Cited by 299Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsAmyotrophic Lateral Sclerosis Research

A systematic review of neurotransmitter deficits and treatments in frontotemporal dementia

Open access
Huey, Edward D., Putnam, Karen T., Grafman, Jordan·2006·Neurology

Abstract

OBJECTIVE: To evaluate neurotransmitter deficiencies and neurotransmitter-based treatments for frontotemporal dementia (FTD). METHODS: The authors conducted a systematic review of the literature on the mechanism and treatment of FTD and a meta-analysis of treatment studies of antidepressants for the behavioral symptoms of FTD. RESULTS: Patients with FTD show deficiencies in the serotonin and dopamine neurotransmitter systems, while the acetylcholine system appears relatively intact. Antidepressant treatment significantly improves behavioral symptoms in FTD, but most studies are small and uncontrolled. Serotonergic treatments appear to improve the behavioral but not cognitive symptoms of FTD. CONCLUSIONS: Studies of neurotransmitter deficiencies in frontotemporal dementia (FTD) can be helpful in developing treatments. Treatment studies on FTD are scarce, given the prevalence and severity of this illness. Larger, well-controlled treatment studies are required to reach more definitive conclusions about treatment efficacy. Multicenter studies are likely the best way to complete treatment studies in a timely manner.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1212/01.wnl.0000191304.55196.4d

Cites

83 of 83 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

1 of the 84 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

  1. [8]Lebert F, Pasquier F. Trazodone in the treatment of behavior in frontotemporal dementia. Hum Psychopharmacol Clin Exp. 1999;14:279–281. [Google Scholar]

Cited by

Sorted by citations

Authors
Huey, E. D., Putnam, K. T., & Grafman, J.
Affiliations
National Institutes of Health (US)
Venue
Neurology
Published
2006-01-10
Volume
66
Issue
1
Pages
17-22
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
OpenAlex
W2148211031
Cited by
299
References
84
Citations by year
2026: 12 · 2025: 11 · 2024: 9 · 2023: 12 · 2022: 11 · 2021: 20 · 2020: 10 · 2019: 14 · 2018: 11 · 2017: 16 · 2016: 20 · 2015: 10 · 2014: 15 · 2013: 18 · 2012: 17
FWCI
2.50
Type
journal article
Language
en
Open access
Locations
  • Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of Neurological Disorders and Stroke (Z01NS002792)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
Keywords
frontotemporal dementia, neurotransmitter deficits, serotonin, dopamine, acetylcholine, antidepressants, behavioral symptoms, cognitive symptoms, treatment efficacy
MeSH terms
Antidepressive Agents, Brain, Clinical Trials as Topic, Dementia, Dopamine, Humans, Serotonin, Dopamine Agents, Treatment Outcome, Serotonin Receptor Agonists, Neurotransmitter Agents

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review