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Cited by 170Sexual Differentiation and DisordersAdrenal Hormones and DisordersOvarian function and disorders

The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

High Prevalence of Reduced Fecundity in Men with Congenital Adrenal Hyperplasia

Reisch, Nicole, Flade, Linda, Scherr, Michael, Rottenkolber, Marietta, Pedrosa Gil, Francesco, Bidlingmaier, Martin, Wolff, Hans, Schwarz, Hans-Peter, Quinkler, Marcus, Beuschlein, Felix, Reincke, Martin·2009·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2008-1414
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Abstract

Context: Testicular adrenal rest tumors (TARTs) are regarded to contribute to the high prevalence of subfertility in males with congenital adrenal hyperplasia (CAH). Objectives: Our objectives were to evaluate reduced fecundity and its possible causes in well-controlled adult males with CAH, and to investigate diagnostic tools for improved treatment monitoring with respect to fertility outcomes. Design: In a cross-sectional study at the Department of Endocrinology at the University Hospital München, Germany, 22 adult male CAH patients (15 salt wasting and seven simple virilizing, age 19–48 yr) were clinically assessed according to their hormonal control. We performed testicular ultrasound (22 of 22), magnetic resonance imaging (18 of 22), and a semen analysis (19 of 22) in the participants. Results: All patients had a pathological semen analysis. TART prevalence was 10 of 22 (eight salt wasting, two simple virilizing). Poor therapy control was present in five patients, and all five had TARTs. Of the other 17 well-controlled patients with normal or suppressed adrenal androgens and 17-hydroxyprogesterone levels, five presented with TARTs. There was a significant correlation between sperm concentration and functional testicular volume (r = 0.70; P = 0.002), TART volume (r = −0.70; P = 0.036), as well as inhibin B levels (r = 0.75; P < 0.0001), respectively. In several men, hormonal control parameters suggested hypogonadism, with glucocorticoid overtreatment as a relevant factor for poor semen quality. Conclusions: Poor semen parameters are common in male CAH patients. TARTs, most likely reflecting undertreatment, as well as inhibin B are important indicators of fecundity. On the other hand, long-term glucocorticoid overtreatment also seems to contribute to low semen quality.

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Crossref · 10.1210/jc.2008-1414

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  1. Bals-Pratsch, 1999, World Health Organization (WHO)-Laborhandbuch

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Metadata

Authors
Reisch, N., Flade, L., Scherr, M., Rottenkolber, M., Pedrosa Gil, F., Bidlingmaier, M., Wolff, H., Schwarz, H.-P., Quinkler, M., Beuschlein, F., & Reincke, M.
Affiliations
  • Ludwig-Maximilians-Universität München (DE)
  • LMU Klinikum (DE)
  • Psychosomatic Ambulance and Outpatient Clinic (F.P.G.), University Hospital München, D-80336 München, Germany
  • München Klinik (DE)
  • Charité – Universitätsmedizin Berlin (DE)
  • Endocrinology and Metabolism (N.R., L.F., M.B., F.B., M.Re.), University Hospital München, D-80336 München, Germany
Corresponding author
Reisch, Nicole
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2009-05-01
Volume
94
Issue
5
Pages
1665-1670
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2008-1414
OpenAlex
W1981718662
Cited by
170
References
22
Citations by year
2026: 6 · 2025: 2 · 2024: 6 · 2023: 5 · 2022: 8 · 2021: 9 · 2020: 9 · 2019: 12 · 2018: 6 · 2017: 12 · 2016: 13 · 2015: 12 · 2014: 11 · 2013: 15 · 2012: 15
FWCI
5.72
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Keywords
congenital adrenal hyperplasia, male subfertility, testicular adrenal rest tumor, semen quality, hypogonadism, inhibin B, 17-hydroxyprogesterone, salt wasting, simple virilizing CAH, testicular volume
MeSH terms
Adrenal Hyperplasia, Congenital, Adrenal Rest Tumor, Adult, Fertility, Follicle Stimulating Hormone, Hormones, Humans, Infertility, Male, Inhibins, Leydig Cells, Luteinizing Hormone, Male, Middle Aged, Saliva, Semen, Sperm Count, Spermatogenesis, Testis, Testosterone, Ultrasonography, Cohort Studies, Treatment Outcome, Young Adult

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