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Cited by 97Thyroid Disorders and TreatmentsAdrenal Hormones and DisordersClinical Nutrition and Gastroenterology

Expression of thyroid hormone transporters during critical illness

Mebis, Liese, Paletta, Deborah, Debaveye, Yves, Ellger, Björn, Langouche, Lies, D'Hoore, André, Darras, Veerle M, Visser, Theo J +1 more·2009·European Journal of Endocrinology
DOI 10.1530/eje-09-0290
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Abstract

Objective: Prolonged critically ill patients have low circulating thyroid hormone (TH) levels without a rise in TSH, a condition labeled ‘the low tri-iodothyronine (T 3) syndrome’. Currently, it is not clear whether this represents an adaptive response. We examined the role of TH transporters monocarboxylate transporter 8 (MCT8, also known as SLC16A2) and MCT10 in the pathogenesis of the low T 3 syndrome in prolonged critical illness. Methods: A clinical observational study in critically ill patients and an intervention study in an in vivo animal model of critical illness. Gene expression levels of MCT8 and MCT10 were measured by real-time PCR. Results: In prolonged critically ill patients, we measured increased MCT8 but not MCT10 gene expression levels in liver and skeletal muscle as compared with patients undergoing acute surgical stress. In a rabbit model of prolonged critical illness, gene expression levels of MCT8 in liver and of MCT10 in skeletal muscle were increased as compared with healthy controls. Treatment of prolonged critically ill rabbits with TH (thyroxine+T 3) resulted in a downregulation of gene expression levels of MCT8 in liver and of MCT10 in muscle. Transporter expression levels correlated inversely with circulating TH parameters. Conclusions: These data suggest that alterations in the expression of TH transporters do not play a major role in the pathogenesis of the ‘low T 3 syndrome’ but rather reflect a compensatory effort in response to hypothyroidism.

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Crossref · 10.1530/eje-09-0290

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  • TH treatment of rabbits with prolonged illness restores muscle transporter expression to normal.

    “In this case, serum TH may play a role as TH treatment of these rabbits restores muscle transporter expression to normal [13].”

    From An update on non-thyroidal illness syndrome (2021) · cites this paper as [13]

  • TH transport in the human liver is differentially affected during illness: MCT8 expression increases in prolonged critical illness compared to acute illness, while MCT10 expression does not differ between these groups.

    “TH transport in the human liver is differentially affected during illness: MCT8 expression increases in prolonged critical illness compared to acute illness, while MCT10 expression does not differ between these groups [13].”

    From An update on non-thyroidal illness syndrome (2021) · cites this paper as [13]

  • MCT8 expression was remarkably low in muscle tissue of patients during acute surgical stress compared to patients with prolonged illness.

    “Similar changes were observed in patients, as MCT8 expression was remarkably low in muscle tissue of patients during acute surgical stress compared to patients with prolonged illness [13].”

    From An update on non-thyroidal illness syndrome (2021) · cites this paper as [13]

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Authors
Mebis, L., Paletta, D., Debaveye, Y., Ellger, B., Langouche, L., D'Hoore, A., Darras, V. M., Visser, T. J., & Van den Berghe, G.
Affiliations
  • KU Leuven (BE)
  • Erasmus MC (NL)
ORCID
Venue
European Journal of Endocrinology
Publisher
Oxford University Press (OUP)
Published
2009-08
Volume
161
Issue
2
Pages
243-250
ISSN
  • 0804-4643 (ISSN-L)
  • 1479-683X
DOI
10.1530/eje-09-0290
OpenAlex
W2071806894
Cited by
97
References
47
Citations by year
2026: 1 · 2025: 3 · 2024: 4 · 2023: 9 · 2022: 5 · 2021: 6 · 2020: 5 · 2019: 6 · 2018: 3 · 2017: 6 · 2016: 7 · 2015: 3 · 2014: 11 · 2013: 9 · 2012: 5
FWCI
4.60
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
  • Lirias (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
Keywords
low triiodothyronine syndrome, thyroid hormone transporters, MCT8, MCT10, critical illness, hypothyroidism, gene expression, liver, skeletal muscle, thyroxine, rabbit model
MeSH terms
Aged, Animals, Base Sequence, Disease Models, Animal, Euthyroid Sick Syndromes, Female, Humans, Liver, Male, Molecular Sequence Data, Rabbits, RNA, Messenger, Thyroxine, Triiodothyronine, Triiodothyronine, Reverse, Critical Illness, Muscle, Skeletal, Reverse Transcriptase Polymerase Chain Reaction, Amino Acid Transport Systems, Neutral, Monocarboxylic Acid Transporters, Symporters

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