Cited by 299Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsAmyotrophic Lateral Sclerosis Research

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A systematic review of neurotransmitter deficits and treatments in frontotemporal dementia

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Huey, Edward D., Putnam, Karen T., Grafman, Jordan·2006·Neurology

DOI 10.1212/01.wnl.0000191304.55196.4dPMC PMC4499854

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Abstract

OBJECTIVE: To evaluate neurotransmitter deficiencies and neurotransmitter-based treatments for frontotemporal dementia (FTD). METHODS: The authors conducted a systematic review of the literature on the mechanism and treatment of FTD and a meta-analysis of treatment studies of antidepressants for the behavioral symptoms of FTD. RESULTS: Patients with FTD show deficiencies in the serotonin and dopamine neurotransmitter systems, while the acetylcholine system appears relatively intact. Antidepressant treatment significantly improves behavioral symptoms in FTD, but most studies are small and uncontrolled. Serotonergic treatments appear to improve the behavioral but not cognitive symptoms of FTD. CONCLUSIONS: Studies of neurotransmitter deficiencies in frontotemporal dementia (FTD) can be helpful in developing treatments. Treatment studies on FTD are scarce, given the prevalence and severity of this illness. Larger, well-controlled treatment studies are required to reach more definitive conclusions about treatment efficacy. Multicenter studies are likely the best way to complete treatment studies in a timely manner.

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[Japanese version of the Neuropsychiatric Inventory--a scoring system for neuropsychiatric disturbance in dementia patients].
Hirono, N., Mori, E., Ikejiri, Y., Imamura, T., Shimomura, T., Hashimoto, M., Yamashita, H., & Ikeda, M. (1997) · PubMed · Cited by 21,012
Special Care Units and Traditional Care in Dementia: Relationship with Behavior, Cognition, Functional Status and Quality of Life - A Review
Kok, J. S., Berg, I. J., & Scherder, E. J. A. (2013) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000353441 · Cited by 20,589
The Neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia
Cummings, J. L., Mega, M., Gray, K., Rosenberg-Thompson, S., Carusi, D. A., & Gornbein, J. (1994) · Neurology · doi:10.1212/wnl.44.12.2308 · Cited by 7,568
Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria
Neary, D., Snowden, J. S., Gustafson, L., Passant, U., Stuss, D., Black, S., Freedman, M., Kertesz, A., Robert, P. H., Albert, M., et al. (1998) · Neurology · doi:10.1212/wnl.51.6.1546 · Cited by 5,047
Primary Progressive Aphasia
Weıntraub, S. (1990) · Archives of Neurology · doi:10.1001/archneur.1990.00530120075013 · Cited by 3,018
Clinical and neuropathological criteria for frontotemporal dementia. The Lund and Manchester Groups.
(1994) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.57.4.416 · Cited by 1,331
The prevalence of frontotemporal dementia
Ratnavalli, E., Brayne, C., Dawson, K. E., & Hodges, J. R. (2002) · Neurology · doi:10.1212/wnl.58.11.1615 · Cited by 1,182
Cerebral Glucose Metabolism in Adults with Hyperactivity of Childhood Onset
Zametkin, A. J., NORDAHL, T. E., Gross, M., King, A. C., Semple, W. E., Rumsey, J. M., Hamburger, S., & Cohen, R. M. (1990) · New England Journal of Medicine · doi:10.1056/nejm199011153232001 · Cited by 975
Pharmacological Treatment of Neuropsychiatric Symptoms of Dementia: A Review of the Evidence
Sink, K. M., Holden, K. F., & Yaffe, K. (2005) · JAMA · doi:10.1001/jama.293.5.596 · Cited by 910
Decreased β-Amyloid1-42and Increased Tau Levels in Cerebrospinal Fluid of Patients With Alzheimer Disease
Sunderland, T., Linker, G., Mirza, N., Putnam, K. T., Friedman, D. L., Kimmel, L. H., Bergeson, J., Manetti, G. J., Zimmermann, M., Tang, B., et al. (2003) · JAMA · doi:10.1001/jama.289.16.2094 · Cited by 656
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Aquilani, R., Ramusino, M. C., Maestri, R., Iadarola, P., Boselli, M., Perini, G., Boschi, F., Dossena, M., Bellini, A., Buonocore, D., et al. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1237469 · Cited by 34
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Peplow, P., & Martinez, B. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.330591 · Cited by 31
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Enhancing caregivers’ understanding of dementia and tailoring activities in frontotemporal dementia: two case studies
O’Connor, C. M. C., Clemson, L. M., Brodaty, H., Gitlin, L. N., Piguet, O., & Mioshi, E. (2015) · Disability and Rehabilitation · doi:10.3109/09638288.2015.1055375 · Cited by 27
Pharmacological Management of Psychiatric Symptoms in Frontotemporal Dementia: A Systematic Review
Buoli, M., Serati, M., Caldiroli, A., Galimberti, D., Scarpini, E., & Altamura, A. (2017) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988717700506 · Cited by 25
Promising therapies for the treatment of frontotemporal dementia clinical phenotypes: from symptomatic to disease-modifying drugs
Logroscino, G., Imbimbo, B. P., Lozupone, M., Sardone, R., Capozzo, R., Battista, P., Zecca, C., Dibello, V., Giannelli, G., Bellomo, A., et al. (2019) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2019.1598377 · Cited by 30
The contribution of behavioral features to caregiver burden in FTLD spectrum disorders
Silverman, H. E., Ake, J. M., Manoochehri, M., Appleby, B. S., Brushaber, D. E., Devick, K. L., Dickerson, B. C., Fields, J. A., Forsberg, L. K., Ghoshal, N., et al. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12494 · Cited by 24
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Loy, C. T., Kril, J. J., Trollor, J. N., Kiernan, M. C., Kwok, J. B., Vucic, S., Halliday, G. M., & Hodges, J. R. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.3 · Cited by 25
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Self-citation
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Khawaja, I. S., Hurwitz, T. D., & Schenck, C. H. (2008) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v69n1219b · Cited by 8
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Teng, E., Marshall, G. A., & Cummings, J. L. (2009) · Cambridge University Press eBooks · doi:10.1017/cbo9780511581410.007 · Cited by 5
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Bu, Y., Li, S., Ye, T., Wang, Y., Song, M., & Chen, J. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1552801 · Cited by 6
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Morrow, C. B., Sah, E., & Onyike, C. U. (2025) · International Review of Psychiatry · doi:10.1080/09540261.2025.2571072 · Cited by 5
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Oberrauch, S., Metha, J. A., Brian, M. L., Barnes, S. A., Featherby, T. J., Lawrence, A. J., Hoyer, D., Murawski, C., & Jacobson, L. H. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.12.017 · Cited by 5
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Pharmacological treatment of non-Alzheimer dementias
Arlt, S., & Jahn, H. (2006) · Current Opinion in Psychiatry · doi:10.1097/01.yco.0000245755.21621.80 · Cited by 5

Authors: Huey, E. D., Putnam, K. T., & Grafman, J.
Affiliations: National Institutes of Health (US)
ORCID: Huey, Edward D.
Putnam, Karen T.
Grafman, Jordan
Venue: Neurology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2006-01-10
Volume: 66
Issue: 1
Pages: 17-22
ISSN: 0028-3878 (ISSN-L)
1526-632X
DOI: 10.1212/01.wnl.0000191304.55196.4d
PMC: PMC4499854
OpenAlex: W2148211031
Cited by: 299
References: 84
Citations by year: 2026: 12 · 2025: 11 · 2024: 9 · 2023: 12 · 2022: 11 · 2021: 20 · 2020: 10 · 2019: 14 · 2018: 11 · 2017: 16 · 2016: 20 · 2015: 10 · 2014: 15 · 2013: 18 · 2012: 17
FWCI: 2.50
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Neurology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of Neurological Disorders and Stroke (Z01NS002792)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
Keywords: frontotemporal dementia, neurotransmitter deficits, serotonin, dopamine, acetylcholine, antidepressants, behavioral symptoms, cognitive symptoms, treatment efficacy
MeSH terms: Antidepressive Agents, Brain, Clinical Trials as Topic, Dementia, Dopamine, Humans, Serotonin, Dopamine Agents, Treatment Outcome, Serotonin Receptor Agonists, Neurotransmitter Agents

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A systematic review of neurotransmitter deficits and treatments in frontotemporal dementia

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