Association of Loneliness With 10-Year Dementia Risk and Early Markers of Vulnerability for Neurocognitive Decline

Salinas, Joel; Beiser, Alexa S.; Samra, Jasmeet K.; O'Donnell, Adrienne; DeCarli, Charles S.; Gonzales, Mitzi M.; Aparicio, Hugo J.; Seshadri, Sudha

doi:10.1212/wnl.0000000000200039

Association of Loneliness With 10-Year Dementia Risk and Early Markers of Vulnerability for Neurocognitive Decline

Background and Objectives Loneliness is common, and its prevalence is rising. The relationship of loneliness with subsequent dementia and the early preclinical course of Alzheimer disease and related dementia (ADRD) remains unclear. Thus, the primary objective of this study was to determine the a…