The impact of intensified exercise training on insulin resistance and fitness in overweight and obese women with and without polycystic ovary syndrome
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Summary: Objective To evaluate mechanisms of insulin resistance (IR) in overweight and obese women with and without polycystic ovary syndrome (PCOS) and explore relationships between IR, fitness and body mass index (BMI) at baseline and following exercise intervention. Design Prospective controlled intensified exercise intervention study. Patients A total of 20 overweight (BMI > 25 kg/m 2 ) and obese (>30 kg/m 2 ), reproductive‐aged PCOS women and 13 non‐PCOS overweight, healthy controls of comparable BMI and age were studied at baseline. Measures were repeated in 13 PCOS and eight control women following three 1‐h exercise sessions per week over 12 weeks. Measurements Insulin resistance was measured by glucose infusion rate on euglycaemic hyperinsulinaemic clamp, and fitness was assessed by VO 2max . Results At baseline, PCOS women were 46% more insulin resistant than controls (175·6 vs 257·2 mg/m 2 /min, P < 0·05) with IR independently associated with VO 2max and BMI in the PCOS group only ( P < 0·01). Postexercise IR improved across both groups ( P < 0·01). In PCOS women, IR improved by 16% ( P < 0·05) but was not restored to the same level as controls ( P < 0·05). Improvement in IR and in VO 2max was related to the PCOS group ( r 2 = 0·85, P < 0·05), yet change in IR and in fitness was not related. No associations were found in controls. Conclusions While intensified exercise improves IR in PCOS women, a higher IR persisted following exercise in PCOS women, and a clear relationship between improved IR and improved fitness was not found. Therefore, other mechanisms of, and therapies for, IR must be explored in PCOS as IR remains higher than observed in non‐PCOS controls.
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High intensity aerobic exercise with heart rate >80% improves insulin resistance in women with PCOS.
“High intensity aerobic exercise with heart rate >80% improves IR in women with PCOS [38].”
From From Prediabetes to Type 2 Diabetes Mellitus in Women with Polycystic Ovary Syndrome: Lifestyle and Pharmacological Management (2020) · cites this paper as [38]
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- Authors
- Harrison, C. L., Stepto, N. K., Hutchison, S. K., & Teede, H. J.
- Affiliations
- Jean Hailes (AU)
- Monash University (AU)
- Corresponding author
- Stepto, Nigel K.
- Venue
- Clinical Endocrinology
- Publisher
- Wiley
- Published
- 2012-02-07
- Volume
- 76
- Issue
- 3
- Pages
- 351-357
- ISSN
- 0300-0664 (ISSN-L)
- 1365-2265
- OpenAlex
- W2100842204
- Cited by
- 80
- References
- 18
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 8 · 2021: 3 · 2020: 8 · 2019: 7 · 2018: 2 · 2017: 8 · 2016: 11 · 2015: 9 · 2014: 9 · 2013: 3 · 2012: 2
- FWCI
- 5.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Clinical Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Victoria University Research Repository (Victoria University) (acceptedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Funders
- Monash University
- Medical Research Council
- National Health and Medical Research Council (606553)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Keywords
- polycystic ovary syndrome, insulin resistance, exercise training, cardiorespiratory fitness, VO2max, obesity, overweight women, body mass index, glucose infusion rate, hyperinsulinemic-euglycemic clamp
- MeSH terms
- Adult, Analysis of Variance, Blood Glucose, Exercise Test, Female, Humans, Insulin Resistance, Obesity, Oxygen Consumption, Polycystic Ovary Syndrome, Prospective Studies, Time Factors, Glucose Clamp Technique, Exercise, Body Mass Index, Linear Models, Overweight
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