Plasma insulin, leptin, adiponectin, resistin, ghrelin, and melatonin in nonalcoholic steatohepatitis patients treated with melatonin

Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

Sanyal, A. J., Chalasani, N., Kowdley, K. V., McCullough, A., Diehl, A. M., Bass, N. M., Neuschwander-Tetri, B. A., Lavine, J. E., Tonascia, J., Unalp, A., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0907929 · Cited by 3,327 · see citing works

Regulation of antioxidant enzymes: a significant role for melatonin

Rodrı́guez, C., Mayo, J. C., Sainz, R. M., Antolı́n, I., Herrera, F., Martı́n, V., & Reiter, R. J. (2003) · Journal of Pineal Research · doi:10.1046/j.1600-079x.2003.00092.x · Cited by 1,990 · see citing works

Risk of Cardiovascular Disease in Patients with Nonalcoholic Fatty Liver Disease

Targher, G., Day, C. P., & Bonora, E. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0912063 · Cited by 1,907 · see citing works

Melatonin as a natural ally against oxidative stress: a physicochemical examination

Galano, A., Tan, D. X., & Reiter, R. J. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00916.x · Cited by 1,154 · see citing works

Effect of Vitamin E or Metformin for Treatment of Nonalcoholic Fatty Liver Disease in Children and Adolescents

Lavine, J. E. (2011) · JAMA · doi:10.1001/jama.2011.520 · Cited by 1,105 · see citing works

Epidemiology of Non-Alcoholic Fatty Liver Disease

Bellentani, S., Scaglioni, F., Marino, M., & Bedogni, G. (2010) · Digestive Diseases · doi:10.1159/000282080 · Cited by 1,026 · see citing works

Obesity and leptin resistance: distinguishing cause from effect

Myers, M. G., Leibel, R. L., Seeley, R. J., & Schwartz, M. W. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.08.002 · Cited by 906 · see citing works

Pathogenesis of non-alcoholic fatty liver disease

Dowman, J. K., Tomlinson, J., & Newsome, P. N. (2009) · QJM · doi:10.1093/qjmed/hcp158 · Cited by 742 · see citing works

Narrative Review: The Role of Leptin in Human Physiology: Emerging Clinical Applications

Kelesidis, T., Kelesidis, I., Chou, S. H.-H., & Mantzoros, C. S. (2010) · Annals of Internal Medicine · doi:10.7326/0003-4819-152-2-201001190-00008 · Cited by 667 · see citing works

Leptin in Human Physiology and Pathophysiology

Mantzoros, C. S., Magkos, F., Brinkoetter, M., Sienkiewicz, E., Dardeno, T. A., Kim, S.-Y., Hamnvik, O.-P. R., & Koniaris, A. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00315.2011 · Cited by 593 · see citing works

A Meta-Analysis of Randomized Trials for the Treatment of Nonalcoholic Fatty Liver Disease

Musso, G., Gambino, R., Cassader, M., & Pagano, G. (2010) · Hepatology · doi:10.1002/hep.23623 · Cited by 561 · see citing works

Melatonin stimulates brain glutathione peroxidase activity

Barlow‐Walden, L., Reiter, R. J., Abe, M., Pablos, M. I., Menéndez-Peláez, A., CHEN, L., & Pöeggeler, B. (1995) · Neurochemistry International · doi:10.1016/0197-0186(94)00154-m · Cited by 549 · see citing works

Circulating Resistin Levels Are Not Associated with Obesity or Insulin Resistance in Humans and Are Not Regulated by Fasting or Leptin Administration: Cross-Sectional and Interventional Studies in Normal, Insulin-Resistant, and Diabetic Subjects

Lee, J. H., Chan, J. L., Yiannakouris, N., Kontogianni, M. D., Estrada, E., Seip, R. L., Orlova, C., & Mantzoros, C. S. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030519 · Cited by 546 · see citing works

From the metabolic syndrome to NAFLD or vice versa?

Vanni, E., Bugianesi, E., Kotronen, A., Minicis, S. D., Yki‐Järvinen, H., & Svegliati‐Baroni, G. (2010) · Digestive and Liver Disease · doi:10.1016/j.dld.2010.01.016 · Cited by 494 · see citing works

Reducing oxidative/nitrosative stress: a newly-discovered genre for melatonin

Reiter, R. J., Paredes, S. D., Manchester, L. C., & Tan, D.-X. (2009) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230903044914 · Cited by 477 · see citing works

Adipokines in liver diseases #

Marra, F., & Bertolani, C. (2009) · Hepatology · doi:10.1002/hep.23046 · Cited by 470 · see citing works

A survey of molecular details in the human pineal gland in the light of phylogeny, structure, function and chronobiological diseases

Stehle, J. H., Saade, A., Rawashdeh, O., Ackermann, K., Jilg, A., Sebesteny, T., & Maronde, E. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00856.x · Cited by 401 · see citing works

Daily Melatonin Administration to Middle-Aged Male Rats Suppresses Body Weight, Intraabdominal Adiposity, and Plasma Leptin and Insulin Independent of Food Intake and Total Body Fat1

Wolden‐Hanson, T., Mitton, D. R., McCants, R. L., Yellon, S. M., Wilkinson, C. W., Matsumoto, A. M., & Rasmussen, D. D. (2000) · Endocrinology · doi:10.1210/endo.141.2.7311 · Cited by 390 · see citing works

Serum total adiponectin in nonalcoholic fatty liver disease: a systematic review and meta-analysis

Pοlyzos, S. A., Toulis, K. A., Goulis, D. G., Zavos, C., & Kountouras, J. (2010) · Metabolism · doi:10.1016/j.metabol.2010.09.003 · Cited by 310 · see citing works

The role of adiponectin in the pathogenesis and treatment of non‐alcoholic fatty liver disease

Pοlyzos, S. A., Kountouras, J., Zavos, C., & Tsiaousi, E. (2009) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2009.01176.x · Cited by 277 · see citing works

Associations of Adiponectin, Resistin, and Tumor Necrosis Factor-α with Insulin Resistance

Hivert, M.-F., Sullivan, L. M., Fox, C. S., Nathan, D. M., D’Agostino, R. B., Wilson, P. W. F., & Meigs, J. B. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0425 · Cited by 262 · see citing works

Adiponectin, a key adipokine in obesity related liver diseases.

Buechler, C., Wanninger, J., & Neumeier, M. (2011) · PubMed Central · doi:10.3748/wjg.v17.i23.2801 · Cited by 261 · see citing works

Adiponectin in health and disease: evaluation of adiponectin-targeted drug development strategies

Shetty, S., Kusminski, C. M., & Scherer, P. E. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.02.004 · Cited by 209 · see citing works

Leptin, insulin resistance, and liver fibrosis in human nonalcoholic fatty liver disease

Angulo, P., Alba, L. M., Petrovic, L. M., Adams, L. A., Lindor, K. D., & Jensen, M. D. (2004) · Journal of Hepatology · doi:10.1016/j.jhep.2004.08.020 · Cited by 197 · see citing works

Increased Serum Resistin in Nonalcoholic Fatty Liver Disease Is Related to Liver Disease Severity and Not to Insulin Resistance

Pagano, C., Soardo, G., Pilon, C., Milocco, C., Basan, L., Milan, G., Donnini, D., Faggian, D., Mussap, M., Plebani, M., et al. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1056 · Cited by 190 · see citing works

Melatonin improves glucose homeostasis in young Zucker diabetic fatty rats

Agil, A., Rosado, I., Ruiz, R., Figueroa, A., Zen, N., & Fernández‐Vázquez, G. (2012) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00928.x · Cited by 169 · see citing works

Melatonin effect on plasma adiponectin, leptin, insulin, glucose, triglycerides and cholesterol in normal and high fat–fed rats

Ríos-Lugo, M. J., Cano, P., Jiménez‐Ortega, V., Fernández‐Mateos, P., Scacchi, P. A., Cardinali, D. P., & Esquifino, A. I. (2010) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2010.00798.x · Cited by 168 · see citing works

Adiponectin, a key adipokine in obesity related liver diseases

Christa, Buechler, Josef, Wanninger, Markus, M. L., & Neumeier (2011) · Acta Scientiarum Naturalium Universitatis Sunyatseni · Cited by 167 · see citing works

Testosterone Administration Suppresses Adiponectin Levels in Men

Page, S. T., Herbst, K. L., Amory, J. K., Coviello, A. D., Anawalt, B. D., Matsumoto, A. M., & Bremner, W. J. (2005) · Journal of Andrology · doi:10.1002/j.1939-4640.2005.tb02876.x · Cited by 162 · see citing works

Role of melatonin in upper gastrointestinal tract.

Konturek, S. J., Konturek, P. C., Brzozowski, T., & Bubenik, G. A. (2007) · PubMed · Cited by 153 · see citing works

Resistin as an Intrahepatic Cytokine

Bertolani, C., Sancho‐Bru, P., Failli, P., Bataller, R. A., Aleffi, S., DeFranco, R., Mazzinghi, B., Romagnani, P., Milani, S., Ginès, P., et al. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.060081 · Cited by 151 · see citing works

Adipokines in Nonalcoholic Steatohepatitis: From Pathogenesis to Implications in Diagnosis and Therapy

Tsochatzis, E. A., Papatheodoridis, G., & Archimandritis, A. J. (2009) · Mediators of Inflammation · doi:10.1155/2009/831670 · Cited by 140 · see citing works

Melatonin enhances leptin expression by rat adipocytes in the presence of insulin

Alonso‐Vale, M. I. C., Andreotti, S., Peres, S. B., Anhê, G. F., Borges‐Silva, C. N., Cipolla‐Neto, J., & Lima, F. B. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00478.2004 · Cited by 135 · see citing works

Removal of Melatonin Receptor Type 1 Induces Insulin Resistance in the Mouse

Contreras‐Alcantara, S., Baba, K., & Tosini, G. (2010) · Obesity · doi:10.1038/oby.2010.24 · Cited by 133 · see citing works

Absence of Melatonin Induces Night-Time Hepatic Insulin Resistance and Increased Gluconeogenesis Due to Stimulation of Nocturnal Unfolded Protein Response

Nogueira, T. C. A., Lellis‐Santos, C., de Jesus, D. S., Taneda, M., Rodrigues, S. C., do Amaral, F. G., Lopes, A. M. S., Cipolla‐Neto, J., Bordin, S. A., & Anhê, G. F. (2011) · Endocrinology · doi:10.1210/en.2010-1088 · Cited by 122 · see citing works

Gene Expression of Leptin, Resistin, and Adiponectin in the White Adipose Tissue of Obese Patients with Non-Alcoholic Fatty Liver Disease and Insulin Resistance

Baranova, A. V., Gowder, S., Schlauch, K. A., Elariny, H. A., Collantes, R. S., Afendy, A., Ong, J. P., Goodman, Z. D., Chandhoke, V., & Younossi, Z. M. (2006) · Obesity Surgery · doi:10.1381/096089206778392149 · Cited by 111 · see citing works

Ghrelin in chronic liver disease

Tacke, F., Brabant, G. E., Kruck, E., Horn, R., Schöffski, P., Hecker, H., Manns, M. P., & Trautwein, C. (2003) · Journal of Hepatology · doi:10.1016/s0168-8278(02)00438-5 · Cited by 109 · see citing works

New paradigms in chronic intestinal inflammation and colon cancer: role of melatonin

Motilva, V., García‐Mauriño, S., Talero, E., & Illanes, M. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00915.x · Cited by 106 · see citing works

Central Resistin Induces Hepatic Insulin Resistance via Neuropeptide Y

Singhal, N. S., Lazar, M. A., & Ahima, R. S. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2443-07.2007 · Cited by 95 · see citing works

EXPRESSION OF CONCERN: Adipocyte differentiation is inhibited by melatonin through the regulation of C/EBPβ transcriptional activity

Alonso‐Vale, M. I. C., Peres, S. B., Vernochet, C., Farmer, S. R., & Lima, F. B. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2009.00705.x · Cited by 92 · see citing works

Insulin sensitizers in nonalcoholic fatty liver disease and steatohepatitis: Current status

Stein, L. L., Dong, M. H., & Loomba, R. S. (2009) · Advances in Therapy · doi:10.1007/s12325-009-0072-z · Cited by 85 · see citing works

Ghrelin and oxidative stress in gastrointestinal tract

Suzuki, H., Matsuzaki, J., & Hibi∥, T. (2010) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.10-16gfr · Cited by 83 · see citing works

The effects of long-term melatonin treatment on plasma liver enzymes levels and plasma concentrations of lipids and melatonin in patients with nonalcoholic steatohepatitis: a pilot study.

Gonciarz, M., Gonciarz, Z., Bielański, W., Mularczyk, A., Konturek, P. C., Brzozowski, T., & Konturek, S. J. (2012) · PubMed · Cited by 82 · see citing works

The Potential Adverse Role of Leptin Resistance in Nonalcoholic Fatty Liver Disease

Pοlyzos, S. A., Kountouras, J., Zavos, C., & Deretzi, G. (2010) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e3181ec5c66 · Cited by 82 · see citing works

Serum resistin is not associated with obesity or insulin resistance in humans.

Iqbal, N., Seshadri, P., Stern, L., Loh, J., Kundu, S., Jafar, T., & Samaha, F. F. (2005) · PubMed · Cited by 82 · see citing works

Ghrelin alleviates biliary obstruction-induced chronic hepatic injury in rats

İşeri, S. Ö., Şener, G., Saǧlam, B., et al. (2007) · Regulatory Peptides · doi:10.1016/j.regpep.2007.08.014 · Cited by 72 · see citing works

Low Ghrelin Concentrations in Nonalcoholic Fatty Liver Disease Are Related to Insulin Resistance

Marchesini, G., Pagotto, U., Bugianesi, E., Iasio, R. D., Manini, R., Vanni, E., Pasquali, R., Melchionda, N., & Rizzetto, M. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031094 · Cited by 64 · see citing works

Preliminary Evidence That Pharmacologic Melatonin Treatment Decreases Rat Ghrelin Levels

Mustonen, A., Nieminen, P., & Hyvärinen, H. (2001) · Endocrine · doi:10.1385/endo:16:1:43 · Cited by 62 · see citing works

Long‐term enteral administration of melatonin reduces plasma insulin and increases expression of pineal insulin receptors in both Wistar and type 2‐diabetic Goto‐Kakizaki rats

Peschke, E., Schucht, H., & Mühlbauer, E. (2010) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2010.00804.x · Cited by 61 · see citing works

Ghrelin and Metabolic Disorders

Ukkola, O. H. (2009) · Current Protein and Peptide Science · doi:10.2174/138920309787315220 · Cited by 57 · see citing works

The pilot study of 3-month course of melatonin treatment of patients with nonalcoholic steatohepatitis: effect on plasma levels of liver enzymes, lipids and melatonin.

Gonciarz, M., Gonciarz, Z., Bielański, W., Mularczyk, A., Konturek, P. C., Brzozowski, T., & Konturek, S. J. (2010) · PubMed · Cited by 57 · see citing works

GH-releasing peptide-2 administration prevents liver inflammatory response in endotoxemia

Granado, M., Martı́n, A. I., López-Menduiña, M., et al. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00308.2007 · Cited by 50 · see citing works

Serum Adipokine and Ghrelin Levels in Nonalcoholic Steatohepatitis

Yalnız, M., Bahçecioğlu, İ. H., Ataseven, H., Üstündağ, B., İlhan, F., Poyrazoğlu, O. K., & Erensoy, A. (2006) · Mediators of Inflammation · doi:10.1155/mi/2006/34295 · Cited by 49 · see citing works

Melatonin or l ‐tryptophan accelerates healing of gastroduodenal ulcers in patients treated with omeprazole

Celiński, K., Konturek, S. J., Konturek, P. C., Brzozowski, T., Cichoż‐Lach, H., Słomka, M., Płonka, M., Bielański, W., & Reiter, R. J. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00855.x · Cited by 41 · see citing works

The insulin–melatonin antagonism: studies in the LEW.1AR1-iddm rat (an animal model of human type 1 diabetes mellitus)

Peschke, E., Hofmann, K., Bähr, I., Streck, S., Albrecht, E., Wedekind, D., & Mühlbauer, E. (2011) · Diabetologia · doi:10.1007/s00125-011-2138-0 · Cited by 40 · see citing works

Altered basal and postprandial plasma melatonin, gastrin, ghrelin, leptin and insulin in patients with liver cirrhosis and portal hypertension without and with oral administration of melatonin or tryptophan

Celiński, K., Konturek, P. C., Słomka, M., et al. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2009.00677.x · Cited by 39 · see citing works

Efficacy of Antioxidant Treatment in Reducing Resistin Serum Levels: A Randomized Study

Bo, S., Ciccone, G., Durazzo, M., et al. (2007) · PLoS Clinical Trials · doi:10.1371/journal.pctr.0020017 · Cited by 34 · see citing works

Altered fasting and postprandial plasma ghrelin levels in patients with liver failure are normalized after liver transplantation

Diz-Lois, M. T., García‐Buela, J., Suarez, F., et al. (2010) · European Journal of Endocrinology · doi:10.1530/eje-10-0508 · Cited by 18 · see citing works

Thiazolidinedione Therapy for Nonalcoholic Steatohepatitis: Go, Stop, or Proceed With Caution?

Harrison, S. A. (2009) · Hepatology · doi:10.1002/hep.23473 · Cited by 11 · see citing works

Serum resistin levels in nonalcoholic fatty liver disease and their relationship to severity of liver disease

Murad, A., Hassan, H., Husein, H., et al. (2010) · Journal of Endocrinology Metabolism and Diabetes of South Africa · doi:10.1080/22201009.2010.10872225 · Cited by 10 · see citing works

Mortality in nonalcoholic fatty liver disease: Clues from the cremona study

Adams, L. A. (2011) · Hepatology · doi:10.1002/hep.24445 · Cited by 9 · see citing works

Relationship between ghrelin and Helicobacter pylori infection in Polish adult shepherds and their children

Płonka, M., Konturek, P. C., Bielański, W., et al. (2006) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.00040.x · Cited by 6 · see citing works

Relationship between ghrelin and Helicobacter pylori infection in Polish adult shepherds and their children

Płonka, M., Konturek, P. C., Bielański, W., et al. (2006) · Alimentary Pharmacology & Therapeutics Symposium Series · doi:10.1111/j.1746-6342.2006.00040.x · Cited by 6 · see citing works

Osteopontin: A missing link between hedgehog signaling and fibrosis in nonalcoholic steatohepatitis

Machado, M. V., & Cortez‐Pinto, H. (2010) · Hepatology · doi:10.1002/hep.24118 · Cited by 5 · see citing works

Melatonin in type 2 diabetes mellitus and obesity

Karamitri, A., & Jockers, R. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0130-1 · Cited by 268 · see citing works

Circulating leptin in non-alcoholic fatty liver disease: A systematic review and meta-analysis

Polyzos, S. A., Aronis, K. N., Kountouras, J., Raptis, D. D., Vasiloglou, M. F., & Mantzoros, C. S. (2016) · Diabetologia · doi:10.1007/s00125-015-3769-3 · Cited by 248 · see citing works

Leptin in nonalcoholic fatty liver disease: A narrative review

Polyzos, S. A., Kountouras, J., & Mantzoros, C. S. (2015) · Metabolism · doi:10.1016/j.metabol.2014.10.012 · Cited by 235 · see citing works

Is Melatonin the Cornucopia of the 21st Century?

Ferlazzo, N., Andolina, G., Cannata, A., Costanzo, M. G., Rizzo, V., Currò, M., Ientile, R., & Caccamo, D. (2020) · Antioxidants · doi:10.3390/antiox9111088 · Cited by 189 · see citing works

Melatonin Supplementation Lowers Oxidative Stress and Regulates Adipokines in Obese Patients on a Calorie‐Restricted Diet

Szewczyk-Golec, K., Rajewski, P., Gackowski, M., Mila-Kierzenkowska, C., Wesołowski, R., Sutkowy, P., Pawłowska, M., & Woźniak, A. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/8494107 · Cited by 92 · see citing works

The effect of melatonin on treatment of patients with non-alcoholic fatty liver disease: a randomized double blind clinical trial

Bahrami, M., Cheraghpour, M., Jafarirad, S., Alavinejad, P., Asadi, F., Hekmatdoost, A., Mohammadi, M., & Yari, Z. (2020) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2020.102452 · Cited by 60 · see citing works

Melatonin supplementation improves glycemic hemostasis, lipid profile, and adipokine concentrations of obese women: A double-blind randomized clinical trial

Mesri Alamdari, N., Namazi Shabestari, A., Najafipour, F., & Mirmazhari, A. (2024) · Biomedicine Advances · doi:10.34172/bma.05 · Cited by 4 · see citing works

Resistin expression study used to develop a simplified mouse model of adipokine expression

Quijada, E., Dean, D. M., & Marcucci, M. (2013) · The FASEB Journal · doi:10.1096/fasebj.27.1_supplement.563.3 · Cited by 1 · see citing works

Serum adiponectin is related to resistin independent of adiposity

Pezhman, A., Mohsen, T., Akbar, A. A., et al. (2012)

[Adipocytokines and assay method in metabolic syndrome].

Abe, A. (2010) · PubMed · Cited by 3 · see citing works

Adipokines as predictors of recovery from upper extremity soft tissue disorders

Rechardt, M., Viikari‐Juntura, E., & Shiri, R. (2014) · Lara D. Veeken · doi:10.1093/rheumatology/keu272 · Cited by 18 · see citing works

Nicotine may affect the secretion of adipokines leptin, resistin, and visfatin through activation of KATP channel

Bai, X., Fan, L., He, Y., et al. (2015) · Nutrition · doi:10.1016/j.nut.2015.12.001 · Cited by 12 · see citing works