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Cited by 100Tryptophan and brain disordersHepatitis C virus researchTreatment of Major Depression

Depression following pegylated interferon-alpha: Characteristics and vulnerability

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Lotrich, Francis E., Rabinovitz, Mordechai, Gironda, Patricia, Pollock, Bruce G.·2007·Journal of Psychosomatic Research
DOI 10.1016/j.jpsychores.2007.05.013PMC PMC2104514
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Abstract

Objective Interferon-alpha2 (IFN-alpha) injections may be capable of triggering depression in some individuals. The first objective was to further characterize this depression and, secondly, to examine whether pre-treatment temperament was correlated with subsequent vulnerability to IFN-alpha.Methods Twenty-three initially euthymic adults undergoing year-long PEG-IFN-alpha treatment for hepatitis C were evaluated at baseline and then prospectively monitored using both the Structured Clinical Interview for DSM-IV (SCID) and self-report questionnaires.Results A major depressive episode developed within 3 months in 39%. Principal component analysis of the change in self-report scores after 1 month of treatment demonstrated three orthogonal factors: (i) a specific increase in depression as manifested in the Beck Depression Inventory (BDI) and Hospital Anxiety and Depression Scale (HADS), (ii) an increase in hostility and anxiety, (iii) and a generalized combination of worse symptoms including somatic symptoms on the Symptom Check List (SCL-90). BDI at 1 month was predicted by baseline BDI (r=0.76, P=.004). Hostility at 1 month was predicted by low baseline agreeableness (r=0.75, P=.01). Controlling for baseline BDI scores, categorical major depression was predicted by combined high baseline neuroticism and low agreeableness (combined r=0.66, P=.03).Conclusion These initial results (i) support the depressogenic nature of IFN-alpha treatment in a subset of vulnerable individuals, (ii) indicate that some individuals are also independently vulnerable to worsened hostility, and (iii) suggest that it may be possible to clinically predict these vulnerabilities in initially euthymic subjects.

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  • Specific symptoms induced by IFNα administration include anxiety, pain, depressed mood, anhedonia, fatigue, cognitive impairment, sleep disturbance, anger, hostility, loss of appetite, and suicidal ideation.

    “Specific symptoms induced by IFNα administration include anxiety, pain, depressed mood, anhedonia, fatigue, cognitive impairment, sleep disturbance, anger, hostility, loss of appetite, and suicidal ideation”

    From From stress to inflammation and major depressive disorder: A social signal transduction theory of depression. (2014) · cites this paper as Lotrich, Rabinovitz, Gironda, & Pollock, 2007

  • IFN-α can induce depressed mood, fatigue, sleep disturbance, loss of appetite, pain, anxiety, anhedonia, anger, hostility, cognitive impairment, and suicidal ideation.

    “Studies of patients receiving this treatment have shown that IFN-α can induce symptoms of depressed mood, fatigue, sleep disturbance, loss of appetite, pain, anxiety, anhedonia, anger, hostility, cognitive impairment, and suicidal ideation (Capuron et al., 2002; Janssen et al., 1994; Lotrich et al., 2007).”

    From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Lotrich et al., 2007

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Authors
Lotrich, F. E., Rabinovitz, M., Gironda, P., & Pollock, B. G.
Affiliations
  • University of Pittsburgh Medical Center (US)
  • University of Toronto (CA)
Corresponding author
Lotrich, Francis E.
ORCID
Pollock, Bruce G.
Venue
Journal of Psychosomatic Research
Publisher
Elsevier BV
Published
2007-08
Volume
63
Issue
2
Pages
131-135
ISSN
0022-3999 (ISSN-L)
DOI
10.1016/j.jpsychores.2007.05.013
PMC
PMC2104514
OpenAlex
W2068465151
Cited by
100
References
60
Citations by year
2026: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 12 · 2015: 7 · 2014: 8 · 2013: 7 · 2012: 14
FWCI
2.60
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Psychosomatic Research (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Mental Health (MH16804, MH74012, K23MH074012, T32MH016804)
Topics
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Health Sciences › Medicine › Hepatology › Hepatitis C virus research
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
pegylated interferon-alpha, depression, hepatitis C, major depressive episode, hostility, neuroticism, agreeableness, temperament, depression vulnerability, adverse drug reactions, anxiety, somatic symptoms
MeSH terms
Adult, Antiviral Agents, Major Depressive Disorder, Drug Hypersensitivity, Female, Hepatitis C, Humans, Male, Middle Aged, Surveys and Questionnaires, Interferon-alpha, Diagnostic and Statistical Manual of Mental Disorders

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