The DOI matches its Crossref record; 121 of the 121 references it cites were found in a registry or an index.
Sirtuin Functions in Health and Disease
Open accessAbstract
Sirtuins or Sir2 (silent information regulator 2)-related enzymes have originally been defined as a family of nicotinamide adenine dinucleotide-dependent enzymes that deacetylate lysine residue on various proteins. Certain sirtuins have in addition an ADP-ribosyltransferase activity. The sirtuins are remarkably conserved throughout evolution from archaebacteria to eukaryotes. The mammalian sirtuins SIRT1-SIRT7 are implicated in a variety of cellular functions ranging from gene silencing, over the control of the cell cycle and apoptosis, to energy homeostasis. On a whole-body level, the wide range of cellular activities of the sirtuins suggests that they could constitute therapeutic targets to combat metabolic, neurodegenerative, and proliferative diseases. Here, we review some of the recent data related to the sirtuins and discuss their mode of action, their biological role in cellular and organismal models, and their possible association to age-related human diseases.
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“A higher intake of soya isoflavones (114 mg/d) for 3 months also did not reduce serum CRP or sE-selectin concentrations in postmenopausal women (814) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [814]
In the citing paper
“However, SRT1720 has been shown in BAT to modify lipid droplet size and gene expression 157,158.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [157]
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“SIRT1, the closest homolog of seven yeast Sir2 homologs in mammals (i.e., SIRT1-SIRT7) 11 , is located in the nucleus 12,13 , where it catalyzes nicotinamide adenine dinucleotide (NAD+)-dependent histone and non-histone lysine deacetylation 14-16 to regulate multiple metabolic functions and signaling pathways that lin…”
BackgroundThe role of MnSOD and sirtuin 3 in thymocyte responses to radiation and lymphomagenesis
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“Mammals have seven sirtuin homologues (from Sirt1 to Sirt7) that are highly conserved NAD-dependent deacetylases and/or ADP-ribosyltransferases [91].”
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Role of SIRT1 in Vascular Complications of Diabetes
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InfluentialKılınçlı, A. (2013) · eArsiv - Adu (Adnan Menderes University)
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정상 및 노화 흰쥐 뇌에서 SIRT2 단백질 발현에 대한 연구
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Metadata
- Authors
- Yamamoto, H., Schoonjans, K., & Auwerx, J.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Auwerx, Johan
- Venue
- Molecular Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2007-08-01
- Volume
- 21
- Issue
- 8
- Pages
- 1745-1755
- ISSN
- 0888-8809 (ISSN-L)
- 1944-9917
- OpenAlex
- W2043932983
- Cited by
- 480
- References
- 121
- Citations by year
- 2026: 11 · 2025: 16 · 2024: 20 · 2023: 22 · 2022: 31 · 2021: 37 · 2020: 41 · 2019: 16 · 2018: 31 · 2017: 10 · 2016: 16 · 2015: 22 · 2014: 21 · 2013: 31 · 2012: 30
- FWCI
- 2.16
- Type
- journal article
- Language
- en
- Open access
- green
- infoscience.epfl.ch
- Locations
- Molecular Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
- Keywords
- sirtuins, Sir2, NAD+-dependent deacetylation, ADP-ribosyltransferase, lysine deacetylation, gene silencing, cell cycle regulation, apoptosis, energy homeostasis, metabolic disorders, neurodegenerative diseases, proliferative diseases, aging, therapeutic target
- MeSH terms
- Animals, Humans, Neoplasms, Neurodegenerative Diseases, Sirtuins, Cell Proliferation
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