The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Cognitive impairment in incident, untreated Parkinson disease: The Norwegian ParkWest Study
Abstract
BACKGROUND: Little is known regarding the cognitive impairment in subjects with early, drug-naïve Parkinson disease (PD). The aim of this study was to explore the proportion with mild cognitive impairment (MCI) and subtypes in an incidence cohort of untreated PD in Southern and Western Norway. METHODS: A total of 196 non-demented, drug-naive patients who were recruited after an extensive search of all new cases of PD in the area and 201 healthy control subjects completed a battery of neuropsychological tests of verbal memory, visuospatial, and attentional-executive functioning. Subjects were classified as MCI if the age- and education-corrected z-score was falling 1.5 standard deviations below the mean for at least one of the cognitive domains. RESULTS: The PD group was more impaired on all neuropsychological tests than controls, but the effect sizes were small. The largest effect size was found for verbal memory. A total of 18.9% of the patients with PD were classified as MCI, with a relative risk of 2.1 (1.2-3.6) in PD compared to the control group. Patients with PD with and without MCI did not differ significantly regarding demographic and motor features. Among PD-MCI patients, nearly two-thirds had a non-amnestic MCI subtype, and one third had an amnestic MCI subtype. CONCLUSIONS: The findings demonstrate a twofold increase in the proportion with cognitive impairment in subjects with early, untreated Parkinson disease (PD) compared to controls. This has implications for diagnosis and management of PD. AD = Alzheimer disease; aMCI-MD = amnestic multiple-domain MCI; aMCI-SD = amnestic single-domain MCI; CVLT-2 = California Verbal Learning Test II; IQCode = Informant Questionnaire on Cognitive decline in the elderly; MADRS = Montgomery and Aasberg Depression Rating Scale; MCI = mild cognitive impairment; MMSE = Mini-Mental State Examination; naMCI-MD = non-amnestic multiple-domain MCI; naMCI-SD = non-amnestic single-domain MCI; PD = Parkinson disease; RR = relative risks; UPDRS = Unified Parkinson's Disease Rating Scale; VOSP = Visual Object and Space Perception Battery.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Mild cognitive impairment has been reported to be twice as common in PD as in people not affected by the disease (Aarsland et al. 2009).”
From The clinical symptoms of Parkinson's disease. (2016) · cites this paper as Aarsland et al. 2009
In the citing paper
“Mild cognitive impairment (MCI) is already present in about a quarter of patients with early PD.[12][13][14]”
From Does vigorous exercise have a neuroprotective effect in Parkinson disease? (2011) · cites this paper as [12]
Citations
Cites
A new depression scale designed to be sensitive to change
Montgomery, S. A., & Åsberg, M. (1979) · British Journal of Psychiatry · doi:10.1192/bjp.134.4.382 · Cited by 13,962
Mild cognitive impairment as a diagnostic entity
Petersen, R. C. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01388.x · Cited by 7,864
Winblad, B., Palmer, K., Kivipelto, M., Jelic, V., Fratiglioni, L., Wahlund, L. ‐., Nordberg, A., Bäckman, L., Albert, M., Almkvist, O., et al. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01380.x · Cited by 4,946
Clinical diagnostic criteria for dementia associated with Parkinson’s disease
Emre, M., Aarsland, D., Brown, R., Burn, D. J., Duyckaerts, C., Mizuno, Y., Broe, G. A., Cummings, J., Dickson, D. W., Gauthier, S., et al. (2007) · Movement Disorders · doi:10.1002/mds.21507 · Cited by 3,027
Self-citationDiagnostic Criteria for Parkinson Disease
Gelb, D. J., Oliver, E., & Gilman, S. (1999) · Archives of Neurology · doi:10.1001/archneur.56.1.33 · Cited by 2,822
Dubois, B., Burn, D. J., Goetz, C. G., Aarsland, D., Brown, R. G., Broe, G. A., Dickson, D. W., Duyckaerts, C. J., Cummings, J., Gauthier, S. G., et al. (2007) · Movement Disorders · doi:10.1002/mds.21844 · Cited by 1,099
Self-citationCognitive profile of patients with newly diagnosed Parkinson disease
Muslimović, D., Post, B., Speelman, J. D., & Schmand, B. (2005) · Neurology · doi:10.1212/01.wnl.0000180516.69442.95 · Cited by 1,007
Evolution of cognitive dysfunction in an incident Parkinson's disease cohort
Williams‐Gray, C. H., Foltynie, T., Brayne, C., Robbins, T. W., & Barker, R. (2007) · Brain · doi:10.1093/brain/awm111 · Cited by 935
The Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE): a review
Jorm, A. F. (2004) · International Psychogeriatrics · doi:10.1017/s1041610204000390 · Cited by 823
Depression rating scales in Parkinson's disease: Critique and recommendations
Schrag, A. E., Barone, P., Brown, R. G., Leentjens, A. F. G., McDonald, W. M., STARKSTEIN, S. E., Weintraub, D. A., Poewe, W. H., Rascol, O., Sampaio, C., et al. (2007) · Movement Disorders · doi:10.1002/mds.21333 · Cited by 690
The cognitive ability of an incident cohort of Parkinson’s patients in the UK. The CamPaIGN study
Foltynie, T., Brayne, C., Robbins, T. W., & Barker, R. A. (2004) · Brain · doi:10.1093/brain/awh067 · Cited by 675
Subtypes of mild cognitive impairment in parkinson's disease: Progression to dementia
Janvin, C. C., Larsen, J. P., Aarsland, D., & Hugdahl, K. (2006) · Movement Disorders · doi:10.1002/mds.20974 · Cited by 592
Self-citationDefining mild cognitive impairment in Parkinson's disease
Caviness, J. N., Driver‐Dunckley, E., Connor, D. J., Sabbagh, M. N., Hentz, J. G., Noble, B., Evidente, V. G. H., Shill, H. A., & Adler, C. H. (2007) · Movement Disorders · doi:10.1002/mds.21453 · Cited by 422
Subtype of Mild Cognitive Impairment and Progression to Dementia and Death
Yaffe, K. S., Petersen, R. C., Lindquist, K. J., Kramer, J. H., & Miller, B. L. (2006) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000095427 · Cited by 339
Zadikoff, C., Fox, S. H., Tang‐Wai, D. F., Thomsen, T. R., de Bie, R. M. A., Wadia, P. M., Miyasaki, J. M., Duff-Canning, S. J., Lang, A. E., & Marras, C. (2007) · Movement Disorders · doi:10.1002/mds.21837 · Cited by 337
Leentjens, A. F. G., Verhey, F. R. J., Lousberg, R. L., Spitsbergen, H., & Wilmink, F. W. (2000) · International Journal of Geriatric Psychiatry · doi:10.1002/1099-1166(200007)15:7 · Cited by 280
Beyer, M. K., Janvin, C. C., Larsen, J. O., & Aarsland, D. (2006) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2006.093849 · Cited by 255
Self-citationPatterns of Atrophy Differ Among Specific Subtypes of Mild Cognitive Impairment
Whitwell, J. L., Petersen, R. C., Negash, S., Weigand, S. D., Kantarci, K., Ivnik, R. J., Knopman, D. S., Boeve, B. F., Smith, G. E., & Jack, C. R. (2007) · Archives of Neurology · doi:10.1001/archneur.64.8.1130 · Cited by 230
Janvin, C. C., Larsen, J. P., Salmon, D. P., Galasko, D. R., Hugdahl, K., & Aarsland, D. (2005) · Movement Disorders · doi:10.1002/mds.20726 · Cited by 119
Self-citationDiscriminative and predictive power of an informant report in mild cognitive impairment
Isella, V (2006) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2005.069765 · Cited by 109
Effects of Depression and Parkinson's Disease on Cognitive Functioning
Norman, S., Tröster, A. I., Fields, J. A., & Brooks, R. A. (2002) · Journal of Neuropsychiatry · doi:10.1176/jnp.14.1.31 · Cited by 95
Brønnick, K., Emre, M., Lane, R. M., Tekin, S., & Aarsland, D. (2007) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2006.108076 · Cited by 89
Self-citationFera, F. S., Nicoletti, G., Cerasa, A., Romeo, N., Gallo, O., Gioia, M. C., Arabia, G., Pugliese, P., Zappia, M., & Quattrone, A. (2007) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2007.05.009 · Cited by 64
STARKSTEIN, S. E., & Merello, M. (2007) · Movement Disorders · doi:10.1002/mds.21521 · Cited by 58
Correlation of Parkinson's disease severity and duration with123I-FP-CIT SPECT striatal uptake
Benamer, H. T. S., Patterson, J., Wyper, D. J., Hadley, D. M., Macphee, G. J. A., & Grosset, D. G. (2000) · Movement Disorders · doi:10.1002/1531-8257(200007)15:4
Research works printed but not linked: 2
- Delis DC Kramer JHEK Ober BA. CVLT-II. California Verbal Learning Test. Second Edition. Adult Version. San Antonio TX: The Psychological Corporation: Harcourt Assessment Inc;
- Emre M. Dementia associated with Parkinson’s disease. Lancet Neurol 2003;2:229–237.
Cited by
Sorted by citations
Parkinson disease-associated cognitive impairment
Aarsland, D., Batzu, L., Halliday, G. M., Geurtsen, G. J., Ballard, C. G., Chaudhuri, К. R., & Weintraub, D. A. (2021) · Nature Reviews Disease Primers · doi:10.1038/s41572-021-00280-3 · Cited by 1,540
Self-citationThe clinical symptoms of Parkinson's disease.
Sveinbjornsdottir, S. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13691 · Cited by 1,410
Validity of the MoCA and MMSE in the detection of MCI and dementia in Parkinson disease
Hoops, S., Nazem, S., Siderowf, A. D., Duda, J. E., Xie, S. X., Stern, M. B., & Weintraub, D. A. (2009) · Neurology · doi:10.1212/wnl.0b013e3181c34b47 · Cited by 1,258
Dalrymple‐Alford, J. C., MacAskill, M. R., Nakas, C. T., Livingston, L., Graham, C., Crucian, G. P., Melzer, T. R., Kirwan, J. P., Keenan, R., Wells, S. R., et al. (2010) · Neurology · doi:10.1212/wnl.0b013e3181fc29c9 · Cited by 965
Kehagia, A. A., Barker, R. A., & Robbins, T. W. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70212-x · Cited by 928
Metadata
- Authors
- Aarsland, D., Brønnick, K., Larsen, J. P., Tysnes, O. B., & Alves, G.
- Affiliations
- Stavanger University Hospital (NO)
- From The Norwegian Centre for Movement Disorders (D.A., K.B., J.P.L., G.A.), Department of Neurology (J.P.L., G.A.), and Department of Psychiatry (D.A.), Stavanger University Hospital, Stavanger; Department of Neurology (O.B.T.), Haukeland University Hospital, Bergen; and School of Medicine (D.A., J.P.L., O.B.T.), University of Bergen, Norway.
- Venue
- Neurology
- Published
- 2009-03-31
- Volume
- 72
- Issue
- 13
- Pages
- 1121-1126
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2120049868
- Cited by
- 625
- References
- 25
- Citations by year
- 2026: 13 · 2025: 19 · 2024: 24 · 2023: 19 · 2022: 33 · 2021: 34 · 2020: 33 · 2019: 39 · 2018: 34 · 2017: 44 · 2016: 43 · 2015: 40 · 2014: 40 · 2013: 53 · 2012: 48
- FWCI
- 22.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
- Keywords
- Parkinson's disease, mild cognitive impairment, early-stage Parkinson's disease, amnestic MCI, non-amnestic MCI, verbal memory impairment, executive function, visuospatial ability, attention, prevalence of cognitive impairment
- MeSH terms
- Aged, Cognition Disorders, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neuropsychological Tests, Norway, Parkinson Disease, Prospective Studies, Incidence
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
