A systematic review of neurotransmitter deficits and treatments in frontotemporal dementia
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OBJECTIVE: To evaluate neurotransmitter deficiencies and neurotransmitter-based treatments for frontotemporal dementia (FTD). METHODS: The authors conducted a systematic review of the literature on the mechanism and treatment of FTD and a meta-analysis of treatment studies of antidepressants for the behavioral symptoms of FTD. RESULTS: Patients with FTD show deficiencies in the serotonin and dopamine neurotransmitter systems, while the acetylcholine system appears relatively intact. Antidepressant treatment significantly improves behavioral symptoms in FTD, but most studies are small and uncontrolled. Serotonergic treatments appear to improve the behavioral but not cognitive symptoms of FTD. CONCLUSIONS: Studies of neurotransmitter deficiencies in frontotemporal dementia (FTD) can be helpful in developing treatments. Treatment studies on FTD are scarce, given the prevalence and severity of this illness. Larger, well-controlled treatment studies are required to reach more definitive conclusions about treatment efficacy. Multicenter studies are likely the best way to complete treatment studies in a timely manner.
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Misdiagnosis of FTD often leads to an unsuitable care approach or wrong medication that can worsen symptoms.
“To date, no FTD-specific diagnostic tests or disease-modifying treatments are available and misdiagnosis often leads to an unsuitable care approach or wrong medication that can worsen the symptoms [10].”
No FTD-specific diagnostic tests or disease-modifying treatments are available.
“To date, no FTD-specific diagnostic tests or disease-modifying treatments are available and misdiagnosis often leads to an unsuitable care approach or wrong medication that can worsen the symptoms [10].”
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- Authors
- Huey, E. D., Putnam, K. T., & Grafman, J.
- Affiliations
- National Institutes of Health (US)
- Venue
- Neurology
- Published
- 2006-01-10
- Volume
- 66
- Issue
- 1
- Pages
- 17-22
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- PMC
- PMC4499854
- OpenAlex
- W2148211031
- Cited by
- 299
- References
- 84
- Citations by year
- 2026: 12 · 2025: 11 · 2024: 9 · 2023: 12 · 2022: 11 · 2021: 20 · 2020: 10 · 2019: 14 · 2018: 11 · 2017: 16 · 2016: 20 · 2015: 10 · 2014: 15 · 2013: 18 · 2012: 17
- FWCI
- 2.50
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (Z01NS002792)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Keywords
- frontotemporal dementia, neurotransmitter deficits, serotonin, dopamine, acetylcholine, antidepressants, behavioral symptoms, cognitive symptoms, treatment efficacy
- MeSH terms
- Antidepressive Agents, Brain, Clinical Trials as Topic, Dementia, Dopamine, Humans, Serotonin, Dopamine Agents, Treatment Outcome, Serotonin Receptor Agonists, Neurotransmitter Agents
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