The DOI matches its Crossref record; 121 of the 121 references it cites were found in a registry or an index.
Sirtuin Functions in Health and Disease
Open accessAbstract
Sirtuins or Sir2 (silent information regulator 2)-related enzymes have originally been defined as a family of nicotinamide adenine dinucleotide-dependent enzymes that deacetylate lysine residue on various proteins. Certain sirtuins have in addition an ADP-ribosyltransferase activity. The sirtuins are remarkably conserved throughout evolution from archaebacteria to eukaryotes. The mammalian sirtuins SIRT1-SIRT7 are implicated in a variety of cellular functions ranging from gene silencing, over the control of the cell cycle and apoptosis, to energy homeostasis. On a whole-body level, the wide range of cellular activities of the sirtuins suggests that they could constitute therapeutic targets to combat metabolic, neurodegenerative, and proliferative diseases. Here, we review some of the recent data related to the sirtuins and discuss their mode of action, their biological role in cellular and organismal models, and their possible association to age-related human diseases.
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“A higher intake of soya isoflavones (114 mg/d) for 3 months also did not reduce serum CRP or sE-selectin concentrations in postmenopausal women (814) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [814]
In the citing paper
“However, SRT1720 has been shown in BAT to modify lipid droplet size and gene expression 157,158.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [157]
Citations
Cites
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Cited by
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Reactive oxygen species, cellular redox systems, and apoptosis
Circu, M. L., & Aw, T. Y. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.12.022 · Cited by 3,340
“Sirt1 acts on numerous substrates that controls cell senescence, proliferation, and apoptosis [74,75].”
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Sirt1 protects against high-fat diet-induced metabolic damage
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“The mammalian sirtuins Sirt1–Sirt7 are implicated in a number of cellular and physiological functions including gene silencing, apoptosis, mitochondrial function, energy homeostasis, and longevity (12).”
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“Sirtuins, a family of NAD+-dependent deacetylases, have recently emerged as integral components of these metabolic networks, which are particularly important for energy homeostasis (Guarente, 2006; Michan and Sinclair, 2007; Yamamoto et al., 2007).”
BackgroundSelf-citation
Metadata
- Authors
- Yamamoto, H., Schoonjans, K., & Auwerx, J.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Auwerx, Johan
- Venue
- Molecular Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2007-08-01
- Volume
- 21
- Issue
- 8
- Pages
- 1745-1755
- ISSN
- 0888-8809 (ISSN-L)
- 1944-9917
- OpenAlex
- W2043932983
- Cited by
- 480
- References
- 121
- Citations by year
- 2026: 11 · 2025: 16 · 2024: 20 · 2023: 22 · 2022: 31 · 2021: 37 · 2020: 41 · 2019: 16 · 2018: 31 · 2017: 10 · 2016: 16 · 2015: 22 · 2014: 21 · 2013: 31 · 2012: 30
- FWCI
- 2.16
- Type
- journal article
- Language
- en
- Open access
- green
- infoscience.epfl.ch
- Locations
- Molecular Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
- Keywords
- sirtuins, Sir2, NAD+-dependent deacetylation, ADP-ribosyltransferase, lysine deacetylation, gene silencing, cell cycle regulation, apoptosis, energy homeostasis, metabolic disorders, neurodegenerative diseases, proliferative diseases, aging, therapeutic target
- MeSH terms
- Animals, Humans, Neoplasms, Neurodegenerative Diseases, Sirtuins, Cell Proliferation
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