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Cited by 373Dementia and Cognitive Impairment ResearchAging and Gerontology ResearchPhysical Activity and Health

Leisure activities and the risk of amnestic mild cognitive impairment in the elderly

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Verghese, J., LeValley, A., Derby, C., Kuslansky, G., Katz, M., Hall, C., Buschke, H., Lipton, R. B.·2006·Neurology
DOI 10.1212/01.wnl.0000202520.68987.48PMC PMC1415273
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Abstract

Objective To study the influence of leisure activity participation on risk of development of amnestic mild cognitive impairment (aMCI). Methods The authors examined the relationship between baseline level of participation in leisure activities and risk of aMCI in a prospective cohort of 437 community-residing subjects older than 75 years, initially free of dementia or aMCI, using Cox analysis adjusted for age, sex, education, and chronic illnesses. The authors derived Cognitive and Physical Activity Scales based on frequency of participation in individual activities. Results Over a median follow-up of 5.6 years, 58 subjects had development of aMCI. A one-point increase on the Cognitive (hazard ratio [HR] 0.95, 95% CI 0.91 to 0.99) but not Physical Activities Scale (HR 0.97, 95% CI 0.93 to 1.01) was associated with lower risk of aMCI. Subjects with Cognitive Activity scores in the highest (HR 0.46, 95% CI 0.24 to 0.91) and middle thirds (HR 0.52, 95% CI 0.29 to 0.96) had a lower risk of aMCI compared with subjects in the lowest third. The association persisted even after excluding subjects who converted to dementia within 2 years of meeting criteria for aMCI. Conclusions Cognitive activity participation is associated with lower risk of development of amnestic mild cognitive impairment, even after excluding individuals at early stages of dementia.

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Crossref · 10.1212/01.wnl.0000202520.68987.48

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  • Participation in cognitive activities reduced the risk of Alzheimer's disease, while physical activities were unrelated to Alzheimer's disease development 4 years later.

    “Wilson and colleagues (Wilson, Mendes de Leon, et al., 2002; Wilson, Bennett, et al., 2002) reported that while participation in cognitive activities (such as reading, listening to the radio, playing games) reduced the risk of succumbing to Alzheimer's disease, participation in physical activities (such as jogging, gardening, bicycle riding, dancing) was unrelated to the development of Alzheimer's”

    From Enrichment Effects on Adult Cognitive Development: Can the Functional Capacity of Older Adults Be Preserved and Enhanced? (2008) · cites this paper as Verghese et al., 2006

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Authors
Verghese, J., LeValley, A., Derby, C., Kuslansky, G., Katz, M., Hall, C., Buschke, H., & Lipton, R. B.
Affiliations
  • Albert Einstein College of Medicine (US)
  • From the Department of Neurology (J.V., C.D., G.K., M.K., C.H., H.B., R.B.L.) and Department of Epidemiology and Population Health (A.L., C.D., C.H., R.B.L.), Albert Einstein College of Medicine, Bronx, NY.
ORCID
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2006-03-28
Volume
66
Issue
6
Pages
821-827
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
DOI
10.1212/01.wnl.0000202520.68987.48
PMC
PMC1415273
OpenAlex
W2006017769
Cited by
373
References
3
Citations by year
2026: 11 · 2025: 16 · 2024: 20 · 2023: 13 · 2022: 14 · 2021: 20 · 2020: 22 · 2019: 14 · 2018: 14 · 2017: 17 · 2016: 19 · 2015: 17 · 2014: 20 · 2013: 21 · 2012: 27
FWCI
12.32
Type
journal article
Language
en
Open access
Locations
  • Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (5r01ag025119-05)
  • National Institute on Aging (R01-AG025119, AG03949, P01AG003949, K23AG024848)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Aging and Gerontology Research
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
Keywords
amnestic mild cognitive impairment, leisure, cognitive activity, physical activity, older adults, dementia risk, cognitive aging
MeSH terms
Aged, Aged, 80 and over, Amnesia, Cognition Disorders, Female, Follow-Up Studies, Humans, Leisure Activities, Male, Neuropsychological Tests, Prospective Studies, Risk Factors, Cohort Studies

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