c and VLDL-c in animals fed a high-fat diet (16).”
Background
Berberine: Is it a Promising Agent for Mental Disorders Treatment?
Shayganfard, M. (2022) · Current Molecular Pharmacology · doi:10.2174/1874467215666220509213122 · Cited by 18
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“In type 2 diabetics with dyslipidaemia, the BBR treatment was associated with a decreased fasting plasma glucose, fasting plasma insulin and HOMA-IR in addition to improvements in triglyceride, cholesterol and low-density lipoprotein cholesterol levels compared to the placebo-treated participants [176].”
Polyherbal dietary supplementation for prediabetic adults: study protocol for a randomized controlled trial
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Berberine inhibits low shear stress-induced glycocalyx degradation via modulating AMPK and p47phox/Hyal2 signal pathway
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Self-citation
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Supplemental Berberine in a High-Fat Diet Reduces Adiposity and Cardiac Dysfunction in Offspring of Mouse Dams with Gestational Diabetes Mellitus
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“A randomized trial showed BBR, though effective for lowering blood sugar, increases hypoglycaemia risk when combined with oral hypoglycaemics [261].”
Self-citation
Berberine and Adiposity in Diabetes-Free Individuals With Obesity and MASLD
Lei, L., Wang, B., Zhao, L., Li, J., Yan, X., Jiang, J., Wang, L., Ren, G., Li, Y., Cheng, X., et al. (2026) · JAMA Network Open · doi:10.1001/jamanetworkopen.2025.54152 · Cited by 19
Self-citation
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Sartore, G., Ragazzi, E., Antonello, G., Cosma, C., & Lapolla, A. (2021) · Nutrients · doi:10.3390/nu13072373 · Cited by 17
“Its pharmacological and biochemical mechanisms of action have been established [6,7].”
Background
The role of autophagy in insulin resistance and glucolipid metabolism and potential use of autophagy modulating natural products in the treatment of type 2 diabetes mellitus
Yang, X., Ding, W., Chen, Z., Lai, K., & Liu, Y. (2024) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3762 · Cited by 18
“142,143 These metabolic improvements attributed to berberine are, at least in part, the result of its promotion of autophagy.”
Background
Composition of Ophiopogon Polysaccharide, Notoginseng Total Saponins and Rhizoma Coptidis Alkaloids Inhibits the Myocardial Apoptosis on Diabetic Atherosclerosis Rabbit
Jin, Z., Gao, P., Liu, Z., Jin, B., Song, G.-Y., & Xiang, T. (2018) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-018-3014-2 · Cited by 17
The Role of Berberine in the Prevention of HIF‐1α Activation to Alleviate Adipose Tissue Fibrosis in High‐Fat‐Diet‐Induced Obese Mice
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“Berberine has shown antihyperlipidemic and antihyperglycemic effects, increased insulin secretion and sensitivity, suggesting a potential application in the prevention or treatment of diabetes [52, 53]; anti-inflammatory and antitumor effects were also described [54, 55].”
Background
Effects of hydroalcoholic extract of Berberis Integerrima on the anthropometric indices and metabolic profile in active rheumatoid arthritis patients
Aryaeian, N., Sedehi, S. K., Khorshidi, M., Zarezadeh, M., Hosseini, A. F., & Shahram, F. (2020) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2020.102331 · Cited by 17
miRNAs and Novel Food Compounds Related to the Browning Process
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Neuroendocrine-associated epigenetic factors in cellular senescence: mechanisms and therapeutic implications
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“…traditional Chinese medications like berberine, cordycepin and more, research studies are needed to target lipid metabolism and fibrotic pathways, such as berberine, cordycepin, and breviscap-ine, but they need more research studies (Zhang et al. 2008; Chang et al. 2016a, b; Lan et al. 2021, 2022).”
The effect of berberine and fenugreek seed co-supplementation on inflammatory factor, lipid and glycemic profile in patients with type 2 diabetes mellitus: a double-blind controlled randomized clinical trial
Nematollahi, S., Pishdad, G. R., Zakerkish, M., Namjoyan, F., Angali, K. A., & Borazjani, F. (2022) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-022-00888-9 · Cited by 17
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Jiaotai pill (交泰丸) enhances insulin signaling through phosphatidylinositol 3-kinase pathway in skeletal muscle of diabetic rats
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Designs, Synthesis, Docking Studies, and Biological Evaluation of Novel Berberine Derivatives Targeting Zika Virus
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“Recent studies revealed that BBR has various pharmacological activities such as antimicrobial [7], antidiabetic [8], antihyperlipidemic action [9], antitumor [10], antiinflammatory [11], and antiparasitic [12].”
Background
The Efficacy and Safety of Chinese Herbal Decoction in Type 2 Diabetes: A 5‐Year Retrospective Study
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Retrospective analysis of the effects of a highly standardized mixture of Berberis aristata, Silybum marianum, and monacolins K and KA in patients with dyslipidemia
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Factors Affecting Insulin-Regulated Hepatic Gene Expression
Guan, H.-P., & Chen, G. (2014) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-800101-1.00006-5 · Cited by 15
New Oral Delivery System to Improve Absorption of Berberine: Likely Interaction of Cationized Chitosan with PG-P Pump.
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Does Adjuvant Treatment with Chinese Herbal Medicine to Antidiabetic Agents Have Additional Benefits in Patients with Type 2 Diabetes? A System Review and Meta-Analysis of Randomized Controlled Trials
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First report of bicolour FISH of Berberis diaphana and B. soulieana reveals interspecific differences and co-localization of (AGGGTTT)3 and rDNA 5S in B. diaphana
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“plant contains berberine [3], which demonstrates anti– neoplastic activities and is used for the treatment of type 2 diabetes [4, 5].”
Background
The pivotal role of protein kinase C zeta (PKCzeta) in insulin- and AMP-activated protein kinase (AMPK)-mediated glucose uptake in muscle cells
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Comparison Among Garlic, Berberine, Resveratrol, Hibiscus sabdariffa , Genus Zizyphus , Hesperidin, Red Beetroot, Catha edulis , Portulaca oleracea , and Mulberry Leaves in the Treatment of Hypertension and Type 2 DM: A Comprehensive Review
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Optimization of ex vivo permeability characteristics of berberine in presence of quercetin using 32 full factorial design
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“In clinical conditions, high dose (up to 1.5 g/day) is needed that may lead to adverse gastrointestinal effects (Zhang et al., 2008).”
BackgroundInfluential
Effects of berberine and barberry on selected inflammatory biomarkers in adults: A systematic review and dose–response meta‐analysis of randomized clinical trials
Vahedi‐Mazdabadi, Y., Shahinfar, H., Toushih, M., & Shidfar, F. (2023) · Phytotherapy Research · doi:10.1002/ptr.7998 · Cited by 14
“Insufficient information caused an unclear risk of bias in four studies in the “ other bias ” domain (Dong et al., 2017; Li et al., 2022a; Sun, 2017; Y. Zhang et al., 2008).”
BackgroundMethodInfluential
Pre-clinical Evidence: Berberine as a Promising Cardioprotective Candidate for Myocardial Ischemia/Reperfusion Injury, a Systematic Review, and Meta-Analysis
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Berberine and lycopene as alternative or add-on therapy to metformin and statins, a review
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Antidiabetic with antilipidemic and antioxidant effects of flindersine by enhanced glucose uptake through GLUT4 translocation and PPARγ agonism in type 2 diabetic rats
Irudayaraj, S. S., Jacob, J., Sunil, C., Duraipandiyan, V., Savarimuthu Ignacimuthu, S. J., Govindasamy, C., & Packiam, S. M. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114883 · Cited by 14
Nanophytomedicine Based Novel Therapeutic Strategies in Liver Cancer
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The effects of phytochemicals on serum triglycerides in subjects with hypertriglyceridemia: A systematic review of randomized controlled trials
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“…berberine reduced TG levels in 7 arms (Di Bisceglie et al., 2020; Gu et al., 2010; Meng et al., 2012; Perez-Rubio et al., 2013; Wei et al., 2012; Zhang et al., 2008), TC levels in 6 arms (Di Bisceglie et al., 2020; Gu et al., 2010; Meng et al., 2012; Wei et al., 2012; Zhang et al., 2008; Zhao…”
BackgroundMethodInfluential
The current trend and challenges of developing red yeast rice-based food supplements for hypercholesterolemia
Chen, G., Chen, W., Jin-hong, X., Ma, G., Hu, X., & Chen, G. (2023) · Journal of Future Foods · doi:10.1016/j.jfutfo.2023.03.003 · Cited by 14
Overall and Sex-Specific Effect of Berberine on Glycemic and Insulin-Related Traits: a Systematic Review and Meta-Analysis of Randomized Controlled Trials
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“Consistent with these processes, berberine also induced a thermogenic program in BAT and WAT via AMPK/PGC-1 α [103].”
Background
Nutraceuticals and Supplements in Management of Prediabetes and Diabetes
Derosa, G., D’Angelo, A., Angelini, F., Belli, L., Cicero, A. F. G., ROS, R. D., Pergola, G. D., Gaudio, G. V., Lupi, A., Sartore, G., et al. (2024) · Nutrients · doi:10.3390/nu17010014 · Cited by 17
Berberine inhibits metastasis of ovarian cancer by blocking lipid metabolism, alleviating aging of adipose tissue and increasing tumor infiltrating immune cells
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“BBR has strong pharmacological effect on various metabolic and chronic inflammation diseases, including diabetes mellitus [11], dyslipidemias [12], and microbial infections [13 – 15].”
Self-citation
Thermodynamic Parameters of Berberine with Kolliphor Mixtures Adsorption and Micellization
Szaniawska, M., Szymczyk, K., Zdziennicka, A., & Jańczuk, B. (2023) · Molecules · doi:10.3390/molecules28073115 · Cited by 13
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Efficacy and Safety of Berberine in Patients with Type 2 Diabetes Mellitus: A Meta-Analysis
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Gut Flora: Novel Therapeutic Target of Chinese Medicine for the Treatment of Cardiovascular Diseases
Ou, Y., Zhang, C., Yao, M., & Wang, L. (2019) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2019/3719596 · Cited by 13
“Furthermore, BBR has recently been demonstrated to significantly reduce fasting and postprandial blood sugar in patients [42].”
BackgroundInfluential
Development and In Vitro and In Vivo Evaluation of Microspheres Containing Sodium N-[8-(2-hydroxybenzoyl)amino]caprylate for the Oral Delivery of Berberine Hydrochloride
Li, Y., & Zhu, C. (2020) · Molecules · doi:10.3390/molecules25081957 · Cited by 13
“The conventional dosage forms of BER for oral administration cannot reach the therapeutic concentration with only a few administration times; it usually takes several months to take therapeutic effect [14].”
Background
The prevalence, awareness and potential of complementary alternative medicine in type 2 diabetics living in Madurai, India
Kasinathan, D., Elango, S., Manikandan, R., & Prabhu, N. M. (2015) · European Journal of Integrative Medicine · doi:10.1016/j.eujim.2015.04.003 · Cited by 13
Berberine: A Rising Star in the Management of Type 2 Diabetes—Novel Insights into Its Anti-Inflammatory, Metabolic, and Epigenetic Mechanisms
Liu, D., Zhao, L., Wang, Y., Wang, L., Wu, D., & Liu, Y. (2025) · Pharmaceuticals · doi:10.3390/ph18121890 · Cited by 12
“…placebo-controlled, multicenter trial demonstrated that berberine monotherapy is effective and safe for treating newly diagnosed diabetes patients with dyslipidemia, resulting in significant reductions in blood glucose, blood lipids, body weight, and blood pressure within 3 months [180].”
Neuroprotective Effects of Berberine Hydrochloride on Methamphetamine-induced Cognitive Dysfunction: Immunohistochemical and Behavioral Studies in Rats
Rezaeian, L., Khaksari, M., Rafaiee, R., & Moghaddam, H. K. (2021) · Basic and Clinical Neuroscience Journal · doi:10.32598/bcn.2021.1444.2 · Cited by 12
“Berberine Hydrochloride is an isoquinoline plant alkaloid originally gained from rhizoma Coptidiscoptidis, Hydrastis Canadensis, and berberis aquifolium with antibiotic, anticancer, anxiolytic, antiamnesic, analgesic, anti-inflammatory, and antipsychotic and antidepressant activities (Kulkarni & Dhir, 2010; Meeran, Ka…”
Background
LC-MS/MS and GC/MS Profiling of Petroselinum sativum Hoffm. and Its Topical Application on Burn Wound Healing and Related Analgesic Potential in Rats
Slighoua, M., Mahdi, I., Moussaid, F. Z., Kamaly, O. M. A., Amrati, F. E., Conte, R., Drioiche, A., Saleh, A., Housseini, A. I., Bari, A., et al. (2023) · Metabolites · doi:10.3390/metabo13020260 · Cited by 13
“Therefore, conventional medicines are often used to mitigate the intensity of pain and inflammation [1].”
Background
Topical application of berberine ameliorates imiquimod-induced psoriasis-like dermatitis in BALB/c mice via suppressing JAK1/STAT1 signaling pathway
Chen, Y., Song, S., Wang, Y., Zhang, X., Zhang, J., Wu, L., Wu, J., & Li, X. (2024) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2024.105612 · Cited by 13
Self-citation
Targeting the mTOR Pathway in Hepatocellular Carcinoma: The Therapeutic Potential of Natural Products
Chen, G., Zhang, Y. P., Zhou, Y., Luo, H., Guan, H., & An, B. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s501270 · Cited by 12
Self-citation
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Luthra, A., & Misra, A. (2015) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(15)00328-9 · Cited by 12
Berberine hydrochloride inhibits migration ability via increasing inducible NO synthase and peroxynitrite in HTR-8/SVneo cells
Yang, L.-J., He, J.-B., Yu, J., Li, J., Zhou, Z.-W., Zhang, C., Tao, X., Chen, A. F., Peng, C., & Xie, H. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.116087 · Cited by 11
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Derosa, G., & Maffioli, P. (2014) · Expert Review of Endocrinology & Metabolism · doi:10.1586/17446651.2015.995630 · Cited by 12
“[29] described similar results when Type 2 diabetic patients and dyslipidemic patients were treated with berberine compared with placebo.”
Result
Ethnopharmacological values of cassava and its potential for diabetes and dyslipidaemia management: knowledge survey and critical review of report
Nwose, E. U., Onodu, B., Anyasodor, A. E., Sedowo, M., Okuzor, J., & Culas, R. (2017) · Journal of Intercultural Ethnopharmacology · doi:10.5455/jice.20170606094119 · Cited by 13
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Background
Intestinal absorption of berberine and 8-hydroxy dihydroberberine and their effects on sugar absorption in rat small intestine
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Method
Development of newly sanguinarine biosynthetic capacity in in vitro rootless shoots of Argemone mexicana L. Mexican prickly poppy
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Self-citation
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Authors: Zhang, Y., Li, X., Zou, D., Liu, W., Yang, J., Zhu, N., Huo, L., Wang, M., Hong, J., Wu, P., Ren, G., & Ning, G.
Affiliations: Shanghai Jiao Tong University (CN)
Second Military Medical University (CN)
Department of Endocrinology (J.Y., G.R.), Min-Hang Hospital, Shanghai 201100, People’s Republic of China
Corresponding author: Ning, Guang
ORCID: Zhang, Yifei
Liu, Wei
Yang, Jialin
Zhu, Na
Wang, Miao
Hong, Jie
Ning, Guang
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 2008-07-01
Volume: 93
Issue: 7
Pages: 2559-2565
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jc.2007-2404
OpenAlex: W1969395627
Cited by: 573
References: 23
Citations by year: 2026: 30 · 2025: 27 · 2024: 28 · 2023: 33 · 2022: 41 · 2021: 54 · 2020: 46 · 2019: 42 · 2018: 33 · 2017: 23 · 2016: 29 · 2015: 32 · 2014: 34 · 2013: 31 · 2012: 25
FWCI: 14.72
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Berberine and alkaloids research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: berberine, type 2 diabetes, dyslipidemia, glucose-lowering effect, insulin sensitivity, glucose disposal rate, hyperinsulinemic-euglycemic clamp, HbA1c, serum lipids, triglycerides, LDL cholesterol, total cholesterol, plant alkaloids, constipation, drug safety, antidiabetic therapy, lipid-lowering therapy
MeSH terms: Adult, Aged, Berberine, Diabetes Mellitus, Type 2, Double-Blind Method, Female, Glycated Hemoglobin, Humans, Insulin, Insulin Resistance, Cholesterol, LDL, Male, Middle Aged, Triglycerides, Dyslipidemias

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Treatment of Type 2 Diabetes and Dyslipidemia with the Natural Plant Alkaloid Berberine

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