Cited by 173Sexual Differentiation and DisordersAdrenal Hormones and DisordersEstrogen and related hormone effects

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Structure of Two in Tandem Human 17β-Hydroxysteroid Dehydrogenase Genes

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Luu-The, Van, Labrie, Claude, Simard, Jacques, Lachance, Yves, Zhao, Hui-Fen, Couët, Jacques, Leblanc, Gilles, Labrie, Fernand·1990·Molecular Endocrinology

DOI 10.1210/mend-4-2-268

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Abstract

Two human 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD) genes (h17 beta-HSDI and h17 beta-HSDII) included in tandem within an approximately 13 kilobase pair fragment were isolated from a genomic lambda EMBL3 DNA library using cDNA encoding human 17 beta-HSD (hpE2DH216) as probe. We have determined the complete exon and intron sequences of the two genes as well as their 5' and 3'-flanking regions. Human 17 beta-HSDII contains six exons and five short introns for a total length of 3250 base pairs. The exon sequence of h17 beta-HSDII is identical to the previously reported hpE2DH216 cDNA while the overlapping nucleotide sequences of the corresponding exons and introns of h17 beta-HSDI and h17 beta-HSDII show 89% homology. In addition, we have used the hpE2DH216 cDNA to demonstrate the widespread expression of 17 beta-HSD mRNAs in steroidogenic and peripheral target tissues. These new findings provide the basis for a better understanding of the molecular mechanisms involved in 17 beta-HSD deficiency and peripheral sex steroid metabolism.

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Labrie, F., Bélanger, A., Luu-The, V., Labrie, C., Simard, J., & Lin, S. (2011) · De Gruyter eBooks · doi:10.1515/9783110811162.299
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Authors: Luu-The, V., Labrie, C., Simard, J., Lachance, Y., Zhao, H.-F., Couët, J., Leblanc, G., & Labrie, F.
Affiliations: Université Laval (CA)
ORCID: Simard, Jacques
Couët, Jacques
Venue: Molecular Endocrinology
Publisher: The Endocrine Society
Published: 1990-02
Volume: 4
Issue: 2
Pages: 268-275
ISSN: 0888-8809 (ISSN-L)
1944-9917
DOI: 10.1210/mend-4-2-268
OpenAlex: W2074285202
Cited by: 173
References: 27
Citations by year: 2024: 1 · 2018: 1 · 2017: 2 · 2015: 5 · 2014: 1
FWCI: 5.75
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Molecular Endocrinology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Keywords: 17β-hydroxysteroid dehydrogenase, tandem gene duplication, gene structure, exon-intron organization, 5' and 3' flanking regions, steroidogenic tissues, mRNA expression
MeSH terms: Amino Acid Sequence, Base Sequence, Chromosome Mapping, Genes, Humans, Molecular Sequence Data, RNA, Messenger, 17-Hydroxysteroid Dehydrogenases, Restriction Mapping, DNA Probes, Genomic Library

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Structure of Two in Tandem Human 17β-Hydroxysteroid Dehydrogenase Genes

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