Asiatic acid derivatives enhance cognitive performance partly by improving acetylcholine synthesis
Abstract
Thirty-six semi-synthesized derivatives of asiatic acid were examined to determine if they had cognitive-enhancing activity in a passive avoidance test. Among the compounds tested, AS-2, AS-2-9-006 and AS-9-006 significantly alleviated scopolamine-induced memory impairment at doses of 1 and 10 mg kg(-1). Furthermore, AS-2 and AS-2-9-006 (1 mg kg(-1) administered four times daily) enhanced cognitive performance as determined in a water maze test. These three asiatic acid derivatives did not show any significant effect on the learning process in active avoidance tests. AS-2, AS-2-9-006 and AS-9-006 enhanced cholineacetyltransferase activity in a cholinergic neuroblastoma cell line, S-20Y, in-vitro. Therefore, AS-2, AS-2-9-006 and AS-9-006 may have therapeutic value in alleviating certain memory impairment observed in dementia.
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Asiatic acid and its derivatives have shown a promising memory improving effect by improving acetylcholine synthesis.
“Asiatic acid and its derivatives have shown a promising memory improving effect [65] by improving ACh synthesis [66,67].”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [66]
Various asiatic acid derivatives demonstrate significant cognitive-enhancing activities in a scopolamine-induced model of memory impairment.
“Various asiatic acid derivatives, as some of the most common phytochemicals found in C. asiatica, demonstrated significant cognitive-enhancing activities when utilizing a scopolamine-induced model of memory impairment [135].”
From The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment (2022) · cites this paper as [135]
Pretreatment with three differing asiatic acid derivatives significantly enhanced memory in comparison to scopolamine-treated mice that were not given any derivatives.
“Utilizing the Morris water maze test and passive avoidance, the study demonstrated that pretreatment with three differing asiatic acid derivatives significantly enhanced memory in comparison to the scopolamine-treated mice that were not given any derivatives [135].”
From The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment (2022) · cites this paper as [135]
The improvement in cognition in treated mice was attributed to elevated choline acetyltransferase activity, yielding enhanced acetylcholine synthesis.
“The improvement in cognition witnessed in the treated mice was attributed to elevated choline acetyltransferase activity, yielding enhanced acetylcholine synthesis [135].”
From The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment (2022) · cites this paper as [135]
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- Authors
- Kim, S. R., Koo, K. A., Lee, M. K., Park, H.-G., Jew, S.-S., Cha, K.-H., & Kim, Y. C.
- Affiliations
- Seoul National University (KR)
- DongKook Pharmaceutical (South Korea) (KR)
- Corresponding author
- Kim, Young Choong
- Venue
- Journal of Pharmacy and Pharmacology
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-10-01
- Volume
- 56
- Issue
- 10
- Pages
- 1275-1282
- ISSN
- 0022-3573 (ISSN-L)
- 2042-7158
- OpenAlex
- W2061622878
- Cited by
- 31
- References
- 32
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 3 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 1 · 2014: 1 · 2012: 4
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Journal of Pharmacy and Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Seoul National University Open Repository (Seoul National University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- cognitive enhancement, acetylcholine synthesis, choline acetyltransferase, memory impairment, scopolamine-induced amnesia, passive avoidance, water maze, dementia, cholinergic drugs
- MeSH terms
- Acetylcholine, Amnesia, Animals, Avoidance Learning, Cricetulus, Dementia, Cricetinae, Male, Memory, Mice, Inbred ICR, Scopolamine, Transfection, Triterpenes, CHO Cells, Nootropic Agents, Maze Learning, Cell Line, Tumor, Mice, Pentacyclic Triterpenes
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