Pathophysiology of Alzheimer’s Disease
Abstract
Alzheimer's disease (AD) is the most common neurodegenerative disease leading to dementia worldwide. While neuritic plaques consisting of aggregated amyloid-beta proteins and neurofibrillary tangles of accumulated tau proteins represent the pathophysiologic hallmarks of AD, numerous processes likely interact with risk and protective factors and one's culture to produce the cognitive loss, neuropsychiatric symptoms, and functional impairments that characterize AD dementia. Recent biomarker and neuroimaging research has revealed how the pathophysiology of AD may lead to symptoms, and as the pathophysiology of AD gains clarity, more potential treatments are emerging that aim to modify the disease and relieve its burden.
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Alzheimer's disease is the most prevalent form of dementia worldwide.
“The most prevalent form of dementia worldwide is Alzheimer's disease (AD), a progressive neurological condition with a high social and caregiver cost.”
From Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights (2023) · cites this paper as [26]
Alzheimer's disease (AD) is a progressive, multifactorial, unremitting neurodegenerative disease characterized by memory loss, personality changes, and cognitive impairment.
“Alzheimer's disease (AD) is a progressive, multifactorial, and unremitting neurodegenerative disease characterized by memory loss, personality changes, and cognitive impairment.”
From Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights (2023) · cites this paper as [26]
Alzheimer's disease is an irreversible neurodegenerative disorder marked by occasional unusual behavior, memory loss, and cognitive impairment.
“It is an irreversible neurodegenerative disorder marked by occasional unusual behavior, memory loss, and cognitive impairment.”
From Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights (2023) · cites this paper as [26]
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- Authors
- Yarns, B. C., Holiday, K. A., Carlson, D. M., Cosgrove, C. K., & Melrose, R. J.
- Affiliations
- University of California, Los Angeles (US)
- VA West Los Angeles Medical Center (US)
- University at Buffalo, State University of New York (US)
- Corresponding author
- Yarns, Brandon C.
- Venue
- Psychiatric Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2022-12
- Volume
- 45
- Issue
- 4
- Pages
- 663-676
- ISSN
- 0193-953X (ISSN-L)
- OpenAlex
- W4306177181
- Cited by
- 68
- References
- 123
- Citations by year
- 2026: 16 · 2025: 26 · 2024: 16 · 2023: 10
- FWCI
- 1.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatric Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Veterans Affairs (IK2CX001884)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, pathophysiology, amyloid-beta, tau protein, neuritic plaques, neurofibrillary tangles, dementia, neuropsychiatric symptoms, functional disability, risk factors, protective factors, biomarkers, neuroimaging, disease-modifying therapy
- MeSH terms
- Alzheimer Disease, Humans, Amyloid beta-Peptides, tau Proteins, Neurodegenerative Diseases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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