Global adiposity rather than abnormal regional fat distribution characterizes women with polycystic ovary syndrome
Abstract
CONTEXT: Obesity-related predisposition to polycystic ovary syndrome (PCOS) could reflect overall adiposity and/or regional accumulation of abdominal visceral fat. OBJECTIVE: The objective of the study was to compare distributions of visceral, abdominal sc, and gluteofemoral sc adipose tissue in PCOS cases vs. control women. DESIGN: This was a cross-sectional study. SETTING AND PARTICIPANTS: Fat depot measurements from axial magnetic resonance imaging scans taken at anatomically predefined sites were compared between 22 body mass index (BMI)/fat mass-matched pairs of PCOS cases and controls; whole-group comparisons included 50 PCOS cases vs. 28 female controls. All subjects were of UK British/Irish origin. MAIN OUTCOME MEASURE(S): We measured cross-sectional areas of adipose tissue within visceral (mid-L4), abdominal (mid-L4) sc, and gluteofemoral (greater trochanteric and midfemoral) sc fat depots. Other measurements included fat mass, BMI, testosterone, SHBG, and homeostasis model assessment of insulin resistance (a measure of insulin sensitivity). Whole-group analyses were adjusted for fat mass and age. RESULTS: There were no significant differences in fat-depot measurements between BMI/fat mass-matched pairs of PCOS cases and controls: mid-L4 visceral (P=0.40), abdominal sc (P=0.22), gluteal sc (P=0.67), and midfemoral sc (P=0.37) depots. Whole-group comparisons gave similar results after adjustments for fat mass and age. Fasting serum insulin concentrations (P=0.03) and homeostasis model assessment of insulin resistance (P=0.03) were significantly higher in the PCOS group than BMI/fat mass-matched controls. CONCLUSIONS: PCOS cases and BMI/fat mass-matched control women are indistinguishable with respect to distribution of fat within visceral, abdominal sc, and gluteofemoral sc depots, despite significant differences in insulin resistance between these two groups.
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Barber et al. reported that visceral fat assessed by MRI was correlated with IR (HOMA2) in a small group of overweight women with PCOS.
“For their part, Barber et al. reported that visceral fat, assessed by MRI, was correlated with IR (HOMA2) in a small group of overweight women with PCOS [33].”
From PCOS and nutritional approaches: Differences between lean and obese phenotype (2021) · cites this paper as [33]
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- Authors
- Barber, T. M., Golding, S. J., Alvey, C., Wass, J. A. H., Karpe, F., Franks, S., & McCarthy, M. I.
- Affiliations
- Churchill Hospital (GB)
- John Radcliffe Hospital (GB)
- Imperial College London (GB)
- Corresponding author
- Barber, Thomas M.
- ORCID
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2008-03-01
- Volume
- 93
- Issue
- 3
- Pages
- 999-1004
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2168664376
- Cited by
- 179
- References
- 30
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 10 · 2023: 5 · 2022: 12 · 2021: 11 · 2020: 7 · 2019: 6 · 2018: 9 · 2017: 14 · 2016: 10 · 2015: 15 · 2014: 10 · 2013: 12 · 2012: 9
- FWCI
- 11.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
- Keywords
- polycystic ovary syndrome, adiposity, regional fat distribution, visceral fat, subcutaneous abdominal fat, insulin resistance, obesity, women
- MeSH terms
- Adipose Tissue, Adolescent, Adult, Body Composition, Cross-Sectional Studies, Female, Humans, Middle Aged, Polycystic Ovary Syndrome, Adiposity
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