Postnatal Lifestyle Intervention for Overweight Women With Previous Gestational Diabetes: A Randomized Controlled Trial
Open accessAbstract
Background: Gestational diabetes mellitus (GDM) is associated with a sevenfold increased lifetime risk of type 2 diabetes. Excessive gestational weight gain and postpartum weight retention are established predictors of long-term obesity. Objective: To determine the impact of a postnatal lifestyle intervention program for overweight women with previous gestational diabetes mellitus (PAIGE). Design: Postnatal overweight women with previous GDM participated in a multicenter randomized controlled trial between June 2013 and December 2014. The intervention comprised a 1-hour educational program, a free 3-month referral to a commercial weight management organization (Slimming World), a pedometer, and structured telephone and text support, in addition to usual care. The control group received usual care only. The primary outcome was weight loss at 6 months. Results: Sixty women were randomized (29 intervention; 31 control) in two centers based on their week of attendance. The intervention group demonstrated significant weight loss at 6 months after randomization compared with the control group: mean ±SD, 3.9 ± 7.0 kg vs 0.7 ±3.8 kg (P = 0.02). Blood glucose levels did not significantly differ. With respect to well-being measures, a bodily pain was significantly reduced in the intervention group (P = 0.007). Conclusions: PAIGE resulted in significantly greater weight loss at 6 months compared with usual care. Such weight loss could prove beneficial in terms of better long-term health and subsequent prevention of type 2 diabetes in overweight women with previous GDM. Future interventions must consider recruitment strategies, timing of the intervention, and inclusion of partners and/or other family members.
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Muralidharan et al and Holmes et al concluded that TM, in addition to TCP, does not have a significant effect on delaying T2DM.
“For example, Muralidharan et al [51] and Holmes et al [52] concluded that TM, in addition to TCP, does not have a significant effect on delaying T2DM.”
From Digital Health Interventions to Prevent Type 2 Diabetes Mellitus: Systematic Review (2025) · cites this paper as [52]
The Abstract reports no significant difference in blood glucose levels between the postnatal lifestyle intervention and usual care. But the intervention combined education, weight-management referral, a pedometer, and telephone and text support; the trial measured weight loss at six months, not whether telemedicine delayed type 2 diabetes. (LLM, conf=0.85)
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- Authors
- Holmes, V. A., Draffin, C. R., Patterson, C. C., Francis, L., Irwin, J., McConnell, M., Farrell, B., Brennan, S. F., McSorley, O., Wotherspoon, A. C., Davies, M., McCance, D. R., & PAIGE Study Group
- Affiliations
- Queen's University Belfast (GB)
- Belfast Health and Social Care Trust (GB)
- Regional Centre for Endocrinology and Diabetes, Belfast Health and Social Care Trust, Belfast, United Kingdom
- Craigavon Area Hospital (GB)
- Public Health Agency (GB)
- Corresponding author
- McCance, David R
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2018-05-11
- Volume
- 103
- Issue
- 7
- Pages
- 2478-2487
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2800110841
- Cited by
- 68
- References
- 44
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 19 · 2023: 13 · 2022: 4 · 2021: 7 · 2020: 5 · 2019: 3 · 2018: 2
- FWCI
- 4.80
- Type
- journal article
- Language
- en
- Open access
- green
- pure.qub.ac.uk
- Licence
- other-oa
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (Queen's University Belfast) (submittedVersion, other-oa)
- Funders
- Queen's University Belfast
- Public Health Agency
- Queen's University
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- gestational diabetes mellitus, postpartum weight retention, gestational weight gain, overweight women, weight loss, type 2 diabetes prevention, pedometers, bodily pain, educational programs
- MeSH terms
- Adult, Female, Humans, Obesity, Pregnancy, Weight Gain, Weight Loss, Diabetes, Gestational, Treatment Outcome, Risk Reduction Behavior, Postpartum Period, Overweight, Weight Reduction Programs
About these checks
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