Ageing of the brain

Neuropathological stageing of Alzheimer-related changes.

Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · see citing works

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429 · see citing works

Alzheimer's Disease: Genes, Proteins, and Therapy

Selkoe, D. J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.741 · Cited by 6,063 · see citing works

Neurodegenerative Tauopathies

Lee, V. M.-Y., Goedert, M., & Trojanowski, J. Q. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1121 · Cited by 2,480 · see citing works

Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

Morgan, D., Diamond, D. M., Gottschall, P. E., Ugen, K. E., Dickey, C. A., Hardy, J., Duff, K., Jantzen, P. T., DiCarlo, G., Wilcock, D. M., et al. (2000) · Nature · doi:10.1038/35050116 · Cited by 1,488 · see citing works

Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

Janus, C., Pearson, J., McLaurin, J., Mathews, P. M., Jiang, Y., Schmidt, S. D., Chishti, M. A., Horne, P., Heslin, D., French, J., et al. (2000) · Nature · doi:10.1038/35050110 · Cited by 1,431 · see citing works

Greenfield's Neuropathology

(1964) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1964.tb115841.x · Cited by 1,411 · see citing works

Gene-expression profile of the ageing brain in mice

Lee, C.-K., Weindruch, R., & Prolla, T. A. (2000) · Nature Genetics · doi:10.1038/77046 · Cited by 1,055 · see citing works

Effects of age on tissues and regions of the cerebrum and cerebellum.

Jernigan, T., Archibald, S., Fennema-Notestine, C., Gamst, A., Stout, J. C., Bonner, J. C., & Hesselink, J. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00217-2 · Cited by 958 · see citing works

Documented head injury in early adulthood and risk of Alzheimer’s disease and other dementias

Plassman, B. L., Havlik, R. J., Steffens, D. C., Helms, M. J., Newman, T. N., Drosdick, D., Phillips, C., Gau, B. A., Welsh–Bohmer, K. A., Burke, J. R., et al. (2000) · Neurology · doi:10.1212/wnl.55.8.1158 · Cited by 896 · see citing works

Neuron numbers and dendritic extent in normal aging and Alzheimer’s disease

Coleman, P. D., & Flood, D. G. (1987) · Neurobiology of Aging · doi:10.1016/0197-4580(87)90127-8 · Cited by 772 · see citing works

Greenfield's Neuropathology

Geddes, J. F. (1997) · Journal of Clinical Pathology · doi:10.1136/jcp.50.9.798-a · Cited by 725 · see citing works

A Portrait of Alzheimer Secretases--New Features and Familiar Faces

Esler, W. P., & Wolfe, M. S. (2001) · Science · doi:10.1126/science.1064638 · Cited by 493 · see citing works

The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Down's syndrome

Mann, D. M. A., & Esiri, M. M. (1989) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(89)90019-1 · Cited by 471 · see citing works

Activation of caspase-3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer's disease. Evidence for apoptotic cell death.

Stadelmann, C., Deckwerth, T., Srinivasan, A., Bancher, C., Brück, W., Jellinger, K. A., & Lassmann, H. (1999) · American Journal of Pathology · doi:10.1016/s0002-9440(10)65460-0 · Cited by 449 · see citing works

Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: A third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques

Braak, H., Braak, E., Grundke-Iqbal, I., & Iqbal, K. (1986) · Neuroscience Letters · doi:10.1016/0304-3940(86)90288-0 · Cited by 432 · see citing works

Quantitative synaptic alterations in the human neocortex during normal aging

Masliah, E., Mallory, M. E., Hansen, L. A., DeTeresa, R. M., & Terry, R. D. (1993) · Neurology · doi:10.1212/wnl.43.1_part_1.192 · Cited by 408 · see citing works

Susceptibility Locus for Alzheimer's Disease on Chromosome 10

Myers, A., Holmans, P., Marshall, H. N., Kwon, J. M., Meyer, D., Ramic, D., Shears, S., Booth, J., DeVriéze, F. W., Crook, R., et al. (2000) · Science · doi:10.1126/science.290.5500.2304 · Cited by 385 · see citing works

Isoform-specific effects of human apolipoprotein E on brain function revealed in <i>ApoE</i> knockout mice: Increased susceptibility of females

Raber, J., Wong, D., Buttini, M., Orth, M., Bellosta, S., Pitas, R. E., Mahley, R. W., & Mucke, L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10914 · Cited by 364 · see citing works

The effects of aging on gene expression in the hypothalamus and cortex of mice

Jiang, C. H., Tsien, J. Z., Schultz, P. G., & Hu, Y. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.1930 · Cited by 318 · see citing works

Head trauma and risk of dementia and Alzheimer’s disease: The Rotterdam Study

Mehta, K. M., Ott, A., Kalmijn, S., Slooter, A. J. C., van Duijn, C. M., Hofman, A., & Breteler, M. M. B. (1999) · Neurology · doi:10.1212/wnl.53.9.1959 · Cited by 178 · see citing works

The role of apolipoprotein E in Alzheimer’s disease, acute brain injury and cerebrovascular disease: evidence of common mechanisms and utility of animal models

Horsburgh, K. J., McCarron, M. O., White, F., & Nicoll, J. A. R. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00097-x · Cited by 169 · see citing works

ALZHEIMER'S DISEASE: PAIRED HELICAL FILAMENTS AND CYTOMEMBRANES

Gray, E. G., Paula-Barbosa, M., & Roher, A. (1987) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1987.tb00174.x · Cited by 165 · see citing works

Dendritic extent in human dentate gyrus granule cells in normal aging and senile dementia

Flood, D. G., Buell, S. J., Horwitz, G. J., & Coleman, P. D. (1987) · Brain Research · doi:10.1016/0006-8993(87)90027-8 · Cited by 164 · see citing works

Life span and synapses: will there be a primary senile dementia?

Terry, R. D., & Katzman, R. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00250-5 · Cited by 160 · see citing works

Memory performance in healthy elderly without Alzheimer’s disease: effects of time and apolipoprotein-E

Mayeux, R. P., Small, S. A., Tang, M., Tycko, B., & Stern, Y. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00223-8 · Cited by 156 · see citing works

Casein kinase 1 delta is associated with pathological accumulation of tau in several neurodegenerative diseases

Schwab, C., DeMaggio, A. J., Ghoshal, N., Binder, L. I., Kuret, J., & McGeer, P. L. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00110-x · Cited by 148 · see citing works

Lack of replication of association findings in complex disease: an analysis of 15 polymorphisms in prior candidate genes for sporadic Alzheimer's disease

Prince, J. A., Feuk, L., Sawyer, S. L., Gottfries, J., Ricksten, A., Nägga, K., Bogdanović, N., Blennow, K., & Brookes, A. J. (2001) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5200651 · Cited by 141 · see citing works

Diffuse Plaques Contain C-terminal Aβ42and not Aβ40: Evidence From Cats and Dogs

Cummings, B. J., Satou, T., Head, E., Milgram, N. W., Cole, G. M., Savage, M. J., Podlisny, M. B., Selkoe, D. J., Siman, R. G., Greenberg, B., et al. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(96)00062-0 · Cited by 140 · see citing works

Alzheimer's disease and aging: Effects on perforant pathway perikarya and synapses

Lippa, C. F., Hamos, J. E., Pulaski-Salo, D., DeGennaro, L. J., & Drachman, D. A. (1992) · Neurobiology of Aging · doi:10.1016/0197-4580(92)90115-e · Cited by 122 · see citing works

Low education is a genuine risk factor for accelerated memory decline and dementia

Schmand, B. A., Smit, J. H., Lindeboom, J., Smits, C. H. M., Hooijer, C., Jonker, C., & Deelman, B. G. (1997) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(97)00121-2 · Cited by 120 · see citing works

Inducible Nitric Oxide Synthase Immunoreactivity in the Alzheimer Disease Hippocampus: Association with Hirano Bodies, Neurofibrillary Tangles, and Senile Plaques

Lee, S. C., Zhao, M., Hirano, A., & Dickson, D. W. (1999) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199911000-00006 · Cited by 113 · see citing works

Hereditary cerebral haemorrhage with amyloidosis, Dutch type (HCHWA-D): clinicopathological studies.

Wattendorff, A. R., Frangione, B., Luyendijk, W., & Bots, G. T. A. M. (1995) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.58.6.699 · Cited by 103 · see citing works

Simplification of complex peptide mixtures for proteomic analysis: Reversible biotinylation of cysteinyl peptides

Spahr, C. S., Susín, S. A., Bures, E. J., Robinson, J. H., Davis, M. T., McGinley, M. D., Kroemer, G., & Patterson, S. D. (2000) · Electrophoresis · doi:10.1002/(sici)1522-2683(20000501)21:9 · Cited by 100 · see citing works

Complex Trait Analysis of the Hippocampus: Mapping and Biometric Analysis of Two Novel Gene Loci with Specific Effects on Hippocampal Structure in Mice

Lu, L., Airey, D. C., & Williams, R. W. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-10-03503.2001 · Cited by 99 · see citing works

Quantitative assessment of possible age-related change in synaptic numbers in the human frontal cortex

Scheff, S. W., PRICE, D. A., & Sparks, D. L. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00222-6 · Cited by 82 · see citing works

Dendritic extent in human CA2–3 hippocampal pyramidal neurons in normal aging and senile dementia

Flood, D. G., Guarnaccia, M. M., & Coleman, P. D. (1987) · Brain Research · doi:10.1016/0006-8993(87)90744-x · Cited by 79 · see citing works

Changes in the ageing brain in health and disease

Anderton, B. H. (1997) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1997.0162 · Cited by 78 · see citing works

Spongiform alterations in brain biopsies of presenile dementia

Flament-Durand, J., & Couck, A. M. (1979) · Acta Neuropathologica · doi:10.1007/bf00684819 · Cited by 73 · see citing works

Stability of neuronal number in the human nucleus basalis of Meynert with age

Chui, H. C., Bondareff, W., Zarow, C., & Slager, U. T. (1984) · Neurobiology of Aging · doi:10.1016/0197-4580(84)90035-6 · Cited by 72 · see citing works

Granulovacuolar degeneration in the hippocampal cortex of aging and demented patients ? a quantitative study

Xu, M., Shibayama, H., Kobayashi, H., Yamada, K., Ishihara, R., Zhao, P., Takeuchi, T., Yoshida, K., Inagaki, T., & Nokura, K. (1992) · Acta Neuropathologica · doi:10.1007/bf00304627 · Cited by 58 · see citing works

Immunohistological study of granulovacuolar degeneration using monoclonal antibodies to neurofilaments.

Kahn, J., Anderton, B. H., Probst, A., ULRICH, J., & Esiri, M. M. (1985) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.48.9.924 · Cited by 43 · see citing works

Ultrastructural and permeability features of microvessels in the hippocampus, cerebellum and pons of senescence-accelerated mice (SAM)

Ueno, M., Sakamoto, H., Kanenishi, K., Onodera, M., Akiguchi, I., & Hosokawa, M. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00213-5 · Cited by 37 · see citing works

Phosphorylated tau immunoreactivity of granulovacuolar bodies (GVB) of Alzheimer's disease: localization of two amino terminal tau epitopes in GVB

Dickson, D. W., Liu, W.-K., Kress, Y., Ku, J., DeJesus, O. T., & Yen, S.-H. C. (1993) · Acta Neuropathologica · doi:10.1007/bf00230483 · Cited by 32 · see citing works

Dementia with leucoaraiosis and dural arteriovenous malformation: clinical and PET case study.

Nencini, P., Inzitari, D., Gibbs, J., & Mangiafico, S. (1993) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.56.8.929 · Cited by 26 · see citing works

Age-related changes in basal dendrite and dendritic spine of hippocampal pyramidal neurons (CA1) among SAMP1TANgs — quantitative analysis by the rapid Golgi method

Kawaguchi, S., Kishikawa, M., Sakae, M., & Nakane, Y. (1995) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(95)01607-2 · Cited by 20 · see citing works

Which synapses are affected in aging and what is the nature of their vulnerability? A commentary on “life span and synapses: will there be a primary senile dementia?”

Morrison, J. H. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00244-x · Cited by 13 · see citing works

Vacuolar neuritic dystrophy in aged mouse superior cervical sympathetic ganglia is strain-specific

Schmidt, R. E., Dorsey, D. A., Beaudet, L. N., Plurad, S. B., Parvin, C. A., & Bruch, L. A. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00678-7 · Cited by 11 · see citing works

Senile cerebral amyloidosis (pathological aging) and cognitive status predictions: A neuropathology perspective

Dickson, D. W. (1996) · Neurobiology of Aging · doi:10.1016/s0197-4580(96)00173-x · Cited by 7 · see citing works

Neocortical neuron number in humans: Effect of sex and age

(1997) · doi:10.1002/(sici)1096-9861(19970728)384:2

Long-chain omega-3 fatty acids and the brain: A review of the independent and shared effects of EPA, DPA and DHA

Dyall, S. C. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00052 · Cited by 943 · see citing works

Ageing and the brain

Peters, R. (2006) · Postgraduate Medical Journal · doi:10.1136/pgmj.2005.036665 · Cited by 894 · see citing works

A “mitochondrial cascade hypothesis” for sporadic Alzheimer’s disease

Swerdlow, R. H., & Khan, S. M. (2004) · Medical Hypotheses · doi:10.1016/j.mehy.2003.12.045 · Cited by 758 · see citing works

Series Introduction: Neurodegeneration: What is it and where are we?

Przedborski, S., Vila, M., & Jackson-Lewis, V. R. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317522 · Cited by 585 · see citing works

Disconnected aging: Cerebral white matter integrity and age-related differences in cognition

Bennett, I. J., & Madden, D. J. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.11.026 · Cited by 492 · see citing works

Mitochondria, metabolic disturbances, oxidative stress and the kynurenine system, with focus on neurodegenerative disorders

Sas, K., Robotka, H., Toldi, J., & Vécsei, L. (2007) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2007.01.033 · Cited by 465 · see citing works

Understanding the gastrointestinal tract of the elderly to develop dietary solutions that prevent malnutrition

Rémond, D., Shahar, D. R., Gille, D., Pinto, P., Kachal, J., Peyron, M., dos Santos, C. N., Walther, B., Bordoni, A., Dupont, D., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.4030 · Cited by 334 · see citing works

Insulin in Central Nervous System: More than Just a Peripheral Hormone

Duarte, A. I., Moreira, P. I., & Oliveira, C. R. (2012) · Journal of Aging Research · doi:10.1155/2012/384017 · Cited by 324 · see citing works

Neurological Benefits of Omega-3 Fatty Acids

Dyall, S. C., & Michael-Titus, A. T. (2008) · NeuroMolecular Medicine · doi:10.1007/s12017-008-8036-z · Cited by 307 · see citing works

Normal Aging Induces Changes in the Brain and Neurodegeneration Progress: Review of the Structural, Biochemical, Metabolic, Cellular, and Molecular Changes

Lee, J., & Kim, H.-J. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.931536 · Cited by 310 · see citing works

Brain aging, Alzheimer's disease, and mitochondria

Swerdlow, R. H. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.08.012 · Cited by 306 · see citing works

Nutrition and the gut microbiome in the elderly

Salazar, N., Valdés-Varela, L., González, S., Gueimonde, M., & de los Reyes-Gavilán, C. G. (2017) · Gut Microbes · doi:10.1080/19490976.2016.1256525 · Cited by 282 · see citing works

How does high DHA fish oil affect health? A systematic review of evidence

Fard, S. G., Wang, F., Sinclair, A. J., Elliott, G., & Turchini, G. M. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1425978 · Cited by 259 · see citing works

Increased Alzheimer pathology in Parkinson's disease related to antimuscarinic drugs

Perry, E. K., Kilford, L., Lees, A. J., Burn, D. J., & Perry, R. H. (2003) · Annals of Neurology · doi:10.1002/ana.10639 · Cited by 229 · see citing works

Review article What causes alzheimer’s disease?

Armstrong, R. A. (2013) · Folia Neuropathologica · doi:10.5114/fn.2013.37702 · Cited by 220 · see citing works

Quantitative Analysis of Retinal Ganglion Cell (RGC) Loss in Aging DBA/2NNia Glaucomatous Mice: Comparison with RGC Loss in Aging C57/BL6 Mice

Danias, J., Lee, K. C., Zamora, M.-F., Chen, B., Shen, F., Filippopoulos, T., Su, Y., Goldblum, D., Podos, S. M., & Mittag, T. W. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.02-1101 · Cited by 205 · see citing works

Symptom Management in the Elderly Cancer Patient: Fatigue, Pain, and Depression

Rao, A. V. (2004) · JNCI Monographs · doi:10.1093/jncimonographs/lgh031 · Cited by 200 · see citing works

Alzheimer's Disease: Redox Dysregulation As a Common Denominator for Diverse Pathogenic Mechanisms

Rommy von Bernhardi, M., & Eugenín, J. L. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4082 · Cited by 189 · see citing works

Role of the ubiquitin proteasome system in Alzheimer's disease

Upadhya, S. C., & Hegde, A. N. (2007) · BMC Biochemistry · doi:10.1186/1471-2091-8-s1-s12 · Cited by 184 · see citing works

Aging, cognition, and culture: a neuroscientific perspective

Park, D. C. (2002) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(02)00072-6 · Cited by 173 · see citing works

Aging, lifestyle and dementia

Wahl, D., Solon‐Biet, S. M., Cogger, V. C., Fontana, L., Simpson, S. J., Couteur, D. G. L., & Ribeiro, R. V. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104481 · Cited by 151 · see citing works

Is aging part of Alzheimer's disease, or is Alzheimer's disease part of aging?

Swerdlow, R. H. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.06.021 · Cited by 144 · see citing works

Contribution of hypoxia to Alzheimer’s disease: is HIF-1α a mediator of neurodegeneration?

Ogunshola, O. O., & Antoniou, X. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0141-0 · Cited by 128 · see citing works

Age-related functional reorganization, structural changes, and preserved cognition

David Meunier, A., Stamatakis, E. A., & TYLER, L. K. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.07.003 · Cited by 118 · see citing works

Evidence for widespread, severe brain copper deficiency in Alzheimer's dementia

Xu, J., Church, S. J., Patassini, S., Begley, P., Waldvogel, H. J., Curtis, M. A., Faull, R. L. M., Unwin, R. D., & Cooper, G. J. S. (2017) · Metallomics · doi:10.1039/c7mt00074j · Cited by 113 · see citing works

Neurological disorders and therapeutics targeted to surmount the blood–brain barrier

Kanwar, J. R., Sriramoju, & Kanwar (2012) · International Journal of Nanomedicine · doi:10.2147/ijn.s30919 · Cited by 113 · see citing works

Nutritional strategies to optimise cognitive function in the aging brain

Wahl, D., Cogger, V. C., Solon‐Biet, S. M., Waern, R. V. R., Gokarn, R., Pulpitel, T., de Cabo, R., Mattson, M. P., Raubenheimer, D., Simpson, S. J., et al. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.06.006 · Cited by 114 · see citing works

The role of the ubiquitin proteasome system in Alzheimer's disease

Riederer, B. M., Leuba, G., Vernay, A., & Riederer, I. M. (2011) · Experimental Biology and Medicine · doi:10.1258/ebm.2010.010327 · Cited by 110 · see citing works

Aging brain mechanics: Progress and promise of magnetic resonance elastography

Hiscox, L. V., Schwarb, H. D., McGarry, M., & Johnson, C. L. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.117889 · Cited by 105 · see citing works

Factors associated with brain ageing - a systematic review

Wrigglesworth, J., Ward, P. G. D., Harding, I. H., Nilaweera, D., Wu, Z., Woods, R. L., & Ryan, J. L. (2021) · BMC Neurology · doi:10.1186/s12883-021-02331-4 · Cited by 108 · see citing works

Possible Mechanisms of Neurodegeneration in Schizophrenia

Pérez‐Neri, I., Ramírez‐Bermúdez, J., Montes, S., & Rı́os, C. (2006) · Neurochemical Research · doi:10.1007/s11064-006-9162-3 · Cited by 100 · see citing works

The untwining of immunosenescence and aging

Xu, W., Wong, G. C. L., Hwang, Y. Y., & Larbi, A. (2020) · Seminars in Immunopathology · doi:10.1007/s00281-020-00824-x · Cited by 104 · see citing works

Age-related differences in the qualities but not the intensity of chronic pain

Gagliese, L., & Melzack, R. (2003) · Pain · doi:10.1016/s0304-3959(03)00117-9 · Cited by 99 · see citing works

Effects of Melatonin on Nervous System Aging: Neurogenesis and Neurodegeneration

Sarlak, G., Jenwitheesuk, A., Chetsawang, B., & Govitrapong, P. (2013) · Journal of Pharmacological Sciences · doi:10.1254/jphs.13r01sr · Cited by 87 · see citing works

Decreased social interaction in aged rats may not reflect changes in anxiety-related behaviour

Salchner, P., Lübec, G., & Singewald, N. (2003) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.07.002 · Cited by 84 · see citing works

Relationship Between Sulcal Characteristics and Brain Aging

Jin, K., Zhang, T., Shaw, M. E., Sachdev, P. S., & Cherbuin, N. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00339 · Cited by 83 · see citing works

The impairment of insulin signaling in Alzheimer's disease

Candeias, E., Duarte, A. I., Carvalho, C., Correia, S. C., Cardoso, S., Santos, R. X., Plácido, A. I., Perry, G. L., & Moreira, P. I. (2012) · IUBMB Life · doi:10.1002/iub.1098 · Cited by 79 · see citing works

Molecular and cellular characterization of the age‐related neuroinflammatory processes occurring in normal rat hippocampus: potential relation with the loss of somatostatin GABAergic neurons

Gavilán, M. P., Revilla, E., Pintado, C., Castaño, A., Vizuete, M., Moreno‐González, I., Baglietto‐Vargas, D., Sanchez-Varo, R. M., Vitórica, J., Gutiérrez, A., et al. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04787.x · Cited by 77 · see citing works

Association between Time Restricted Feeding and Cognitive Status in Older Italian Adults

Currenti, W., Godos, J., Castellano, S., Caruso, G., Ferri, R., Caraci, F., Grosso, G., & Galvano, F. (2021) · Nutrients · doi:10.3390/nu13010191 · Cited by 75 · see citing works

Friend or Foe? Defining the Role of Glutamate in Aging and Alzheimer’s Disease

Cox, M. F., Hascup, E. R., Bartke, A., & Hascup, K. N. (2022) · Frontiers in Aging · doi:10.3389/fragi.2022.929474 · Cited by 70 · see citing works

Sex and symmetry differences in hippocampal volumetrics: Before and beyond the opening of the crus of the fornix

Maller, J. J., Réglade‐Meslin, C., Anstey, K. J., & Sachdev, P. S. (2005) · Hippocampus · doi:10.1002/hipo.20133 · Cited by 65 · see citing works

A perspective on brain-age estimation and its clinical promise

Gaser, C., Kalc, P., & Cole, J. H. (2024) · Nature Computational Science · doi:10.1038/s43588-024-00659-8 · Cited by 62 · see citing works

Beneficial effects of dietary restriction in aging brain

Hadem, I. K. H., Majaw, T., Kharbuli, B., & Sharma, R. (2019) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2017.10.001 · Cited by 59 · see citing works

HIF‐1α cytoplasmic accumulation is associated with cell death in old rat cerebral cortex exposed to intermittent hypoxia

Rapino, C., Bianchi, G., Giulio, C. D., Centurione, L., Cacchio, M., Antonucci, A. T., & Cataldi, A. (2005) · Aging Cell · doi:10.1111/j.1474-9726.2005.00161.x · Cited by 60 · see citing works

The aging brain: sleep, the circadian clock and exercise

Panagiotou, M., Michel, S. H., Meijer, J. H., & Deboer, T. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114563 · Cited by 59 · see citing works

Glutamate changes in healthy young adulthood

Marsman, A., Mandl, R. C. W., van den Heuvel, M. P., Boer, V. O., Wijnen, J. P., Klomp, D. W. J., Luijten, P. R., & Pol, H. E. H. (2012) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.11.003 · Cited by 64 · see citing works

MRI-based evaluation of structural degeneration in the ageing brain: Pathophysiology and assessment

Grajauskas, L. A., Siu, W. W. Y., Medvedev, G., Guo, H., D’Arcy, R. C. N., & Song, X. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.11.004 · Cited by 56 · see citing works

Cognitive effects of a dietary supplement made from extract of Bacopa monnieri, astaxanthin, phosphatidylserine, and vitamin E in subjects with mild cognitive impairment: A noncomparative, exploratory clinical study

Zanotta, D., Puricelli, S., & Bonoldi, G. (2014) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s51092 · Cited by 54 · see citing works

Sex steroid hormones and cognitive functioning in healthy, older men

Matousek, R. H., & Sherwin, B. B. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.01.004 · Cited by 54 · see citing works

Glucose hypometabolism is highly localized, but lower cortical thickness and brain atrophy are widespread in cognitively normal older adults

Nugent, S., Castellano, C., Goffaux, P., Whittingstall, K., Lepage, M., Paquet, N., Bocti, C., Fülöp, T., & Cunnane, S. C. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00067.2014 · Cited by 47 · see citing works

Age-related changes in vagal afferents innervating the gastrointestinal tract

Phillips, R. J., Walter, G. C., & Powley, T. L. (2009) · Autonomic Neuroscience · doi:10.1016/j.autneu.2009.07.009 · Cited by 46 · see citing works

Neuron loss associated with age but not Alzheimer's disease pathology in the chimpanzee brain

Edler, M. K., Munger, E. L., Meindl, R. S., Hopkins, W. D., Ely, J. J., ERWIN, J. M., Mufson, E. J., Hof, P. R., Sherwood, C. C., & Raghanti, M. A. (2020) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2019.0619 · Cited by 44 · see citing works

The therapeutic potential of exercise for neuropsychiatric diseases: A review

Swenson, S., Blum, K., McLaughlin, T., Gold, M. S., & Thanos, P. K. (2020) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2020.116763 · Cited by 42 · see citing works

d-serine in physiological and pathological brain aging

Ploux, E., Fréret, T., & Billard, J. (2020) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2020.140542 · Cited by 42 · see citing works

Mesenchymal stem cells-based therapy as a potential treatment in neurodegenerative disorders: is the escape from senescence an answer?

Castorina, A., Szychlinska, M. A., Marzagalli, R., & Musumeci, G. (2015) · Neural Regeneration Research · doi:10.4103/1673-5374.158352 · Cited by 42 · see citing works

Advanced brain ageing in adult psychopathology: A systematic review and meta-analysis of structural MRI studies

Blake, K. V., Ntwatwa, Z., Kaufmann, T., Stein, D. J., Ipser, J., & Groenewold, N. A. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.11.011 · Cited by 40 · see citing works

Effect of aging on the cerebral processing of thermal pain in the human brain

Tseng, M., Chiang, M.-C., Yazhuo, K., Chao, C., Tseng, W. I., & Hsieh, S. (2013) · Pain · doi:10.1016/j.pain.2013.06.041 · Cited by 40 · see citing works

Exogenous melatonin decreases age-induced lipid peroxidation in the brain

AKBULUT, K. G., Gönül, B., & Akbulut, H. (2008) · Brain Research · doi:10.1016/j.brainres.2008.08.014 · Cited by 40 · see citing works

Plasma vitamin C, cholesterol and homocysteine are associated with grey matter volume determined by MRI in non-demented old people

Whalley, L. J., Staff, R. T., Murray, A. D., Duthie, S. J., Collins, A. R., Lemmon, H. A., Starr, J. M., & Deary, I. J. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(02)01452-0 · Cited by 39 · see citing works

Effect of Chronic Administration of Resveratrol on Cognitive Performance during Aging Process in Rats

Navarro-Cruz, A. R., y Ayala, R. R., Ochoa‐Velasco, C. E., Brambila, E., Ávila-Sosa, R., Pérez-Fernández, S., Morales‐Medina, J. C., & Aguilar‐Alonso, P. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/8510761 · Cited by 39 · see citing works

Brain white matter tract integrity and cognitive abilities in community-dwelling older people: The Lothian Birth Cohort, 1936.

Booth, T., Bastin, M. E., Penke, L., Maniega, S. M., Murray, C. L., Royle, N. A., Gow, A. J., Corley, J., Henderson, R. D., Hernández, M. D. C. V., et al. (2013) · Neuropsychology · doi:10.1037/a0033354 · Cited by 38 · see citing works

Effects of cerebrovascular risk factors on gray matter volume in adults aged 60–64 years: A voxel-based morphometric study

Chen, X., Wen, W. X., Anstey, K. J., & Sachdev, P. S. (2006) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2006.01.009 · Cited by 37 · see citing works

Dietary Epicatechin, A Novel Anti-aging Bioactive Small Molecule

Si, H., Lai, C., & Liu, D. (2019) · Current Medicinal Chemistry · doi:10.2174/0929867327666191230104958 · Cited by 36 · see citing works

Protective Role of Capsaicin in Neurological Disorders: An Overview

Tyagi, S., Shekhar, N., & Thakur, A. K. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03549-5 · Cited by 37 · see citing works

Influences of brain development and ageing on cortical interactive networks

Zhu, C., Guo, X., Jin, Z., Sun, J., Qiu, Y., Zhu, Y., & Tong, S. (2010) · Clinical Neurophysiology · doi:10.1016/j.clinph.2010.06.016 · Cited by 34 · see citing works

Age-dependent changes in the medial prefrontal cortex and medial amygdala structure, and elevated plus-maze performance in the healthy male Wistar rats

Sotoudeh, N., Namavar, M. R., Zarifkar, A., & Heidarzadegan, A. R. (2020) · IBRO Reports · doi:10.1016/j.ibror.2020.08.002 · Cited by 34 · see citing works

Role of 3D Printing in the Development of Biodegradable Implants for Central Nervous System Drug Delivery

Kutlehria, S., D’souza, A. A., Bleier, B. S., & Amiji, M. M. (2022) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.2c00344 · Cited by 30 · see citing works

Subthreshold Depressive Symptoms have a Negative Impact on Cognitive Functioning in Middle-Aged and Older Males

Brevik, E. J., Eikeland, R., & Lundervold, A. J. (2013) · Frontiers in Psychology · doi:10.3389/fpsyg.2013.00309 · Cited by 30 · see citing works

Stroke Induces a BDNF-Dependent Improvement in Cognitive Flexibility in Aged Mice

Houlton, J., Zhou, L. Y. Y., Barwick, D., Gowing, E. K., & Clarkson, A. N. (2019) · Neural Plasticity · doi:10.1155/2019/1460890 · Cited by 30 · see citing works

Is there an association between daytime napping, cognitive function, and brain volume? A Mendelian randomization study in the UK Biobank

Paz, V., Dashti, H. S., & Garfield, V. (2023) · Sleep Health · doi:10.1016/j.sleh.2023.05.002 · Cited by 29 · see citing works

Brain age prediction across the human lifespan using multimodal MRI data

Guan, S., Jiang, R., Meng, C., & Biswal, B. B. (2023) · GeroScience · doi:10.1007/s11357-023-00924-0 · Cited by 31 · see citing works

Fasting and Fast Food Diet Play an Opposite Role in Mice Brain Aging

Castrogiovanni, P., Volti, G. L., Sanfilippo, C., Tibullo, D., Galvano, F., Vecchio, M. M., Avola, R., Barbagallo, I. A., Malaguarnera, L., Castorina, S., et al. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-0891-5 · Cited by 28 · see citing works

Optical imaging of resting-state functional connectivity in a novel arterial stiffness model

Guevara, E., Sadekova, N., Girouard, H., & Lesage, F. (2013) · Biomedical Optics Express · doi:10.1364/boe.4.002332 · Cited by 28 · see citing works

Curcumin improves D-galactose and normal-aging associated memory impairment in mice: In vivo and in silico-based studies

Rahman, M. A., Shuvo, A. A., Bepari, A. K., Apu, M. H., Shill, M. C., Hossain, M., Uddin, M. J., Islam, M. R., Bakshi, M. K., Hasan, J., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0270123 · Cited by 27 · see citing works

A large-scale ENIGMA multisite replication study of brain age in depression

Han, L. K. M., Dinga, R., Leenings, R., Hahn, T., Cole, J. H., Aftanas, L., Amod, A. R., Besteher, B., Colle, R., Corruble, E., et al. (2022) · bioRxiv · doi:10.1016/j.ynirp.2022.100149 · Cited by 29 · see citing works

Healthy Brain Aging

Kaye, J. A. (2002) · Archives of Neurology · doi:10.1001/archneur.59.11.1721 · Cited by 27 · see citing works

rTMS alleviates AD-induced cognitive impairment by inhibitng apoptosis in SAMP8 mouse

Bao, Z., Bao, L., Han, N., Hou, Y., & Feng, F. (2021) · Aging · doi:10.18632/aging.203796 · Cited by 26 · see citing works

Effects of gender, age, and body parameters on the ventricular volume of Korean people

Chung, S.-C., Tack, G., Yi, J., Lee, B., Choi, M., Lee, B.-Y., & Lee, S. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.10.066 · Cited by 26 · see citing works

Calorie restriction attenuates astrogliosis but not amyloid plaque load in aged rhesus macaques: A preliminary quantitative imaging study

Sridharan, A., Pehar, M., Salamat, M. S., Pugh, T. D., Bendlin, B. B., Willette, A. A., Anderson, R. M., Kemnitz, J. W., Colman, R. J., Weindruch, R. H., et al. (2013) · Brain Research · doi:10.1016/j.brainres.2013.02.046 · Cited by 26 · see citing works

Metallothionein isoforms (I + II and III) and interleukin-6 in the hippocampus of old rats: may their concomitant increments lead to neurodegeneration?

Mocchegiani, E., Giacconi, R., Fattoretti, P., Casoli, T., Cipriano, C., Muti, E., Malavolta, M., Stefano, G. D., & Bertoni–Freddari, C. (2004) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2004.02.004 · Cited by 24 · see citing works

Selective Atrophy of Left Hemisphere and Frontal Lobe of the Brain in Old Men

Shan, Z., Liu, J., Sahgal, V., Wang, B., & Yue, G. H. (2005) · The Journals of Gerontology Series A · doi:10.1093/gerona/60.2.165 · Cited by 23 · see citing works

Comparative bioenergetic study of neuronal and muscle mitochondria during aging

Li, H., Sharma, L. K., Li, Y.-F., Hu, P., Idowu, A., Liu, D., Lü, J., & Bai, Y. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.04.030 · Cited by 22 · see citing works

Anticipatory Motor Planning in Older Adults

Wunsch, K., Weigelt, M., & Stöckel, T. (2015) · The Journals of Gerontology Series B · doi:10.1093/geronb/gbv078 · Cited by 22 · see citing works

Alcohol use disorder is associated with DNA methylation-based shortening of telomere length and regulated by TESPA1: implications for aging

Jung, J., McCartney, D. L., Wagner, J., Rosoff, D. B., Schwandt, M. L., Sun, H., Wiers, C. E., de Carvalho, L. M., Volkow, N. D., Walker, R. M., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01624-5 · Cited by 21 · see citing works

Differences in scalp-to-cortex tissues across age groups, sexes and brain regions: Implications for neuroimaging and brain stimulation techniques

Hoornweder, S. V., Geraerts, M., Verstraelen, S., Nuyts, M., Caulfield, K. A., & Meesen, R. (2024) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2024.02.011 · Cited by 21 · see citing works

Disease-directed engineering for physiology-driven treatment interventions in neurological disorders

Wood, T. R., & Nance, E. A. (2019) · APL Bioengineering · doi:10.1063/1.5117299 · Cited by 20 · see citing works

Carnosine research in relation to aging brain and neurodegeneration: A blessing for geriatrics and their neuronal disorders

Banerjee, S., & Poddar, M. K. (2020) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2020.104239 · Cited by 20 · see citing works

Quantitative age-related changes in dorsal lateral geniculate nucleus relay neurons of the rat

Vidal, L., Ruı́z, C., Villena, A., Dı́az, F., & de Vargas, I. P. (2004) · Neuroscience Research · doi:10.1016/j.neures.2003.12.004 · Cited by 20 · see citing works

Caloric restriction modulates the monoaminergic system and metabolic hormones in aged rats

Tresserra, M. P., Rojic-Becker, D., Vega-Carbajal, C., Guillazo‐Blanch, G., Vale-Martı́nez, A., & Martí‐Nicolovius, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-76219-7 · Cited by 19 · see citing works

Sex as a Determinant of Age-Related Changes in the Brain

Burmistrov, D., Gudkov, S., Franceschi, C., & Vedunova, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137122 · Cited by 19 · see citing works

Age-related appearance of dendritic inclusions in catecholaminergic brainstem neurons

Braak, H., Thal, D. R., Matschke, J., Ghebremedhin, E., & Tredici, K. D. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.02.031 · Cited by 19 · see citing works

Aging and Neuroinflammatory Disorders: New Biomarkers and Therapeutic Targets

Gambino, C. M., Sasso, B. L., Bivona, G., Agnello, L., & Ciaccio, M. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666191112093034 · Cited by 19 · see citing works

‘When an old rat smells a cat’: A decline in defense-related, but not accessory olfactory, Fos expression in aged rats

Hunt, G. E., Nieuwenhuijzen, P. S. V., Chan‐Ling, T., & McGregor, I. S. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.03.014 · Cited by 19 · see citing works

Self-perception and Experiential Schemata in the Addicted Brain

Cannon, R. L., Lubar, J., & Baldwin, D. R. (2008) · Applied Psychophysiology and Biofeedback · doi:10.1007/s10484-008-9067-9 · Cited by 20 · see citing works

Recent Advancements in Nanocarrier-assisted Brain Delivery of Phytochemicals Against Neurological Diseases

Mishra, K., Rana, R., Tripathi, S., Siddiqui, S., Yadav, P. K., Yadav, P. N., & Chourasia, M. K. (2023) · Neurochemical Research · doi:10.1007/s11064-023-03955-3 · Cited by 18 · see citing works

Apparent diffusion coefficient in the aging mouse brain: A magnetic resonance imaging study

Rau, P., Sellner, J., Heiland, S., Plaschke, K., Schellinger, P. D., Meyding‐Lamadé, U., & Lamadé, W. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.06.032 · Cited by 18 · see citing works

Mesenchymal stem cells: A revolution in therapeutic strategies of age-related diseases

Peng, Y., Huang, S., Cheng, B., Nie, X., Jirigala, E., Feng, C., & Fu, X. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2012.04.005 · Cited by 17 · see citing works

Oxidation and ubiquitination in neurodegeneration

Riederer, B. M., Leuba, G., & ElHajj, Z. (2013) · Experimental Biology and Medicine · doi:10.1177/1535370213488484 · Cited by 16 · see citing works

The effect of camel milk curd masses on rats blood serum biochemical parameters: Preliminary study

Dikhanbayeva, F., Zhaxybayeva, E., Смаилова, Ж., Issimov, A., Dimitrov, Z., Наурзбаевна, К. У., & Bansal, N. (2021) · PLoS ONE · doi:10.1371/journal.pone.0256661 · Cited by 16 · see citing works

Pain in the elderly

Ellis, W., Melzack, R., & Gagliese, L. (2004) · Journal of Pain · doi:10.1016/j.jpain.2004.02.137 · Cited by 16 · see citing works

Changes in the ageing brain in health and disease

Anderton, B. H. (1997) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1997.0162 · Cited by 78 · see citing works

Patogenia do envelhecimento cerebral

Pimentel, J. G. (1988) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) · doi:10.17575/rpsicol.v6i2.800 · Cited by 1 · see citing works

Alzheimer’s Disease and the Aging Brain

Terry, R. D. (2006) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988706291079 · Cited by 115 · see citing works

Pathophysiology of Ageing Brain

DAVISON, A. N. (2009) · Gerontology · doi:10.1159/000212866 · Cited by 22 · see citing works

Neuropathology of the ageing brain

Hof, P. R., Bussière, T., & Morrison, J. H. (2004) · Cambridge University Press eBooks · doi:10.1017/cbo9780511526886.008