Pulse wave velocity is associated with β-amyloid deposition in the brains of very elderly adults
Open accessAbstract
OBJECTIVE: To determine arterial stiffness and β-amyloid (Aβ) deposition in the brain of dementia-free older adults. METHODS: We studied a cohort of 91 dementia-free participants aged 83-96 years. In 2009, participants completed brain MRI and PET imaging using Pittsburgh compound B (PiB; a marker of amyloid plaques in human brain). In 2011, we measured resting blood pressure (BP), mean arterial pressure (MAP), and arterial stiffness by pulse wave velocity (PWV) in the central, peripheral, and mixed (e.g., brachial ankle PWV [baPWV]) vascular beds, using a noninvasive and automated waveform analyzer. RESULTS: A total of 44/91 subjects were Aβ-positive on PET scan. Aβ deposition was associated with mixed PWV, systolic BP, and MAP. One SD increase in baPWV resulted in a 2-fold increase in the odds of being Aβ-positive (p = 0.007). High white matter hyperintensity (WMH) burden was associated with increased central PWV, systolic BP, and MAP. Compared to Aβ-negative individuals with low WMH burden, each SD increase in PWV was associated with a 2-fold to 4-fold increase in the odds of being Aβ-positive and having high WMH. CONCLUSIONS: Arterial stiffness was associated with Aβ plaque deposition in the brain, independent of BP and APOE ε4 allele. The associations differed by type of brain abnormality and vascular bed measured (e.g., WMH with central stiffness and Aβ deposition and mixed stiffness). Arterial stiffness was highest in individuals with both high Aβ deposition and WMH, which has been suggested to be a "double hit" contributing to the development of symptomatic dementia.
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Aβ accumulation hinders glymphatic circulation to aggravate parenchymal Aβ deposition and neuronal death.
“On the other hand, Aβ accumulation hinders glymphatic circulation to aggravate parenchymal Aβ deposition and neuronal death.”
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- Authors
- Hughes, T. M., Kuller, L. H., Barinas-Mitchell, E. J. M., Mackey, R. H., McDade, E. M., Klunk, W. E., Aizenstein, H. J., Cohen, A. D., Snitz, B. E., Mathis, C. A., DeKosky, S. T., & Lopez, O. L.
- Affiliations
- University of Pittsburgh (US)
- From the Department of Epidemiology, Graduate School of Public Health (T.M.H., L.H.K., E.J.M.B.-M., R.H.M.), and the Departments of Neurology (E.M.M., B.E.S., O.L.L.), Psychiatry (W.E.K., H.J.A., A.D.C.), and Radiology (C.A.M.), School of Medicine, University of Pittsburgh, PA; and the Office of the Dean and Department of Neurology (S.T.D.), School of Medicine, University of Virginia, Charlottesville.
- ORCID
- Venue
- Neurology
- Published
- 2013-11-05
- Volume
- 81
- Issue
- 19
- Pages
- 1711-1718
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- PMC
- PMC3812104
- OpenAlex
- W2008132676
- Cited by
- 190
- References
- 45
- Citations by year
- 2026: 10 · 2025: 12 · 2024: 13 · 2023: 14 · 2022: 14 · 2021: 20 · 2020: 17 · 2019: 11 · 2018: 17 · 2017: 14 · 2016: 13 · 2015: 22 · 2014: 13
- FWCI
- 10.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (P01AG025204, RF1AG025516, P50AG005133, K23AG038479, R37AG025516, T32AG000181, T32AG033534)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- pulse wave velocity, arterial stiffness, amyloid-beta deposition, amyloid plaques, white matter hyperintensities, dementia-free older adults, blood pressure, Pittsburgh compound B PET, brachial-ankle pulse wave velocity, central arterial stiffness, APOE ε4, double-hit hypothesis, dementia risk
- MeSH terms
- Aged, Aged, 80 and over, Aging, Blood Pressure, Brain, Double-Blind Method, Female, Humans, Male, Nerve Fibers, Myelinated, Neuropsychological Tests, Plant Extracts, Radionuclide Imaging, Regression Analysis, Retrospective Studies, Geriatric Assessment, Case-Control Studies, Amyloid beta-Peptides, Ginkgo biloba, Vascular Stiffness, Pulse Wave Analysis
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