Loneliness in Older Persons: A Predictor of Functional Decline and Death
Open accessAbstract
BACKGROUND: Loneliness is a common source of distress, suffering, and impaired quality of life in older persons. We examined the relationship between loneliness, functional decline, and death in adults older than 60 years in the United States. METHODS: This is a longitudinal cohort study of 1604 participants in the psychosocial module of the Health and Retirement Study, a nationally representative study of older persons. Baseline assessment was in 2002 and follow-up assessments occurred every 2 years until 2008. Subjects were asked if they (1) feel left out, (2) feel isolated, or (3) lack companionship. Subjects were categorized as not lonely if they responded hardly ever to all 3 questions and lonely if they responded some of the time or often to any of the 3 questions. The primary outcomes were time to death over 6 years and functional decline over 6 years on the following 4 measures: difficulty on an increased number of activities of daily living (ADL), difficulty in an increased number of upper extremity tasks, decline in mobility, or increased difficulty in stair climbing. Multivariate analyses adjusted for demographic variables, socioeconomic status, living situation, depression, and various medical conditions. RESULTS: The mean age of subjects was 71 years. Fifty-nine percent were women; 81% were white, 11%, black, and 6%, Hispanic; and 18% lived alone. Among the elderly participants, 43% reported feeling lonely. Loneliness was associated with all outcome measures. Lonely subjects were more likely to experience decline in ADL (24.8% vs 12.5%; adjusted risk ratio [RR], 1.59; 95% CI, 1.23-2.07); develop difficulties with upper extremity tasks (41.5% vs 28.3%; adjusted RR, 1.28; 95% CI, 1.08-1.52); experience decline in mobility (38.1% vs 29.4%; adjusted RR, 1.18; 95% CI, 0.99-1.41); or experience difficulty in climbing (40.8% vs 27.9%; adjusted RR, 1.31; 95% CI, 1.10-1.57). Loneliness was associated with an increased risk of death (22.8% vs 14.2%; adjusted HR, 1.45; 95% CI, 1.11-1.88). CONCLUSION: Among participants who were older than 60 years, loneliness was a predictor of functional decline and death.
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Loneliness is linked to a variety of negative health outcomes, including high blood pressure, disability, functional decline, depression, and cognitive decline.
“research demonstrates that loneliness is linked to a variety of negative health outcomes, including high blood pressure [4], disability [5], functional decline [2], depression [6], and cognitive decline [7].”
In a sample of over 1600 older adults participating in the Health and Retirement Study, 43% reported feeling lonely.
“In a sample of over 1600 older adults participating in the Health and Retirement Study, 43% reported feeling lonely105.”
From Psychobiological factors of resilience and depression in late life (2019) · cites this paper as [105]
Surveys in Europe and the USA estimate the prevalence of loneliness ranges from 5% to 43% in the elderly.
“Surveys in Europe and the USA estimate the prevalence of loneliness ranges from 5% to 43% in the elderly 1-4 , with similar figures for China 5 .”
From An overview of systematic reviews on the public health consequences of social isolation and loneliness (2017) · cites this paper as [4]
Social isolation and loneliness are common in populations throughout the world.
“In populations throughout the world, social isolation (defined as an objective lack of interactions with others or the wider community) and loneliness (defined as the subjective feeling of the absence of a social network or a companion) are common.”
From An overview of systematic reviews on the public health consequences of social isolation and loneliness (2017) · cites this paper as [4]
Theeke estimated that 19.3% of noninstitutionalized or community-dwelling US adults over age 65 reported feeling lonely for much of the previous week.
“using a single-item direct question from the 2002 Health and Retirement Study (HRS; n = 8,932), Theeke [14] estimated that 19.3% of noninstitutionalized or community-dwelling US adults over the age of 65 years reported feeling lonely for much of the previous week.”
From Loneliness and health in older adults: a mini-review and synthesis (2016) · cites this paper as [14]
Perceived isolation, or loneliness, is associated with worse physical and mental health and higher mortality.
“even just the perception of isolation (colloquially referred to as loneliness) is associated with poor physical and mental health10,11 and higher mortality rates6,8,12,13.”
From Neural mechanisms of social homeostasis (2019) · cites this paper as [13]
Loneliness, independent of social network size, is associated with higher mortality.
“Consistent with this, loneliness—independent of social network size—is associated with higher mortality13,193 increased blood pressure11,194, higher rate of diabetes, hypertension, arthritis, emphysema195, and Alzheimer’s disease196, along with poor health habits stemming from a lack of self-control197,198.”
From Neural mechanisms of social homeostasis (2019) · cites this paper as [13]
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- Authors
- Perissinotto, C. M., Stijacic Cenzer, I., & Covinsky, K. E.
- Affiliations
- University of California, San Francisco (US)
- San Francisco VA Medical Center (US)
- Corresponding author
- Perissinotto, Carla M.
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 2012-07-23
- Volume
- 172
- Issue
- 14
- Pages
- 1078-83
- ISSN
- 0003-9926 (ISSN-L)
- PMC
- PMC4383762
- OpenAlex
- W2008067465
- Cited by
- 1,269
- References
- 25
- Citations by year
- 2026: 60 · 2025: 130 · 2024: 117 · 2023: 125 · 2022: 135 · 2021: 157 · 2020: 120 · 2019: 99 · 2018: 52 · 2017: 59 · 2016: 62 · 2015: 58 · 2014: 42 · 2013: 39 · 2012: 11
- FWCI
- 54.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Archives of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Health Resources and Services Administration
- U.S. Public Health Service (K01HP20489)
- National Institute on Aging (R01AG028481, K24AG029812)
- Topics
- Social Sciences › Health › Health disparities and outcomes
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Aging and Gerontology Research
- Keywords
- loneliness, older adults, functional decline, activities of daily living, mobility decline, stair climbing, mortality, social isolation, companionship, quality of life, living alone, Health and Retirement Study, psychosocial well-being, depression, socioeconomic status, living situation, social connectedness
- MeSH terms
- Activities of Daily Living, Aged, Aged, 80 and over, Female, Humans, Loneliness, Longitudinal Studies, Male, Middle Aged, Mortality, United States, Walking, Upper Extremity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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