Self-reported head injury and risk of late-life impairment and AD pathology in an AD center cohort
Open accessAbstract
Aims: To evaluate the relationship between self-reported head injury and cognitive impairment, dementia, mortality, and Alzheimer's disease (AD)-type pathological changes. Methods: Clinical and neuropathological data from participants enrolled in a longitudinal study of aging and cognition (n = 649) were analyzed to assess the chronic effects of self-reported head injury. Results: The effect of self-reported head injury on the clinical state depended on the age at assessment: for a 1-year increase in age, the OR for the transition to clinical mild cognitive impairment (MCI) at the next visit for participants with a history of head injury was 1.21 and 1.34 for the transition from MCI to dementia. Without respect to age, head injury increased the odds of mortality (OR = 1.54). Moreover, it increased the odds of a pathological diagnosis of AD for men (OR = 1.47) but not women (OR = 1.18). Men with a head injury had higher mean amyloid plaque counts in the neocortex and entorhinal cortex than men without. Conclusions: Self-reported head injury is associated with earlier onset, increased risk of cognitive impairment and dementia, increased risk of mortality, and AD-type pathological changes.
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This might explain why family carer proxies show only low-to-moderate agreement with stated end-of-life treatment preferences of people with dementia.
“This might explain why family carer proxies show only low-to-moderate agreement with stated end-of-life treatment preferences of people with dementia.309”
From Dementia prevention, intervention, and care: 2020 report of the Lancet Commission (2020) · cites this paper as [309]
The Methods (Statistical Analysis; page not provided) and Results (Clinical Data; page not provided) examine head injury and transitions to cognitive impairment or dementia. Searches for family-carer proxies, surrogate decisions, and agreement about end-of-life treatment preferences found no passage addressing the cited claim. (LLM, conf=0.77)
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- Authors
- Abner, E. L., Nelson, P. T., Schmitt, F. A., Browning, S. R., Fardo, D. W., Wan, L., Jicha, G. A., Cooper, G. E., Smith, C. D., Caban-Holt, A. M., Van Eldik, L. J., & Kryscio, R. J.
- Affiliations
- University of Kentucky (US)
- Central Baptist Hospital (US)
- ORCID
- Venue
- Dementia and Geriatric Cognitive Disorders
- Publisher
- S. Karger AG
- Published
- 2013-12-31
- Volume
- 37
- Issue
- 5-6
- Pages
- 294-306
- ISSN
- 1420-8008 (ISSN-L)
- 1421-9824
- PMC
- PMC4057973
- OpenAlex
- W2044868747
- Cited by
- 84
- References
- 39
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 5 · 2023: 8 · 2022: 8 · 2021: 10 · 2020: 11 · 2019: 8 · 2018: 4 · 2017: 6 · 2016: 10 · 2015: 5
- FWCI
- 3.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Dementia and Geriatric Cognitive Disorders (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- UKnowledge (University of Kentucky) (submittedVersion)
- Funders
- University of Kentucky (P30 AG028383, AG028383, UL1 TR000117)
- National Institutes of Health (UL1TR000117, 5r01ag038651-10)
- National Institute on Aging (AG-028383, R01AG019241, R01‐AG038651, P30AG028383, K25AG043546)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, mild cognitive impairment, dementia, mortality, amyloid plaques, entorhinal cortex, sex differences, cognitive aging, neuropathology, late-life cognitive impairment
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, Alzheimer Disease, Brain, Brain Concussion, Educational Status, Female, Craniocerebral Trauma, Humans, Male, Markov Chains, Middle Aged, Retrospective Studies, Risk Factors, Unconsciousness, Cohort Studies, Linear Models, Cognitive Dysfunction
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