E2 Supplementation Selectively Relieves GH’s Autonegative Feedback on GH-Releasing Peptide-2-Stimulated GH Secretion

Anderson, Stacey M.; Wideman, Laurie; Patrie, James T.; Weltman, Arthur; Bowers, Cyril Y.; Veldhuis, Johannes D.

doi:10.1210/jcem.86.12.8076

Cited by 50Growth Hormone and Insulin-like Growth FactorsHypothalamic control of reproductive hormonesPituitary Gland Disorders and Treatments

E2 Supplementation Selectively Relieves GH’s Autonegative Feedback on GH-Releasing Peptide-2-Stimulated GH Secretion

Anderson, Stacey M., Wideman, Laurie, Patrie, James T., Weltman, Arthur, Bowers, Cyril Y., Veldhuis, Johannes D.·2001·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jcem.86.12.8076

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Abstract

Female gender confers resistance to GH autonegative feedback in the adult rat, thereby suggesting gonadal or estrogenic modulation of autoregulation of the somatotropic axis. Here we test the clinical hypothesis that short-term E2 replacement in ovariprival women reduces GH's repression of spontaneous, GHRH-, and GH-releasing peptide (GHRP)-stimulated GH secretion. To this end, we appraised GH autoinhibition in nine healthy postmenopausal volunteers during a prospective, randomly ordered supplementation with placebo vs. E [1 mg micronized 17 beta-E2 orally twice daily for 6-23 d]. The GH autofeedback paradigm consisted of a 6-min pulsed i.v. infusion of recombinant human GH (10 microg/kg square-wave injection) or saline (control) followed by i.v. bolus GHRH (1 microg/kg), GHRP-2 (1 microg/kg), or saline 2 h later. Blood was sampled every 10 min and serum GH concentrations were measured by chemiluminescence. Poststimulus GH release was quantitated by multiparameter deconvolution analysis using published biexponential kinetics and by the incremental peak serum GH concentration response (maximal poststimulus value minus prepeak nadir). Outcomes were analyzed on the logarithmic scale by mixed-effects ANOVA at a multiple-comparison type I error rate of 0.05. E2 supplementation increased the (mean +/- SEM) serum E2 concentration from 43 +/- 1.8 (control) to 121 +/- 4 pg/ml (E2) (158 +/- 6.6 to 440 +/- 15 pmol/liter; P < 0.001), lowered the 0800 h (preinfusion) serum IGF-I concentra…

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E2 supplementation in postmenopausal women augments stimulation by GHRP-2 and submaximal drive by GHRH.
“clinical investigations indicate that E 2 supplementation in postmenopausal women augments stimulation by GHRP-2 and submaximal drive by GHRH”
From Determinants of dual secretagogue drive of burst-like growth hormone secretion in premenopausal women studied under a selective estradiol clamp (2005) · cites this paper as [46]
The measured distribution volume of GH does not differ significantly among young women and men; pre-, mid-, and postpubertal boys; and postmenopausal women receiving estradiol and placebo.
“The measured distribution volume of GH does not differ significantly among young women and men; pre-, mid-, and postpubertal boys; and postmenopausal women receiving estradiol and placebo (46,61,62).”
From Determinants of dual secretagogue drive of burst-like growth hormone secretion in premenopausal women studied under a selective estradiol clamp (2005) · cites this paper as [46]

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Estradiol supplementation selectively relieves growth hormone (GH)'s autonegative feedback on GH-releasing peptide-2 (GHRP-2)-stimulated GH secretion
NC DOCKS at The University of North Carolina at Greensboro, & Wideman, L. (2001) · NC Digital Online Collection of Knowledge and Scholarship (The University of North Carolina at Greensboro)
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Short-Term Estradiol Supplementation Augments Growth Hormone (GH) Secretory Responsiveness to Dose-Varying GH-Releasing Peptide Infusions in Healthy Postmenopausal Women
Anderson, S. M., Shah, N., Evans, W. S., Patrie, J. T., Bowers, C. Y., & Veldhuis, J. D. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.2.7240 · Cited by 83 · see citing works
Self-citation

Authors: Anderson, S. M., Wideman, L., Patrie, J. T., Weltman, A., Bowers, C. Y., & Veldhuis, J. D.
Affiliations: University of Virginia Health System (US)
Health and Human Services (L.W., A.W.), Charlottesville, Virginia 22908
Tulane University (US)
University of Virginia (US)
Corresponding author: Anderson, Stacey M.
ORCID: Anderson, Stacey M.
Wideman, Laurie
Patrie, James T.
Weltman, Arthur
Veldhuis, Johannes D.
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 2001-12-01
Volume: 86
Issue: 12
Pages: 5904-5911
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jcem.86.12.8076
OpenAlex: W2004341224
Cited by: 50
References: 72
Citations by year: 2024: 1 · 2016: 2 · 2015: 1
FWCI: 4.37
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (R01-AG14799, R01AG014799)
National Center for Research Resources (M01RR000847, MO1-RR00847)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
Keywords: growth hormone secretion, growth hormone-releasing hormone, postmenopausal women, estrogen replacement therapy, insulin-like growth factor I, somatotropic axis, recombinant human growth hormone
MeSH terms: Administration, Oral, Estradiol, Feedback, Female, Humans, Injections, Intravenous, Middle Aged, Oligopeptides, Prospective Studies, Recombinant Proteins, Growth Hormone-Releasing Hormone, Postmenopause, Human Growth Hormone

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E2 Supplementation Selectively Relieves GH’s Autonegative Feedback on GH-Releasing Peptide-2-Stimulated GH Secretion

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