Cited by 1,269Health disparities and outcomesAging, Health, and DisabilityAging and Gerontology Research

Loneliness in Older Persons: A Predictor of Functional Decline and Death

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Perissinotto, Carla M., Stijacic Cenzer, Irena, Covinsky, Kenneth E.·2012·Archives of Internal Medicine

Abstract

BACKGROUND: Loneliness is a common source of distress, suffering, and impaired quality of life in older persons. We examined the relationship between loneliness, functional decline, and death in adults older than 60 years in the United States. METHODS: This is a longitudinal cohort study of 1604 participants in the psychosocial module of the Health and Retirement Study, a nationally representative study of older persons. Baseline assessment was in 2002 and follow-up assessments occurred every 2 years until 2008. Subjects were asked if they (1) feel left out, (2) feel isolated, or (3) lack companionship. Subjects were categorized as not lonely if they responded hardly ever to all 3 questions and lonely if they responded some of the time or often to any of the 3 questions. The primary outcomes were time to death over 6 years and functional decline over 6 years on the following 4 measures: difficulty on an increased number of activities of daily living (ADL), difficulty in an increased number of upper extremity tasks, decline in mobility, or increased difficulty in stair climbing. Multivariate analyses adjusted for demographic variables, socioeconomic status, living situation, depression, and various medical conditions. RESULTS: The mean age of subjects was 71 years. Fifty-nine percent were women; 81% were white, 11%, black, and 6%, Hispanic; and 18% lived alone. Among the elderly participants, 43% reported feeling lonely. Loneliness was associated with all outcome measures. Lonely subjects were more likely to experience decline in ADL (24.8% vs 12.5%; adjusted risk ratio [RR], 1.59; 95% CI, 1.23-2.07); develop difficulties with upper extremity tasks (41.5% vs 28.3%; adjusted RR, 1.28; 95% CI, 1.08-1.52); experience decline in mobility (38.1% vs 29.4%; adjusted RR, 1.18; 95% CI, 0.99-1.41); or experience difficulty in climbing (40.8% vs 27.9%; adjusted RR, 1.31; 95% CI, 1.10-1.57). Loneliness was associated with an increased risk of death (22.8% vs 14.2%; adjusted HR, 1.45; 95% CI, 1.11-1.88). CONCLUSION: Among participants who were older than 60 years, loneliness was a predictor of functional decline and death.

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Authors
Perissinotto, C. M., Stijacic Cenzer, I., & Covinsky, K. E.
Affiliations
  • University of California, San Francisco (US)
  • San Francisco VA Medical Center (US)
Corresponding author
Perissinotto, Carla M.
Venue
Archives of Internal Medicine
Published
2012-07-23
Volume
172
Issue
14
Pages
1078-83
ISSN
0003-9926 (ISSN-L)
OpenAlex
W2008067465
Cited by
1,269
References
25
Citations by year
2026: 60 · 2025: 130 · 2024: 117 · 2023: 125 · 2022: 135 · 2021: 157 · 2020: 120 · 2019: 99 · 2018: 52 · 2017: 59 · 2016: 62 · 2015: 58 · 2014: 42 · 2013: 39 · 2012: 11
FWCI
54.93
Type
journal article
Language
en
Open access
Locations
  • Archives of Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • Health Resources and Services Administration
  • U.S. Public Health Service (K01HP20489)
  • National Institute on Aging (R01AG028481, K24AG029812)
Topics
  • Social Sciences › Health › Health disparities and outcomes
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
  • Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Aging and Gerontology Research
Keywords
loneliness, older adults, functional decline, activities of daily living, mobility decline, stair climbing, mortality, social isolation, companionship, quality of life, living alone, Health and Retirement Study, psychosocial well-being, depression, socioeconomic status, living situation, social connectedness
MeSH terms
Activities of Daily Living, Aged, Aged, 80 and over, Female, Humans, Loneliness, Longitudinal Studies, Male, Middle Aged, Mortality, United States, Walking, Upper Extremity

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