CoChat
Sign Up
Cited by 140Nutritional Studies and DietDementia and Cognitive Impairment ResearchFatty Acid Research and Health

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

Mediterranean-type diet and brain structural change from 73 to 76 years in a Scottish cohort

Open access
Luciano, Michelle, Corley, Janie, Cox, Simon R., Valdés Hernández, Maria C., Craig, Leone C.A., Dickie, David Alexander, Karama, Sherif, McNeill, Geraldine M., Bastin, Mark E., Wardlaw, Joanna M., Deary, Ian J.·2017·Neurology
DOI 10.1212/wnl.0000000000003559PMC PMC5278943
Open this paper in CoChat — free accountOpen PDF

Abstract

OBJECTIVE: To assess the association between Mediterranean-type diet (MeDi) and change in brain MRI volumetric measures and mean cortical thickness across a 3-year period in older age (73-76 years). METHODS: We focused on 2 longitudinal brain volumes (total and gray matter; n = 401 and 398, respectively) plus a longitudinal measurement of cortical thickness (n = 323), for which the previous cross-sectional evidence of an association with the MeDi was strongest. Adherence to the MeDi was calculated from data gathered from a food frequency questionnaire at age 70, 3 years prior to the baseline imaging data collection. RESULTS: In regression models adjusting for relevant demographic and physical health indicators, we found that lower adherence to the MeDi was associated with greater 3-year reduction in total brain volume (explaining 0.5% of variance, p < 0.05). This effect was half the size of the largest covariate effect (i.e., age). Cross-sectional associations between MeDi and baseline MRI measures in 562 participants were not significant. Targeted analyses of meat and fish consumption did not replicate previous associations with total brain volume or total gray matter volume. CONCLUSIONS: Lower adherence to the MeDi in an older Scottish cohort is predictive of total brain atrophy over a 3-year interval. Fish and meat consumption does not drive this change, suggesting that other components of the MeDi or, possibly, all of its components in combination are responsible for the association.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1212/wnl.0000000000003559

Cites

29 of 29 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The positive effects of a GM-favorable diet are likely due to the availability of prebiotics, probiotics, SCFAs, and polyphenols.

    “This is likely due to the availability of prebiotics, probiotics, SCFAs, and polyphenols.”

    From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [507]

  • A significant body of evidence demonstrates that consuming a GM-favorable diet can positively influence the GM, improve health status, and enhance cognitive function.

    “A comprehensive review of this topic is beyond the scope of this review, however, a significant body of evidence demonstrates that consuming a GM-favorable diet can positively influence the GM, improve health status, and enhance cognitive function (506–510).”

    From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [507]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 1

  1. Nelson HE, Willison JR. National Adult Reading Test (NART) Test Manual (Part II). Windsor, UK: NFER-Nelson; 1991.

Cited by

Sorted by citations

Related

Metadata

Authors
Luciano, M., Corley, J., Cox, S. R., Valdés Hernández, M. C., Craig, L. C. A., Dickie, D. A., Karama, S., McNeill, G. M., Bastin, M. E., Wardlaw, J. M., & Deary, I. J.
Affiliations
  • From the Centre for Cognitive Ageing and Cognitive Epidemiology (M.L., J.C., S.R.C., I.J.D.), Department of Psychology (M.L., J.C., S.R.C., I.J.D.), Brain Research Imaging Centre (M.C.V.H., D.A.D., M.E.B., J.M.W.), Centre for Clinical Brain Sciences (M.C.V.H., D.A.D., M.E.B., J.M.W.), and Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Department of Neuroimaging Sciences (S.R.C., M.C.V.H., D.A.D., M.E.B., J.M.W.), University of Edinburgh; Rowett Institute of...
  • Montreal Neurological Institute and Hospital (CA)
ORCID
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2017-01-31
Volume
88
Issue
5
Pages
449-455
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
DOI
10.1212/wnl.0000000000003559
PMC
PMC5278943
OpenAlex
W2569405552
Cited by
140
References
29
Citations by year
2026: 10 · 2025: 5 · 2024: 11 · 2023: 27 · 2022: 13 · 2021: 15 · 2020: 14 · 2019: 17 · 2018: 22 · 2017: 6
FWCI
15.09
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Neurology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion)
  • Aberdeen University Research Archive (Aberdeen University) (submittedVersion)
  • Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, cc-by)
Funders
  • Medical Research Council (MR/K026992/1, MR/M013111/1, MR/N003403/1, MR/N027558/1)
  • Biotechnology and Biological Sciences Research Council
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Keywords
dietary adherence, brain atrophy, total brain volume, gray matter volume, cortical thickness, older adults, longitudinal brain MRI, fish consumption, meat consumption
MeSH terms
Aged, Aging, Brain, Cross-Sectional Studies, Female, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Organ Size, Prospective Studies, Surveys and Questionnaires, Regression Analysis, Scotland, Sex Characteristics, Diet, Mediterranean, Gray Matter

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review