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Reciprocal Relations of Subcutaneous and Visceral Fat to Bone Structure and Strength
Open accessAbstract
CONTEXT: Increased body fat is a risk factor for cardiovascular and metabolic disease, yet it is uncertain whether obesity protects against osteoporosis or adiposity is harmful to bone. OBJECTIVE: The aim of the study was to assess whether the pattern of adipose tissue deposition influences bone structure and strength. DESIGN: The relations between sc and visceral adiposity and the cross-sectional dimensions and polar and principal moments of the femur in 100 healthy women ages 15 to 25 years were obtained using computed tomography. RESULTS: Multiple linear regression analyses indicated that, after adjusting for leg length and thigh musculature, both sc and visceral fat had strong and independent associations with femoral cross-sectional area, cortical bone area, principal moment maximum, principal moment minimum, and polar moment (all P values < 0.03). However, whereas sc fat had a positive predictive value with all femoral bone phenotypes, a similar but negative effect was observed between visceral fat and these measures (all P values < 0.01). CONCLUSIONS: We found that visceral and sc fat have opposite effects on the appendicular skeleton; whereas sc fat is beneficial to bone structure and strength, visceral fat serves as an unique pathogenic fat depot.
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“Relative to body weight, microarchitecture and strength are lower in obese women compared to controls 23.”
From Bone loss after bariatric surgery: causes, consequences, and management (2014) · cites this paper as [23]
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Metadata
- Authors
- Gilsanz, V., Chalfant, J., Mo, A. O., Lee, D. C., Dorey, F. J., & Mittelman, S. D.
- Affiliations
- University of Southern California (US)
- Corresponding author
- Gilsanz, Vicente
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2009-09-01
- Volume
- 94
- Issue
- 9
- Pages
- 3387-3393
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- PMC
- PMC2741723
- OpenAlex
- W1971193583
- Cited by
- 351
- References
- 45
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 18 · 2023: 19 · 2022: 23 · 2021: 14 · 2020: 23 · 2019: 13 · 2018: 17 · 2017: 29 · 2016: 26 · 2015: 17 · 2014: 30 · 2013: 37 · 2012: 23
- FWCI
- 23.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR052744)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Infectious Diseases › HIV-related health complications and treatments
- Health Sciences › Medicine › Physiology (medical) › Body Composition Measurement Techniques
- Keywords
- subcutaneous adipose tissue, visceral fat, body fat distribution, bone structure, bone strength, femur, cortical bone area, cross-sectional area, young women, osteoporosis risk
- MeSH terms
- Adolescent, Adult, Bone and Bones, Female, Humans, Tomography, X-Ray Computed, Linear Models, Subcutaneous Fat, Intra-Abdominal Fat
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