The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Cortisol Secretion Is Inhibited during Sleep in Normal Man*
Abstract
In order to test the hypothesis that cortisol secretion is inhibited during sleep, six healthy young men (ages 18-24) were studied in a 4-day protocol. A baseline nocturnal sleep period was followed by one night's total sleep deprivation, then sleep at 180 degrees phase shift, and then return to a normal nocturnal sleep episode (SP-3). Plasma cortisol concentrations were measured every 20 min (obtained by an indwelling venous catheter), rectal temperature was measured every minute, and sleep was polygraphically defined. During the first 4 h of sustained sleep, cortisol secretion was decreased even when sleep occurred during a time when the subject was usually awake; conversely, it was elevated if awake at the usual daily time of sleeping. This was not the case for the last 4 h of sleep. Body temperature was also decreased but during each entire 7- to 8-h sleep period. Meals produced only a small brief rise of cortisol and produced no change in body temperature. Stage 4 sleep was increased during the 180 degrees inverted sleep episode and decreased during SP-3, REM sleep however was increased during SP-3. A reciprocal relationship was found between REM and stages 3 and 4 for the second, third, and fourth, and sixth h of sleep for SP-3. These results demonstrate the inhibitory effect of the behavioral complex of sleeping on cortisol secretion superimposed on its endogenous circadian and ultradian rhythm. These neurophysiological events may be used to entrain and time the period and phase of biological rhythms in relation to shift work, sleep deprivation, and transmeridian jet travel.
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In the citing paper
“Sleep onset exerts an inhibitory effect on cortisol secretion while awakenings and sleep offset are accompanied by cortisol stimulation.”
From Impact of Sleep and Its Disturbances on Hypothalamo-Pituitary-Adrenal Axis Activity (2010) · cites this paper as [35]
In the citing paper
“Sleep has modest but clearly detectable modulatory effects on HPA axis activity.”
From Impact of Sleep and Its Disturbances on Hypothalamo-Pituitary-Adrenal Axis Activity (2010) · cites this paper as [35]
In the citing paper
“The inhibitory effect that sleep onset seems to exert on HPA axis has been mostly attributed to SWS.”
From Impact of Sleep and Its Disturbances on Hypothalamo-Pituitary-Adrenal Axis Activity (2010) · cites this paper as [35]
In the citing paper
“Several studies have reported an elevation of cortisol levels both during the night of total sleep deprivation [13, 35, 72] and, if wakefulness was further prolonged, during the following day, particularly in the afternoon and evening [63, 73].”
From Impact of Sleep and Its Disturbances on Hypothalamo-Pituitary-Adrenal Axis Activity (2010) · cites this paper as [35]
Citations
Cites
Twenty-four hour pattern of the episodic secretion of cortisol in normal subjects
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Self-citationCharacterization of the normal temporal pattern of plasma corticosteroid levels.
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Self-citationCortisol Is Secreted Episodically by Normal Man
HELLMAN, L., Nakada, F., Curti, J. T., Weitzman, E. D., Kream, J., Roffwarg, H. P., Ellman, S. J., Fukushima, D. K., & Gallagher, T. F. (1970) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-30-4-411 · Cited by 394
Self-citationChronotherapy: Resetting the Circadian Clocks of Patients with Delayed Sleep Phase Insomnia
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Self-citationMathematical model of the human circadian system with two interacting oscillators
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Self-citationWEITZMAN, E. D., NOGEIRE, C., PERLOW, M., FUKUSHIMA, D., SASSIN, J., MCGREGOR, P., GALLAGHER, T. F., & HELLMAN, L. (1974) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-38-6-1018 · Cited by 235
Self-citationSimple Method for the Determination of Plasma Corticoids
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STUDIES OF THE DIURNAL VARIATION OF PLASMA 17-HYDROXYCORTICOSTEROIDS IN MAN*
Perkoff, G. T., Eik‐Nes, K. B., Nugent, C. A., FRED, H. L., NIMER, R., RUSH, L., Samuels, L. T., & Tyler, F. H. (1959) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-19-4-432 · Cited by 189
Experimental Alteration of the Circadian Rhythm in Plasma Cortisol (17-OHCS) Concentration in Man
Orth, D. N., Island, D. P., & Liddle, G. W. (1967) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-27-4-549 · Cited by 153
Thermoregulation during sleep and hibernation.
Heller, H. C., & Glotzbach, S. F. (1977) · PubMed · Cited by 109
Plasma 17-Hydroxycorticosteroid Levels During Sleep in Man
Weitzman, E. D., Schaumburg, H. H., & Fishbein, W. I. (1966) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-26-2-121 · Cited by 107
Self-citationTiming of REM and Stages 3 + 4 Sleep During Temporal Isolation in Man
Elliot, D. W., Charles, A. C., Janet, C. Z., & Joseph, M. R. (1980) · SLEEP · doi:10.1093/sleep/2.4.391 · Cited by 102
Weitzman, E. D., Ca, C., Jc, Z., & Moore‐Ede, M. C. (1981) · PubMed · Cited by 48
Self-citationLuteinizing hormone: Changes in secretory pattern during sleep in adult women
Kapen, S., BOYAR, R. M., Perlow, M. J., HELLMAN, L., & Weitzman, E. D. (1973) · Life Sciences · doi:10.1016/0024-3205(73)90286-5 · Cited by 37
Self-citationAschoff, J., Fatranská, M., Gerecke, U., & Giedke, H. (1974) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00595708 · Cited by 32
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Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk
Meier-Ewert, H. K., Ridker, P. M., Rifai, N., Regan, M. M., Price, N. J., Dinges, D. F., & Mullington, J. M. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.07.050 · Cited by 1,195
Effects of early and late nocturnal sleep on declarative and procedural memory
Plihal, W., & Born, J. (1997) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.1997.9.4.534 · Cited by 1,026
Buckley, T. M., & Schatzberg, A. F. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1056 · Cited by 964
Meerlo, P., Sgoifo, A., & Suchecki, D. (2008) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2007.07.007 · Cited by 948
Vgontzas, A. N., Bixler, E. O., Lin, H.-M., Prolo, P., Mastorakos, G., Vela-Bueno, A., Kales, A., & Chrousos, G. P. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.8.7778 · Cited by 884
Metadata
- Authors
- WEITZMAN, E. D., ZIMMERMAN, J. C., CZEISLER, C. A., & RONDA, J.
- Affiliations
- Albert Einstein College of Medicine (US)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1983-02
- Volume
- 56
- Issue
- 2
- Pages
- 352-358
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2134199290
- Cited by
- 265
- References
- 17
- Citations by year
- 2025: 6 · 2024: 6 · 2023: 3 · 2022: 6 · 2021: 9 · 2020: 2 · 2019: 6 · 2018: 4 · 2017: 4 · 2016: 7 · 2015: 13 · 2014: 7 · 2013: 8 · 2012: 9
- FWCI
- 3.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- cortisol secretion, sleep, circadian rhythm, ultradian rhythms, sleep deprivation, 180-degree phase shift, body temperature, REM sleep, stage 4 sleep, sleep stages, shift work, jet lag, biological rhythms
- MeSH terms
- Adolescent, Adult, Body Temperature, Humans, Hydrocortisone, Male, Sleep, Sleep Deprivation, Sleep Stages
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