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Cited by 731

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Regulation of Maternal Thyroid during Pregnancy*

Open access
GLINOER, DANIEL, NAYER, PHILIPPE DE, BOURDOUX, PIERRE, LEMONE, MARC, ROBYN, CLAUDE, STEIRTEGHEM, ANDRÉ VAN, KINTHAERT, JACQUES, LEJEUNE, BERNARD·1990·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem-71-2-276
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Abstract

A prospective study was undertaken in 606 healthy women during pregnancy to evaluate the changes occurring in maternal thyroid economy as a result of 1) the increased thyroid hormone-binding capacity of serum, 2) the effects of increased levels of hCG on TSH and on the thyroid, and 3) a marginally low iodine intake in the population (50-75 micrograms/day). Four main features were observed. First, thyroidal activity adjusted to the marked increase in serum T4-binding globulin: pregnancy was accompanied by an overall reduction in the T4/T4-binding globulin ratio, with lower free T4 and T3 levels, although in most cases free hormone levels remained within the normal range. The adjustment of thyroidal output of T4 and T3 did not occur similarly in all subjects. In approximately one third of the women, there was relative hypothyroxinemia, higher T3/T4 ratios (presumably indicating preferential T3 secretion), and higher, although normal, serum TSH concentrations. Second, high hCG levels were associated with thyroid stimulation, both functionally (lower serum TSH) and anatomically (increased thyroid size). The data are consistent with a TSH-like effect of hCG on the thyroid. Hence, regulation of the maternal thyroid is complex, resulting from both elevated hCG (mainly in the first half of gestation) and increasing TSH (mainly in the second half of gestation). Third, a significant increase in serum thyroglobulin levels was observed throughout gestation, especially during the last trimester. Fourth, increased thyroid volume was common, and goiter formation not uncommon (goiter was found in 9% of women at delivery). In conclusion, the alterations in maternal thyroid function during gestation are intricate and far from fully understood. In areas of marginally low iodine intake, gestation is associated in a significant number of women with relative hypothyroxinemia, increased thyroglobulin, and enlarged thyroid.

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Metadata

Authors
GLINOER, D., NAYER, P. D., BOURDOUX, P., LEMONE, M., ROBYN, C., STEIRTEGHEM, A. V., KINTHAERT, J., & LEJEUNE, B.
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1990-08
Volume
71
Issue
2
Pages
276-287
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem-71-2-276
OpenAlex
W1964693382
Cited by
731
References
1
FWCI
8.96
Type
journal article
Language
en
Open access
green

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