Cited by 68Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

Pathophysiology of Alzheimer’s Disease

Yarns, Brandon C., Holiday, Kelsey A., Carlson, David M., Cosgrove, Coleman K., Melrose, Rebecca J.·2022·Psychiatric Clinics of North America

Abstract

Alzheimer's disease (AD) is the most common neurodegenerative disease leading to dementia worldwide. While neuritic plaques consisting of aggregated amyloid-beta proteins and neurofibrillary tangles of accumulated tau proteins represent the pathophysiologic hallmarks of AD, numerous processes likely interact with risk and protective factors and one's culture to produce the cognitive loss, neuropsychiatric symptoms, and functional impairments that characterize AD dementia. Recent biomarker and neuroimaging research has revealed how the pathophysiology of AD may lead to symptoms, and as the pathophysiology of AD gains clarity, more potential treatments are emerging that aim to modify the disease and relieve its burden.

Integrity signals

Registry

Crossref · 10.1016/j.psc.2022.07.003

Cites

124 of 124 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

1 retracted

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Yarns, B. C., Holiday, K. A., Carlson, D. M., Cosgrove, C. K., & Melrose, R. J.
Affiliations
  • University of California, Los Angeles (US)
  • VA West Los Angeles Medical Center (US)
  • University at Buffalo, State University of New York (US)
Corresponding author
Yarns, Brandon C.
Venue
Psychiatric Clinics of North America
Publisher
Elsevier BV
Published
2022-12
Volume
45
Issue
4
Pages
663-676
ISSN
0193-953X (ISSN-L)
OpenAlex
W4306177181
Cited by
68
References
123
Citations by year
2026: 16 · 2025: 26 · 2024: 16 · 2023: 10
FWCI
1.79
Type
journal article
Language
en
Open access
closed
Locations
  • Psychiatric Clinics of North America (publishedVersion)
  • PubMed (publishedVersion)
Funders
U.S. Department of Veterans Affairs (IK2CX001884)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
Alzheimer's disease, pathophysiology, amyloid-beta, tau protein, neuritic plaques, neurofibrillary tangles, dementia, neuropsychiatric symptoms, functional disability, risk factors, protective factors, biomarkers, neuroimaging, disease-modifying therapy
MeSH terms
Alzheimer Disease, Humans, Amyloid beta-Peptides, tau Proteins, Neurodegenerative Diseases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review