Asiatic acid protects primary neurons against C2-ceramide-induced apoptosis

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

Mosmann, T. (1983) · Journal of Immunological Methods · doi:10.1016/0022-1759(83)90303-4 · Cited by 56,104 · see citing works

Mitochondria and Apoptosis

Green, D. R., & Reed, J. C. (1998) · Science · doi:10.1126/science.281.5381.1309 · Cited by 8,998 · see citing works

The Bcl-2 Protein Family: Arbiters of Cell Survival

Adams, J. M., & Cory, S. (1998) · Science · doi:10.1126/science.281.5381.1322 · Cited by 5,303 · see citing works

Molecular characterization of mitochondrial apoptosis-inducing factor

Susin, S. A., Lorenzo, H. K., Zamzami, N., Marzo, I., Snow, B. E., Brothers, G. M., Mangion, J., Jacotot, E., Costantini, P., Loeffler, M., et al. (1999) · Nature · doi:10.1038/17135 · Cited by 4,060 · see citing works

Optimized survival of hippocampal neurons in B27‐supplemented neurobasal™, a new serum‐free medium combination

Brewer, G. J., Torricelli, J. R., Evege, E. K., & Price, P. J. (1993) · Journal of Neuroscience Research · doi:10.1002/jnr.490350513 · Cited by 2,094 · see citing works

BCL-2 FAMILY: Regulators of Cell Death

Chao, D. T., & Korsmeyer, S. J. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.395 · Cited by 1,686 · see citing works

Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease

Cutler, R. G., Kelly, J., Storie, K., Pedersen, W. A., Tammara, A., Hatanpaa, K. J., Troncoso, J. C., & Mattson, M. P. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305799101 · Cited by 1,135 · see citing works

Caspase Cleaved BID Targets Mitochondria and Is Required for Cytochrome c Release, while BCL-XL Prevents This Release but Not Tumor Necrosis Factor-R1/Fas Death

Gross, A., Yin, X.-M., Wang, K., Wei, M. C., Jockel, J., Milliman, C., Erdjument-Bromage, H., Tempst, P., & Korsmeyer, S. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.2.1156 · Cited by 1,045 · see citing works

Proteomic identification of nitrated proteins in Alzheimer's disease brain

Castegna, A., Thongboonkerd, V., Klein, J. B., Lynn, B. C., Markesbery, W. R., & Butterfield, D. A. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01786.x · Cited by 535 · see citing works

Activation of the inducible form of nitric oxide synthase in the brains of patients with multiple sclerosis.

Bagasra, O., Michaels, F. H., Zheng, Y., Bobroski, L. E., Spitsin, S. V., Fu, Z., Tawadros, R., & Koprowski, H. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.26.12041 · Cited by 456 · see citing works

Inactivation of Human Manganese-superoxide Dismutase by Peroxynitrite Is Caused by Exclusive Nitration of Tyrosine 34 to 3-Nitrotyrosine

Yamakura, F., Taka, H., Fujimura, T., & Murayama, K. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.23.14085 · Cited by 442 · see citing works

Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity

Harada, H., Quearry, B., Ruiz‐Vela, A., & Korsmeyer, S. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406837101 · Cited by 287 · see citing works

Dehydroepiandrosterone (DHEA) protects hippocampal cells from oxidative stress-induced damage

Bastianetto, S., Ramassamy, C., Poirier, J., & Quirion, R. (1999) · Molecular Brain Research · doi:10.1016/s0169-328x(99)00002-9 · Cited by 257 · see citing works

Ceramide and neurodegeneration: Susceptibility of neurons and oligodendrocytes to cell damage and death

Jana, A., Hogan, E. L., & Pahan, K. (2009) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2008.12.010 · Cited by 233 · see citing works

Mitochondrial Free Radical Signal in Ceramide‐Dependent Apoptosis: A Putative Mechanism for Neuronal Death in Parkinson's Disease

France‐Lanord, V., Brugg, B., Michel, P. P., Agid, Y., & Ruberg, M. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69041612.x · Cited by 182 · see citing works

Characterization of 2′,7′-dichlorofluorescin fluorescence in dissociated mammalian brain neurons: estimation on intracellular content of hydrogen peroxide

Oyama, Y., Hayashi, A., Ueha, T., & Maekawa, K. (1994) · Brain Research · doi:10.1016/0006-8993(94)91429-x · Cited by 176 · see citing works

Asiatic acid, a pentacyclic triterpene from <i>Centella asiatica</i>, is neuroprotective in a mouse model of focal cerebral ischemia

Krishnamurthy, R. G., Senut, M., Zemke, D., Min, J., Frenkel, M. B., Greenberg, E. J., Yu, S., Ahn, N., Goudreau, J., Kassab, M., et al. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22071 · Cited by 155 · see citing works

Serotonin is a novel survival factor of cardiomyocytes: mitochondria as a target of 5‐HT 2B ‐receptor signaling

Nebigil, C. G., Étienne-Selloum, N., Messaddeq, N., & Maroteaux, L. (2003) · The FASEB Journal · doi:10.1096/fj.02-1122fje · Cited by 155 · see citing works

Proteomic identification of nitrated brain proteins in early Alzheimer’s disease inferior parietal lobule

Reed, T. T., Pierce Jr., W. M., Turner, D. M., Markesbery, W. R., & Allan Butterfield, D. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00478.x · Cited by 135 · see citing works

Emerging pathways in genetic Parkinson's disease: Potential role of ceramide metabolism in Lewy body disease

Brás, J., Singleton, A., Cookson, M., & Hardy, J. (2008) · FEBS Journal · doi:10.1111/j.1742-4658.2008.06709.x · Cited by 132 · see citing works

Neuroprotective effects of icaritin against beta amyloid-induced neurotoxicity in primary cultured rat neuronal cells via estrogen-dependent pathway

Wang, Z., Zhang, X., Wang, H., et al. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.12.059 · Cited by 132 · see citing works

Ceramide‐induced apoptosis in cortical neurons is mediated by an increase in p38 phosphorylation and not by the decrease in ERK phosphorylation

Willaime‐Morawek, S., Vanhoutte, P., Caboche, J., Lemaigre‐Dubreuil, Y., Mariani, J., & Brugg, B. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01581.x · Cited by 127 · see citing works

Asiatic acid derivatives protect cultured cortical neurons from glutamate-induced excitotoxicity.

Mk, L., Kim, Sung, S. H., Lím, D., Kim, H., Choi, H. J., Hk, P., Je, S., & Yc, K. (2000) · PubMed · Cited by 111 · see citing works

The Differentiation-dependent Desmosomal Cadherin Desmoglein 1 Is a Novel Caspase-3 Target That Regulates Apoptosis in Keratinocytes

Dusek, R. L., Getsios, S., Chen, F., Park, J. K., Amargo, E. V., Cryns, V. L., & Green, K. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508258200 · Cited by 106 · see citing works

Regulation of ceramide-induced neuronal death: Cell metabolism meets neurodegeneration

Arboleda, G., Morales, L. C., Benítez, B. A., & Arboleda, H. (2008) · Brain Research Reviews · doi:10.1016/j.brainresrev.2008.10.001 · Cited by 105 · see citing works

Ceramide induces neuronal apoptosis through the caspase-9/caspase-3 pathway

Movsesyan, V. A., Yakovlev, A. G., Dabaghyan, E. A., Stoica, B. A., & Faden, A. I. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02593-7 · Cited by 99 · see citing works

Ceramide induces neuronal apoptosis through mitogen-activated protein kinases and causes release of multiple mitochondrial proteins

Stoica, B. A., Movsesyan, V. A., Knoblach, S. M., & Faden, A. I. (2005) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.02.009 · Cited by 98 · see citing works

Ceramide and Mitochondria in Ischemia/Reperfusion

Novgorodov, S. A., & Gudz, T. I. (2009) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e31819b52d5 · Cited by 94 · see citing works

Protective Effects of Asiatic Acid on Rotenone- or H2O2-Induced Injury in SH-SY5Y Cells

Xiong, Y., Ding, H., Minfang, X., & Gao, J. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9844-0 · Cited by 85 · see citing works

Free 3-Nitrotyrosine Causes Striatal NeurodegenerationIn Vivo

Mihm, M. J., Schanbacher, B. L., Wallace, B. L., et al. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-11-j0003.2001 · Cited by 75 · see citing works

Pharmacokinetics of the total triterpenic fraction of Centella asiatica after single and multiple administrations to healthy volunteers. A new assay for asiatic acid

Grimaldi, R., Ponti, F. D., D'Angelo, L., et al. (1990) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(90)90033-p · Cited by 71 · see citing works

Sensitive and reliable JC‐1 and TOTO‐3 double staining to assess mitochondrial transmembrane potential and plasma membrane integrity: Interest for cell death investigations

Zuliani, T., Duval, R. E., Jayat‐Vignoles, C., Schnébert, S., André, P., Dumas, M., & Ratinaud, M. (2003) · Cytometry Part A · doi:10.1002/cyto.a.10059 · Cited by 70 · see citing works

Minocycline or iNOS inhibition block 3-nitrotyrosine increases and blood–brain barrier leakiness in amyloid beta-peptide-injected rat hippocampus

Ryu, J. K., & McLarnon, J. G. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2005.12.016 · Cited by 66 · see citing works

Mannose receptor is present in a functional state in rat microglial cells

Marzolo, M., Rommy von Bernhardi, M., & Inestrosa, N. C. (1999) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19991101)58:3 · Cited by 65 · see citing works

Reaction of nitrogen dioxide with Griess-type reagents

Huygen, C. (1970) · Analytical Chemistry · doi:10.1021/ac60285a018 · Cited by 63 · see citing works

IGF-I protects cortical neurons against ceramide-induced apoptosis via activation of the PI-3K/Akt and ERK pathways; is this protection independent of CREB and Bcl-2?

Willaime‐Morawek, S., Arbez, N., Mariani, J., & Brugg, B. (2005) · Molecular Brain Research · doi:10.1016/j.molbrainres.2005.09.020 · Cited by 39 · see citing works

Determination of asiatic acid in beagle dog plasma after oral administration of Centella asiatica extract by precolumn derivatization RP-HPLC

Zheng, X., & Wang, S. (2008) · Journal of Chromatography B · doi:10.1016/j.jchromb.2008.11.045 · Cited by 34 · see citing works

Enhanced HtrA2/Omi Expression in Oxidative Injury to Retinal Pigment Epithelial Cells and Murine Models of Neurodegeneration

Ding, X., Patel, M. M., Shen, D., Herzlich, A. A., Cao, X., Villasmil, R., Klupsch, K., Tuo, J., Downward, J., & Chan, C. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-3381 · Cited by 34 · see citing works

Asiatic acid derivatives enhance cognitive performance partly by improving acetylcholine synthesis

Kim, S. R., Koo, K. A., Lee, M. K., Park, H.-G., Jew, S.-S., Cha, K.-H., & Kim, Y. C. (2004) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357044391 · Cited by 31 · see citing works

Structure-activity relationship study of asiatic acid derivatives for new wound healing agent

Jeong, B. (2006) · Archives of Pharmacal Research · doi:10.1007/bf02969264 · Cited by 28 · see citing works

Neuroprotective effect of neural stem cell-conditioned media in in vitro model of Huntington's disease

Lim, H.-C., Lee, S., Chu, K., et al. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.02.035 · Cited by 21 · see citing works

Centella asiatica: Phytochemistry and mechanisms of neuroprotection and cognitive enhancement

Gray, N. E., Alcazar Magana, A., Lak, P., Wright, K. M., Quinn, J., Stevens, J. F., Maier, C. S., & Soumyanath, A. (2018) · Phytochemistry Reviews · doi:10.1007/s11101-017-9528-y · Cited by 299 · see citing works

Ceramides in Alzheimer’s Disease: Key Mediators of Neuronal Apoptosis Induced by Oxidative Stress and A <b> <i>β</i> </b> Accumulation

Jazvinšćak Jembrek, M., Hof, P. R., & Šimić, G. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/346783 · Cited by 244 · see citing works

Multi-Target-Directed Ligands and other Therapeutic Strategies in the Search of a Real Solution for Alzheimer’s Disease

Agis-Torres, A., Sollhuber, M., Fernandez, M., & Sanchez-Montero, J. M. (2014) · Current Neuropharmacology · doi:10.2174/1570159x113116660047 · Cited by 202 · see citing works

Caffeoylquinic Acids in Centella asiatica Protect against Amyloid-β Toxicity

Gray, N. E., Morré, J., Kelley, J., Maier, C. S., Stevens, J. F., Quinn, J. F., & Soumyanath, A. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-131913 · Cited by 101 · see citing works

Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice

Matthews, D. G., Caruso, M., Murchison, C. F., Zhu, J. Y., Wright, K. M., Harris, C. J., Gray, N. E., Quinn, J. F., & Soumyanath, A. (2019) · Antioxidants · doi:10.3390/antiox8120630 · Cited by 86 · see citing works

Actions and Therapeutic Potential of Madecassoside and Other Major Constituents of Centella asiatica: A Review

Tan, S. C., Bhattamisra, S. K., Chellappan, D. K., & Candasamy, M. (2021) · Applied Sciences · doi:10.3390/app11188475 · Cited by 72 · see citing works

Asiatic acid attenuates aluminium chloride-induced behavioral changes, neuronal loss and astrocyte activation in rats

Suryavanshi, J., Prakash, C., & Sharma, D. (2022) · Metabolic Brain Disease · doi:10.1007/s11011-022-00998-3 · Cited by 27 · see citing works

Role of ceramide in mitogenesis induced by exogenous sphingoid bases.

Hauser, J., Buehrer, B. M., & Bell, R. M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37447-1 · Cited by 55 · see citing works

Role of Sphingolipids in Bacterial Infections

Becker, K. A., Boudreau, R. M., Gardner, A. I., Seitz, A. P., Caldwell, C. C., Li, X., Zhang, Y., Brodlie, M., Edwards, M. J., & Gulbins, E. (2020) · Springer eBooks · doi:10.1007/978-3-030-15147-8_4 · Cited by 1 · see citing works

Sphingolipid metabolic changes during chiral C2-ceramides induced apoptosis in human leukemia cells

Baek, M.-Y., Yoo, H., Nakaya, K., et al. (2001) · Archives of Pharmacal Research · doi:10.1007/bf02976482 · Cited by 6 · see citing works

Sphingolipid Signaling Pathways as Potential Therapeutic Targets in Gliomas

Brocklyn, J. R. V. (2007) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955707782110123 · Cited by 36 · see citing works

[3] Ceramide synthase

Wang, E., & Merrill, A. H. (2000) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(00)11062-6 · Cited by 39 · see citing works