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A Prospective Study of the Prevalence of the Polycystic Ovary Syndrome in Unselected Caucasian Women from Spain1

Open access
Asunción, Miryam, Calvo, Rosa M., San Millán, José L., Sancho, José, Avila, Sergio, Escobar-Morreale, Héctor F.·2000·The Journal of Clinical Endocrinology & Metabolism

Abstract

We prospectively estimated the prevalence of the polycystic ovary syndrome (PCOS), as defined by the NIH/NICHHD 1990 endocrine criteria, in a population of 154 Caucasian women of reproductive age reporting spontaneously for blood donation. Anthropometric data; the presence of hirsutism, acne, and androgenic alopecia; and the menstrual history were recorded by a single investigator. In 145 women, blood samples were also obtained for measurement of serum androgen levels. PCOS was defined by the presence of 1) oligomenorrhea, 2) clinical and/or biochemical hyperandrogenism, and 3) exclusion of hyperprolactinemia, thyroid disorders, and nonclassic 21-hydroxylase deficiency. Hirsutism was defined by a modified Ferriman- Gallwey score of 8 or more, acne was considered as a sign of hyperandrogenism when persistent after the second decade of life, and hyperandrogenemia was defined by an increase in circulating testosterone or dehydroepiandrosterone sulfate or an increase in the free androgen index above the 95th percentile of the control values derived from the nonhirsute, nonacneic women having regular menses who were not receiving hormonal therapy. PCOS was present in 10 (6.5%), hirsutism was present in 11 (7.1%), and acne was present in 19 (12.3%) of the 154 women. Our results demonstrate a 6.5% prevalence of PCOS, as defined, in a minimally biased population of Caucasian women from Spain. The polycystic ovary syndrome, hirsutism, and acne are common endocrine disorders in women.

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Citations

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Research works printed but not linked: 19

  1. Carmina, 1999, Polycystic ovary syndrome (PCOS): arguably the most common endocrinopathy is associated with significant morbidity in women., J Clin Endocrinol Metab, 84, 1897, 10.1210/jcem.84.6.5803 · DOI · Paper page
  2. Clayton, 1992, How common are polycystic ovaries in normal women and what is their significance for the fertility of the population?, Clin Endocrinol (Oxf), 37, 127, 10.1111/j.1365-2265.1992.tb02296.x · DOI · Paper page
  3. Farquhar, 1994, The prevalence of polycystic ovaries on ultrasound scanning in a population of randomly selected women., Aust NZ J Obstet Gynecol, 34, 67, 10.1111/j.1479-828X.1994.tb01041.x · DOI · Paper page
  4. Polson, 1988, Polycystic ovaries–a common finding in normal women., Lancet, 1, 870, 10.1016/S0140-6736(88)91612-1 · DOI · Paper page
  5. Koivunen, 1999, The prevalence of polycystic ovaries in healthy women., Acta Obstet Gynecol Scand, 78, 137, 10.1080/j.1600-0412.1999.780212.x · DOI
  6. Swanson, 1981, Medical implications of ultrasonically detected polycystic ovaries., J Clin Ultrasound, 9, 219, 10.1002/jcu.1870090504 · DOI · Paper page
  7. Escobar-Morreale, 1994, Ovarian suppression with triptorelin and adrenal stimulation with adrenocorticotropin in functional hyperadrogenism: role of adrenal and ovarian cytochrome P450c17α., Fertil Steril, 62, 521, 10.1016/S0015-0282(16)56940-4 · DOI
  8. Escobar-Morreale, 1997, Lack of an ovarian function influence on the increased adrenal androgen secretion present in women with functional ovarian hyperandrogenism., Fertil Steril, 67, 654, 10.1016/S0015-0282(97)81362-3 · DOI
  9. Knochenhauer, 1998, Prevalence of the polycystic ovary syndrome in unselected black and white women of the Southeastern United States: a prospective study., J Clin Endocrinol Metab, 83, 3078
  10. Diamanti-Kandarakis, 1999, A survey of the polycystic ovary syndrome in the greek island of Lesbos: hormonal and metabolic profile., J Clin Endocrinol Metab, 84, 4006, 10.1210/jcem.84.11.6148 · DOI · Paper page
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  12. 1994, Hormonal treatment of postmenopausal women., N Engl J Med, 330, 1062, 10.1056/NEJM199404143301508 · DOI · Paper page
  13. Goldzieher, 1962, The polycystic ovary. I. Clinical and histologic features., J Clin Endocrinol Metab, 22, 325, 10.1210/jcem-22-3-325 · DOI · Paper page
  14. Hartz, 1979, The association of obesity with infertility and related menstrual abnormalities in women., Int J Obes, 3, 57
  15. 1964, The prevalence of “hirsutism” in young women., Lancet, 1, 410
  16. Raj, 1977, Clinical aspects of the polycystic ovary syndrome., Obstet Gynecol, 49, 552
  17. Ferriman, 1961, Clinical assessment of body hair growth in women., J Clin Endocrinol Metab, 21, 1440, 10.1210/jcem-21-11-1440 · DOI · Paper page
  18. Escobar-Morreale, 1998, Abnormalities in the serum insulin-like growth factor-I axis in women with hyperandrogenism., Fertil Steril, 70, 1090, 10.1016/S0015-0282(98)00388-4 · DOI
  19. Parker, 2000, Effects of aging on adrenal function in the human: responsiveness and sensitivity of adrenal androgens and cortisol to adrenocorticotropin in premenopausal and postmenopausal women., J Clin Endocrinol Metab, 85, 48

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Metadata

Authors
Asunción, M., Calvo, R. M., San Millán, J. L., Sancho, J., Avila, S., & Escobar-Morreale, H. F.
Venue
The Journal of Clinical Endocrinology & Metabolism
Published
2000-07-01
Volume
85
Issue
7
Pages
2434-2438
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
OpenAlex
W2145360267
Cited by
1,318
References
4
FWCI
25.08
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: A Prospective Study of the Prevalence of the Polycystic Ovary Syndrome in Unselected Caucasian Women from Spain1. https://app.cochat.ai/papers/10.1210/jcem.85.7.6682
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Asunción, M., Calvo, R. M., San Millán, J. L., Sancho, J., Avila, S., & Escobar-Morreale, H. F. (2000). A Prospective Study of the Prevalence of the Polycystic Ovary Syndrome in Unselected Caucasian Women from Spain1. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jcem.85.7.6682

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