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Cited by 318Neuroendocrine regulation and behaviorSexual function and dysfunction studiesHypothalamic control of reproductive hormones

The DOI matches its Crossref record.

Changes In Oxytocin and Vasopressin Secretion During Sexual Activity in Men

MURPHY, MICHAEL R., SECKL, JONATHAN R., BURTON, STEVEN, CHECKLEY, STUART A., LIGHTMAN, STAFFORD L.·1987·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem-65-4-738
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Abstract

We measured plasma oxytocin (OT) and arginine vasopressin (AVP) concentrations in 13 normal men during sexual arousal and ejaculation. Mean plasma AVP increased from 1.4 +/- 0.2 (+/- SE) to 5.3 +/- 1.7 pmol/L (P less than 0.05) during arousal, but there was no significant change in OT. In contrast, at ejaculation mean plasma OT rose from a basal value of 1.4 +/- 0.3 to 7.3 +/- 0.6 pmol/L (P less than 0.01) and then fell to basal concentrations in 30 min. AVP, however, had returned to basal levels at the time of ejaculation and remained stable thereafter. We conclude that in man AVP is secreted during sexual arousal, and there is, subsequently, a selective release of OT at the time of ejaculation.

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Metadata

Authors
MURPHY, M. R., SECKL, J. R., BURTON, S., CHECKLEY, S. A., & LIGHTMAN, S. L.
Affiliations
Charing Cross Hospital (GB)
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1987-10
Volume
65
Issue
4
Pages
738-741
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem-65-4-738
OpenAlex
W2014539594
Cited by
318
References
0
Citations by year
2026: 2 · 2025: 5 · 2024: 2 · 2023: 8 · 2022: 8 · 2021: 14 · 2020: 8 · 2019: 9 · 2018: 23 · 2017: 8 · 2016: 6 · 2015: 11 · 2014: 10 · 2013: 10 · 2012: 12
FWCI
8.78
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
  • Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
oxytocin, vasopressin, sexual arousal, ejaculation, plasma hormone levels, male sexual behavior, neurosecretion
MeSH terms
Adult, Arginine Vasopressin, Ejaculation, Humans, Male, Oxytocin, Penile Erection, Pituitary Gland, Posterior

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