Direct access of drugs to the human brain after intranasal drug administration?
Abstract
It has been suggested that intranasal (IN) drug delivery could be used to administer drugs directly to the brain, bypassing the blood-brain barrier. Conclusive evidence of this proposed route of drug transport has not been observed by IN-IV comparison. In eight neurosurgery patients with a CSF drain, the uptake in CSF and plasma after IN and IV drug administration was compared. No evidence of direct access of the drugs from the nose to the CSF was found.
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The nasal cavity can only accommodate about 100 l of liquid per nostril.
“It has been reported the nasal cavity can only accommodate about 100 l of liquid per nostril (Merkus et al., 2003) and a double-dummy design would increase the volume to an unacceptable level.”
From Low dose intranasal oxytocin delivered with Breath Powered device dampens amygdala response to emotional stimuli: A peripheral effect-controlled within-subjects randomized dose-response fMRI trial (2016) · cites this paper as Merkus et al., 2003
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Nasal Route for Direct Delivery of Solutes to the Central Nervous System: Fact or Fiction?
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(2001) · Neurology · doi:10.1212/wnl.56.8.1079 · Cited by 12 · see citing works
Population pharmacokinetics of intranasally administered low dose melatonin
Helfrich, E., Neef, C., & Merkus, F. W. H. M. (2002) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.2002.16133.x · Cited by 2 · see citing works
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- Authors
- Merkus, P., Guchelaar, H.-J., Bosch, D. A., & Merkus, F. W. H. M.
- Affiliations
- Leiden University (NL)
- Venue
- Neurology
- Published
- 2003-05-27
- Volume
- 60
- Issue
- 10
- Pages
- 1669-1671
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2155644613
- Cited by
- 81
- References
- 9
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2022: 5 · 2021: 3 · 2020: 3 · 2019: 1 · 2018: 4 · 2017: 7 · 2016: 7 · 2015: 7 · 2014: 2 · 2013: 5 · 2012: 3
- FWCI
- 3.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Surgery › Head and Neck Surgical Oncology
- Keywords
- intranasal drug delivery, blood-brain barrier bypass, cerebrospinal fluid, plasma drug concentration, intravenous administration, neurosurgical patients
- MeSH terms
- Administration, Intranasal, Adult, Blood-Brain Barrier, Brain, Female, Humans, Hydroxocobalamin, Injections, Intravenous, Male, Melatonin, Middle Aged
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