Dietary Sources and Bioactivities of Melatonin
Open accessAbstract
Insomnia is a serious worldwide health threat, affecting nearly one third of the general population. Melatonin has been reported to improve sleep efficiency and it was found that eating melatonin-rich foods could assist sleep. During the last decades, melatonin has been widely identified and qualified in various foods from fungi to animals and plants. Eggs and fish are higher melatonin-containing food groups in animal foods, whereas in plant foods, nuts are with the highest content of melatonin. Some kinds of mushrooms, cereals and germinated legumes or seeds are also good dietary sources of melatonin. It has been proved that the melatonin concentration in human serum could significantly increase after the consumption of melatonin containing food. Furthermore, studies show that melatonin exhibits many bioactivities, such as antioxidant activity, anti-inflammatory characteristics, boosting immunity, anticancer activity, cardiovascular protection, anti-diabetic, anti-obese, neuroprotective and anti-aging activity. This review summaries the dietary sources and bioactivities of melatonin, with special attention paid to the mechanisms of action.
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Melatonin is present in nearly all bodily fluids: cerebrospinal fluid, saliva, bile, synovial fluid, amniotic fluid, urine, feces, semen, and breast milk.
“It is present in nearly all bodily fluids: cerebrospinal fluid, saliva, bile, synovial fluid, amniotic fluid, urine, feces, semen, and breast milk [16,19,20].”
From Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements (2022) · cites this paper as [19]
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Mitochondria: Central Organelles for Melatonin′s Antioxidant and Anti-Aging Actions
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The effects and molecular mechanism of heat stress on spermatogenesis and the mitigation measures
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Impact of Melatonin on Skeletal Muscle and Exercise
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Brain foods - the role of diet in brain performance and health
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Functions of Melatonin during Postharvest of Horticultural Crops
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Melatonin Target Proteins: Too Many or Not Enough?
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Association Between Night-Shift Work and Cancer Risk: Updated Systematic Review and Meta-Analysis
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Insight into the roles of melatonin in bone tissue and bone‑related diseases (Review)
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Natural Products for Prevention and Treatment of Chemical‐Induced Liver Injuries
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New insights on neurotransmitters signaling mechanisms in plants
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Melatonin and cancer: From the promotion of genomic stability to use in cancer treatment
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Cardiovascular Benefits of Dietary Melatonin: A Myth or a Reality?
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Diet Composition and Objectively Assessed Sleep Quality: A Narrative Review
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Dietary Fish, Fish Nutrients, and Immune Function: A Review
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Dual sources of melatonin and evidence for different primary functions
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Tryptophan Metabolism, Inflammation, and Oxidative Stress in Patients with Neurovascular Disease
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Wine, Polyphenols, and Mediterranean Diets. What Else Is There to Say?
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Dietary Antioxidants in the Treatment of Male Infertility: Counteracting Oxidative Stress
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The Role of Melatonin on NLRP3 Inflammasome Activation in Diseases
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The Complex Effects of Light on Metabolism in Humans
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Tumor-associated Macrophages (TAMs) in Cancer Resistance; Modulation by Natural Products
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Melatonin–Microbiome Two-Sided Interaction in Dysbiosis-Associated Conditions
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Melatonin and Prostate Cancer: Anti-tumor Roles and Therapeutic Application
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Self-citationProtective rules of natural antioxidants against gamma‐induced damage—A review
Jameel, Q. Y., & Mohammed, N. K. (2021) · Food Science & Nutrition · doi:10.1002/fsn3.2469 · Cited by 29 · see citing works
Wang, Y., Fan, H., Ren, Z., Liu, X., & Niu, X. (2023) · BMC Public Health · doi:10.1186/s12889-023-15870-x · Cited by 29 · see citing works
Castellucci, B., Barrea, L., Laudisio, D., Aprano, S., Pugliese, G., Savastano, S., Colao, A., & Muscogiuri, G. (2020) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2020.1851659 · Cited by 28 · see citing works
Sharebiani, H., Mokaram, M., Mirghani, M., Fazeli, B., & Stanek, A. (2024) · Nutrients · doi:10.3390/nu16111641 · Cited by 28 · see citing works
Melatonin Improves Endoplasmic Reticulum Stress-Mediated IRE1α Pathway in Zücker Diabetic Fatty Rat
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Therapeutic Effects of Melatonin on Ocular Diseases: Knowledge Map and Perspective
Yu, H., Wang, Q., Wu, W., Zeng, W., & Feng, Y. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.721869 · Cited by 26 · see citing works
- Authors
- Meng, X., Li, Y., Li, S., Zhou, Y., Gan, R.-Y., Xu, D.-P., & Li, H.-B.
- Affiliations
- Sun Yat-sen University (CN)
- University of Hong Kong (HK)
- Corresponding author
- Li, Sha
- Li, Hua-Bin
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2017-04-07
- Volume
- 9
- Issue
- 4
- Pages
- 367
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC5409706
- OpenAlex
- W2604956152
- Cited by
- 362
- References
- 336
- Citations by year
- 2026: 27 · 2025: 50 · 2024: 48 · 2023: 53 · 2022: 40 · 2021: 45 · 2020: 40 · 2019: 34 · 2018: 18 · 2017: 4 · 2014: 1
- FWCI
- 3.20
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (2014B020205002, 81372976)
- Sun Yat-sen University (81372976, 2014B020205002)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Keywords
- melatonin, insomnia, sleep, eggs, fish, nuts, mushrooms, cereals, serum melatonin, antioxidant activity, anti-inflammatory activity, immune enhancement, anticancer activity, cardioprotection, antidiabetic activity, anti-obesity, neuroprotection, anti-aging effects, mechanism of action
- MeSH terms
- Biological Availability, Circadian Rhythm, Diet, Humans, Melatonin, Sleep Deprivation, Randomized Controlled Trials as Topic, Nutrition Policy
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