The DOI matches its Crossref record; 26 of the 29 references it cites were found in a registry or an index.
Memory complaints and risk of cognitive impairment after nearly 2 decades among older women
Open accessAbstract
OBJECTIVES: To investigate the association between subjective memory complaints (SMCs) and long-term risk of cognitive impairment in aging because most previous studies have followed individuals for only a few years. METHODS: Participants were 1,107 cognitively normal, community-dwelling older women (aged 65 years and older at baseline) in a prospective study of aging. SMCs were assessed shortly after baseline and repeatedly over time with the yes/no question, "Do you feel you have more problems with memory than most?" Cognitive status 18 years later (normal or impaired with mild cognitive impairment or dementia) was determined by an expert panel. Using logistic regression, we investigated the association between SMCs over time and risk of cognitive impairment, adjusting for demographics, baseline cognition, and characteristics that differed between those with and without SMCs. RESULTS: At baseline, 8.0% of participants (n = 89) endorsed SMCs. Baseline SMCs were associated with increased risk of cognitive impairment 18 years later (adjusted odds ratio [OR] = 1.7, 95% confidence interval 1.1-2.8). Results were unchanged after excluding participants with depression. The association between SMCs and cognitive impairment was greatest at the last SMC assessment time point (18 years before diagnosis: adjusted OR = 1.7 [1.1-2.9]; 14 years before diagnosis: adjusted OR = 1.6 [0.9-2.7]; 10 years before diagnosis: adjusted OR = 1.9 [1.1-3.1]; 4 years before diagnosis: adjusted OR = 3.0 [1.8-5.0]). CONCLUSIONS: SMCs are associated with cognitive impairment nearly 2 decades later among older women. SMCs may be a very early symptom of an insidious neurodegenerative disease process, such as Alzheimer disease.
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“Individuals with SCD may eventually be diagnosed with MCI, MCI due to Alzheimer's disease, or another form of dementia.[251][252][253]”
From 2023 Alzheimer's disease facts and figures (2023) · cites this paper as [251]
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“Not all those who experience subjective cognitive decline go on to develop MCI or dementia, but many do.”
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Sperling, R. A., Aisen, P. S., Beckett, L. A., Bennett, D. A., Craft, S., Fagan, A. M., Iwatsubo, T., Jack, C. R., Kaye, J., Montine, T. J., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.003 · Cited by 7,155
Self-citationA compendium of neuropsychological tests: administration, norms, and commentary
(1991) · Choice Reviews Online · doi:10.5860/choice.29-2400 · Cited by 6,118
A Compendium of Neuropsychological Tests: Administration, Norms, and Commentary
Levin, H. S. (1993) · Archives of Neurology · doi:10.1001/archneur.1993.00540050007005 · Cited by 4,796
Current concepts in mild cognitive impairment
Petersen, R. C., Doody, R., Kurz, A., Mohs, R. C., Morris, J. C., Rabins, P. V., Ritchie, K., Rossor, M., Thal, L., & Winblad, B. (2001) · Archives of Neurology · doi:10.1001/archneur.58.12.1985 · Cited by 4,781
Jack, C. R., Knopman, D. S., Jagust, W. J., Petersen, R. C., Weiner, M. W., Aisen, P. S., Shaw, L. M., Vemuri, P., Wiste, H. J., Weigand, S. D., et al. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70291-0 · Cited by 4,396
Jessen, F., Amariglio, R. E., van Boxtel, M., Breteler, M., Ceccaldi, M., Chételat, G., Dubois, B., Dufouil, C., Ellis, K. A., van der Flier, W. M., et al. (2014) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2014.01.001 · Cited by 3,014
(1987) · PubMed · Cited by 2,657
The Mini-Mental State Examination
Folstein, M. F. (1983) · Archives of General Psychiatry · doi:10.1001/archpsyc.1983.01790060110016 · Cited by 2,016
Mitchell, A. J., Beaumont, H., Ferguson, D. Y., Yadegarfar, M., & Stubbs, B. (2014) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12336 · Cited by 1,228
Jorm, A. F., & Jacomb, P. A. (1989) · Psychological Medicine · doi:10.1017/s0033291700005742 · Cited by 1,104
Clinical Gerontology; A Guide to Assessment and Intervention
Essa, M. (1987) · American Journal of Psychotherapy · doi:10.1176/appi.psychotherapy.1987.41.3.478 · Cited by 1,064
California verbal learning test-second edition
Delis, D. C. (2000) · Medical Entomology and Zoology · Cited by 769
Neuropathology and Cognitive Impairment in Alzheimer Disease: A Complex but Coherent Relationship
Nelson, P. T., Braak, H., & Markesbery, W. R. (2009) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181919a48 · Cited by 643
Older adults with cognitive complaints show brain atrophy similar to that of amnestic MCI
Saykin, A. J., Wishart, H. A., Rabin, L. A., Santulli, R. B., Flashman, L. A., West, J. D., McHugh, T., & Mamourian, A. C. (2006) · Neurology · doi:10.1212/01.wnl.0000234032.77541.a2 · Cited by 594
Tranah, G. J., Blackwell, T., Stone, K. L., Ancoli‐Israel, S., Paudel, M. L., Ensrud, K. E., Cauley, J. A., Redline, S., Hillier, T. A., Cummings, S. R., et al. (2011) · Annals of Neurology · doi:10.1002/ana.22468 · Cited by 525
Self-citationSubjective cognitive complaints and amyloid burden in cognitively normal older individuals
Amariglio, R. E., Becker, J. A., Carmasin, J., Wadsworth, L. P., Lorius, N., Sullivan, C., Maye, J. E., Gidicsin, C., Pepin, L. C., Sperling, R. A., et al. (2012) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2012.08.011 · Cited by 472
Perrotin, A. (2012) · Archives of Neurology · doi:10.1001/archneurol.2011.666 · Cited by 300
Self-reported memory complaints
Kryscio, R. J., Abner, E. L., Cooper, G. E., Fardo, D. W., Jicha, G. A., Nelson, P. T., Smith, C. D., Eldik, L. J. V., Wan, L., & Schmitt, F. A. (2014) · Neurology · doi:10.1212/wnl.0000000000000856 · Cited by 196
Buckley, R., Saling, M. M., Ames, D., Rowe, C. C., Lautenschlager, N. T., Macaulay, S. L., Martins, R. N., Masters, C. L., O'Meara, T., Savage, G., et al. (2013) · International Psychogeriatrics · doi:10.1017/s1041610213000665 · Cited by 173
Gray matter atrophy pattern in elderly with subjective memory impairment
Peter, J., Scheef, L., Abdulkadir, A., Boecker, H., Heneka, M., Wagner, M., Koppara, A., Klöppel, S., Jessen, F., & Initiative, A. D. N. (2014) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2013.05.1764 · Cited by 165
Modified Mini-Mental State Examination (3MS) 1987
Teng, E. L., & Chui, H. (2006) · Open Scholarship Institutional Repository (Washington University in St. Louis) · Cited by 71
Hollands, S., for the AIBL Research Group, Lim, Y. Y., Buckley, R., Pietrzak, R. H., Snyder, P. J., Ames, D., Ellis, K. A., Harrington, K., Lautenschlager, N., et al. (2014) · Journal of Alzheimer's Disease · doi:10.3233/jad-140678 · Cited by 67
Cappeliez, P., Quintal, M., Blouin, M., Gagne, S., Bourgeois, A., Finlay, M., & Robillard, E. A. (1996) · The Canadian Journal of Psychiatry · doi:10.1177/070674379604100209 · Cited by 48
Cerebral microbleeds are related to subjective cognitive failures: the RUN DMC study
van Norden, A. G. W., van Uden, I. W. M., de Laat, K. F., Gons, R. A. R., Kessels, R. P. C., van Dijk, E. J., & de Leeuw, F.-E. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.03.021 · Cited by 37
Subjective Memory Complaints and the Risk of Stroke
Sajjad, A., Mirza, S. S., Portegies, M. L. P., Bos, M. J., Albert Hofman, D., Koudstaal, P. J., Tiemeier, H. W., & Ikram, M. A. (2014) · Stroke · doi:10.1161/strokeaha.114.006616 · Cited by 30
Espeland, M. A., Rapp, S. R., Robertson, J., Granek, I. A., Murphy, C. V., Albert, M., & Bassford, T. L. (2006) · Clinical Trials · doi:10.1191/1740774506cn140oa · Cited by 22
Research works printed but not linked: 1
- Reitan RM. Trail Making Test: Manual for Administration and Scoring. Tucson: Reitan Neuropsychology Laboratory; 1992.
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Metadata
- Authors
- Kaup, A. R., Nettiksimmons, J., LeBlanc, E. S., & Yaffe, K.
- Affiliations
- San Francisco VA Medical Center (US)
- Venue
- Neurology
- Published
- 2015-11-24
- Volume
- 85
- Issue
- 21
- Pages
- 1852-1858
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- PMC
- PMC4662698
- OpenAlex
- W2193383487
- Cited by
- 109
- References
- 29
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 9 · 2023: 4 · 2022: 4 · 2021: 16 · 2020: 16 · 2019: 20 · 2018: 10 · 2017: 11 · 2016: 4
- FWCI
- 6.76
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- other-oa
- Locations
- Neurology (publishedVersion, other-oa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- U.S. Department of Veterans Affairs (IK2 RX001629)
- Kaiser Permanente
- University of Minnesota
- University of Pittsburgh
- National Institute on Aging (R01AG005394, R01AG005407, R01AG027576, K24AG031155, R01AG026720, R01AG027574)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01-AR35582, R01AR035584, R01AR35583, R01AR035582, R01AR035583, R01‐AR‐35584)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
- Social Sciences › Psychology › Developmental and Educational Psychology › Aging and Gerontology Research
- Keywords
- subjective memory complaints, cognitive impairment, older women, long-term risk, mild cognitive impairment, dementia, Alzheimer's disease, aging, early detection of neurodegeneration
- MeSH terms
- Aged, Aging, Female, Humans, Memory Disorders, Prospective Studies, Risk Factors, Time Factors, Cohort Studies, Cognitive Dysfunction
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