Fetuin-A and change in body composition in older persons
Open accessAbstract
CONTEXT: Fetuin-A inhibits the insulin receptor in vitro. Higher serum fetuin-A concentrations are associated with type 2 diabetes longitudinally and greater adiposity in cross-sectional analyses. Whether higher fetuin-A concentrations are associated with accumulation of adiposity over time is unknown. OBJECTIVE: To determine the association of fetuin-A levels with changes in body composition over 5 yr. STUDY DESIGN: Observational cohort study nested in the Health Aging and Body Composition Study. PREDICTOR: Serum fetuin-A levels. OUTCOMES: Visceral adipose tissue (VAT), abdominal sc adipose tissue, and thigh muscle area by computed tomography, and waist circumference and body mass index were measured at baseline and again after 5 yr. Percent change and extreme change (>1.5 sds) in each measure were calculated. RESULTS: Over 5 yr, subjects lost body mass in each measure, including 6% decline in VAT. Yet each sd (0.42 g/liter) higher fetuin-A concentration was associated with a 5.5% increase in VAT over 5 yr (95% confidence interval 1.9-9.2%; P = 0.003) in models adjusted for age, sex, race, clinical site, diabetes, physical activity, triglycerides, kidney function, and the baseline VAT score. Similarly, higher fetuin-A concentrations were associated with extreme VAT gain (relative risk 1.70, 95% confidence interval 1.12-2.60, P = 0.01). Fetuin-A concentrations were not statistically significant associated with change in any other measures of body composition (P > 0.20). CONCLUSIONS: Higher fetuin-A concentrations are associated with the accumulation of VAT in well-functioning, community-living older persons. The mechanisms linking fetuin-A, VAT, and insulin resistance remain to be determined.
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Increasing levels of fetuin A are associated with increasing VAT mass in elderly adults over a 5-year follow-up.
“Concordantly, increasing levels of fetuin A were associated with increasing VAT mass in elderly adults over a 5-year follow-up [191].”
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- Authors
- Ix, J. H., Wassel, C. L., Chertow, G. M., Koster, A., Johnson, K. C., Tylavsky, F. A., Cauley, J. A., Cummings, S. R., Harris, T. B., Shlipak, M. G., & Study, F. T. H. A. A. B. C.
- Affiliations
- University of California San Diego (US)
- Stanford University (US)
- National Institutes of Health (US)
- University of Tennessee Health Science Center (US)
- University of Pittsburgh (US)
- University of California, San Francisco (US)
- San Francisco VA Medical Center (US)
- Corresponding author
- Ix, Joachim H.
- ORCID
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2009-11-01
- Volume
- 94
- Issue
- 11
- Pages
- 4492-4498
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- PMC
- PMC2775641
- OpenAlex
- W2146349293
- Cited by
- 51
- References
- 27
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 4 · 2018: 2 · 2017: 3 · 2016: 1 · 2015: 5 · 2014: 7 · 2013: 4 · 2012: 7
- FWCI
- 2.69
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (N01‐AG‐6–2101, N01AG62106, N01-AG-62103)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- fetuin-A, body composition, visceral adipose tissue, subcutaneous abdominal fat, thigh muscle area, older adults, insulin resistance, insulin receptor, type 2 diabetes, body mass index, waist circumference
- MeSH terms
- Adipose Tissue, Aged, Aging, Blood Proteins, Body Composition, Diabetes Mellitus, Type 1, Female, Humans, Male, Receptor, Insulin, Tomography, X-Ray Computed, Cohort Studies, Weight Gain, Weight Loss, Body Mass Index, Muscle, Skeletal, Racial Groups, Waist Circumference, alpha-2-HS-Glycoprotein
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