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Cited by 192Ovarian function and disordersDiabetes, Cardiovascular Risks, and LipoproteinsPhysical Activity and Health

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Effects of Exercise on Insulin Resistance and Body Composition in Overweight and Obese Women with and without Polycystic Ovary Syndrome

Hutchison, Samantha K., Stepto, Nigel K., Harrison, Cheryce L., Moran, Lisa J., Strauss, Boyd J., Teede, Helena J.·2011·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2010-0828
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Abstract

CONTEXT: Polycystic ovary syndrome (PCOS) is an insulin-resistant (IR) state. Visceral fat (VF) is independently associated with IR. OBJECTIVES: The objectives of the study were to explore mechanisms underpinning IR by assessing the effect of exercise training on IR and body composition in overweight PCOS and non-PCOS women. DESIGN: This was a prospective exercise intervention study. SETTING AND PARTICIPANTS: The study was conducted at an academic medical center. Participants included 20 overweight PCOS and 14 overweight non-PCOS women. INTERVENTION: The intervention included 12 wk of intensified aerobic exercise (3 h/wk). MAIN OUTCOME MEASURES: IR on euglycemic hyperinsulinemic clamp, body composition including abdominal visceral and sc fat distribution by computer tomography and lipids was measured. RESULTS: PCOS subjects were more IR (P = 0.02) and had more VF (P = 0.04 age adjusted) than non-PCOS women. In PCOS women, IR correlated with VF (r = -0.78, P < 0.01). With exercise training, both groups maintained weight but within PCOS, VF (-12.0 cm(2), P = 0.03) and within non-PCOS abdominal sc fat (-40.2 cm(2), P = 0.02) decreased. Despite exercise-induced improvement in IR within PCOS (+27.9 mg · m(-2) · min(-1), P = 0.03), no relationship with decreased VF (r = -0.08, P = 0.84) and no differential changes in IR and VF between groups were noted. Triglycerides decreased within PCOS (-0.27 mmol/liter, P = 0.02) and decreased differentially between groups (P < 0.01). CONCLUSIONS: Higher IR was related to increased VF in PCOS, suggesting an etiological role for VF in intrinsic IR in PCOS; however, changes with exercise intervention did not support a causal relationship. Triglycerides were modulated more by exercise training in PCOS than non-PCOS women. Within-group exercise-induced reductions in cardiometabolic risk factors including IR, triglycerides, and VF in PCOS were observed without significant weight loss and if confirmed in future controlled trials, suggest weight loss should not be the sole focus of exercise programs.

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Metadata

Authors
Hutchison, S. K., Stepto, N. K., Harrison, C. L., Moran, L. J., Strauss, B. J., & Teede, H. J.
Affiliations
  • Jean Hailes (AU)
  • Monash University (AU)
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2011-01
Volume
96
Issue
1
Pages
E48-E56
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2010-0828
OpenAlex
W2098058136
Cited by
192
References
40
Citations by year
2026: 4 · 2025: 4 · 2024: 10 · 2023: 14 · 2022: 14 · 2021: 17 · 2020: 16 · 2019: 13 · 2018: 9 · 2017: 11 · 2016: 20 · 2015: 18 · 2014: 17 · 2013: 9 · 2012: 8
FWCI
9.49
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Victoria University Research Repository (Victoria University) (submittedVersion)
  • Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
Keywords
polycystic ovary syndrome, insulin resistance, aerobic exercise training, visceral fat, body composition, subcutaneous abdominal fat, triglycerides, overweight women, obesity, hyperinsulinemic-euglycemic clamp, cardiometabolic risk factors, weight maintenance, exercise-induced weight loss, dyslipidemia
MeSH terms
Adult, Analysis of Variance, Body Composition, Exercise Therapy, Female, Humans, Insulin Resistance, Obesity, Polycystic Ovary Syndrome, Prospective Studies, Radioimmunoassay, Risk Factors, Glucose Clamp Technique, Exercise, Absorptiometry, Photon, Body Mass Index, Linear Models, Treatment Outcome, Patient Selection, Overweight

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