The DOI matches its Crossref record; 238 of the 238 references it cites were found in a registry or an index.
Central Control of Body Weight and Appetite
Open accessAbstract
Context: Energy balance is critical for survival and health, and control of food intake is an integral part of this process. This report reviews hormonal signals that influence food intake and their clinical applications. Evidence Acquisition: A relatively novel insight is that satiation signals that control meal size and adiposity signals that signify the amount of body fat are distinct and interact in the hypothalamus and elsewhere to control energy homeostasis. This review focuses upon recent literature addressing the integration of satiation and adiposity signals and therapeutic implications for treatment of obesity. Evidence Synthesis: During meals, signals such as cholecystokinin arise primarily from the GI tract to cause satiation and meal termination; signals secreted in proportion to body fat such as insulin and leptin interact with satiation signals and provide effective regulation by dictating meal size to amounts that are appropriate for body fatness, or stored energy. Although satiation and adiposity signals are myriad and redundant and reduce food intake, there are few known orexigenic signals; thus, initiation of meals is not subject to the degree of homeostatic regulation that cessation of eating is. There are now drugs available that act through receptors for satiation factors and which cause weight loss, demonstrating that this system is amenable to manipulation for therapeutic goals. Conclusions: Although progress on effective medical therapies for obesity has been relatively slow in coming, advances in understanding the central regulation of food intake may ultimately be turned into useful treatment options.
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Cites
Central nervous system control of food intake
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Self-citationGhrelin induces adiposity in rodents
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BackgroundCentral nervous system control of food intake and body weight
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Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein
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Cited by
Steinert, R. E., Feinle-Bisset, C., Asarian, L., Horowitz, M., Beglinger, C., & Geary, N. (2017) · Physiological Reviews · doi:10.1152/physrev.00031.2014 · Cited by 578
Sex differences in the physiology of eating
Asarian, L., & Geary, N. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00446.2012 · Cited by 513
Rinaman, L. (2010) · Brain Research · doi:10.1016/j.brainres.2010.03.059 · Cited by 311
“…IH -PA Author M anuscript N IH -PA Author M anuscript information regarding the involvement of particular diencephalic and limbic forebrain regions in the central neural control of food intake and energy expenditure (Berthoud, 2002; Berthoud, 2008; Broberger, 2005; Woods and D'Alessio, 2008).”
BackgroundInterplay between the gut-brain axis, obesity and cognitive function
Agustí, A., García-Pardo, M. P., López-Almela, I., Campillo, I., Maes, M., Romaní-Pérez, M., & Sanz, Y. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00155 · Cited by 294
Moiz, A., Filion, K. B., Tsoukas, M. A., Yu, O. H., Peters, T. M., & Eisenberg, M. J. (2025) · The American Journal of Medicine · doi:10.1016/j.amjmed.2025.01.021 · Cited by 241
Metadata
- Authors
- Woods, S. C., & D'Alessio, D. A.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2008-11-01
- Volume
- 93
- Issue
- 11_supplement_1
- Pages
- s37-s50
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W1972062612
- Cited by
- 458
- References
- 238
- FWCI
- 15.62
- Type
- journal article
- Language
- en
- Open access
- green
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