The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Diabetes mellitus and risk of dementia in the Kungsholmen project: A 6-year follow-up study
Abstract
BACKGROUND: Research on diabetes mellitus as a risk factor for dementia and its main subtypes has produced conflicting results. The authors investigated the relationship between diabetes mellitus and risk of dementia, Alzheimer disease (AD), and vascular dementia (VaD). METHODS: A dementia-free cohort of 1,301 community dwellers aged 75 years and older in Stockholm, Sweden, was longitudinally examined twice over 6 years to detect dementia cases (Diagnostic and Statistical Manual of Mental Disorders-III-R diagnostic criteria). Cox proportional hazards models were used to analyze the data with adjustment for several potential confounders. RESULTS: During the 5,584 person-years of follow-up, 350 subjects developed dementia, including 260 AD and 49 VaD cases. Diabetes mellitus was associated with hazard ratios (HR) of 1.5 (95% CI 1.0 to 2.1, p = 0.04) for dementia, 2.6 (95% CI 1.2 to 6.1) for VaD, and 1.3 (95% CI 0.9 to 2.1) for AD. Patients who were treated with oral antidiabetic medications had HRs of 1.7 (95% CI 1.0 to 2.8, p = 0.04) for dementia and 3.6 (95% CI 1.3 to 9.5) for VaD. There were significant interactions of diabetes with severe systolic hypertension (> or =180 mm Hg) on dementia and its main subtypes, and of diabetes with heart disease on VaD. CONCLUSIONS: Diabetes mellitus increases the risk of dementia, and VaD in particular, in very old people. The risk for dementia and VaD is especially high when diabetes mellitus occurs together with severe systolic hypertension or heart disease.
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Cites
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
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Silent Brain Infarcts and the Risk of Dementia and Cognitive Decline
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Type 2 Diabetes, APOE Gene, and the Risk for Dementia and Related Pathologies
Peila, R., Rodriguez, B. L., & Launer, L. J. (2002) · Diabetes · doi:10.2337/diabetes.51.4.1256 · Cited by 1,207
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Risk of Dementia among Persons with Diabetes Mellitus: A Population-based Cohort Study
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Type 2 diabetes mellitus, cognitive impairment and dementia
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Impact of diabetes on cognitive function among older Latinos
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Cited by
Risk of dementia in diabetes mellitus: a systematic review
Biessels, G. J., Staekenborg, S., Brunner, E., Brayne, C., & Scheltens, P. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(05)70284-2 · Cited by 2,187
Cheng, G., Huang, C., Deng, H., & Wang, H. (2012) · Internal Medicine Journal · doi:10.1111/j.1445-5994.2012.02758.x · Cited by 1,040
Diabetes mellitus and risk of dementia: A meta‐analysis of prospective observational studies
Gudala, K., Bansal, D., Schifano, F., & Bhansali, A. (2013) · Journal of Diabetes Investigation · doi:10.1111/jdi.12087 · Cited by 727
Meta-analysis of Alzheimer’s disease risk with obesity, diabetes, and related disorders
Profenno, L. A., Porsteinsson, A. P., & Faraone, S. V. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.02.013 · Cited by 718
Chatterjee, S., Peters, S. A. E., Woodward, M., Mejia Arango, S., Batty, G. D., Beckett, N., Beiser, A., Borenstein, A. R., Crane, P. K., Haan, M., et al. (2016) · Diabetes Care · doi:10.2337/dc15-1588 · Cited by 711
Self-citation
Metadata
- Authors
- Xu, W. L., Qiu, C. X., Wahlin, A., Winblad, B., & Fratiglioni, L.
- Venue
- Neurology
- Published
- 2004-10-12
- Volume
- 63
- Issue
- 7
- Pages
- 1181-1186
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2115309909
- Cited by
- 407
- References
- 8
- FWCI
- 9.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- Xu, W. L., Qiu, C. X., Wahlin, A., Winblad, B., & Fratiglioni, L. (2004). Diabetes mellitus and risk of dementia in the Kungsholmen project: A 6-year follow-up study. Neurology. https://doi.org/10.1212/01.wnl.0000140291.86406.d1
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