Cited by 116Bone health and osteoporosis researchBone Metabolism and DiseasesAdipokines, Inflammation, and Metabolic Diseases

Inverse relationship between serum osteocalcin levels and visceral fat area in Chinese men

Bao, Yuqian, Ma, Xiaojing, Yang, Rong, Wang, Feifei, Hao, Yaping, Dou, Jianxin, He, Hongyuan, Jia, Weiping·2013·The Journal of Clinical Endocrinology & Metabolism

Abstract

OBJECTIVE: The relationship between serum osteocalcin levels and body fat distribution remains unclear. This study aimed to investigate the association between serum osteocalcin levels and visceral fat area (VFA) in Chinese men. DESIGN: Total serum osteocalcin levels were measured in 1768 Chinese men (22-75 yr old) by electrochemiluminescence immunoassay. VFA was quantified via magnetic resonance imaging. Correlation analyses were carried out for serum osteocalcin levels and clinical parameters. Subgroup analysis was carried out to confirm the correlations using subjects with normal glucose tolerance and normal body mass index chosen from the entire study population. RESULTS: Increased serum osteocalcin levels were accompanied by a decreasing trend in all anthropometric indices of obesity, systolic blood pressure, blood glucose, insulin resistance index, triglycerides, free fatty acid, and C-reactive protein levels (all P < 0.05). The 50-75th (osteocalcin level: 16.18-19.88 ng/ml) and 75th (≥19.89 ng/ml) percentile groups had lower VFA than the 25th (≤13.11 ng/ml) and 25-50th (13.12-16.17 ng/ml) percentile groups (96.0 ± 44.4 and 89.8 ± 44.4 cm(2) vs. 108.1 ± 41.9 and 102.9 ± 44.9 cm(2), P < 0.05). A decreasing trend in serum osteocalcin levels was found to accompany the increase in VFA. Multiple stepwise regression analysis showed that VFA, as an independent factor, was inversely associated with serum osteocalcin levels both in the entire study population and subgroup population (all P < 0.01). CONCLUSIONS: Serum osteocalcin levels were inversely correlated with VFA in Chinese men.

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Crossref · 10.1210/jc.2012-2906

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Authors
Bao, Y., Ma, X., Yang, R., Wang, F., Hao, Y., Dou, J., He, H., & Jia, W.
Affiliations
Shanghai Jiao Tong University (CN)
Corresponding author
Jia, Weiping
Venue
The Journal of Clinical Endocrinology & Metabolism
Published
2013-01
Volume
98
Issue
1
Pages
345-351
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
OpenAlex
W2034200476
Cited by
116
References
29
Citations by year
2025: 3 · 2024: 5 · 2023: 3 · 2022: 11 · 2021: 9 · 2020: 11 · 2019: 6 · 2018: 13 · 2017: 8 · 2016: 15 · 2015: 14 · 2014: 11 · 2013: 7
FWCI
11.03
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (973 Program, 11JC1409600, 81170788, 2012CB524906, 81100563)
  • Shanghai Jiao Tong University
  • National Key Research and Development Program of China (11JC1409600, 2012BAI02B03)
Topics
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
osteocalcin, visceral fat area, body fat distribution, obesity, insulin resistance, Chinese men, metabolic risk factors
MeSH terms
Adult, Aged, Humans, Hyperlipidemias, Insulin Resistance, Male, Middle Aged, Osteocalcin, Case-Control Studies, Asian People, Intra-Abdominal Fat, Body Fat Distribution, Young Adult, Obesity, Abdominal

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