The ALS-FTD-Q: A new screening tool for behavioral disturbances in ALS
Open accessAbstract
OBJECTIVE: The assessment of behavioral disturbances in amyotrophic lateral sclerosis (ALS) is important because of the overlap with the behavioral variant of frontotemporal dementia (ALS-bvFTD). Motor symptoms and dysarthria are not taken into account in currently used behavioral questionnaires. We examined the clinimetric properties of a new behavioral questionnaire for patients with ALS (Amyotrophic Lateral Sclerosis-Frontotemporal Dementia-Questionnaire [ALS-FTD-Q]). METHODS: In addition to other clinimetric properties, we examined reliability, clinical validity, and construct validity of the ALS-FTD-Q, using data from patients with ALS (n = 103), ALS-bvFTD (n = 10), bvFTD (n = 25), muscle disease control subjects (n = 39), and control subjects (n = 31). Construct validity of the ALS-FTD-Q was assessed using the Frontal Systems Behavior scale (FrSBe), Frontal Behavioral Inventory (FBI), Hospital Anxiety and Depression Scale, ALS Functional Rating Scale-Revised, Frontal Assessment Battery, Mini-Mental State Examination, and a fluency index. In addition, the point prevalence of behavioral disturbances according to the ALS-FTD-Q was compared with those obtained with the FrSBe and FBI. RESULTS: The internal consistency of the ALS-FTD-Q was good (Cronbach α = 0.92). The ALS-FTD-Q showed construct validity because it correlated highly with other behavioral measures (r = 0.80 and 0.79), moderately with measures of frontal functions and global cognitive functioning (r = 0.37; r = 0.32), and poorly with anxiety/depression and motor impairment (r = 0.18 for both). The ALS-FTD-Q discriminated between patients with ALS-bvFTD, patients with ALS, and control subjects. The point prevalence of behavioral disturbances in patients with ALS measured with the ALS-FTD-Q was lower than that for the FrSBe and FBI. CONCLUSION: The ALS-FTD-Q is a feasible and clinimetrically validated instrument for the screening of behavioral disturbances in ALS.
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The ALS-FTD-Q shows good internal consistency (Cronbach's alpha = 0.92) as well as construct validity.
“The ALS-FTD-Q shows good internal consistency (Cronbach’s alpha = 0.92) as well as construct validity [36].”
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Self-citationRegional prefrontal cortical atrophy predicts specific cognitive-behavioral symptoms in ALS-FTD
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Japanese version of the ALS-FTD-Questionnaire (ALS-FTD-Q-J)
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- Authors
- Raaphorst, J., Beeldman, E., Schmand, B., Berkhout, J., Linssen, W. H. J. P., van den Berg, L. H., Pijnenburg, Y. A., Grupstra, H. F., Weikamp, J. G., Schelhaas, H. J., Papma, J. M., van Swieten, J. C., de Visser, M., & de Haan, R. J.
- Affiliations
- Radboud University Nijmegen (NL)
- From the Department of Neurology (J.R., E.B., B.S., J.B., M.d.V.), Rehabilitation Medicine (H.F.G.) and Clinical Research Unit (R.J.d.H.), Academic Medical Centre, University of Amsterdam, Amsterdam; Department of Psychology (B.S.), University of Amsterdam, Amsterdam; Department of Neurology (W.H.J.P.L.), Sint Lucas Andreas Hospital, Amsterdam; Department of Neurology (L.H.v.d.B.), Rudolf Magnus Institute, University Medical Center, Utrecht; Department of Neurology (Y.A.P.), Alzheimer Centre VU...
- ORCID
- Venue
- Neurology
- Published
- 2012-09-25
- Volume
- 79
- Issue
- 13
- Pages
- 1377-1383
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2162851271
- Cited by
- 111
- References
- 38
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 9 · 2023: 4 · 2022: 10 · 2021: 6 · 2020: 12 · 2019: 9 · 2018: 7 · 2017: 8 · 2016: 12 · 2015: 10 · 2014: 6 · 2013: 5 · 2012: 2
- FWCI
- 4.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- UvA-DARE (University of Amsterdam) (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion, other-oa)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- VU Research Portal (publishedVersion, other-oa)
- Pure Amsterdam UMC (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- UvA-DARE (University of Amsterdam) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
- Keywords
- amyotrophic lateral sclerosis, behavioral variant frontotemporal dementia, behavioral problems, clinimetric validation, construct validity, reliability statistics, screening tool, Frontal Systems Behavior Scale, Frontal Behavioral Inventory, point prevalence
- MeSH terms
- Aged, Amyotrophic Lateral Sclerosis, Female, Humans, Male, Middle Aged, Muscular Diseases, Neuropsychological Tests, Psychometrics, Surveys and Questionnaires, Frontotemporal Dementia
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