Cited by 51Adipokines, Inflammation, and Metabolic DiseasesRegulation of Appetite and ObesityNutrition and Health in Aging

Fetuin-A and change in body composition in older persons

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Ix, Joachim H., Wassel, Christina L., Chertow, Glenn M., Koster, Annemarie, Johnson, Karen C., Tylavsky, Frances A., Cauley, Jane A., Cummings, Steven R. +3 more·2009·The Journal of Clinical Endocrinology & Metabolism

Abstract

CONTEXT: Fetuin-A inhibits the insulin receptor in vitro. Higher serum fetuin-A concentrations are associated with type 2 diabetes longitudinally and greater adiposity in cross-sectional analyses. Whether higher fetuin-A concentrations are associated with accumulation of adiposity over time is unknown. OBJECTIVE: To determine the association of fetuin-A levels with changes in body composition over 5 yr. STUDY DESIGN: Observational cohort study nested in the Health Aging and Body Composition Study. PREDICTOR: Serum fetuin-A levels. OUTCOMES: Visceral adipose tissue (VAT), abdominal sc adipose tissue, and thigh muscle area by computed tomography, and waist circumference and body mass index were measured at baseline and again after 5 yr. Percent change and extreme change (>1.5 sds) in each measure were calculated. RESULTS: Over 5 yr, subjects lost body mass in each measure, including 6% decline in VAT. Yet each sd (0.42 g/liter) higher fetuin-A concentration was associated with a 5.5% increase in VAT over 5 yr (95% confidence interval 1.9-9.2%; P = 0.003) in models adjusted for age, sex, race, clinical site, diabetes, physical activity, triglycerides, kidney function, and the baseline VAT score. Similarly, higher fetuin-A concentrations were associated with extreme VAT gain (relative risk 1.70, 95% confidence interval 1.12-2.60, P = 0.01). Fetuin-A concentrations were not statistically significant associated with change in any other measures of body composition (P > 0.20). CONCLUSIONS: Higher fetuin-A concentrations are associated with the accumulation of VAT in well-functioning, community-living older persons. The mechanisms linking fetuin-A, VAT, and insulin resistance remain to be determined.

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Crossref · 10.1210/jc.2009-0916

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Authors
Ix, J. H., Wassel, C. L., Chertow, G. M., Koster, A., Johnson, K. C., Tylavsky, F. A., Cauley, J. A., Cummings, S. R., Harris, T. B., Shlipak, M. G., & Study, F. T. H. A. A. B. C.
Affiliations
  • University of California San Diego (US)
  • Stanford University (US)
  • National Institutes of Health (US)
  • University of Tennessee Health Science Center (US)
  • University of Pittsburgh (US)
  • University of California, San Francisco (US)
  • San Francisco VA Medical Center (US)
Corresponding author
Ix, Joachim H.
Venue
The Journal of Clinical Endocrinology & Metabolism
Published
2009-11-01
Volume
94
Issue
11
Pages
4492-4498
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
OpenAlex
W2146349293
Cited by
51
References
27
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 4 · 2018: 2 · 2017: 3 · 2016: 1 · 2015: 5 · 2014: 7 · 2013: 4 · 2012: 7
FWCI
2.69
Type
journal article
Language
en
Open access
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute on Aging (N01‐AG‐6–2101, N01AG62106, N01-AG-62103)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
Keywords
fetuin-A, body composition, visceral adipose tissue, subcutaneous abdominal fat, thigh muscle area, older adults, insulin resistance, insulin receptor, type 2 diabetes, body mass index, waist circumference
MeSH terms
Adipose Tissue, Aged, Aging, Blood Proteins, Body Composition, Diabetes Mellitus, Type 1, Female, Humans, Male, Receptor, Insulin, Tomography, X-Ray Computed, Cohort Studies, Weight Gain, Weight Loss, Body Mass Index, Muscle, Skeletal, Racial Groups, Waist Circumference, alpha-2-HS-Glycoprotein

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