The DOI matches its Crossref record; 111 of the 111 references it cites were found in a registry or an index.
Insulin and Leptin as Adiposity Signals
Open accessAbstract
There is now considerable consensus that the adipocyte hormone leptin and the pancreatic hormone insulin are important regulators of food intake and energy balance. Leptin and insulin fulfill many of the requirements to be putative adiposity signals to the brain. Plasma leptin and insulin levels are positively correlated with body weight and with adipose mass in particular. Furthermore, both leptin and insulin enter the brain from the plasma. The brain expresses both insulin and leptin receptors in areas important in the control of food intake and energy balance. Consistent with their roles as adiposity signals, exogenous leptin and insulin both reduce food intake when administered locally into the brain in a number of species under different experimental paradigms. Additionally, central administration of insulin antibodies increases food intake and body weight. Recent studies have demonstrated that both insulin and leptin have additive effects when administered simultaneously. Finally, we recently have demonstrated that leptin and insulin share downstream neuropeptide signaling pathways. Hence, insulin and leptin provide important negative feedback signals to the central nervous system, proportional to peripheral energy stores and coupled with catabolic circuits.
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“Thus, leptin insufficiency together with decreased insulin levels may act in conjunction to suppress melanocortin tone and limit weight loss via a reduction in T3 levels and energy expenditure.”
From Prospective study of gut hormone and metabolic changes after adjustable gastric banding and Roux-en-Y gastric bypass (2009) · cites this paper as [40]
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Metadata
- Authors
- Benoit, S. C.
- Affiliations
- University of Cincinnati Medical Center (US)
- Corresponding author
- Benoit, S. C.
- Venue
- Recent Progress in Hormone Research
- Publisher
- The Endocrine Society
- Published
- 2004-01-01
- Volume
- 59
- Issue
- 1
- Pages
- 267-285
- ISSN
- 0079-9963 (ISSN-L)
- OpenAlex
- W2125667577
- Cited by
- 266
- References
- 111
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 5 · 2022: 5 · 2021: 6 · 2020: 9 · 2019: 9 · 2018: 4 · 2017: 12 · 2016: 10 · 2015: 16 · 2014: 22 · 2013: 22 · 2012: 19
- FWCI
- 6.27
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Recent Progress in Hormone Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Cincinnati
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- leptin, insulin, adiposity signals, food intake regulation, energy balance, leptin receptor, insulin receptor, brain, negative feedback, neuropeptide signaling, body weight, insulin antibodies
- MeSH terms
- Adipose Tissue, alpha-MSH, Body Composition, Brain, Humans, Hypothalamus, Insulin, Neuropeptide Y, Signal Transduction, Leptin
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