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Increased DNA Methylation and Decreased Expression of PDX-1 in Pancreatic Islets from Patients with Type 2 Diabetes
Open accessAbstract
Mutations in pancreatic duodenal homeobox 1 (PDX-1) can cause a monogenic form of diabetes (maturity onset diabetes of the young 4) in humans, and silencing Pdx-1 in pancreatic β-cells of mice causes diabetes. However, it is not established whether epigenetic alterations of PDX-1 influence type 2 diabetes (T2D) in humans. Here we analyzed mRNA expression and DNA methylation of PDX-1 in human pancreatic islets from 55 nondiabetic donors and nine patients with T2D. We further studied epigenetic regulation of PDX-1 in clonal β-cells. PDX-1 expression was decreased in pancreatic islets from patients with T2D compared with nondiabetic donors (P = 0.0002) and correlated positively with insulin expression (rho = 0.59, P = 0.000001) and glucose-stimulated insulin secretion (rho = 0.41, P = 0.005) in the human islets. Ten CpG sites in the distal PDX-1 promoter and enhancer regions exhibited significantly increased DNA methylation in islets from patients with T2D compared with nondiabetic donors. DNA methylation of PDX-1 correlated negatively with its gene expression in the human islets (rho = -0.64, P = 0.0000029). Moreover, methylation of the human PDX-1 promoter and enhancer regions suppressed reporter gene expression in clonal β-cells (P = 0.04). Our data further indicate that hyperglycemia decreases gene expression and increases DNA methylation of PDX-1 because glycosylated hemoglobin (HbA1c) correlates negatively with mRNA expression (rho = -0.50, P = 0.0004) and positively with DNA methylation (rho = 0.54, P = 0.00024) of PDX-1 in the human islets. Furthermore, while Pdx-1 expression decreased, Pdx-1 methylation and Dnmt1 expression increased in clonal β-cells exposed to high glucose. Overall, epigenetic modifications of PDX-1 may play a role in the development of T2D, given that pancreatic islets from patients with T2D and β-cells exposed to hyperglycemia exhibited increased DNA methylation and decreased expression of PDX-1. The expression levels of PDX-1 were further associated with insulin secretion in the human islets.
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“further suggest that hyperglycemia alters DNA methylation of PDX1 and INS ( 22 – 25 ).”
From β-Cell Failure in Type 2 Diabetes: Postulated Mechanisms and Prospects for Prevention and Treatment (2014) · cites this paper as [22]
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Cites
Andersen, C. L., Jensen, J. L., & Ørntoft, T. F. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0496 · Cited by 7,127
β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes
Butler, A. E., Janson, J., Bonner-Weir, S., Ritzel, R., Rizza, R. A., & Butler, P. C. (2003) · Diabetes · doi:10.2337/diabetes.52.1.102 · Cited by 4,011
Epigenetic Transgenerational Actions of Endocrine Disruptors and Male Fertility
Anway, M. D., Cupp, A. S., Uzumcu, M., & Skinner, M. K. (2005) · Science · doi:10.1126/science.1108190 · Cited by 2,563
Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring
Ng, S.-F., Lin, R. C. Y., Laybutt, D. R., Barres, R., Owens, J. A., & Morris, M. J. (2010) · Nature · doi:10.1038/nature09491 · Cited by 1,327
An epigenetic mutation responsible for natural variation in floral symmetry
Cubas, P., Vincent, C. A., & Coen, E. (1999) · Nature · doi:10.1038/43657 · Cited by 1,262
El-Osta, A., Brasacchio, D., Yao, D., Pocai, A., Jones, P. L., Roeder, R. G., Cooper, M. E., & Brownlee, M. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20081188 · Cited by 1,115
Ahlgren, U., Jönsson, J., Jönsson, L., Simu, K., & Edlund, H. (1998) · Genes & Development · doi:10.1101/gad.12.12.1763 · Cited by 918
Early-onset type-ll diabetes mellitus (MODY4) linked to IPF1
Staffers, D. A., Ferrer, J. P., Clarke, W. L., & Habener, J. F. (1997) · Nature Genetics · doi:10.1038/ng1097-138 · Cited by 880
Beyond DNA: integrating inclusive inheritance into an extended theory of evolution
Danchin, É., Charmantier, A., Champagne, F. A., Mesoudi, A., Pujol, B., & Blanchet, S. (2011) · Nature Reviews Genetics · doi:10.1038/nrg3028 · Cited by 860 · cited 1×
“Epigenetic modifications may be passed on from one cell generation to the next (mitotic inheritance) and/or between generations of a species (meiotic inheritance) (44).”
Park, J. H., Stoffers, D. A., Nicholls, R. D., & Simmons, R. A. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33655 · Cited by 640
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Self-citationRibel‐Madsen, R., Fraga, M. F., Jacobsen, S. B., Bork‐Jensen, J., Lara, E., Calvanese, V., Fernández, A. F., Friedrichsen, M. H., Vind, B. F., Højlund, K., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051302 · Cited by 204
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Agardh, E., Lundstig, A., Perfilyev, A., Volkov, P., Freiburghaus, T., Lindholm, E., Rönn, T., Agardh, C., & Ling, C. (2015) · BMC Medicine · doi:10.1186/s12916-015-0421-5 · Cited by 143
Self-citationHall, E., Volkov, P., Dayeh, T., Bacos, K., Rönn, T., Nitert, M. D., & Ling, C. (2014) · BMC Medicine · doi:10.1186/1741-7015-12-103 · Cited by 145
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Self-citationVolkov, P., Olsson, A. H., Gillberg, L., Jørgensen, S. W., Brøns, C., Eriksson, K., Groop, L., Jansson, P., Nilsson, E., Rönn, T., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0157776 · Cited by 129
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Wu, P., Farrell, W. E., Haworth, K. E., Emes, R. D., Kitchen, M., Glossop, J. R., Hanna, F. W., & Fryer, A. A. (2016) · Epigenetics · doi:10.1080/15592294.2016.1166321 · Cited by 78
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de Mello, V. D., Pulkkinen, L., Lalli, M., Kolehmainen, M., Pihlajamäki, J., & Uusitupa, M. I. J. (2014) · Annals of Medicine · doi:10.3109/07853890.2013.857259 · Cited by 78
Rönn, T., Ofori, J. K., Perfilyev, A., Hamilton, A., Pircs, K., Eichelmann, F., García-Calzón, S., Karagiannopoulos, A., Stenlund, H. C., Wendt, A., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-43719-9 · Cited by 81
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Malmgren, S., Spégel, P., Danielsson, A. P. H., Nagorny, C. L., Andersson, L. E., Nitert, M. D., Ridderstråle, M., Mulder, H., & Ling, C. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.422527 · Cited by 71
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Papuc, C. P., GORAN, G. V., Predescu, N. C., Tudoreanu, L., & Ștefan, G. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1815644 · Cited by 68
Frantz, E. D. C., Crespo-Mascarenhas, C., Vianna, A. R. D. C. B., Águila, M. B., & Mandarim‐de‐Lacerda, C. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067192 · Cited by 66
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Portha, B., Grandjean, V., & Movassat, J. (2019) · Nutrients · doi:10.3390/nu11020233 · Cited by 64
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Alipour, S., Nouri, M., Sakhinia, E., Samadi, N., Roshanravan, N., Ghavami, A., & Khabbazi, A. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.04.106 · Cited by 60
Ishikawa, K., Tsunekawa, S., Ikeniwa, M., Izumoto, T., Iida, A., Ogata, H., Uenishi, E., Seino, Y., Ozaki, N., Sugimura, Y., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0115350 · Cited by 58
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Al-Haddad, R., Karnib, N., Assaad, R. A., Bilen, Y., Emmanuel, N., Ghanem, A., Younes, J., Zibara, V., Stephan, J. S., & Sleiman, S. F. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.04.046 · Cited by 59
Keller, M., Kralisch, S., Rohde, K., Schleinitz, D., Dietrich, A., Schön, M., Gärtner, D., Lohmann, T., Dressler, M., Tönjes, A., et al. (2014) · Diabetologia · doi:10.1007/s00125-014-3356-z · Cited by 46
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Sandovici, I., Hammerle, C. M., Ozanne, S. E., & Constância, M. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1297-1 · Cited by 52
Xue, W., Chen, R.-Q., Zhang, Q., Li, X., Cao, L., Li, M.-Y., Li, Y., Lin, G., Chen, Y., Wang, M.-J., et al. (2020) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00406.2019 · Cited by 50
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Schwenk, R. W., Jonas, W., Ernst, S., Kammel, A., Jähnert, M., & Schürmann, A. (2013) · Hormone and Metabolic Research · doi:10.1055/s-0033-1348263 · Cited by 48
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Liu, J., Banerjee, A., Herring, C. A., Attalla, J., Hu, R., Xu, Y., Shao, Q., Simmons, A. J., Dadi, P. K., Wang, S., et al. (2019) · Developmental Cell · doi:10.1016/j.devcel.2018.11.048 · Cited by 43
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Metadata
- Authors
- Yang, B. T., Dayeh, T. A., Volkov, P. A., Kirkpatrick, C. L., Malmgren, S., Jing, X., Renström, E., Wollheim, C. B., Nitert, M. D., & Ling, C.
- Affiliations
- Lund University (SE)
- Department of Cell Physiology and Metabolism (C.L.K., C.B.W.), University Medical Center, 1211 Geneva 4, Switzerland
- Corresponding author
- Ling, Charlotte
- ORCID
- Venue
- Molecular Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2012-07-01
- Volume
- 26
- Issue
- 7
- Pages
- 1203-1212
- ISSN
- 0888-8809 (ISSN-L)
- 1944-9917
- PMC
- PMC5416998
- OpenAlex
- W2116017402
- Cited by
- 301
- References
- 50
- Citations by year
- 2026: 13 · 2025: 14 · 2024: 25 · 2023: 20 · 2022: 18 · 2021: 21 · 2020: 26 · 2019: 24 · 2018: 18 · 2017: 21 · 2016: 18 · 2015: 25 · 2014: 32 · 2013: 19 · 2012: 6
- FWCI
- 26.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Molecular Endocrinology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (publishedVersion, other-oa)
- Lund University Publications (Lund University) (submittedVersion, other-oa)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Funders
- National Science Foundation
- Eli Lilly and Company
- European Foundation for the Study of Diabetes (B31 5631/2006)
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Lunds Universitet
- Knut och Alice Wallenbergs Stiftelse
- Novo Nordisk
- Vetenskapsrådet
- Uppsala Universitet
- Università di Pisa
- Region Skåne
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Keywords
- PDX1, DNA methylation, type 2 diabetes, pancreatic islets, pancreatic beta cells, epigenetic regulation, hyperglycemia, HbA1c, DNMT1, insulin secretion, gene silencing
- MeSH terms
- Diabetes Mellitus, Type 2, Female, Glucose, Humans, Hyperglycemia, Insulin, Male, Middle Aged, Pancreas, Promoter Regions, Genetic, RNA, Messenger, Trans-Activators, Homeodomain Proteins, DNA Methylation, Insulin-Secreting Cells
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