Vitamin B12status, cognitive decline and dementia: a systematic review of prospective cohort studies
Open accessAbstract
Poor vitamin B₁₂ status may lead to the development of cognitive decline and dementia but there is a large variation in the quality, design of and results reported from these investigations. We have undertaken a systematic review of the evidence for the association between vitamin B₁₂ status and cognitive decline in older adults. A database search of the literature to 2011 was undertaken, using keywords related to vitamin B₁₂ and cognition. All prospective cohort studies assessing the association of serum vitamin B₁₂ or biomarkers were included. Quality assessment and extraction of the data were undertaken by two researchers. The quality assessment tool assigns a positive, neutral or negative rating. Of 3772 published articles, thirty-five cohort studies (n 14 325 subjects) were identified and evaluated. No association between serum vitamin B₁₂ concentrations and cognitive decline or dementia was found. However, four studies that used newer biomarkers of vitamin B₁₂ status (methylmalonic acid and holotranscobalamin (holoTC)) showed associations between poor vitamin B₁₂ status and the increased risk of cognitive decline or dementia diagnosis. In general, the studies were of reasonable quality (twenty-one positive, ten neutral and four negative quality) but of short duration and inadequate subject numbers to determine whether an effect exists. Future studies should be of adequate duration (at least 6 years), recruit subjects from the seventh decade, choose markers of vitamin B₁₂ status with adequate specificity such as holoTC and/or methylmalonic acid and employ standardised neurocognitive assessment tools and not screening tests in order to ascertain any relationship between vitamin B₁₂ status and cognitive decline.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000100 · Cited by 28,164 · see citing works
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2009.06.006 · Cited by 10,578 · see citing works
Plasma Homocysteine as a Risk Factor for Dementia and Alzheimer's Disease
Seshadri, S., Beiser, A., Selhub, J., Jacques, P. F., Rosenberg, I. H., D'Agostino, R. B., Wilson, P. W. F., & Wolf, P. A. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa011613 · Cited by 3,237 · see citing works
Vitamin B12, folic acid, and the nervous system
Reynolds, E. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70598-1 · Cited by 860 · see citing works
Smith, A. D., Smith, S. M., de Jager, C. A., Whitbread, P., Johnston, C., Agacinski, G., Oulhaj, A., Bradley, K. M., Jacoby, R., & Refsum, H. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012244 · Cited by 813 · see citing works
Neurologic Aspects of Cobalamin Deficiency
Healton, E. B., Savage, D. G., Brust, J. C. M., Garrett, T. J., & Lindenbaum, J. (1991) · Medicine · doi:10.1097/00005792-199107000-00001 · Cited by 770 · see citing works
Is folic acid good for everyone?
Smith, A. D., Kim, Y., & Refsum, H. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.3.517 · Cited by 617 · see citing works
Morris, M. S., Jacques, P. F., Rosenberg, I. H., & Selhub, J. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.1.193 · Cited by 607 · see citing works
ApoE genotype accounts for the vast majority of AD risk and AD pathology
Raber, J., Huang, Y., & Ashford, J. W. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.12.023 · Cited by 599 · see citing works
Vitamin B12 in Health and Disease
O’Leary, F., & Samman, S. (2010) · Nutrients · doi:10.3390/nu2030299 · Cited by 524 · see citing works
Self-citationHomocysteine and folate as risk factors for dementia and Alzheimer disease
Ravaglia, G., Forti, P., Maioli, F., Martelli, M., Servadei, L., Brunetti, N., Porcellini, E., & Licastro, F. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn.82.3.636 · Cited by 500 · see citing works
Homocysteine and folate as risk factors for dementia and Alzheimer disease
Ravaglia, G., Forti, P., Maioli, F., Martelli, M., Servadei, L., Brunetti, N., Porcellini, E., & Licastro, F. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.3.636 · Cited by 500 · see citing works
Vitamin B 12 and folate in relation to the development of Alzheimer’s disease
Wang, H., Wåhlin, Å., Basun, H., Fastbom, J., Winblad, B. G., & Fratiglioni, L. (2001) · Neurology · doi:10.1212/wnl.56.9.1188 · Cited by 469 · see citing works
Update on Cobalamin, Folate, and Homocysteine
Carmel, R., Green, R., Rosenblatt, D. S., & Watkins, D. (2003) · Hematology · doi:10.1182/asheducation-2003.1.62 · Cited by 386 · see citing works
Tucker, K. L., Qiao, N., Scott, T. M., Rosenberg, I. H., & Spiro, A. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn.82.3.627 · Cited by 351 · see citing works
Tucker, K. L., Qiao, N., Scott, T., Rosenberg, I., & Spiro, A. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.3.627 · Cited by 351 · see citing works
Kovács, I. A., Palotai, R., Szalay, M., & Csermely, P. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012528 · Cited by 341 · see citing works
Nutritional status and cognitive functioning in a normally aging sample: a 6-y reassessment
Rue, A. L., Koehler, K., Wayne, S., Chiulli, S. J., Haaland, K., & Garry, P. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/65.1.20 · Cited by 339 · see citing works
Kado, D. M., Karlamangla, A. S., Huang, M.-H., Troen, A., Rowe, J. W., Selhub, J., & Seeman, T. E. (2005) · The American Journal of Medicine · doi:10.1016/j.amjmed.2004.08.019 · Cited by 268 · see citing works
Brain S‐Adenosylmethionine Levels Are Severely Decreased in Alzheimer's Disease
Morrison, L. D., Smith, D. D., & Kish, S. J. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.67031328.x · Cited by 266 · see citing works
Haan, M. N., Miller, J. W., Aiello, A. E., Whitmer, R. A., Jagust, W. J., Mungas, D. M., Allen, L. H., & Green, R. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.2.511 · Cited by 260 · see citing works
Homocysteine, white matter hyperintensities, and cognition in healthy elderly people
Dufouil, C., Alpérovitch, A., Ducros, V., & Tzourio, C. (2002) · Annals of Neurology · doi:10.1002/ana.10440 · Cited by 241 · see citing works
Selhub, J., Morris, M. S., & Jacques, P. F. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709487104 · Cited by 220 · see citing works
The Worldwide Challenge of the Dementias: A Role for B Vitamins and Homocysteine?
Smith, A. D. (2008) · Food and Nutrition Bulletin · doi:10.1177/15648265080292s119 · Cited by 216 · see citing works
Homocysteine and Cognitive Decline in Healthy Elderly
McCaddon, A., Hudson, P. R., Davies, G. K., Hughes, A., Williams, J. H. H., & Wilkinson, C. (2001) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000051275 · Cited by 206 · see citing works
Low vitamin B-12 status and risk of cognitive decline in older adults
Clarke, R., Birks, J., Nexo, E., Ueland, P. M., Schneede, J., Scott, J., Molloy, A., & Evans, J. G. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.5.1384 · Cited by 203 · see citing works
Green, R. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.009613 · Cited by 193 · see citing works
Vitamin B 12 status and rate of brain volume loss in community-dwelling elderly
Vogiatzoglou, A., Refsum, H., Johnston, C., Smith, S. M., Bradley, K. M., de Jager, C., Budge, M. M., & Smith, A. D. (2008) · Neurology · doi:10.1212/01.wnl.0000325581.26991.f2 · Cited by 192 · see citing works
Ravaglia, G., Forti, P., Maioli, F., Martelli, M., Servadei, L., Brunetti, N., Pantieri, G., & Mariani, E. (2005) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000089515 · Cited by 183 · see citing works
Time Dependency of Cognitive Recovery with Cobalamin Replacement: Report or a Pilot Study
Martin, D. C., Francis, J., Protetch, J., & Huff, F. J. (1992) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1992.tb01939.x · Cited by 174 · see citing works
Plasma homocysteine levels and risk of Alzheimer disease
Luchsinger, J. A., Tang, M. X., Shea, S., Miller, J., Green, R., & Mayeux, R. (2004) · Neurology · doi:10.1212/01.wnl.0000129504.60409.88 · Cited by 171 · see citing works
Hyperhomocysteinemia and Alzheimer's disease: A systematic review
Dam, F. V., & van Gool, W. A. (2008) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2008.03.009 · Cited by 163 · see citing works
Mooijaart, S. P., Gussekloo, J., Frölich, M., Jolles, J., Stott, D. J., Westendorp, R. G., & de Craen, A. J. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.4.866 · Cited by 159 · see citing works
Plasma total homocysteine and memory in the elderly: The Hordaland Homocysteine study
Nurk, E., Refsum, H., Tell, G. S., Engedal, K., Vollset, S. E., Ueland, P. M., Nygaard, H. A., & Smith, A. D. (2005) · Annals of Neurology · doi:10.1002/ana.20645 · Cited by 153 · see citing works
Plasma Homocysteine Levels and Risk of Alzheimer Disease
Bissell, M. G. (2006) · Yearbook of Pathology and Laboratory Medicine · doi:10.1016/s1077-9108(08)70193-2 · Cited by 151 · see citing works
Nilsson, K. H., Gustafson, L., & Hultberg, B. L. (2001) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.388 · Cited by 141 · see citing works
Homocysteine and Cognitive Performance in the Framingham Offspring Study: Age Is Important
Elias, M. F., Sullivan, L. M., D'Agostino, R. B., Elias, P. K., Jacques, P. F., Selhub, J., Seshadri, S., Au, R., Beiser, A., & Wolf, P. A. (2005) · American Journal of Epidemiology · doi:10.1093/aje/kwi259 · Cited by 136 · see citing works
Homocysteine and Cognitive Function in a Population‐Based Study of Older Adults
Schafer, J. H., Glass, T. A., Bolla, K. I., Mintz, M., Jedlicka, A. E., & Schwartz, B. S. (2005) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2005.53153.x · Cited by 124 · see citing works
Homocysteine as a predictor of cognitive decline in Alzheimer's disease
Oulhaj, A., Refsum, H., Beaumont, H., Williams, J. H., King, E., Jacoby, R. J., & Smith, A. D. (2009) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2303 · Cited by 124 · see citing works
Vogel, T., Dali‐Youcef, N., Kaltenbach, G., & Andrès, E. (2009) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2009.02026.x · Cited by 123 · see citing works
Homocysteine and holotranscobalamin and the risk of Alzheimer disease: A longitudinal study
Hooshmand, B., Solomon, A., Kåreholt, I., Leiviskä, J., Rusanen, M., Ahtiluoto, S., Winblad, B., Laatikainen, T., Soininen, H., & Kivipelto, M. (2010) · Neurology · doi:10.1212/wnl.0b013e3181f88162 · Cited by 122 · see citing works
Serum homocysteine and dementia: Meta‐analysis of eight cohort studies including 8669 participants
Wald, D. S., Kasturiratne, A., & Simmonds, M. C. (2011) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2010.08.234 · Cited by 120 · see citing works
Biochemical indicators of vitamin B 12 and folate insufficiency and cognitive decline
Tangney, C., Tang, Y., Evans, D. A., & Morris, M. C. (2009) · Neurology · doi:10.1212/01.wnl.0000341272.48617.b0 · Cited by 117 · see citing works
Plasma vitamin B12 status and cerebral white-matter lesions
de Lau, L. M. L., Smith, A. D., Refsum, H., Johnston, C., & Breteler, M. M. B. (2008) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2008.149286 · Cited by 117 · see citing works
Crystal, H., Ortof, E., Frishman, W. H., Gruber, A., Hershman, D. L., & Aronson, M. K. (1994) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1994.tb06583.x · Cited by 104 · see citing works
Ho, R. C. M., Cheung, M. W. L., Fu, E., Win, H. H., Zaw, M. H., Ng, A., & Mak, A. (2011) · The American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3181f17eed · Cited by 99 · see citing works
The Impact of Genetic Research on our Understanding of Normal Cognitive Ageing: 1995 to 2009
Payton, A. (2009) · Neuropsychology Review · doi:10.1007/s11065-009-9116-z · Cited by 95 · see citing works
Hooshmand, B., Solomon, A., Kåreholt, I., Rusanen, M., Hänninen, T., Leiviskä, J., Winblad, B. G., Laatikainen, T. K., Soininen, H., & Kivipelto, M. (2011) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2011.02484.x · Cited by 93 · see citing works
Ellinson, M., Thomas, J. E., & Patterson, A. (2004) · Journal of Human Nutrition and Dietetics · doi:10.1111/j.1365-277x.2004.00532.x · Cited by 92 · see citing works
Changes in folate, vitamin B12 and homocysteine associated with incident dementia
Kim, J.-M., Stewart, R., Kim, S.-W., Shin, I.-S., Yang, S.-J., Shin, H.-Y., & Yoon, J.-S. (2008) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2007.131482 · Cited by 85 · see citing works
Homocysteine: a marker for cognitive performance? A longitudinal follow-up study.
Teunissen, C. E., Blom, A. H. J., van Boxtel, M. P. J., Bosma, H., Bruijn, C. D., Jolles, J., Wauters, B. A., Steinbusch, H. W. M., & de Vente, J. (2003) · PubMed · Cited by 79 · see citing works
Midlife homocysteine and late-life dementia in women. A prospective population study
Zylberstein, D. E., Lissner, L., Björkelund, C., Mehlig, K., Thelle, D. S., Gustafson, D., Östling, S., Waern, M., Guo, X., & Skoog, I. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.02.024 · Cited by 76 · see citing works
McCracken, C., Hudson, P. R., Ellis, R., & McCaddon, A. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.6.1406 · Cited by 66 · see citing works
Annerbo, S., Wahlund, L., & Lökk, J. (2006) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317506289282 · Cited by 65 · see citing works
Kivipelto, M., Annerbo, S., Hultdin, J., Bäckman, L., Viitanen, M. H., Fratiglioni, L., & Lökk, J. (2009) · European Journal of Neurology · doi:10.1111/j.1468-1331.2009.02590.x · Cited by 61 · see citing works
Cobalamin deficiency, hyperhomocysteinemia, and dementia
Werder (2010) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s6564 · Cited by 57 · see citing works
Abyad, A. (2002) · PubMed · Cited by 56 · see citing works
Homocysteine and inflammation: Predictors of cognitive decline in older persons?
van den Kommer, T. N., Dik, M. G., Comijs, H. C., Jonker, C., & Deeg, D. J. H. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.09.009 · Cited by 53 · see citing works
Neuropsychology of Vitamin B₁₂ Deficiency in Elderly Dementia Patients and Control Subjects
Osimani, A., Berger, A., Friedman, J. A., et al. (2005) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988704272308 · Cited by 52 · see citing works
Garcia, A. A., Haron, Y., Pulman, K., et al. (2004) · The Journals of Gerontology Series A · doi:10.1093/gerona/59.12.1323 · Cited by 50 · see citing works
Genetic and environmental risk factors for alzheimer’s disease in israeli arabs
Bowirrat, A., Friedland, R. P., Farrer, L. A., Baldwin, C. T., & Korczyn, A. D. (2002) · Journal of Molecular Neuroscience · doi:10.1007/s12031-002-0040-4 · Cited by 50 · see citing works
Raman, G., Tatsioni, A., Chung, M. C., Rosenberg, I. H., Lau, J., Lichtenstein, A. H., & Balk, E. M. (2007) · Journal of Nutrition · doi:10.1093/jn/137.7.1789 · Cited by 49 · see citing works
Eussen, S. J. P. M., Ferry, M., Hininger‐Favier, I., et al. (2002) · PubMed · Cited by 43 · see citing works
Prospective Study of Plasma Folate, Vitamin B12, and Cognitive Function and Decline
Kang, J. H., Irizarry, M. C., & Grodstein, F. (2006) · Epidemiology · doi:10.1097/01.ede.0000239727.59575.da · Cited by 43 · see citing works
B vitamins and berries and age-related neurodegenerative disorders.
Balk, E., Chung, M., Raman, G., et al. (2006) · PubMed · Cited by 42 · see citing works
Vitamin B12 Deficiency and Dementia
Cunha, U. G. D. V., Rocha, F. L., Peixoto, J. M. D. S., Motta, M. F. D. M., & Barbosa, M. T. (1995) · International Psychogeriatrics · doi:10.1017/s1041610295001876 · Cited by 41 · see citing works
Folate, Vitamin B12, and Homocysteine as Risk Factors for Cognitive Decline in the Elderly
Kim, J.-M., Kim, S.-W., Shin, I.-S., Yang, S.-J., Park, W.-Y., Kim, S.-J., Shin, H.-Y., & Yoon, J.-S. (2008) · Psychiatry Investigation · doi:10.4306/pi.2008.5.1.36 · Cited by 37 · see citing works
Tu, M.-C., Huang, C., Chen, N.-C., Chang, W., Lui, C., Chen, C., Chen, C., Wang, Y., Lin, Y.-T., & Chang, C. (2010) · PubMed · Cited by 33 · see citing works
Small, B. J., Viitanen, M. H., Winblad, B. G., & Bäckman, L. (1997) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/01688639708403855 · Cited by 30 · see citing works
Bunce, D. J., Kivipelto, M., & Wåhlin, Å. (2004) · Neuropsychology · doi:10.1037/0894-4105.18.2.362 · Cited by 30 · see citing works
Andrès, E., & Kaltenbach, G. (2003) · PubMed · Cited by 30 · see citing works
Annerbo, S., Wahlund, L., & Lökk, J. (2005) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000087297 · Cited by 28 · see citing works
Vitamin B12 Levels in Senile Dementia and Confusional States
Droller, H., & Dossett, J. A. (2009) · Gerontologia Clinica · doi:10.1159/000244550 · Cited by 26 · see citing works
Apolipoprotein E, B Vitamins, and Cognitive Function in Older Adults
Bunce, D. J., Kivipelto, M., & Wåhlin, Å. (2005) · The Journals of Gerontology Series B · doi:10.1093/geronb/60.1.p41 · Cited by 25 · see citing works
Vitamin B12 levels in senile dementia and confusional states.
Droller, H., & Dossett, J. A. (1959) · PubMed · Cited by 25 · see citing works
Effects of Folate and Vitamin B 12 on Cognitive Function in Adults and the Elderly
Rosenberg, I. H. (2008) · Food and Nutrition Bulletin · doi:10.1177/15648265080292s118 · Cited by 23 · see citing works
Huang, C., Chang, W., Lui, C., et al. (2010) · Current Alzheimer Research · doi:10.2174/156720510792231702 · Cited by 21 · see citing works
Small, B. J., & Bäckman, L. (1998) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000017070 · Cited by 19 · see citing works
Diagnostic performance of serum cobalamin tests: a systematic review and meta-analysis
Willis, C. D., Elshaug, A. G., Milverton, J. L., Watt, A. M., Metz, M. P., & Hiller, J. E. (2011) · Pathology · doi:10.1097/pat.0b013e3283486435 · Cited by 19 · see citing works
Brown, B. M., Huang, M., Karlamangla, A. S., Seeman, T. E., & Kado, D. M. (2010) · The journal of nutrition health & aging · doi:10.1007/s12603-010-0277-5 · Cited by 18 · see citing works
Corder, E. H., & Beaumont, H. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.11.014 · Cited by 17 · see citing works
Camicioli, R. M., & Rockwood, K. J. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-6231-8.10051-0 · Cited by 1 · see citing works
Tu, M. C., Huang, C. W., Chen, N. C., Chang, W. N., Lui, C. C., Chen, C. F., Chen, C., Wang, Y. L., Lin, Y. T., & Chang, C. C. (2010) · Acta Neurologica Taiwanica · doi:10.29819/ant.201009.0004 · cited 2×
“Tu et al.((38)), Taiwan 73·8 years 33 % M 0·5 years n 92 Cr .”
Background
Flagged first, then by citations
Cited by
Sorted by citations
B Vitamins and the Brain: Mechanisms, Dose and Efficacy—A Review
Kennedy, D. (2016) · Nutrients · doi:10.3390/nu8020068 · Cited by 1,055 · see citing works
Green, R., Allen, L. H., Bjørke-Monsen, A.-L., Brito, A., Guéant, J.-L., Miller, J. W., Molloy, A. M., Nexo, E., Stabler, S., Toh, B.-H., et al. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.40 · Cited by 970 · see citing works
Tardy, A.-L., Pouteau, E., Marquez, D., Yilmaz, C., & Scholey, A. (2020) · Nutrients · doi:10.3390/nu12010228 · Cited by 541 · see citing works
Hersi, M., Irvine, B., Gupta, P., Gomes, J., Birkett, N., & Krewski, D. (2017) · NeuroToxicology · doi:10.1016/j.neuro.2017.03.006 · Cited by 332 · see citing works
Nutrition for the ageing brain: Towards evidence for an optimal diet
Vauzour, D., Camprubi-Robles, M., Miquel-Kergoat, S., Andres-Lacueva, C., Bánáti, D., Barberger-Gateau, P., Bowman, G. L., Caberlotto, L., Clarke, R., Hogervorst, E., et al. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.09.010 · Cited by 241 · see citing works
McCleery, J., Abraham, R. P., Denton, D. A., Rutjes, A. W., Chong, L.-Y., Al-Assaf, A. S., Griffith, D. J., Rafeeq, S., Yaman, H., Malik, M. A., et al. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011905.pub2 · Cited by 162 · see citing works
Micronutrient needs of the elderly
Montgomery, S. C., Streit, S. M., Beebe, M. L., & Maxwell, P. J. (2014) · Nutrition in Clinical Practice · doi:10.1177/0884533614537684 · Cited by 50 · see citing works
- Authors
- O'Leary, F., Allman-Farinelli, M., & Samman, S.
- Affiliations
- The University of Sydney (AU)
- Corresponding author
- Samman, Samir
- Venue
- British Journal Of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2012-10-19
- Volume
- 108
- Issue
- 11
- Pages
- 1948-1961
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2161568765
- Cited by
- 96
- References
- 84
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 5 · 2023: 6 · 2022: 8 · 2021: 5 · 2020: 6 · 2019: 4 · 2018: 11 · 2017: 9 · 2016: 11 · 2015: 10 · 2014: 9 · 2013: 1
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Porphyrin Metabolism and Disorders
- Keywords
- vitamin B12 status, cognitive decline, dementia, serum vitamin B12, methylmalonic acid, holotranscobalamin, older adults, neuropsychological assessment
- MeSH terms
- Aged, Aged, 80 and over, Cognition, Cognition Disorders, Dementia, Female, Humans, Male, Methylmalonic Acid, Middle Aged, Nutritional Status, Transcobalamins, Vitamin B 12, Vitamin B 12 Deficiency, Biomarkers, Disease Progression, Cognitive Dysfunction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
