Diabetes as a risk factor for dementia and mild cognitive impairment: a meta‐analysis of longitudinal studies
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This study examined the association of diabetes with the onset of dementia (including Alzheimer's disease (AD), vascular dementia (VD) and any dementia) and mild cognitive impairment (MCI) by using a quantitative meta‐analysis of longitudinal studies. EMBASE and MEDLINE were searched for articles published up to December 2010. All studies that examined the relationship between diabetes and the onset of dementia or MCI were included. Pooled relative risks were calculated using fixed and random effects models. Nineteen studies met our inclusion criteria for this meta‐analysis, and 6184 subjects with diabetes and 38 530 subjects without diabetes were included respectively. All subjects were without dementia or MCI at baseline. The quantitative meta‐analysis showed that subjects with diabetes had higher risk for AD (relative risk (RR):1.46, 95% confidence interval (CI): 1.20–1.77), VD (RR: 2.48, 95% CI: 2.08–2.96), any dementia (RR: 1.51, 95% CI: 1.31–1.74) and MCI (RR: 1.21, 95% CI: 1.02–1.45) than those without. The quantitative meta‐analysis showed that diabetes was a risk factor for incident dementia (including AD, VD and any dementia) and MCI.
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Vascular risk factors including hypertension, diabetes, hyperlipidemia, and cardiovascular disease, as well as environment and lifestyle, all affect cerebrovascular and BBB dysfunction.
“Vascular risk factors including hypertension (169, 272), diabetes (43, 110), hyperlipidemia (74), and cardiovascular disease (594), as well as environment (e.g., pollution) (87-89, 207) and lifestyle (e.g., obesity, sedentary lifestyle) (281, 643) all affect cerebrovascular and BBB dysfunction (429, 571), and may influence onset and progression of AD.”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [110]
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- Authors
- Cheng, G., Huang, C., Deng, H., & Wang, H.
- Affiliations
- Chongqing Medical University (CN)
- Mianyang Third People's Hospital (CN)
- Corresponding author
- Deng, H.
- Venue
- Internal Medicine Journal
- Publisher
- Wiley
- Published
- 2012-05
- Volume
- 42
- Issue
- 5
- Pages
- 484-491
- ISSN
- 1444-0903 (ISSN-L)
- 1445-5994
- OpenAlex
- W1593393815
- Cited by
- 1,040
- References
- 8
- Citations by year
- 2026: 47 · 2025: 73 · 2024: 76 · 2023: 87 · 2022: 92 · 2021: 86 · 2020: 111 · 2019: 85 · 2018: 73 · 2017: 74 · 2016: 73 · 2015: 61 · 2014: 56 · 2013: 31 · 2012: 14
- FWCI
- 6.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Internal Medicine Journal (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Sichuan University
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- diabetes mellitus, dementia, mild cognitive impairment, Alzheimer's disease, vascular dementia, risk factors, incident dementia, longitudinal study
- MeSH terms
- Dementia, Diabetes Mellitus, Humans, Longitudinal Studies, Retrospective Studies, Risk Factors, Cognitive Dysfunction
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