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Cited by 178

Head trauma and risk of dementia and Alzheimer’s disease: The Rotterdam Study

Mehta, K.M., Ott, A., Kalmijn, S., Slooter, A.J. C., van Duijn, C.M., Hofman, A., Breteler, M.M. B.·1999·Neurology
DOI 10.1212/wnl.53.9.1959
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Abstract

Objective To investigate the relation between head trauma and incidence of dementia in a prospective population-based study. Background Whether head trauma increases the risk of dementia and AD remains controversial. It has been suggested that the risk might be particularly increased for carriers of the APOE-epsilon4 allele. Methods The study population included 6645 participants of the prospective population-based Rotterdam Study, aged 55 years or older, who were free of dementia at baseline. Head trauma with loss of consciousness was measured at baseline by a self-report to a physician and detailed the number of head traumas, time since head trauma, and duration of loss of consciousness. The cohort was followed for incident dementia that was diagnosed according to international criteria. Logistic regression was used to calculate the risk of dementia after adjusting for age, gender, and education. Results No increased risk of dementia or AD was found for persons with a history of head trauma with loss of consciousness (relative risk [RR] for dementia = 1.0, 95% CI, 0.5-2.0; RR for AD = 0.8, 95% CI, 0.4-1.9). Multiple head traumas, time since head trauma, and duration of unconsciousness did not significantly influence the risk of dementia. In addition, the APOE-epsilon4 allele did not modify the relationship. Conclusions This study suggests that mild head trauma is not a major risk factor for dementia or AD in the elderly. In addition, this study does not concur with previous…

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  • Synergistic effects of head injury and APOE genotypes in AD were reported by some studies but not all.

    “Synergistic effects of head injury and APOE genotypes in AD were reported by some (30–32), but not all studies (53;54).”

    From Association of ALS with head injury, cigarette smoking and APOE genotypes (2010) · cites this paper as [54]

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Authors
Mehta, K. M., Ott, A., Kalmijn, S., Slooter, A. J. C., van Duijn, C. M., Hofman, A., & Breteler, M. M. B.
Affiliations
From the Department of Epidemiology and Biostatistics (Drs. MehtaOtt, Kalmijn, Slooter, van Duijn, Hofman, and Breteler), Erasmus University Medical School; and Netherlands Institute for Health Sciences (NIHES) (Dr. Mehta), Erasmus University Medical School, Rotterdam, The Netherlands.
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1999-12
Volume
53
Issue
9
Pages
1959-1959
ISSN
  • 0028-3878
  • 1526-632X
DOI
10.1212/wnl.53.9.1959
Cited by
178
References
2
Language
en

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